<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 167
Isolates 176
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL185IL185cAY529558NFV132D30N T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NIC
 IL267IL267AY529619IDV, RTV, SQV, NFV229L90M I13IV, K14R, I15V, G16GE, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LC
Non-B Workgroup (2005)UK320UK320AY900769NFV57L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, H69K, T74S, L89I, I93LC
 UK445UK445AY900772IDV, RTV   T12S, K14R, I15V, L19I, M36I, R41K, L63P, H69K, L89I, I93LC
 UK598UK598AY900779IDV97L90M T12S, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89I, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 UK2069UK2069AY900845NFV D30NN88DT12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93LC
 TK2018TK2018 IDV, RTV, NFV218M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93LC
 TK3020TK3020 RTV, NFV, SQV120  T12S, I15V, L19I, E35D, M36I, R41K, L63AT, H69K, T74S, L89I, I93LC
  TK3020a RTV, NFV, SQV120  T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93LC
 TK3026TK3026 RTV, SQV, NFV292L90M I15V, L19I, K20T, E35D, M36I, R41RK, L63P, H69K, A71I, T74S, L89I, I93LC
 TK3027TK3027 RTV, SQV, NFV190D30N, L90MN88DT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93LC
 PL2421663450 NFV84D30DN, L90LM T12S, I13IV, I15V, L19T, K20T, E35EDG, M36I, N37E, L63LP, H69K, V82VI, L89I, I93ILC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
 PL4205672786 IDV, RTV275V82AL10F, L24I, I54CT12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
  91776 IDV, RTV, LPV340V82AL10F, L24I, I54CG17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
  69936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Weber (2005)F68541F68541AY677417NFV198M46MI, L90M T12S, I13V, I15V, L19I, K20T, E35X, M36I, R41K, H69K, T74AS, L89I, I93LC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
Doualla-Bell (2006)Pt2FDB_Pt2 NFV L90M T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93LC
 Pt8FDB_Pt8 NFV D30NL33F, N88DT12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89IC
Sanabani (2006)04BR13704BR137AY727526PINA  I15V, N37K, R41N, H69K, L89I, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
 DR58DR58AY589910NFV D30N T12S, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45Q, I64V, H69K, L89I, I93LC
 DR10003ZA.DR100AY589936RTV M46I, I54V, V82A I15E, G16GE, L19E, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
 DR10203ZA.DR102AY589937RTV I54V, V82L, L90M I13IV, I15V, K20R, M36I, R41RK, L63LP, H69K, L89IC
Riddler (2008)RG49532RG49532w9 LPV2  T12S, I15V, L19I, M36I, R41K, D60E, L63S, H69K, L89I, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Rodrigues (2010)319_07BR07SC319GQ401303LPV   K14R, I15V, M36I, N37K, R41N, L63LP, H69K, L89I, I93LC
Kouri (2012)CU1452-09CU1452-09JQ585296PINAD30N, I54M, L90ML33F, N88DT12S, I13V, K14R, I15V, E35D, M36I, N37S, R41K, L63P, H69K, T74S, L89I, I93LC
 CU2016-09CU2016-09JQ585331PINAM46I, I54M, V82A, L90MK43TL10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 CU2035-09CU2035-09JQ585332PINAM46I, I54M, V82A, L90MK43TQ2H, L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91S, I93LC
