<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation V77I
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 73
Isolates 92
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weber (2003)85H610185H-12AY140821RTV13  L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93LC
  610185H-48AY140823RTV48I54V, V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69R, T74S, V77I, L89M, I93LC
Grossman (2004)IL369IL369AY529591NFV111M46I, L90M T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93LC
Non-B Workgroup (2005)UK186bUK186bAY900763SQV, RTV183I84V, L90MV11VI, G73GSL10I, I15V, G16E, L19I, R41K, L63H, H69K, A71V, V77I, I93LC
 UK538UK538 SQV, RTV4  V11X, T12S, I15V, L19T, K20R, M36I, R41K, D60E, L63P, H69K, V77I, L89M, I93LC
 SA78_DR20SA78_DR20AY901102NFV   T12S, I15V, L19I, M36I, R41K, H69K, V77I, L89M, I93LC
 TK3013TK3013 SQV, NFV205L90MG73SL10V, R41K, L63P, A71I, V77I, L89M, I93LC
Baxter (2006)48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
Doualla-Bell (2006)Pt11FDB_Pt11 NFV M46I, L90M T12S, I15V, L19I, M36I, R41K, L63V, H69K, V77I, L89M, I93LC
Sen (2007)T093NPT93EF186929RTV, IDV M46I, I54L, L90ML23LI, G73STL10Y, T12S, L19T, K20I, L24LF, R41K, K45KR, K55KR, L63P, H69K, A71V, I72IM, V77I, I93LC
  NPT93-PLEF186978RTV, IDV M46I, I54IL, L90MG73STL10Y, T12S, L19T, K20I, L24F, R41K, K45R, K55R, L63P, H69K, A71V, V77I, I93LC
Pillay (2008)DR32DR32AY589889LPV   T12S, I15V, Q18E, L19I, K20R, M36I, R41K, L63P, H69K, V77I, L89M, I93LC
 DR2002ZA.DR20AY589881NFV   T12S, I15V, L19I, M36I, R41K, H69K, V77I, L89M, I93LC
El-Khatib (2010)Pat10411ZA_SAVE2119JF960554LPV   I15V, L19I, K20R, E35D, N37A, P39T, R41K, D60E, L63P, H69K, V77I, L89MC
 Pat11311ZA_SAVE2319JF960563LPV   T12S, I15V, L19I, K20R, M36I, R41K, D60E, Q61E, L63P, H69K, V77I, L89M, I93LC
 Pat11511ZA_SAVE2347JF960565LPV   T12S, I15V, L19I, N37S, R41K, L63P, H69K, V77I, V82I, I93LC
 Pat12611ZA_SAVE2455JF960576LPV   T12S, I15V, L19M, K20R, M36I, R41K, L63P, H69K, V77I, L89LM, I93LC
 Pat12711ZA_SAVE2466JF960577LPV   T12S, I15V, L19I, R41K, L63Q, H69K, T74A, V77I, L89M, I93LC
Kouri (2012)CU728-10CU728-10JQ585411PINAM46I, I50V, L90ML33FW6G, L10V, N37S, R41K, K55R, Q61E, L63P, H69K, T74S, V77I, V82VI, I85V, L89M, I93LC
Mollan (2012)MK142MK142w36 RTV, ATV36 L33FT12S, L19T, R41K, H69K, K70R, V77I, L89M, I93LC
Rawizza (2013)PJ9169PJ9169KF241499LPV   H69K, T74S, V77I, L89M, I93LC
Van Zyl (2013)907525KC424117LPV26  T12S, I15V, L19I, N37S, R41K, L63P, H69K, V77I, V82I, I93LC
 14641389KC423112LPV26  T12S, I15V, L19I, N37NS, R41K, H69K, V77I, L89M, I93LC
 15462873KC423868LPV26  T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, V77I, L89LM, I93LC
 2921151KC422917LPV157  T12S, I15V, L19T, K20R, M36I, R41K, L63LP, H69K, V77I, L89M, I93LC
 52695KC423791LPV26  T12S, G16E, L19I, E35D, W42W*, L63A, H69K, V77I, L89M, I93LC
