<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation L10I
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 118
Isolates 121
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Chantratita (2002)VL337VL337AF172706PINAG48V, V82AF53L, L89VL10I, I13V, K20I, E35D, M36I, N37D, L63P, H69K, A71V, T74SCRF01_AE
 VL245VL245AF191208PINAG48V, L90ML33F, F53L, N83DL10I, I13V, E35D, M36I, R41K, K43Q, L63P, H69K, L89ICRF01_AE
 G25G25AF193893PINA  L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G78G78AF240399PINAM46I, L76V, V82F L10I, I13V, K20I, E35N, M36I, R41K, Q61H, L63C, H69K, K70R, L89MCRF01_AE
 G72G72AF240395PINAG48M, I54V, V82A L10I, I13V, K20I, E35D, M36I, R41K, H69K, L89ICRF01_AE
 G70G70AF240394PINAG48V, I54V, V82AF53LL10I, I13V, K20I, E35D, M36I, R41K, H69K, T74S, L89ICRF01_AE
 G67G67AF240392PINAI54V, V82F, L90M L10I, I13V, K20I, E35N, M36I, R41K, L63P, H69K, T74S, L89M, I93MCRF01_AE
 G66G66AF240391PINAI54V, V82F, L90M L10I, I13V, K20I, E35N, M36I, R41K, L63P, H69K, T74S, L89M, I93MCRF01_AE
 G65G65AF240390PINAG48V, I54M, V82AL33F, F53L, N83DL10I, G16A, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93LCRF01_AE
 G63G63AF240388PINAG48V, I54V, V82A L10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69K, L89ICRF01_AE
Gibb (2002)DMG66_w2 NFV3  L10I, I13V, Q18E, M36I, R41K, L63V, H69K, L89ICRF01_AE
Papa (2002)6GR6AF385359SQV   L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
Ariyoshi (2003)JPN38JPN38 IDV, NFV129I54V, V82F L10I, I13V, G16E, K20I, E35D, M36I, R41K, K45V, L63LH, H69K, K70R, L89M, F99FLCRF01_AE
 JPN3JPN3 IDV56V82VF L10I, I13V, I15V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 JPN7JPN7AY900867NFV7  L10I, I13V, E35D, M36I, G40GR, R41K, H69K, I72V, L89MCRF01_AE
 JPN41JPN41A IDV, SQV, NFV125G48ST, I54V, V82F, L90M L10I, I13V, G16E, K20I, E35D, M36I, P39Q, R41K, K45V, I62V, L63P, H69K, L89MCRF01_AE
  JPN41BAY900873IDV, SQV, NFV, APV195I54V, V82F, L90LM L10I, I13V, G16E, K20I, E35DN, M36I, P39Q, R41K, K45V, G48X, I62V, L63P, H69K, L89MCRF01_AE
Montes (2004)MB_patBRI01_BRI705AJ577746SQV, NFV, RTV, LPV146I54V, V82AL33F, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, H69K, K70R, L89MCRF01_AE
Nukoolkarn (2004)7474 RTV I54V, V82AL33F, N83DL10I, I13V, E35D, M36I, R41K, D60E, Q61D, L63T, C67Y, H69K, L89MCRF01_AE
 220220 RTV, IDV I54V, V82AG48I, F53L, L89VL10I, I13V, K20I, E35D, M36I, N37D, R41K, L63P, H69K, A71VCRF01_AE
 238238 LPV L90M L10I, I13V, E35D, M36I, R41K, L63P, H69K, T74S, L89MCRF01_AE
 245245 SQV, RTV, IDV I54V, V82FL33IL10I, I13V, E35D, M36I, R41K, L63H, H69K, L89MCRF01_AE
Chantratita (2005)14-000114-0001DQ130423PINA  L10I, I13V, L19P, K20I, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 14-001214-0012DQ130428PINAM46I, V82F L10I, I13V, G16E, E35D, M36I, R41K, H69K, L89M, I93MCRF01_AE
 14-001514-0015DQ130430PINA  L10I, M36I, R41K, H69K, I93LCRF01_AE
 14-001914-0019DQ130434PINA I47ML10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 14-003714-0037DQ130439PINAI54V L10I, I13V, K20T, E35D, M36I, R41K, H69K, L89MCRF01_AE