Van Zyl (2013)1581971KC424406LPV26  T12P, I15V, G16E, L19T, M36I, R41K, I62IV, L63NSTY, I64L, H69K, P79PA, V82VI, L89I, I93LC
 4921309KC423046LPV26  T12S, I15V, G16E, L19I, M36I, P39S, D60E, H69K, L89I, I93LC
 15672032KC423577LPV26M46L, I54V, L76V, V82AL10FI15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, L89I, I93LC
 4291405KC423127LPV26  T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89IC
 14532172KC423667LPV26M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, M36I, R41K, K43R, L63V, H69K, L89I, I93LC
 14522906KC423888LPV26M46I, I54V, L76V, V82AL10FT12TS, I15V, L19T, K20R, M36I, R41K, L63V, H69K, L89I, I93LC
 6321066KC422852LPV26I54IV T12S, I15V, L19I, E35D, M36I, R41K, H69K, V82I, L89I, I93LC
 351912KC424356LPV26  T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89IC
 8681762KC423385LPV209  K14N, I15V, G16E, L19T, K20R, M36I, L63T, H69K, L89I, I93LC
 1208820KC424296LPV26  M36I, R41K, K45R, L63S, H69K, L89I, I93LC
 15442438KC423708LPV26 V11IT12S, I15V, G16E, L19I, R41K, K55R, D60E, L63H, H69K, V77I, L89I, I93LC
 15292746KC423811LPV26  L5X, T12S, I15V, L19I, M36I, N37D, L63H, H69K, L89I, I93LC
 13931541KC423216LPV26M46I, I54V T12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
  1512KC423198LPV27I54V T12S, I15V, L19T, K20R, E35D, M36I, R41K, E65EG, H69K, L89I, I93LC
  3002KC423927LPV130M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
 1274883KC424337LPV26  I13V, G16E, L19T, L33V, P39S, D60E, L63P, H69K, L89I, I93LC
  909KC424352LPV27  I13V, G16E, L19T, L33V, P39S, D60E, L63P, H69K, L89I, I93LC
 11211187KC422948LPV26  T12S, I15V, L19I, K20R, M36I, R41K, H69K, L89I, I93LC
 17252001KC423554LPV26  T12S, I15IV, G16E, L19I, M36MI, R41K, K43R, L63Q, H69K, V77I, V82I, L89I, I93LC
 64879KC424334LPV26  T12S, L19V, K20R, M36I, R41K, L63P, H69K, L89I, I93LC
 56450KC424098LPV26  T12S, I15V, L19I, A22D, M36I, R41K, D60E, Q61E, L63P, H69K, A71D, L89I, I93LC
 13231687KC423326LPV26  T12S, I15V, L19V, M36I, R41K, L63P, H69K, L89I, I93LC
 11281379KC423106LPV26I54V, V82AL10F, L24I, L33F, N83DG16GA, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, I85V, L89I, T91S, I93LC
Grossman (2014)882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 250250KF135030SQV, LPV52L90M K14R, I15V, M36I, N37D, R41K, I62V, H69K, T74S, V82I, I85V, L89I, I93LC
 613613KF135114NFV, LPV52L90M Q7R, I15V, L19T, K20I, E35N, M36I, R41K, K43R, H69K, T74S, L89I, I93LC
 183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 217217KF135024NFV, LPV52D30N, I54V, V82AL33F, N88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, H69Q, V75I, L89I, I93LC
  217KF135025NFV, LPV273M46I, I50V, I54V, V82A, L90ML33FL10I, I13V, K14R, I15V, K20R, E35D, M36I, N37DE, R41K, K55R, L63E, G68GE, H69Q, A71AV, L89I, I93LC
 488488KF135085SQV, LPV52G48A, I54V, V82AL10F, L24I, Q58EK20R, M36I, R41K, L63P, H69K, A71V, I72V, N83S, L89I, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 311311KF135048LPV148M46L, I47A T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93LC
 805805KF135148SQV, LPV52M46I, I54IV, L76V, V82VAL10LFT12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93LC
 260260KF135035IDV, LPV384I54V, V82A, L90ML10FI15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93LC
