Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	N88D
Rx	>= 1 PI
IncludeMixtures	No

References	14
Patients	52
Isolates	54

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gibb (2002)	DMG86	86_w82		NFV	65	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
	DMG91	91_w22		NFV	22	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
Grossman (2004)	IL160	IL160	AY529612	SQV, NFV	128	D30N	N88D	T12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93L	C
	IL217	IL217	AY529576	NFV	104	D30N	N88D	L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93L	C
	IL477	IL477	AY529602	NFV	208	D30N	L10F, N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L	C
Non-B Workgroup (2005)	UK1518	UK1518	AY900807	NFV	68	D30N	N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93L	C
	UK2069	UK2069	AY900845	NFV		D30N	N88D	T12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93L	C
	SA75_DR16	SA75_DR16	AY901099	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
	TK3027	TK3027		RTV, SQV, NFV	190	D30N, L90M	N88D	T12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93L	C
		TK3027b		RTV, SQV, NFV, LPV	276	D30DN, L90LM	N88D	T12S, I13IV, I15V, L19I, K20R, E35D, M36I, N37ND, R41RK, L63P, H69K, T74S, L89IM, I93L	C
	TK3031	TK3031		SQV, NFV	203	D30N	N88D	I15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93L	C
	PL47066	85002		IDV, NFV	104	D30N	N88D	T12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93L	C
Rhee (2005)	CA7907	CA24813	AY797580	IDV, NFV	260	D30N	L10F, N88D	T12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93L	C
Doualla-Bell (2006)	Pt13	FDB_Pt13		NFV		D30N, M46I	L10F, N88D	I15V, M36I, R41K, L63P, H69K, I93L	C
	Pt8	FDB_Pt8		NFV		D30N	L33F, N88D	T12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89I	C
	Pt9	FDB_Pt9		NFV		D30N	L33F, N88D	T12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93L	C
von Wyl (2007)	41	662849	EF449918	PI	NA	D30N	N88D	I15V, E35D, M36I, N37K, R41HN, L63P, H69K, A71AV, I85IV, I93L	C
Pillay (2008)	DR16	02ZA.DR16	AY589877	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
Waleria-Aleixo (2008)	08PR050258	08PR050258	FJ591287	PI	NA	D30N	N88D	E35D, M36I, N37K, R41N, Q61H, L63P, I64IV, H69K, V75I, I93L	C
	08PR050264	08PR050264	FJ591293	PI	NA	D30N, L90LM	L10F, N88D	I13V, I15V, K20T, E35N, M36I, N37K, R41N, K45R, L63P, H69K, T74A, L89M, I93L	C
	08RJ050431	08RJ050431	FJ591648	PI	NA	D30N	L10F, N88D	I13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, V75I, I93L	C
	08PR050391	08PR050391	FJ591416	PI	NA	D30N	N88D	L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, I62V, L63S, H69K, T74A, L89M, I93L	C
	08PR060708	08PR060708	FJ591531	PI	NA	D30N	N88D	I13V, G16A, K20R, E35D, M36V, N37Q, R41N, H69K, T74S, L89M, I93L	C
	08PR050433	08PR050433	FJ591430	PI	NA	I54V, V82A, L90M	N88D	I15V, G16A, K20R, E35D, M36I, N37E, R41H, K45R, D60N, L63P, H69K, K70KT, A71V, L89I, I93L	C
	RES224	RES224	FJ591941	PI	NA	D30N	I47KR, N88D	I15V, E35D, M36I, N37K, R41N, L63P, H69K, T74S, V75I, I93L	C
	08PR040159	08PR040159	FJ591190	PI	NA	D30N, I50L	L10F, L33F, N83D, N88D	I13V, I15V, E35D, M36I, N37K, R41N, H69K, T74S, L89I, I93L	C
	08PR040195	08PR040195	FJ591225	PI	NA	D30N	N88D	I15V, K20T, E35D, M36I, N37K, R41N, K45R, L63P, H69K, T74A, L89M, I93L	C
	08PR050444	08PR050444	FJ591441	PI	NA	D30N, I50L	N88D	K14R, I15V, G16E, E35D, M36I, N37K, R41Y, K45R, K55N, L63T, H69K, A71V, L89I, I93L	C
	08PR060752	08PR060752	FJ591548	PI	NA	D30N	N88D	I13IV, I15V, K20T, M36I, N37K, R41N, L63P, H69K, A71V, I72IM, L89I, I93L	C
Kandathil (2009)	vl05_247	vl05_247	EU030408	NFV		D30N, M46I	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, K55N, Q61E, L63P, H69K, T74S, I93L	C
