<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I85V
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 50
Isolates 59
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kantor (2002)TCDD-30TCDD-30_1AY090856NFV, IDV14I54FLL33FL10I, T12S, I15V, L19I, E34D, M36I, R41K, Q58QP, D60E, L63P, H69K, T74E, P79PL, I85V, L89M, I93LC
Grossman (2004)IL185IL185cAY529558NFV132D30N T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NIC
Non-B Workgroup (2005)UK955UK955AY900786SQV, RTV, IDV137I54V, I84V, L90MG73S, L89VL10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93LC
 IL201IL201dAY900813IDV, RTV123L90M T12S, I15V, L19T, M36I, R41K, L63P, I64IL, H69K, I85V, L89M, I93LC
 IL257IL257AY900818IDV, RTV110V82A L10I, I15V, L19I, D29DV, M36I, R41K, L63P, H69K, I85V, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015c SQV, IDV, LPV, RTV, TPV375I54V, V82T, I84IV, L90MK43TL10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93LC
 TK5007TK5007 IDV, RTV261 G73STL10I, T12S, I15V, L19I, E35D, M36I, N37S, R41K, K45R, I62V, L63P, H69K, I85V, I93LC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
  69936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-14071407-30410DQ877803PINAI54V, V82A, L90ML10FI, K43TT12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
 48-93029302-30918DQ877587PINAI54V, V82A, L90ML10F, G73GS, L89IMVI15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93LC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Kassaye (2009)TCDD-31TC31_2003FJ445704SQV, APV, IDV, LPV198M46MI, L76VV32VG, I47IMR41R*K, D60DE, L63P, H69K, T74A, I85V, L89M, I93LC
 TC-68TC68_2004FJ445724NFV, LPV17I54L, L90LML10LFI15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93LC
Knops (2010)ID2137ID2137-GT1GU271172IDV, LPV V32I, I47A, V82A L10I, T12S, I15V, L19AP, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
  ID2137-GT2GU271173IDV, LPV, DRV, RTV33V32I, I54L, L76V, V82AL89VL5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
Kouri (2012)CU728-10CU728-10JQ585411PINAM46I, I50V, L90ML33FW6G, L10V, N37S, R41K, K55R, Q61E, L63P, H69K, T74S, V77I, V82VI, I85V, L89M, I93LC
Van Zyl (2013)11281379KC423106LPV26I54V, V82AL10F, L24I, L33F, N83DG16GA, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, I85V, L89I, T91S, I93LC
Grossman (2014)250250KF135030SQV, LPV52L90M K14R, I15V, M36I, N37D, R41K, I62V, H69K, T74S, V82I, I85V, L89I, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 581581KF135103IDV, LPV52L90M L10I, T12TA, L19I, K20I, E35ED, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93LC
  581KF135104IDV, LPV187L90M L10I, L19I, K20I, E35D, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93LC
 20632063KF135018LPV52M46I, I54V, V82AL10F, G73S, L89VT12S, I15V, G16E, L19I, K20I, M36I, N37D, R41K, L63R, H69K, I85V, I93LC
 464464 NFV, IDV, LPV52V32I, I47V, I54MN83DL10I, M36I, R41K, I62V, L63V, T74S, V82I, I85V, L89I, I93LC
Diaz (2015)RenG17238RenG17238KT748266PINA  I15V, K20I, E35G, M36I, N37K, R41N, K45R, H69K, A71V, T74S, I85V, L89T, I93LC
 RenG16802RenG16802KT747830PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, D60E, Q61D, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93LC
 RenG16128RenG16128KT747156PINAM46I, I54V, I84VL10FI15V, K20T, E35DN, M36I, N37K, R41N, I62IV, L63V, H69K, T74E, I85V, L89M, I93LC