 464464 NFV, IDV, LPV52V32I, I47V, I54MN83DL10I, M36I, R41K, I62V, L63V, T74S, V82I, I85V, L89I, I93LC
 283283 SQV, RTV, IDV, LPV52I54V, V82AL10F, D30DET12S, I13IV, K14R, I15V, K20I, E35D, M36I, Q61H, H69K, T74A, L89I, I93LC
Steegen (2014)11ZAKS16511ZAKS165KJ176447LPV I50IV, I54V, V82A R41K, H69K, A71V, T74S, L89I, I93LC
 12ZAKS32312ZAKS323KJ176602LPV M46I, I54V, L76V, V82A Q61H, I62V, L63P, H69K, L89I, T91S, I93LC
 12ZAKS35512ZAKS355KJ176634LPV M46I, I54V, L76V, V82A R41K, K55R, R57K, I62V, L63P, H69K, L89I, I93LC
 12ZAKS26712ZAKS267KJ176546LPV   R41N, I62V, L63H, H69K, I72IV, V82I, L89I, I93LC
Diaz (2015)RenG17227RenG17227KT748255PINA L23IL10M, I13V, K20T, E35N, M36I, N37K, R41N, K45Q, I62V, L63P, H69K, T74K, V82VI, L89I, I93LC
 RenG16485RenG16485KT747513PINA  I15V, M36T, N37K, R41N, H69K, V82I, L89I, I93LC
 RenG17053RenG17053KT748081PINAI50L, L90ML33IL10Y, I13IV, I15V, K20T, E34EQ, E35N, M36I, N37E, R41N, K45R, D60N, I62IV, L63LP, C67CF, G68GE, H69KR, A71I, L89I, I93LC
 RenG15838RenG15838KT746866PINA  K14KR, I15V, M36T, N37K, R41N, L63LP, H69K, V82I, L89I, I93LC
 RenG16604RenG16604KT747632PINA  I15V, M36T, N37K, R41N, K45R, L63LP, H69K, L89I, I93LC
 RenG17457RenG17457KT748485PINA  T12TA, K14R, I15V, G16E, M36I, N37K, R41N, R57K, L63H, H69K, L89I, I93LC
 RenG16610RenG16610KT747638PINA  K14R, I15V, M36I, N37KR, R41N, L63P, H69K, L89I, I93LC
 RenG15719RenG15719KT746747PINAI54V, L90ML23I, K43T, F53LI13V, I15V, L19I, K20T, E35D, M36I, N37K, R41N, I62IV, L63P, H69K, A71IV, T74S, V77I, L89I, I93LC
 RenG16300RenG16300KT747328PINAD30N, L90LML10LF, N88DI13V, I15V, E35D, M36I, N37K, R41N, K45R, L63AP, I64IV, H69K, L89I, I93LC
 RenG16064RenG16064KT747092PINA  I15V, M36T, N37K, R41N, Q61N, L63PQ, H69K, L89I, I93LC
 RenG17435RenG17435KT748463PINA  T12S, I15V, L19I, M36I, N37K, R41N, H69K, L89I, I93LC
 RenG16730RenG16730KT747758PINAM46I, L90ML10F, L33FI15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, N88E, L89I, I93LC
 RenG16791RenG16791KT747819PINAM46I, I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, K20T, E35N, M36I, N37Q, R41N, I62IV, L63V, H69K, I72V, L89I, I93LC
 RenG15937RenG15937KT746965PINA  I13V, I15V, E35D, N37E, R41N, D60N, L63P, H69K, K70KR, V82I, L89I, I93LC
 RenG15586RenG15586KT746614PINAM46I, I54V, I84V, L90M L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, D60E, I62V, L63P, H69K, A71V, L89I, I93LC
 RenG17418RenG17418KT748446PINAM46I, I54V, V82F, L90M L10I, V11L, I13V, I15V, K20IT, E35G, M36I, N37K, P39Q, R41N, F53Y, L63P, I64IV, H69K, T74S, L89I, I93LC
 RenG16046RenG16046KT747074PINA  I15V, L19LV, M36T, N37K, R41N, L63P, H69K, L89I, I93LC
 RenG15557RenG15557KT746585PINAM46I, I54V, L76V, V82C, L90M T12AS, I15V, G16E, L19P, K20T, E35G, M36I, N37K, R41N, K55R, R57RK, Q61N, L63N, H69K, A71V, I72R, L89I, I93LC
 RenG16418RenG16418KT747446PINA  M36I, N37K, R41N, L63P, H69K, L89I, I93LC
 RenG15962RenG15962KT746990PINAI54V, V82AL10FV, L24II15IV, G16E, K20R, E35D, M36I, N37E, R41N, K43R, K45V, R57K, Q58R, L63H, I66V, H69K, L89I, I93LC
 RenG16315RenG16315KT747343PINA  T12N, I15V, M36T, N37K, R41N, H69K, V82I, L89I, I93LC
 RenG15801RenG15801KT746829PINAI50L, V82L I15V, G16E, K20R, E35D, M36I, N37K, P39S, R41N, K45R, G68E, H69R, A71V, L89I, I93LC
