Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	V82I
Rx	>= 1 PI
IncludeMixtures	No

References	17
Patients	30
Isolates	33

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Yahi (2001)	NY_M6	M6	AY010422	SQV				T12S, I15V, G16E, L19Q, M36I, N37R, R41N, Q61N, L63A, H69K, V82I, L89M, I93L	C
	NY_M62	M62	AY010425	SQV				T12S, I15V, G16E, L19Q, M36I, N37R, R41N, Q61N, L63A, H69K, V82I, L89M, I93L	C
Gibb (2002)	DMG85	85_w19		NFV	17			T12S, I15V, L19I, E35D, M36I, R41K, D60DE, L63LAPV, H69K, V82I, L89M, I93L	C
		85_w50		NFV	36			T12S, I15V, L19I, K20KT, E35D, M36I, R41K, L63LV, H69K, V82I, L89M, I93L	C
Kantor (2002)	TCDD-01	TCDD-01	AY090840	NFV	22			T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63I, E65D, H69K, V82I, L89M, I93L	C
	TCDD-13	TCDD-13_1	AY090847	SQV	69			T12TS, I15V, L19LI, L24L*, M36I, R41K, L63LAPV, H69K, V82I, L89LM, I93L	C
	TCDD-26	TCDD-26	AY090852	SQV	38			I15V, L19X, M36I, R41K, L63V, H69K, V82I, L89M, I93L	C
	TCDD-23	TCDD-23_1	AY090850	SQV	205	L90M		I15V, L19I, M36I, R41K, D60E, L63P, H69K, V82I, L89M, I93L	C
Shafer (2003)	A384_0973	0973b	EF548178	Unknown, RTV, IDV	>5			I15V, L19IMT, M36I, R41K, H69K, K70KR, V82I, L89M, I93L	C
Montes (2004)	MB_patNIB	01_NIB719	AJ577965	NFV	94	L90M	L23I	T12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93L	C
Non-B Workgroup (2005)	UK243	UK243	AY900766	IDV, NFV		L90M	L23I	T12S, I15V, L19I, E35G, M36I, R41K, L63P, H69K, K70R, V82I, I93L	C
	UK449	UK449		SQV, NFV, RTV		L90M	L23I	T12S, L19I, E35D, M36I, R41K, D60E, L63S, H69K, V82I, L89M, I93L, L97X	C
	UK1154	UK1154	AY900795	NFV		L90M		T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, D60E, L63P, I64V, H69K, V82I, L89M, I93L	C
	UK1461	UK1461	AY900805	NFV	35		L23I	T12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93L	C
	IL273	IL273		NFV, IDV, RTV	137			I15V, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	UK1461b	UK1461b		NFV	35	L90LM	L23I	T12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93L	C
	TK4001	TK4001		NFV	2			T12S, I15V, L19T, M36I, R41K, Q61E, L63P, H69K, V82I, L89M, I93L	C
Weber (2005)	M83284	M83284	AY677471	SQV	82			T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93L	C
Baxter (2006)	12-3102	3102-30610	DQ877250	PI	NA	L90M	L23I, L33F, F53L, Q58E	L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L	C
	48-8032	8032-30707	DQ879070	PI	NA	L90LM		T12S, I15V, L19I, M36I, R41K, L63P, H69K, K70KR, V82I, I93L	C
	48-8056	8056-30930	DQ879080	PI	NA	V32I, I47A	L33F, Q58E	L10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93L	C
Doualla-Bell (2006)	Pt2	FDB_Pt2		NFV		L90M		T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93L	C
von Wyl (2007)	73	5326978	EF449871	PI	NA			T12S, I15V, G16E, L19Q, M36I, R41K, L63P, H69K, V82I, I93L	C
Marconi (2008)	SW090	SW090	EU308099	LPV				T12S, I15V, L19T, E35D, M36I, R41K, K45R, D60E, I62V, L63P, H69K, V82I, L89M, I93L	C
Kandathil (2009)	VL06_253	VL06_253	EU030406	PI	NA	D30N	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93L	C
Kassaye (2009)	TCDD-13	TC13_2003	FJ445709	SQV, NFV	178			I15V, L19LI, M36I, R41K, L63V, H69K, V82I, I93L	C
	TCDD-23	TC23_2003	FJ445712	SQV	304	L90M		I15V, L19I, K20M, M36I, R41K, D60E, L63P, H69Q, V82I, L89M, I93L	C
	TC-68	TC68_2004	FJ445724	NFV, LPV	17	I54L, L90LM	L10LF	I15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93L	C
Dau (2010)	07344A	07344A	GU581841	PI	NA	L90M		T12S, I13V, I15V, L19I, K20T, M36I, N37ND, R41K, L63P, H69K, V82I, L89M, I93L	C
El-Khatib (2010)	Pat115	11ZA_SAVE2347	JF960565	LPV				T12S, I15V, L19I, N37S, R41K, L63P, H69K, V77I, V82I, I93L	C
	Pat122	11ZA_SAVE2434	JF960572	LPV				T12S, I15V, L19T, M36I, R41K, H69K, V82I, L89M, I93L	C
Rodrigues (2010)	305_07	BR07SC305	GQ401315	NFV		L90M	L89V	I13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93L	C
Barber (2012)	51030	51030	JQ361665	LPV		I54V		T12S, I15V, L19I, E35D, M36I, R41K, R57K, H69K, V82I, L89M, I93L	C

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