	VL06_253	VL06_253	EU030406	PI	NA	D30N	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93L	C
Kouri (2012)	CU1452-09	CU1452-09	JQ585296	PI	NA	D30N, I54M, L90M	L33F, N88D	T12S, I13V, K14R, I15V, E35D, M36I, N37S, R41K, L63P, H69K, T74S, L89I, I93L	C
Saravanan (2013)	YRG07	YRG07	KC016202	PI	NA	D30N	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21N, E35N, M36I, P39A, R41K, K45R, K55N, Q61D, L63P, H69K, T74S, V82I, I93L	C
	YRG05	YRG05	KC016200	PI	NA	D30N, M46MI, I54V, V82A	L10F, L33F, N88D	I15V, L19T, K20T, E35X, M36I, N37NT, R41K, L63P, I64IL, H69X, A71V, I93L	C
Acharya (2014)	DGP142	DGP142	KJ185312	RTV, ATV		I54V, L90M	N88D	T12S, I15V, L19I, M36L, N37S, R41K, L63P, H69K, K70R, A71V, V82I, L89M, I93L	C
Grossman (2014)	255	255	KF135031	SQV, LPV	52	I54V, V82A	L10F, N88D, L89V	T12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93L	C
		255	KF135032	SQV, LPV	90	M46I, I54V, V82A	L10F, L33F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93L	C
	217	217	KF135024	NFV, LPV	52	D30N, I54V, V82A	L33F, N88D	L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, H69Q, V75I, L89I, I93L	C
	943	943		LPV	379	M46I, L90M	L10F, N88D	T12S, I15V, L19I, K20R, E35D, M36I, R41K, K55R, L63P, H69K, L89M, I93L	C
	160	160	KF134989	SQV, LPV	52	D30N	N88D	T12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93L	C
Diaz (2015)	RenG16894	RenG16894	KT747922	PI	NA	D30N, M46I, I54V, V82A	L10F, L24I, L33F, N88D	T12P, I13IV, K14KR, I15V, L19LP, K20KM, E35D, M36L, N37K, R41N, K55KR, R57RK, L63P, H69K, Q92QK	C
	RenG16300	RenG16300	KT747328	PI	NA	D30N, L90LM	L10LF, N88D	I13V, I15V, E35D, M36I, N37K, R41N, K45R, L63AP, I64IV, H69K, L89I, I93L	C
	RenG16715	RenG16715	KT747743	PI	NA	D30N, I54L	N88D	L10Y, I15V, L19Q, K20T, E35D, M36I, N37K, R41N, L63V, H69K, A71T, L89T, I93L	C
	RenG16280	RenG16280	KT747308	PI	NA	D30N, I50IL	N88D, L89AITV	K14KR, I15V, L19I, K20T, M36IV, N37KR, R41NY, Q61H, H69K, A71IV, T74S, I85V, I93L	C
	RenG14709	RenG14709	KT745737	PI	NA	D30N, M46MI, V82A	L10F, L24I, L33F, N88D	T12P, I15V, K20T, E35N, M36I, N37K, R41N, K45R, L63P, H69K, V75I, I93L	C
	RenG14050	RenG14050	KT745078	PI	NA	D30N	L10F, N88D	K14KR, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69Q, I72IV, V75I, L89M, I93L	C
	RenG14536	RenG14536	KT745564	PI	NA	D30N, I54ILM, I84IV	L10F, L33F, N88D	I15V, G16E, K20T, E35D, M36I, N37EK, P39S, R41N, K45I, L63T, H69K, T74AS, I85V, L89M, I93IL	C
	RenG14186	RenG14186	KT745214	PI	NA	D30N, M46L, I54V, V82A	Q58QE, N88D	L10R, I15V, K20T, E35D, M36I, N37K, R41N, D60DE, Q61QH, L63P, I64IL, H69K, A71V, L89I, I93L	C
	RenG14024	RenG14024	KT745052	PI	NA	D30N, I50L, V82A	L33F, N88D	L10LR, I13V, I15IV, K20KRT, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, H69K, A71AV, T74S, V77VI, L89IM, I93L	C
	RenG11098	RenG11098	KT742126	PI	NA	D30N	N88D	I13V, K14KR, I15V, K20T, E35D, M36I, N37Q, R41NS, D60E, Q61N, L63Q, H69K, T74A, V77VI, L89M, I93L	C
	RenG11593	RenG11593	KT742621	PI	NA	D30N	N88D	I13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, T74S, L89M, I93L	C
	RenG10573	RenG10573	KT741601	PI	NA	D30N	N88D	I13V, I15V, K20Q, E35G, M36I, N37K, R41N, K45R, L63P, H69K, T74S, L89I, I93L	C
	RenG11741	RenG11741	KT742769	PI	NA	M46MI, I54V, V82A, L90M	L33F, K43T, N88D	L10V, I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74KR, L89M, I93L	C
	RenG10498	RenG10498	KT741526	PI	NA	D30N, I50L, V82VA	L33F, N88D	I13V, I15V, K20R, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, G68GE, H69K, A71AITV, T74S, L89M, I93L	C

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