<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 30
Isolates 35
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL185IL185cAY529558NFV132D30N T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NIC
 IL267IL267AY529619IDV, RTV, SQV, NFV229L90M I13IV, K14R, I15V, G16GE, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LC
Non-B Workgroup (2005)UK320UK320AY900769NFV57L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, H69K, T74S, L89I, I93LC
 UK445UK445AY900772IDV, RTV   T12S, K14R, I15V, L19I, M36I, R41K, L63P, H69K, L89I, I93LC
 UK598UK598AY900779IDV97L90M T12S, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89I, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 UK2069UK2069AY900845NFV D30NN88DT12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93LC
 TK2018TK2018 IDV, RTV, NFV218M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93LC
 TK3020TK3020 RTV, NFV, SQV120  T12S, I15V, L19I, E35D, M36I, R41K, L63AT, H69K, T74S, L89I, I93LC
  TK3020a RTV, NFV, SQV120  T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93LC
 TK3026TK3026 RTV, SQV, NFV292L90M I15V, L19I, K20T, E35D, M36I, R41RK, L63P, H69K, A71I, T74S, L89I, I93LC
 TK3027TK3027 RTV, SQV, NFV190D30N, L90MN88DT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93LC
 PL2421663450 NFV84D30DN, L90LM T12S, I13IV, I15V, L19T, K20T, E35EDG, M36I, N37E, L63LP, H69K, V82VI, L89I, I93ILC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
 PL4205672786 IDV, RTV275V82AL10F, L24I, I54CT12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
  91776 IDV, RTV, LPV340V82AL10F, L24I, I54CG17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
  69936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Weber (2005)F68541F68541AY677417NFV198M46MI, L90M T12S, I13V, I15V, L19I, K20T, E35X, M36I, R41K, H69K, T74AS, L89I, I93LC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
Doualla-Bell (2006)Pt2FDB_Pt2 NFV L90M T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93LC
 Pt8FDB_Pt8 NFV D30NL33F, N88DT12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89IC
Sanabani (2006)04BR13704BR137AY727526PINA  I15V, N37K, R41N, H69K, L89I, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
 DR58DR58AY589910NFV D30N T12S, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45Q, I64V, H69K, L89I, I93LC
 DR10003ZA.DR100AY589936RTV M46I, I54V, V82A I15E, G16GE, L19E, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
 DR10203ZA.DR102AY589937RTV I54V, V82L, L90M I13IV, I15V, K20R, M36I, R41RK, L63LP, H69K, L89IC
Riddler (2008)RG49532RG49532w9 LPV2  T12S, I15V, L19I, M36I, R41K, D60E, L63S, H69K, L89I, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Rodrigues (2010)319_07BR07SC319GQ401303LPV   K14R, I15V, M36I, N37K, R41N, L63LP, H69K, L89I, I93LC

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