 RenG15890RenG15890KT746918PINA  I13V, K14KR, I15V, L19Q, N37K, R41N, H69K, T74S, V77VI, L89I, I93LC
 RenG16564RenG16564KT747592PINA  I15V, G16E, L19I, M36T, N37K, R41N, R57K, Q61K, H69K, K70R, L89I, I93LC
 RenG16022RenG16022KT747050PINAI50L, V82ILL33FK14KR, I15V, K20T, M36I, N37K, R41N, H69K, A71V, L89I, I93LC
 RenG15516RenG15516KT746544PINAI54V, V82VA, I84V, L90ML10F, L23I, Q58EI15V, K20R, E35D, M36I, N37K, R41N, R57RK, D60DE, I62IV, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 RenG16982RenG16982KT748010PINAM46L, I54IV, V82AL10LFPS, L23I, L33F, F53FLP9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93LC
 RenG17445RenG17445KT748473PINAI50IL, L90ML23LI, L33LFI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, D60DE, I62V, L63LP, H69K, T74S, V82I, L89I, I93LC
 RenG14474RenG14474KT745502PINAM46I, I54V, V82A, I84V, L90ML10F, K43KTI15V, L19I, K20R, E35D, M36I, N37K, R41N, L63P, H69K, A71V, I85V, L89I, Q92K, I93LC
 RenG14917RenG14917KT745945PINAM46I, I47A, L90ML10FI15V, G16E, L19P, K20I, N37K, R41N, F53Y, D60E, Q61HN, L63H, H69K, V77I, I85V, L89I, I93LC
 RenG14859RenG14859KT745887PINA  I15V, G16E, K20R, M36I, N37K, R41N, I62V, L63R, H69K, L89I, I93LC
 RenG15065RenG15065KT746093PINAM46I, I50L, L90MQ58EI13V, I15V, L19I, K20R, E35D, M36I, N37K, R41N, K55R, L63P, H69K, A71T, L89I, I93LC
 RenG15244RenG15244KT746272PINAM46I, I54V, I84VL10FI15V, G16A, K20Q, M36I, N37K, R41N, L63P, I66V, H69K, I85V, L89I, Q92K, I93LC
 RenG15067RenG15067KT746095PINA  T12A, I13V, K14R, I15V, G16E, M36I, N37K, R41N, K45R, D60E, Q61N, L63T, H69K, L89I, I93LC
 RenG15215RenG15215KT746243PINAM46L, I50IL, I54V, V82AL24I, L33FL10Y, E35D, M36L, N37EK, R41N, R57K, D60E, L63P, H69K, A71AT, L89I, Q92QK, I93LC
 RenG14916RenG14916KT745944PINAI50L, V82M, L90ML23I, L33FI13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93LC
 RenG14962RenG14962KT745990PINAM46I, I54V, V82AL10F, L24I, L33FI15V, G16E, L19Q, K20R, E35D, M36I, N37K, R41N, Q61H, L63T, H69K, L89I, Q92K, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG13855RenG13855KT744883PINAL90ML23I, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71I, T74A, L89I, I93LC
 RenG14577RenG14577KT745605PINA  I15V, M36T, N37K, R41I, L63I, H69K, T74S, L89I, I93LC
 RenG14286RenG14286KT745314PINAV32I, M46MIL33LI, K43T, T74PI15V, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, A71AV, I85V, L89I, I93LC
 RenG14243RenG14243KT745271PINA  T12P, I13V, K14KR, G16E, M36I, N37E, R41N, D60N, L63HR, H69K, L89I, I93LC
 RenG14330RenG14330KT745358PINA  L10I, I13V, I15V, K20R, M36I, N37K, R41N, H69K, I72V, L89I, I93LC
 RenG15013RenG15013KT746041PINAM46I, I84VL10FI15V, G16A, K20I, E35G, M36I, N37K, R41N, K55R, R57K, D60E, Q61E, L63P, H69K, I85V, L89I, I93LC
 RenG14186RenG14186KT745214PINAD30N, M46L, I54V, V82AQ58QE, N88DL10R, I15V, K20T, E35D, M36I, N37K, R41N, D60DE, Q61QH, L63P, I64IL, H69K, A71V, L89I, I93LC
 RenG15313RenG15313KT746341PINAM46L, G48A, I54V, V82A, L90ML33F, N83DL10V, K14KR, I15IV, G16E, K20R, E35D, M36I, N37K, R41N, R57K, Q61N, L63T, H69K, T74S, I85V, L89I, Q92K, I93LC
 RenG14848RenG14848KT745876PINA  K14R, I15V, M36MIT, N37K, R41N, L63LI, H69K, L89I, I93LC