 14-004314-0043DQ130444PINA  L10I, I13V, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 14-007014-0070DQ130456PINA  L10I, I13V, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 14-007814-0078DQ130458PINA V11IL10I, T12A, I13V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 14-009014-0090DQ130464PINA  W6R, L10I, I13V, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 14-011514-0115DQ130483PINAV82AL33F, K43T, N83DL10I, I13V, E35D, M36I, R41K, I62V, H69K, L89MCRF01_AE
 14-011714-0117DQ130484PINA  W6R, L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 14-014614-0146DQ130511PINAM46I, I54V, L76V, V82FL33FW6R, L10I, E35D, M36I, R41K, K55R, Q61H, L63P, H69K, T74S, L89M, I93LCRF01_AE
 14-014814-0148DQ130513PINAM46I, I54A, V82A L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63T, I64L, H69K, L89MCRF01_AE
 G508G508DQ130104PINA  L10I, I13V, G16E, E35D, M36I, R41K, C67G, H69K, L89MCRF01_AE
 G509G509DQ130105PINA  L10I, I13V, G16E, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G522G522DQ130114PINAM46I, L90MQ58EL10I, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, A71V, T74S, V77I, V82I, L89I, I93L, L97MCRF01_AE
 G531G531DQ130121PINAG48V L10I, I13V, E35D, M36I, R41K, H69K, K70R, T74S, L89ICRF01_AE
 G551G551DQ130127PINA  L10I, I13V, E35D, M36I, R41K, R57K, D60E, Q61E, L63S, H69K, P79D, L89MCRF01_AE
 G558G558DQ130132PINAI54V, V82AL33F, N83DL10I, I13V, E35D, M36I, R41K, D60E, Q61D, L63T, C67Y, H69K, L89MCRF01_AE
 G569G569DQ130138PINAI54V, I84VF53LL10I, I13V, I15V, K20R, E35D, M36I, R41K, D60E, L63P, I66F, H69K, A71V, L89ICRF01_AE
 G577G577DQ130142PINA  L10I, I13V, E35D, M36I, R41K, L63T, H69K, L89MCRF01_AE
 G579G579DQ130144PINA  L10I, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G587G587DQ130151PINA  L10I, I13V, E35D, M36I, R41K, L63T, I64V, E65D, H69KCRF01_AE
 G602G602DQ130159PINAI54V, I84VN83DL10I, I13V, A22V, L33M, E35D, M36I, R41K, I62V, H69K, T74A, L89ICRF01_AE
 G614G614DQ130166PINAM46I, I54A, V82A L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63T, I64L, H69K, T74S, L89MCRF01_AE
 G617G617DQ130168PINAI54A, V82F, L90ML33F, L89VL10I, I13V, K20R, E35D, M36I, R41K, H69K, A71VCRF01_AE
 G619G619DQ130169PINA  L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63I, H69K, K70R, L89MCRF01_AE
 G621G621DQ130171PINA  L10I, I13V, G16E, E35D, M36I, G40V, R41K, K55R, R57K, H69K, I72T, L89MCRF01_AE
 G624G624DQ130173PINA  L10I, I13V, G16E, E35D, M36I, P39S, R41K, H69K, I72V, L89MCRF01_AE
 G629G629DQ130177PINAG48V, I54V, V82AF53LL10I, I13V, K20R, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 G655G655DQ130189PINA  L10I, I13V, E35D, M36I, R41K, L63C, C67Y, H69K, L89MCRF01_AE
 G658G658DQ130190PINAI54V, V82F, L90ML33I, L89VL10I, I13V, L19I, K20I, E35D, M36I, R41K, H69KCRF01_AE
 G670G670DQ130197PINA  L10I, I13V, E35D, M36I, R41K, H69K, L89M, L97ICRF01_AE
 G673G673DQ130199PINA  L10I, I13V, G16E, E35D, M36I, R41K, R57K, C67S, H69K, K70R, L89MCRF01_AE
 G676G676DQ130200PINA L89VL10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69KCRF01_AE
 G707G707DQ130216PINAI54V, V82T, I84V L10I, I13A, K20I, E35D, M36I, R41K, I66F, H69K, A71V, L89MCRF01_AE
 G732G732DQ130227PINA L33FL10I, I13V, E35D, M36I, R41K, L63P, H69K, L89M, T91ICRF01_AE
 G742G742DQ130233PINA  L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63H, H69K, K70R, L89M, I93VCRF01_AE
 G746G746DQ130234PINA  L10I, I13V, G16E, E35D, M36I, R41K, H69K, I72V, L89MCRF01_AE
