Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	N88D
Rx	>= 1 PI
IncludeMixtures	No

References	10
Patients	23
Isolates	25

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gibb (2002)	DMG86	86_w82		NFV	65	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
	DMG91	91_w22		NFV	22	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
Grossman (2004)	IL160	IL160	AY529612	SQV, NFV	128	D30N	N88D	T12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93L	C
	IL217	IL217	AY529576	NFV	104	D30N	N88D	L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93L	C
	IL477	IL477	AY529602	NFV	208	D30N	L10F, N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L	C
Non-B Workgroup (2005)	UK1518	UK1518	AY900807	NFV	68	D30N	N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93L	C
	UK2069	UK2069	AY900845	NFV		D30N	N88D	T12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93L	C
	SA75_DR16	SA75_DR16	AY901099	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
	TK3027	TK3027		RTV, SQV, NFV	190	D30N, L90M	N88D	T12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93L	C
		TK3027b		RTV, SQV, NFV, LPV	276	D30DN, L90LM	N88D	T12S, I13IV, I15V, L19I, K20R, E35D, M36I, N37ND, R41RK, L63P, H69K, T74S, L89IM, I93L	C
	TK3031	TK3031		SQV, NFV	203	D30N	N88D	I15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93L	C
	PL47066	85002		IDV, NFV	104	D30N	N88D	T12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93L	C
Rhee (2005)	CA7907	CA24813	AY797580	IDV, NFV	260	D30N	L10F, N88D	T12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93L	C
Doualla-Bell (2006)	Pt13	FDB_Pt13		NFV		D30N, M46I	L10F, N88D	I15V, M36I, R41K, L63P, H69K, I93L	C
	Pt8	FDB_Pt8		NFV		D30N	L33F, N88D	T12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89I	C
	Pt9	FDB_Pt9		NFV		D30N	L33F, N88D	T12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93L	C
von Wyl (2007)	41	662849	EF449918	PI	NA	D30N	N88D	I15V, E35D, M36I, N37K, R41HN, L63P, H69K, A71AV, I85IV, I93L	C
Pillay (2008)	DR16	02ZA.DR16	AY589877	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
Kandathil (2009)	VL06_253	VL06_253	EU030406	PI	NA	D30N	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93L	C
Kouri (2012)	CU1452-09	CU1452-09	JQ585296	PI	NA	D30N, I54M, L90M	L33F, N88D	T12S, I13V, K14R, I15V, E35D, M36I, N37S, R41K, L63P, H69K, T74S, L89I, I93L	C
Grossman (2014)	255	255	KF135031	SQV, LPV	52	I54V, V82A	L10F, N88D, L89V	T12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93L	C
		255	KF135032	SQV, LPV	90	M46I, I54V, V82A	L10F, L33F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93L	C
	217	217	KF135024	NFV, LPV	52	D30N, I54V, V82A	L33F, N88D	L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, H69Q, V75I, L89I, I93L	C
	943	943		LPV	379	M46I, L90M	L10F, N88D	T12S, I15V, L19I, K20R, E35D, M36I, R41K, K55R, L63P, H69K, L89M, I93L	C
	160	160	KF134989	SQV, LPV	52	D30N	N88D	T12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93L	C

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