 729769KC424275LPV26  T12S, I15V, L19I, K20R, M36L, N37D, L63P, H69K, V77I, L89M, I93LC
 16151058KC422843LPV26  T12S, I15V, G16E, L19I, K20R, M36I, R41K, L63A, H69K, V77I, L89M, I93LC
 13182942KC423904LPV130  T12S, I15V, L19T, E35D, L63P, H69K, V77I, L89M, I93LC
 61843KC424312LPV26  T12S, I15V, G16E, L19I, N37S, L63H, H69K, V77I, I93ILC
 16841723KC423355LPV26  T12S, L19I, E35D, M36L, R41K, L63P, H69K, V77I, L89M, I93LC
 1542970KC424405LPV26  T12S, I15V, L19I, L63P, H69K, V77I, V82I, L89M, I93LC
 836556KC424138LPV26  T12S, I15V, L19I, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
  61KC424172LPV27  T12S, I15V, L19I, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
  284KC423852LPV78  T12S, I15V, L19I, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
  1064KC422850LPV130  T12S, I15IV, L19I, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
  1320KC423055LPV182  T12S, I15V, L19I, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
  1813KC423429LPV235  T12S, I15IV, L19I, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
 7732932KC423898LPV26  I15V, L19I, N37S, R41K, L63P, H69K, V77I, I93LC
 15351279KC423026LPV26  T12S, I15V, G16E, L19I, N37S, H69K, V77I, L89M, I93LC
 9911596KC423257LPV52  T12S, I15IV, G16E, L19I, K20R, M36I, R41K, H69K, K70R, T74S, V77I, L89M, I93LC
 859617KC424179LPV26  T12S, I15V, L19I, R41K, L63Q, H69K, T74AS, V77I, L89M, I93LC
 18072458KC423722LPV26  T12S, I15V, L19T, K20KR, E35D, Q61E, L63P, H69K, V77I, V82I, L89M, I93LC
 306516KC424109LPV26  T12S, I15V, L19IT, N37NS, R41K, K43KR, Q61E, L63P, C67CS, H69K, V77I, I93LC
 14742008KC423558LPV26  T12S, L19I, N37S, P39S, R41K, L63P, H69K, V77I, V82I, L89M, I93LC
 173089KC423962LPV26  T12S, I15V, L19V, E35D, M36I, R41K, L63P, H69K, T74S, V77I, L89M, I93LC
 6911305KC423043LPV52  I15V, L19T, R41K, Q61E, L63P, H69K, V77I, L89M, I93LC
  1780KC423402LPV104  I15V, L19T, P39PS, R41K, Q61E, L63P, H69K, V77I, L89M, I93LC
 4462808KC423841LPV261  T12S, I15V, L19T, K20R, E35D, M36I, N37D, R57RK, D60E, Q61E, L63P, H69K, V77I, L89M, I93LC
 1074987KC424418LPV26  T12S, I15V, L19I, M36T, N37S, R41K, L63P, H69K, V77I, L89M, I93LC
 15442438KC423708LPV26 V11IT12S, I15V, G16E, L19I, R41K, K55R, D60E, L63H, H69K, V77I, L89I, I93LC
 14331475KC423167LPV26  T12S, I15V, L19K, R41K, L63P, H69K, V77I, I93LC
 16812549KC423742LPV26  T12S, G16E, L19V, R41K, L63V, I64L, H69K, V77I, L89M, I93LC
 22171KC424238LPV26  T12S, I15V, L19I, N37NCSY, R41K, Q61E, L63P, H69K, V77I, I93LC
 4541641KC423291LPV26  I15V, L19T, K20R, E35D, N37D, L63P, I64M, H69K, V77I, L89M, I93LC
 284916KC424359LPV26  I15V, L19I, N37S, R41K, L63S, H69K, V77I, I93LC
 16971317KC423053LPV26  T12S, I15V, L19I, N37NS, R41K, L63P, H69K, V77I, I93LC
 687392KC424035LPV26  K20R, M36I, R41K, I62V, L63P, H69K, V77I, L89M, I93LC
  1546KC423221LPV183  K20R, M36I, R41K, I62V, L63P, H69K, V77I, L89M, I93LC