 G775G775DQ130242PINA  L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP129NP129DQ130245PINA  L10I, I13V, M36I, N37D, R41K, H69K, K70R, L89ICRF01_AE
 NP138NP138DQ130253PINAI47V, G48V, I54A, V82A L10I, I13V, G16E, L19P, K20I, E35D, M36I, R41K, H69K, A71V, I72R, L89ICRF01_AE
 NP144NP144DQ130258PINAG48V, V82AL33I, F53LL10I, I13V, E35D, M36I, R41K, H69K, T74S, L89ICRF01_AE
 NP162NP162DQ130266PINA  L10I, I13V, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP163NP163DQ130267PINA Q58EL10I, I13V, K20R, E35D, M36I, R41K, R57K, L63P, H69K, L89MCRF01_AE
 NP173NP173DQ130277PINA  L10I, I13V, K14R, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP188NP188DQ130292PINA  L10I, I13V, G16E, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 NP223NP223DQ130308PINA  L10I, I13V, K14R, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP227NP227DQ130312PINA  L10I, I13V, G17R, K20R, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP230NP230DQ130315PINA  L10I, I13V, E35D, M36I, R41K, L63T, H69K, P79A, L89MCRF01_AE
 NP231NP231DQ130316PINAV82F W6L, L10I, I13V, G16E, K20I, E35D, M36I, R41K, K43R, K45Q, R57K, L63V, H69K, K70R, L89MCRF01_AE
 NP233NP233DQ130318PINA  L10I, I13V, G16E, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP237NP237DQ130321PINAM46I, I54V, L76V, V82FQ58EL10I, I13V, K20I, E35G, M36I, R41K, F53Y, K55R, L63P, H69K, L89MCRF01_AE
 NP249NP249DQ130332PINA  L10I, I13V, G16E, K20I, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP254NP254DQ130336PINAG48V, L90MQ58EW6R, L10I, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89ICRF01_AE
 NP265NP265DQ130347PINA  W6R, L10I, I13V, G17E, E35D, M36I, L63T, H69K, K70R, L89MCRF01_AE
 NP269NP269DQ130351PINA  L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP275NP275DQ130357PINA  L10I, I13V, K20R, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP281NP281DQ130362PINA  L10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 NP288NP288DQ130368PINA  L10I, I13V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 NP299NP299DQ130379PINAG48V, I54V, V82A L10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69K, K70R, L89I, T91SCRF01_AE
 NP302NP302DQ130382PINA  W6R, L10I, I13V, E35D, M36I, R41K, H69Q, V82I, L89MCRF01_AE
 NP315NP315DQ130393PINAG48V, I54V, V82A L10I, I15V, E35D, M36I, R41K, Q61E, L63P, H69K, L89I, I93LCRF01_AE
 NP317NP317DQ130395PINA  L10I, I13V, L19M, E35D, M36I, H69K, L89MCRF01_AE
 NP323NP323DQ130401PINA  W6L, L10I, I13V, G16E, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP324NP324DQ130402PINAG48V, I50V, I54S, V82AL33F, F53L, N83DL10I, I13V, K20R, E34V, E35D, M36I, I62V, I66F, H69K, T74A, L89MCRF01_AE
 NP326NP326DQ130403PINA  L10I, I13V, E35D, M36I, R41K, H69Q, L89MCRF01_AE
 NP329NP329DQ130406PINA  L10I, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
Hsu (2005)BAA150627BAA150627AY870159SQV, RTV61G48V, I54IV, V82AL33F, F53L, N83DL10I, I13V, M36L, R41K, I62IV, L63P, H69K, T74S, L89IM, I93IVCRF01_AE
 BAA161430BAA161430AY870232IDV, SQV88G48V, I54V, V82AF53LL10I, I13V, L19LV, K20R, E35D, M36I, N37D, R41K, I62V, L63LP, H69K, A71T, T74S, L89ICRF01_AE
 BAA161433BAA161433AY870233IDV, SQV, RTV270G48V, L90ML33F, N83DL10I, I13V, E35D, M36I, R41K, L63T, H69K, L89IMCRF01_AE
