<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I84V
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 50
Isolates 54
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL266IL266AY529621SQV, RTV, IDV, NFV180I54IL, I84V, L90MT74TPR8RG, L10I, I15V, K20KI, E35EG, M36I, R41RK, L63P, H69K, A71V, L89M, Q92QR, I93LC
 IL280IL280aAY529617SQV, IDV180I84V, L90M T12S, I15V, K20KR, M36I, R41RK, L63P, H69K, A71V, T74S, L89M, I93LC
  IL280bAY529616SQV, IDV201M46MI, I84V, L90M T12S, I15V, Q18L, D29DG, M36I, R41RK, L63P, H69KR, A71V, T74S, R87RT, L89M, I93LC
 IL287IL287AY529620SQV, RTV, IDV, NFV184I84V, L90M L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93LC
Non-B Workgroup (2005)UK186bUK186bAY900763SQV, RTV183I84V, L90MV11VI, G73GSL10I, I15V, G16E, L19I, R41K, L63H, H69K, A71V, V77I, I93LC
 UK955UK955AY900786SQV, RTV, IDV137I54V, I84V, L90MG73S, L89VL10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93LC
 UK1447UK1447AY900803IDV, SQV, RTV83G48GA, I54V, V82A, I84V, L90ML23LI, K43KTL10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93LC
 IL80IL80AY900811RTV, NFV, SQV114I54V, V82A, I84VK43TW6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93LC
 BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
Weber (2005)F16446F16446AY677447SQV, NFV, APV, LPV208M46I, I54V, I84V, L90M L10I, T12S, L19I, K20M, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
Baxter (2006)12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 12-30823082-30430DQ877155PINAM46I, I84V, L90MG73SL10I, T12S, I13N, I15V, L19I, M36I, R41RK, Q61H, L63P, H69K, A71V, I72L, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Kassaye (2009)TCDD-28TC28_2004FJ445727SQV, LPV378M46I, I84V, L90MG73SI15V, L19I, K20I, M36I, L63P, H69K, A71V, I93LC
 TCDD-30TC30_2003FJ445708NFV, IDV99I54V, I84V L10I, T12A, I15V, L19I, K20KR, E35D, M36I, R41K, L63P, H69Q, L89M, I93LC
Kouri (2012)CU1316-09CU1316-09JQ585291PINAI84V, L90M E35D, M36I, R41K, L63P, H69K, L89M, I93LC
 CU2104-09CU2104-09JQ585341PINAG48GV, I54MV, I84V, L90LML33F, Q58QE, T74PS, N83NDL10I, E34K, E35D, M36I, N37S, R41K, L63LP, G68GE, H69K, A71AV, L89IM, I93LC
Van Zyl (2013)16721580KC423245LPV26M46I, I54IL, L76V, I84V E35D, M36I, R41K, L63P, H69K, L89MC
 16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
 14071550KC423222LPV26I54V, I84V T12S, I13V, I15V, G16E, L19I, K20T, M36I, R41K, K45V, D60E, Q61E, I66V, H69K, K70R, I72V, V82I, L89M, I93LC
 222915KC423893LPV26I84VQ58ET12S, I15V, L19I, M36I, R41K, D60K, Q61E, L63P, H69K, I93LC
 402656KC423765LPV26M46I, I54V, V82C, I84VL10FT12S, I15V, L19T, K20R, A22T, M36I, H69K, L89M, I93L, N98KC
 202459KC423723LPV26M46I, I54V, L76V, I84VL10FI15V, L19I, K20R, M36I, R41K, Q61QH, L63PS, H69K, A71V, I93LC
Grossman (2014)9797KF135173IDV, LPV52M46I, I54V, V82A, I84V, L90ML10FI13IV, I15V, K20R, M36I, R41K, L63P, H69K, A71V, L89LM, I93LC
  97KF135174IDV, LPV133M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
  97KF135175IDV, LPV228M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC
Steegen (2014)10ZAKS03710ZAKS037KJ176319LPV M46MI, I54V, L76V, V82A, I84V R41RK, Q61QR, L63P, H69K, A71V, I93LC
