<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L89V
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 20
Isolates 24
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG8686_w82 NFV65D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
 DMG9191_w22 NFV22D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
Non-B Workgroup (2005)UK955UK955AY900786SQV, RTV, IDV137I54V, I84V, L90MG73S, L89VL10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93LC
 BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 TK1027TK1027 IDV, RTV216 L89VI15V, L19I, M36I, R41K, H69K, I93ILC
Kandathil (2009)VL06_253VL06_253EU030406PINAD30NN88D, L89VL10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93LC
Knops (2010)ID2137ID2137-GT2GU271173IDV, LPV, DRV, RTV33V32I, I54L, L76V, V82AL89VL5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
Rodrigues (2010)305_07BR07SC305GQ401315NFV L90ML89VI13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93LC
Van Zyl (2013)16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
Grossman (2014)609609KF135112LPV52M46I, I54V, V82A, L90MN83D, L89VL10I, V11L, I13A, K20R, A22V, E35N, M36I, N37D, R41K, I62V, L63P, H69K, A71V, I93LC
  609 LPV134M46I, I54V, V82A, L90MG73S, N83D, L89VL10I, V11L, I13V, K20R, A22V, E35N, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, T91S, I93LC
  609 LPV292M46I, I54V, V82A, L90MG73GS, N83D, L89VL10I, V11L, I13AV, K20R, A22V, E35N, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71IV, T91S, I93LC
 255255KF135031SQV, LPV52I54V, V82AL10F, N88D, L89VT12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93LC
  255KF135032SQV, LPV90M46I, I54V, V82AL10F, L33F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 20632063KF135018LPV52M46I, I54V, V82AL10F, G73S, L89VT12S, I15V, G16E, L19I, K20I, M36I, N37D, R41K, L63R, H69K, I85V, I93LC
Diaz (2015)RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG17080RenG17080KT748108PINAI50L, V82M, L90MQ58E, L89VI13V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, K70T, A71V, I93LC
 RenG15346RenG15346KT746374PINAM46MI, I54V, V82VA, I84V, L90ML10F, L23LI, L33F, F53FL, G73S, T74PS, L89VV11L, I13V, I15V, K20T, E34Q, E35D, M36IL, N37K, R41N, I62V, L63P, G68D, H69R, A71V, I93LC
 RenG14844RenG14844KT745872PINAM46I, I54V, V82A, N88SL10F, L33F, L89VI13V, I15V, K20T, E21EK, E35D, M36IL, N37K, R41N, I62V, L63P, H69K, G73D, T74S, I93ILC
 RenG14901RenG14901KT745929PINAM46ML, G48GA, I54V, I84V, L90ML10F, T74P, L89VI15V, K20T, E35DN, M36I, N37K, R41H, Q61QH, I62IV, L63P, H69K, A71V, I85V, T91CS, I93LC
 RenG12144RenG12144KT743172PINAV32I, I54L, I84VL10F, L33I, L89VI13V, I15V, K20T, M36I, N37K, R41N, Q61N, L63P, I66FV, H69K, A71V, T74S, V77I, Q92KC
 RenG11076RenG11076KT742104PINAI54V, V82A, L90ML23I, G73S, L89VL10I, I15V, G16GW, L19LP, K20IM, E35D, M36I, N37K, R41N, K45R, K55KR, I62V, L63P, H69K, A71T, I85V, I93LC