 RenG15434RenG15434KT746462PINA  I15V, G16E, N37K, R41N, L63R, H69K, L89I, I93LC
 RenG14857RenG14857KT745885PINA  I15V, G16E, M36T, N37K, R41N, L63T, H69K, L89I, I93LC
 RenG15285RenG15285KT746313PINA  I15IV, G16E, M36I, N37K, R41N, L63H, H69K, L89I, I93LC
 RenG14113RenG14113KT745141PINAG48V, I50V, I54V, V82AL33IL10I, I13V, L19IV, E35D, M36I, N37R, R41N, Q61E, I62V, L63P, H69K, T74S, I85V, L89IC
 RenG13600RenG13600KT744628PINAM46I, I50L, L90ML23II15V, K20T, E35D, M36I, N37K, R41N, L63PT, H69K, A71V, T74S, I85IV, L89I, I93LC
 RenG13560RenG13560KT744588PINA  K14R, M36I, N37DE, R41N, D60N, I62IV, L63P, H69K, A71AT, L89I, I93LC
 RenG15500RenG15500KT746528PINAM46I, I47IV, I54V, V82F, L90ML23I, L33LI, F53FL, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, L89I, Q92QK, I93LC
 RenG14493RenG14493KT745521PINAI50LL33LFI15V, E35D, M36I, N37K, R41N, R57K, Q61QH, L63V, H69K, A71V, T74A, L89I, I93LC
 RenG12839RenG12839KT743867PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, L19I, K20KT, M36L, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG13401RenG13401KT744429PINAM46I, I54V, V82F, L90MT74PSL10V, I13V, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, Q61QHKN, H69K, L89I, I93LC
 RenG13044RenG13044KT744072PINAI54V, V82A, L90ML10FI13V, K14KR, I15V, G16A, K20I, E35D, M36I, N37K, R41N, Q61QH, L63LP, H69K, T74S, L89I, T91TS, I93ILC
 RenG12763RenG12763KT743791PINA  K14KR, I15V, L19IT, M36T, N37K, R41N, L63LP, H69K, L89I, I93LC
 RenG13275RenG13275KT744303PINAN88SL10F, Q58EI13V, I15V, E35D, M36I, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG13403RenG13403KT744431PINA  I13V, M36T, N37K, R41N, L63P, H69K, L89I, I93LC
 RenG13419RenG13419KT744447PINAL90M I13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG13267RenG13267KT744295PINA  T12A, K14R, I15V, G16E, M36I, N37K, R41N, Q61KN, L63T, H69K, L89I, I93LC
 RenG13298RenG13298KT744326PINAM46I, I54V, L76V, L90M I15V, L19I, K20T, E35D, M36I, N37E, R41H, R57K, Q61R, I62V, L63LP, H69R, A71V, V82I, L89I, I93LC
 RenG13175RenG13175KT744203PINAI54V, V82AL33F, T74PI13V, K20R, E35D, M36I, N37K, R41N, R57K, Q61H, H69K, L89I, I93LC
 RenG11945RenG11945KT742973PINA  K14R, I15V, M36T, N37KR, R41N, H69K, V82I, L89I, I93LC
 RenG12764RenG12764KT743792PINA  I15V, M36T, N37K, R41N, H69K, L89I, I93LC
 RenG12879RenG12879KT743907PINA  T12TS, I13V, K14R, I15V, G16E, K20M, M36IT, N37K, R41N, R57K, Q61K, H69K, L89I, I93LC
 RenG13041RenG13041KT744069PINA  K14KR, I15V, G16E, K20KR, M36I, N37K, P39S, R41N, I62IV, G68GE, H69R, L89I, I93LC
 RenG12519RenG12519KT743547PINAM46I, I54V, V82A, L90ML10F, L23II13V, K14R, I15V, K20I, E35N, M36I, N37E, R41N, Q61H, I62V, L63P, H69K, A71T, T74S, L89I, I93LC
 RenG13056RenG13056KT744084PINA  K14R, I15V, G16E, M36T, N37K, R41N, R57K, L63H, H69K, L89I, I93LC
 RenG13037RenG13037KT744065PINAG48V, I54V, V82A I15V, K20R, E35D, M36I, N37K, R41N, I62IV, H69K, T74S, L89I, I93LC
 RenG12228RenG12228KT743256PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, I15IV, K20M, E35D, M36I, N37K, R41H, I62V, L63P, H69K, L89I, T91TSC
 RenG12987RenG12987KT744015PINA  T12A, K14R, I15V, G16E, N37KR, R41N, I62IV, L63H, I64L, H69K, L89I, I93LC