 11ZAKS10611ZAKS106KJ176388LPV M46L, I47A, I84V R41K, L63P, H69Q, I72V, I93LC
 09ZAKS00509ZAKS005KJ176289LPV M46I, I54V, L76V, I84V G52X, D60E, Q61G, H69KN, A71V, L89M, I93LC
 11ZAKS11711ZAKS117KJ176399LPV M46L, I47A, I84V R41K, K45R, L63P, H69Q, I72V, V82I, I93LC
Diaz (2015)RenG15586RenG15586KT746614PINAM46I, I54V, I84V, L90M L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, D60E, I62V, L63P, H69K, A71V, L89I, I93LC
 RenG16802RenG16802KT747830PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, D60E, Q61D, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93LC
 RenG16128RenG16128KT747156PINAM46I, I54V, I84VL10FI15V, K20T, E35DN, M36I, N37K, R41N, I62IV, L63V, H69K, T74E, I85V, L89M, I93LC
 RenG16641RenG16641KT747669PINAM46I, I84V L10V, I15V, G16E, E35G, M36I, N37K, P39S, R41N, I62V, L63T, I64V, H69K, T74A, I85V, L89M, I93LC
 RenG15516RenG15516KT746544PINAI54V, V82VA, I84V, L90ML10F, L23I, Q58EI15V, K20R, E35D, M36I, N37K, R41N, R57RK, D60DE, I62IV, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 RenG15346RenG15346KT746374PINAM46MI, I54V, V82VA, I84V, L90ML10F, L23LI, L33F, F53FL, G73S, T74PS, L89VV11L, I13V, I15V, K20T, E34Q, E35D, M36IL, N37K, R41N, I62V, L63P, G68D, H69R, A71V, I93LC
 RenG14474RenG14474KT745502PINAM46I, I54V, V82A, I84V, L90ML10F, K43KTI15V, L19I, K20R, E35D, M36I, N37K, R41N, L63P, H69K, A71V, I85V, L89I, Q92K, I93LC
 RenG15244RenG15244KT746272PINAM46I, I54V, I84VL10FI15V, G16A, K20Q, M36I, N37K, R41N, L63P, I66V, H69K, I85V, L89I, Q92K, I93LC
 RenG15013RenG15013KT746041PINAM46I, I84VL10FI15V, G16A, K20I, E35G, M36I, N37K, R41N, K55R, R57K, D60E, Q61E, L63P, H69K, I85V, L89I, I93LC
 RenG14901RenG14901KT745929PINAM46ML, G48GA, I54V, I84V, L90ML10F, T74P, L89VI15V, K20T, E35DN, M36I, N37K, R41H, Q61QH, I62IV, L63P, H69K, A71V, I85V, T91CS, I93LC
 RenG12144RenG12144KT743172PINAV32I, I54L, I84VL10F, L33I, L89VI13V, I15V, K20T, M36I, N37K, R41N, Q61N, L63P, I66FV, H69K, A71V, T74S, V77I, Q92KC
 RenG13278RenG13278KT744306PINAI54IL, I84V, N88SL33F, Q58EL10Y, I13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, D60E, Q61E, I62V, L63P, H69K, A71T, L89M, I93LC
 RenG11141RenG11141KT742169PINAM46I, V82VA, I84VL10F, L23I, Q58QE, T74PSK14R, I15V, K20R, M36I, N37K, R41N, L63P, H69K, L89M, I93LC
 RenG11086RenG11086KT742114PINAM46I, I47A, I84VF53LL10V, G16E, E35D, M36V, N37E, P39S, R41N, I62V, L63T, H69R, A71V, T74S, L89M, I93LC
 RenG10789RenG10789KT741817PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, K55KN, D60E, Q61DN, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93ILC
 RenG10964RenG10964KT741992PINAM46I, I54V, V82C, I84V, L90ML10FT12R, I15V, L19LP, K20T, L33L_L, E35D, M36I, N37K, R41N, D60E, L63P, I66IV, H69K, A71AT, V77I, I85V, L89I, Q92K, I93L, C95FC
 RenG10990RenG10990KT742018PINAI84V L10Y, I13IV, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, A71IV, I85IV, L89T, I93LC
 RenG10774RenG10774KT741802PINAV82F, I84V, L90ML33FI13V, I15V, K20AT, E35D, M36I, R41N, K45V, I62V, L63P, H69K, T74S, L89M, I93LC
 RenG10631RenG10631KT741659PINAM46L, I54V, V82A, I84VV11I, L24I, K43TL10I, T12E, I13V, L19I, K20I, M36I, Q61N, L63T, I64V, H69K, A71V, I72IV, T74S, I93LC