 BAA161449BAA161449AY870242SQV, RTV100G48GMRV, I54V, I84IV, L90MQ58QEL10I, I13V, G16E, K20I, E35D, M36I, R41K, H69K, L89MCRF01_AE
Non-B Workgroup (2005)TH_220TH_220AY605624IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, I62V, H69K, L89M, L97ICRF01_AE
 TH_223TH_223AY605628IDV   L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 TK5004TK5004 SQV, IDV, NFV, RTV, LPV145G48V, I54A, V82A L10I, V11VL, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
  TK5004b SQV, IDV, NFV, RTV, LPV162G48V, I54AV, V82AL89IVL10I, V11VL, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, K70R, A71ATCRF01_AE
Baxter (2006)48-14261426-30225DQ877815PINAG48V, I54A, V82A T4TS, L10I, V11L, I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 48-41134113-30319DQ878344PINAI54V, V82A L10I, I13V, G16E, L19I, K20I, E35D, M36I, P39S, R41K, D60DE, I62V, H69K, K70R, A71IV, I72V, T74A, L89ICRF01_AE
Tee (2006)MYKL181404MYKL1814AY960954RTV, IDV I54V, V82T L10I, E35D, M36I, R41K, I62V, I66F, H69K, A71V, I72V, L89MCRF01_AE
 MYKL185504MYKL1855AY960955LPV I54V, V82FL33I, L89VL10I, I13V, Q18H, A22V, E35D, M36I, N37D, H69K, A71V, I93MCRF01_AE
 MYKL182204MYKL1822AY960956RTV, IDV M46I, I84VL89VL10I, I13A, K14R, K20I, E35D, M36I, R41K, K55R, I66F, H69K, A71TCRF01_AE
von Wyl (2007)345869337EF449787PINAI54VN83DL10I, I13V, G16A, A22V, E35D, M36I, R41K, L63V, H69K, L89ICRF01_AE
Rosen-Zvi (2008)1602p16-1 SQV, RTV, IDV47  L10I, T12A, I13V, E35D, M36I, R41K, R57K, L63LAPV, H69K, K70KR, L89MCRF01_AE
  06p16-2 SQV, RTV, IDV, LPV287V82F L10I, T12A, I13V, E35D, M36I, R41K, R57K, H69K, L89ICRF01_AE
Nerrienet (2014)R0917161R0917161JN675781LPV   L10I, I13V, G16E, M36I, R41K, H69K, L89ICRF01_AE
 Q0920081Q0920081JN675744LPV M46I, I54V, V82SL24I, L33I, Q58E, L89VL10I, I13V, K20KR, E35D, M36I, N37DE, K55KR, R57K, I62V, L63P, H69K, T74SCRF01_AE
 T0914094T0914094JN675802LPV   L10I, T12A, I13V, G16E, E35D, M36I, R41K, R57K, H69K, K70R, I72IV, L89MCRF01_AE
 U0218166U0218166JN675811LPV   L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63C, H69E, K70R, L89MCRF01_AE
 U0316214U0316214JN675765LPV G48V, I54V, V82AL89VT4S, L10I, V11L, I13V, K20I, E35D, M36I, I62IV, L63P, H69K, A71TCRF01_AE
 S0428149S0428149JN675749LPV M46I, L76V, I84VF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, K55R, D60E, L63P, I66F, H69K, K70R, L89MCRF01_AE
 S0723170S0723170JN675784LPV   L10I, I13V, M36I, R41K, L63P, H69K, L89M, Q92KCRF01_AE
 S1119066S1119066JN675786LPV   L10I, I13V, E35D, M36I, N37D, R41K, H69K, K70R, L89MCRF01_AE
 S0822156S0822156JN675752LPV M46L, I47V, G48V, I54V, V82T, I84VF53L, L89VL10I, I13A, K20I, M36I, R41K, L63P, I66F, H69K, A71VCRF01_AE
 U0519246U0519246JN675768LPV V82A L10I, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, T74A, L89M, I93VCRF01_AE
Sutherland (2015)1010_POSTKT351803LPV   L10I, E35D, M36I, R41K, R57K, Q61E, C67Y, H69K, L89MCRF01_AE
Zain (2015)MYHIVDR021MYHIVDR021KT281530PINA  L10I, I13V, I15V, E35D, M36I, R41K, L63LV, H69K, L89MCRF01_AE
 MYHIVDR116MYHIVDR116KT281520PINA  L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYHIVDR102MYHIVDR102KT281516PINA  L10I, I13V, K14R, I15V, K20KI, E35D, M36I, R41K, H69K, V82I, L89M, F99FLCRF01_AE
 MYHIVDR170MYHIVDR170KT281492PINA  L10I, I13V, K14R, G16E, E35D, M36L, R41K, H69K, K70R, I72V, L89MCRF01_AE