 RenG16280RenG16280KT747308PINAD30N, I50ILN88D, L89AITVK14KR, I15V, L19I, K20T, M36IV, N37KR, R41NY, Q61H, H69K, A71IV, T74S, I85V, I93LC
 RenG17259RenG17259KT748287PINAI54V, V82T L10I, I15V, K20R, M36I, N37K, R41N, I62V, L63P, H69K, A71AV, T74S, I85V, L89IM, I93LC
 RenG16641RenG16641KT747669PINAM46I, I84V L10V, I15V, G16E, E35G, M36I, N37K, P39S, R41N, I62V, L63T, I64V, H69K, T74A, I85V, L89M, I93LC
 RenG14474RenG14474KT745502PINAM46I, I54V, V82A, I84V, L90ML10F, K43KTI15V, L19I, K20R, E35D, M36I, N37K, R41N, L63P, H69K, A71V, I85V, L89I, Q92K, I93LC
 RenG14917RenG14917KT745945PINAM46I, I47A, L90ML10FI15V, G16E, L19P, K20I, N37K, R41N, F53Y, D60E, Q61HN, L63H, H69K, V77I, I85V, L89I, I93LC
 RenG13840RenG13840KT744868PINAI54A, V82M, L90MQ58EL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62IV, L63P, H69K, A71IV, I72IT, I85V, L89M, Q92QK, I93LC
 RenG15244RenG15244KT746272PINAM46I, I54V, I84VL10FI15V, G16A, K20Q, M36I, N37K, R41N, L63P, I66V, H69K, I85V, L89I, Q92K, I93LC
 RenG14536RenG14536KT745564PINAD30N, I54ILM, I84IVL10F, L33F, N88DI15V, G16E, K20T, E35D, M36I, N37EK, P39S, R41N, K45I, L63T, H69K, T74AS, I85V, L89M, I93ILC
 RenG14286RenG14286KT745314PINAV32I, M46MIL33LI, K43T, T74PI15V, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, A71AV, I85V, L89I, I93LC
 RenG15013RenG15013KT746041PINAM46I, I84VL10FI15V, G16A, K20I, E35G, M36I, N37K, R41N, K55R, R57K, D60E, Q61E, L63P, H69K, I85V, L89I, I93LC
 RenG14901RenG14901KT745929PINAM46ML, G48GA, I54V, I84V, L90ML10F, T74P, L89VI15V, K20T, E35DN, M36I, N37K, R41H, Q61QH, I62IV, L63P, H69K, A71V, I85V, T91CS, I93LC
 RenG15313RenG15313KT746341PINAM46L, G48A, I54V, V82A, L90ML33F, N83DL10V, K14KR, I15IV, G16E, K20R, E35D, M36I, N37K, R41N, R57K, Q61N, L63T, H69K, T74S, I85V, L89I, Q92K, I93LC
 RenG14927RenG14927KT745955PINAL90M I15V, G16E, L19I, K20T, N37K, R41H, K45R, L63H, H69K, V82I, I85V, L89LIM, I93LC
 RenG14113RenG14113KT745141PINAG48V, I50V, I54V, V82AL33IL10I, I13V, L19IV, E35D, M36I, N37R, R41N, Q61E, I62V, L63P, H69K, T74S, I85V, L89IC
 RenG14545RenG14545KT745573PINAM46L, I50L, I54IV, V82VA, L90ML33LF, G73SL10V, I13IV, I15IV, K20KR, E35ED, N37K, R41N, K45R, L63P, H69K, A71AITV, T74S, V77VI, I85V, I93LC
 RenG12354RenG12354KT743382PINAM46I, I54V, V82A, L90ML33LI, K43KT, G73SL10I, I15V, L19LP, K20KI, A22AV, E35DN, M36I, N37K, P39PQ, R41N, K45KR, I62V, L63P, C67F, H69K, A71IV, I72L, I85V, I93ILC
 RenG10449RenG10449KT741477PINAI50LL33FI15V, E35D, M36L, N37K, R41N, R57RK, L63P, H69K, T74S, V82I, I85V, L89M, I93LC
 RenG11780RenG11780KT742808PINAI54IV L10Y, I15V, K20I, E35G, M36I, N37K, R41N, K45R, H69K, A71I, T74S, I85V, L89T, I93LC
 RenG10789RenG10789KT741817PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, K55KN, D60E, Q61DN, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93ILC
 RenG10964RenG10964KT741992PINAM46I, I54V, V82C, I84V, L90ML10FT12R, I15V, L19LP, K20T, L33L_L, E35D, M36I, N37K, R41N, D60E, L63P, I66IV, H69K, A71AT, V77I, I85V, L89I, Q92K, I93L, C95FC
 RenG11076RenG11076KT742104PINAI54V, V82A, L90ML23I, G73S, L89VL10I, I15V, G16GW, L19LP, K20IM, E35D, M36I, N37K, R41N, K45R, K55KR, I62V, L63P, H69K, A71T, I85V, I93LC
 RenG10394RenG10394KT741422PINAG48V, I54T, V82A L10I, I15V, K20R, E35D, M36I, N37K, R41N, Q61H, L63V, H69K, A71V, I72IR, T74S, I85V, L89I, I93LC