<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation L10I
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 26
Isolates 29
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Ariyoshi (2003)JPN38JPN38 IDV, NFV129I54V, V82F L10I, I13V, G16E, K20I, E35D, M36I, R41K, K45V, L63LH, H69K, K70R, L89M, F99FLCRF01_AE
 JPN3JPN3 IDV56V82VF L10I, I13V, I15V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 JPN7JPN7AY900867NFV7  L10I, I13V, E35D, M36I, G40GR, R41K, H69K, I72V, L89MCRF01_AE
 JPN41JPN41A IDV, SQV, NFV125G48ST, I54V, V82F, L90M L10I, I13V, G16E, K20I, E35D, M36I, P39Q, R41K, K45V, I62V, L63P, H69K, L89MCRF01_AE
  JPN41BAY900873IDV, SQV, NFV, APV195I54V, V82F, L90LM L10I, I13V, G16E, K20I, E35DN, M36I, P39Q, R41K, K45V, G48X, I62V, L63P, H69K, L89MCRF01_AE
Montes (2004)MB_patBRI01_BRI705AJ577746SQV, NFV, RTV, LPV146I54V, V82AL33F, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, H69K, K70R, L89MCRF01_AE
Nukoolkarn (2004)7474 RTV I54V, V82AL33F, N83DL10I, I13V, E35D, M36I, R41K, D60E, Q61D, L63T, C67Y, H69K, L89MCRF01_AE
 220220 RTV, IDV I54V, V82AG48I, F53L, L89VL10I, I13V, K20I, E35D, M36I, N37D, R41K, L63P, H69K, A71VCRF01_AE
 238238 LPV L90M L10I, I13V, E35D, M36I, R41K, L63P, H69K, T74S, L89MCRF01_AE
 245245 SQV, RTV, IDV I54V, V82FL33IL10I, I13V, E35D, M36I, R41K, L63H, H69K, L89MCRF01_AE
Hsu (2005)BAA150627BAA150627AY870159SQV, RTV61G48V, I54IV, V82AL33F, F53L, N83DL10I, I13V, M36L, R41K, I62IV, L63P, H69K, T74S, L89IM, I93IVCRF01_AE
 BAA161430BAA161430AY870232IDV, SQV88G48V, I54V, V82AF53LL10I, I13V, L19LV, K20R, E35D, M36I, N37D, R41K, I62V, L63LP, H69K, A71T, T74S, L89ICRF01_AE
 BAA161433BAA161433AY870233IDV, SQV, RTV270G48V, L90ML33F, N83DL10I, I13V, E35D, M36I, R41K, L63T, H69K, L89IMCRF01_AE
 BAA161436BAA161436AY870234SQV, RTV26 L33FL10I, I13V, R41K, I62V, L63I, H69K, K70R, V82I, L89MCRF01_AE
 BAA161449BAA161449AY870242SQV, RTV100G48GMRV, I54V, I84IV, L90MQ58QEL10I, I13V, G16E, K20I, E35D, M36I, R41K, H69K, L89MCRF01_AE
Non-B Workgroup (2005)TH_220TH_220AY605624IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, I62V, H69K, L89M, L97ICRF01_AE
 TH_223TH_223AY605628IDV   L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 TK5004TK5004 SQV, IDV, NFV, RTV, LPV145G48V, I54A, V82A L10I, V11VL, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
  TK5004b SQV, IDV, NFV, RTV, LPV162G48V, I54AV, V82AL89IVL10I, V11VL, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, K70R, A71ATCRF01_AE
Baxter (2006)48-14261426-30225DQ877815PINAG48V, I54A, V82A T4TS, L10I, V11L, I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 48-30333033-30227DQ877944PINAG48Q, I50V, I54A, V82MK43T, F53LL10I, I13V, G16E, L19R, K20I, E35D, M36I, R41K, Q61D, L63C, I66F, H69K, L89MCRF01_AE
 48-41134113-30319DQ878344PINAI54V, V82A L10I, I13V, G16E, L19I, K20I, E35D, M36I, P39S, R41K, D60DE, I62V, H69K, K70R, A71IV, I72V, T74A, L89ICRF01_AE
Tee (2006)MYKL181404MYKL1814AY960954RTV, IDV I54V, V82T L10I, E35D, M36I, R41K, I62V, I66F, H69K, A71V, I72V, L89MCRF01_AE
 MYKL182204MYKL1822AY960956RTV, IDV M46I, I84VL89VL10I, I13A, K14R, K20I, E35D, M36I, R41K, K55R, I66F, H69K, A71TCRF01_AE
von Wyl (2007)345869337EF449787PINAI54VN83DL10I, I13V, G16A, A22V, E35D, M36I, R41K, L63V, H69K, L89ICRF01_AE
Rosen-Zvi (2008)1602p16-1 SQV, RTV, IDV47  L10I, T12A, I13V, E35D, M36I, R41K, R57K, L63LAPV, H69K, K70KR, L89MCRF01_AE
  06p16-2 SQV, RTV, IDV, LPV287V82F L10I, T12A, I13V, E35D, M36I, R41K, R57K, H69K, L89ICRF01_AE
Van Zyl (2013)4631671KC423313LPV26  L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, E65D, H69K, I72V, L89MCRF01_AE
Grossman (2014)16871687KC184219LPV52  Q7QK, L10I, K14R, G17GR, E35D, M36I, N37D, R41K, C67Y, H69K, L89MCRF01_AE