 5091492KC423182LPV26  T12S, I15V, L19T, E35D, M36I, R41K, L63P, H69K, V77I, V82I, L89M, I93LC
 940739KC424257LPV104  I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
  1295KC423037LPV157  I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
  1978KC423539LPV209  I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
 70850KC424317LPV26  T12S, I15V, L19I, R41K, L63P, H69K, V77I, L89M, I93LC
 1230965KC424400LPV52M46I T12S, I15V, L19I, E35ED, R41K, D60E, H69K, V77I, L89M, I93LC
  1599KC423260LPV104 M46VL10LS, T12S, I15V, L19I, R41K, D60E, H69K, V77I, L89M, I93LC
  1294KC423036LPV105M46I T12S, I15V, L19I, R41K, D60E, H69K, V77I, L89M, I93LC
 88978KC424280LPV26  T12S, I15V, L19I, N37S, R41K, H69K, V77I, L89M, I93LC
  306KC423949LPV78  T12S, I15V, L19I, N37S, R41K, H69K, V77I, L89M, I93LC
  1399KC423121LPV182  T12S, I15V, L19I, N37S, R41K, H69K, V77I, L89M, I93LC
  1785KC423407LPV235  T12S, I15V, L19I, N37S, R41K, H69K, V77I, L89M, I93LC
 16352887KC423876LPV26  T12S, I15V, L19IV, K20R, E35D, M36L, R41K, L63P, H69K, V77I, L89M, I93LC
 6471624KC423279LPV209  T12S, I15V, G16E, L19T, N37S, R57K, L63V, H69K, V77I, V82I, L89M, I93LC
 1285723KC424246LPV26  L5LF, T12S, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, V77I, L89M, I93LC
  1422KC423139LPV78  T12S, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, V77I, L89M, I93LC
  1702KC423338LPV130  T12S, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, V77I, L89M, I93LC
 14161350KC423082LPV26  T12S, I15V, L19I, N37A, R41K, K55R, D60E, H69K, V77I, L89M, I93LC
 17252001KC423554LPV26  T12S, I15IV, G16E, L19I, M36MI, R41K, K43R, L63Q, H69K, V77I, V82I, L89I, I93LC
 16851038KC422825LPV26  T12S, I15V, G16E, L19T, K20R, L63A, H69K, V77I, L89M, I93LC
 980491KC424092LPV26  T12S, K14R, I15V, L19I, K20R, M36L, N37S, R41K, H69K, I72V, V77I, L89M, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
 253614KC424176LPV26  T12S, I15V, L19I, K20R, M36I, R41K, L63P, H69K, V77I, L89LM, I93LC
  967KC424401LPV78  T12S, I15V, L19I, K20R, M36I, R41K, L63P, H69K, V77I, I93LC
 3462990KC423920LPV104  T12S, I15V, L19I, R41K, D60E, Q61N, H69K, I72IV, T74TA, V77I, L89M, I93LC
 1305985KC424416LPV26  T12S, G16E, L19IM, E35D, N37NH, L63C, H69K, V77I, L89M, I93LC
 12231501KC423190LPV26  T12S, I15V, G16E, L19I, R41K, K45R, L63N, H69K, T74TS, V77I, P79PL, L89M, I93LC
 13031054KC422839LPV26  T12S, I15V, L19I, M36I, R41K, L63P, H69K, V77I, L89M, I93LC
 6192891KC423878LPV26  T12S, I15V, L19I, K20R, M36I, R41K, H69K, V77I, V82I, L89M, I93LC
 9582147KC423651LPV26  I15V, L19T, K20R, M36I, R41K, H69K, V77I, V82I, L89M, I93LC
Grossman (2014)183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 16131613KC213589LPV52  T12S, G16E, L19I, D60E, I62V, H69K, V77I, L89M, I93LC
 16251625KF134990LPV52  K14R, I15V, G16A, L19I, K20R, E35D, M36L, N37A, R41K, L63M, H69K, V77I, L89M, I93LC