 RenG11955RenG11955KT742983PINA V11VIT12A, I13IV, K14R, I15V, G16E, M36I, N37K, R41N, Q61K, L63T, H69K, L89I, I93LC
 RenG10128RenG10128KT741156PINA L23LIL10V, I13V, K14KR, I15V, K20T, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, H69K, A71AT, T74S, L89I, I93LC
 RenG10282RenG10282KT741310PINAM46MIV, L90MV11VIL10V, I13V, K14R, I15V, K20I, N37K, R41N, Q61QH, H69K, K70KR, T74S, L89I, I93LC
 RenG11093RenG11093KT742121PINA  I15V, G16E, M36T, N37K, R41N, L63R, H69K, L89I, I93LC
 RenG11612RenG11612KT742640PINAI54V, V82F, L90ML23LI, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, L63P, H69K, A71IV, T74S, L89I, I93LC
 RenG10565RenG10565KT741593PINA  P39T, K43R, L63T, H69K, L89I, I93LC
 RenG10964RenG10964KT741992PINAM46I, I54V, V82C, I84V, L90ML10FT12R, I15V, L19LP, K20T, L33L_L, E35D, M36I, N37K, R41N, D60E, L63P, I66IV, H69K, A71AT, V77I, I85V, L89I, Q92K, I93L, C95FC
 RenG10573RenG10573KT741601PINAD30NN88DI13V, I15V, K20Q, E35G, M36I, N37K, R41N, K45R, L63P, H69K, T74S, L89I, I93LC
 RenG10624RenG10624KT741652PINAL90MQ58EI13V, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, Q61N, L63T, I64IV, H69K, A71T, T74A, V82I, L89I, I93LC
 RenG11084RenG11084KT742112PINAL90LML10FR8RH, I13V, I15V, K20T, E35D, M36I, N37AEKT, R41N, H69K, T74S, L89I, I93LC
 RenG10445RenG10445KT741473PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16A, N37K, R41N, K55R, R57K, L63P, H69K, L89IC
 RenG10945RenG10945KT741973PINA  K14R, L19I, L33V, R41K, D60E, L63P, C67S, H69K, L89I, I93LC
 RenG10518RenG10518KT741546PINAM46I, I47A L10V, I13V, I15V, G16A, L19P, K20I, M36MI, N37K, R41N, R57K, L63P, H69K, T74S, L89I, I93LC
 RenG11227RenG11227KT742255PINAI50L, V82A, L90ML33FT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37E, R41N, K45R, L63P, H69K, A71V, T74A, L89I, I93LC
 RenG11040RenG11040KT742068PINAV82VA, L90LML10F, T74PSK14R, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63V, H69K, L89I, I93LC
 RenG10079RenG10079KT741107PINAL90M I15V, L19I, K20T, E35DN, M36I, N37E, R41N, K45R, L63LP, H69K, T74S, L89I, I93LC
 RenG10242RenG10242KT741270PINAM46I, I54V, V82A, L90M I13V, I15V, K20T, L33L_L, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG11250RenG11250KT742278PINAM46I, I50IL, I54V, V82F, L90M L10V, V11VL, K14R, I15V, Q18P, K20T, E35D, M36I, N37K, R41N, K55H, Q61QE, I62V, L63P, H69K, A71AV, T74A, L89I, I93ILC
 RenG10491RenG10491KT741519PINAI50L, V82VA, N88S, L90LML33FL10M, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, K45R, H69K, A71V, L89I, I93LC
 RenG10474RenG10474KT741502PINAG48S, I54V, V82F, L90ML33F, K43T, T74P, N83DL10I, I13V, K14R, I15V, E35D, M36L, N37K, R41IN, Q61N, I62V, C67CR, H69Q, L89I, I93LC
 RenG10394RenG10394KT741422PINAG48V, I54T, V82A L10I, I15V, K20R, E35D, M36I, N37K, R41N, Q61H, L63V, H69K, A71V, I72IR, T74S, I85V, L89I, I93LC
Rossouw (2015)RP126RP126KT032045RTV, LPV348M46I, I54V, L76V, V82L Q7E, K14R, I15V, G16E, L19I, K20T, E35D, M36I, Q61N, L63C, H69K, L89I, I93LC
 RP167RP167KT032058LPV, RTV312M46I, I54V, V82AL10F, L24I, K43TI15V, L19I, K20R, E35D, M36V, N37E, R57K, I62V, L63P, H69K, V77I, L89I, I93LC
 RP099RP099KT032033LPV121M46I, I54V, V82AL10LF, L24LI, L33F, T74TPI13IV, K14KR, I15V, Q18E, L19IT, K20KR, M36L, R41K, Q61H, I62V, L63LP, H69K, L89I, I93L, L97LIC