<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I85V
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 22
Isolates 31
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL185IL185cAY529558NFV132D30N T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NIC
Non-B Workgroup (2005)UK955UK955AY900786SQV, RTV, IDV137I54V, I84V, L90MG73S, L89VL10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93LC
 IL201IL201dAY900813IDV, RTV123L90M T12S, I15V, L19T, M36I, R41K, L63P, I64IL, H69K, I85V, L89M, I93LC
 IL257IL257AY900818IDV, RTV110V82A L10I, I15V, L19I, D29DV, M36I, R41K, L63P, H69K, I85V, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015c SQV, IDV, LPV, RTV, TPV375I54V, V82T, I84IV, L90MK43TL10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93LC
 TK5007TK5007 IDV, RTV261 G73STL10I, T12S, I15V, L19I, E35D, M36I, N37S, R41K, K45R, I62V, L63P, H69K, I85V, I93LC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
  69936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-14071407-30410DQ877803PINAI54V, V82A, L90ML10FI, K43TT12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
 48-93029302-30918DQ877587PINAI54V, V82A, L90ML10F, G73GS, L89IMVI15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93LC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Kassaye (2009)TCDD-31TC31_2003FJ445704SQV, APV, IDV, LPV198M46MI, L76VV32VG, I47IMR41R*K, D60DE, L63P, H69K, T74A, I85V, L89M, I93LC
 TC-68TC68_2004FJ445724NFV, LPV17I54L, L90LML10LFI15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93LC
Knops (2010)ID2137ID2137-GT1GU271172IDV, LPV V32I, I47A, V82A L10I, T12S, I15V, L19AP, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
  ID2137-GT2GU271173IDV, LPV, DRV, RTV33V32I, I54L, L76V, V82AL89VL5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
Van Zyl (2013)11281379KC423106LPV26I54V, V82AL10F, L24I, L33F, N83DG16GA, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, I85V, L89I, T91S, I93LC
Grossman (2014)250250KF135030SQV, LPV52L90M K14R, I15V, M36I, N37D, R41K, I62V, H69K, T74S, V82I, I85V, L89I, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 581581KF135103IDV, LPV52L90M L10I, T12TA, L19I, K20I, E35ED, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93LC
  581KF135104IDV, LPV187L90M L10I, L19I, K20I, E35D, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93LC
 20632063KF135018LPV52M46I, I54V, V82AL10F, G73S, L89VT12S, I15V, G16E, L19I, K20I, M36I, N37D, R41K, L63R, H69K, I85V, I93LC