<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L76V
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 65
Isolates 72
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)K5009TK5009 RTV, IDV96M46I, L76V, V82AL10LFT12S, I15V, L19I, K20KR, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
Kassaye (2009)TCDD-31TC31_2003FJ445704SQV, APV, IDV, LPV198M46MI, L76VV32VG, I47IMR41R*K, D60DE, L63P, H69K, T74A, I85V, L89M, I93LC
Dau (2010)06552A06552AGU581760PINAM46I, I54V, L76V, V82A L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93LC
Knops (2010)ID2137ID2137-GT2GU271173IDV, LPV, DRV, RTV33V32I, I54L, L76V, V82AL89VL5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
Green (2011)707PKE19F707PKE19FHM623509RTV, LPV131M46I, I54V, L76V, V82AQ58EL10I, T12S, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Barber (2012)4723547235JQ361673LPV L76V T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93LC
Kouri (2012)CU1737-09CU1737-09JQ585309PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, Q61QH, L63P, H69K, A71V, L89M, I93LC
 CU1124-09CU1124-09JQ585275PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, L63P, H69K, A71V, L89M, I93LC
Van Zyl (2013)314909.ZA.GT1000KC422857LPV M46MI, L76V T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93LC
 356710.ZA.GT1335KC423147LPV M46I, I54V, L76V, V82AQ58EI15V, L19I, K20R, L23LF, E35D, M36I, R41K, L63P, H69K, L89MC
 17411.ZA.WC194KC423723LPV M46I, I54V, L76V, I84VL10FI15V, L19I, K20R, M36I, R41K, Q61QH, L63PS, H69K, A71V, I93LC
 28811.ZA.WC125KC423356LPV M46I, I54V, L76V, V82M, L90MV11VI, L33FL10V, T12S, I13V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63V, I64L, H69K, A71V, T74S, L89M, I93LC
 40108.ZA.WC014KC423987LPV I54V, L76V, V82A L10V, T12TS, I15V, L19I, K20R, M36I, N37D, K55R, R57RK, D60E, I62V, L63P, H69K, A71V, L89M, I93LC
 54811.ZA.EC064KC423577LPV M46L, I54V, L76V, V82AL10FI15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, L89I, I93LC
 327211.ZA.GT1915KC423704LPV M46I, I54V, L76V, V82AL10FT12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93LC
 111808.ZA.EC010KC423322LPV M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 62512.ZA.WC208KC423813LPV M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
 115211.ZA.NL004KC423718LPV M46I, I54V, L76V, V82AL10FI15V, L19IT, K20R, E35D, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, A71V, L89M, I93LC
 523810.ZA.WC103KC423245LPV M46I, I54IL, L76V, I84V E35D, M36I, R41K, L63P, H69K, L89MC
 291110.ZA.GT1381KC423192LPV I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
 280909.ZA.GT932KC424424LPV M46I, I54V, L76V, V82A L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, L63P, H69K, A71V, L89M, I93LC
  10.ZA.GT1191KC423030LPV M46I, I54V, L76V, V82A L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, I62V, L63P, H69K, A71V, L89M, I93LC
 389512.ZA.GT2215KC423888LPV M46I, I54V, L76V, V82AL10FT12TS, I15V, L19T, K20R, M36I, R41K, L63V, H69K, L89I, I93LC
Acharya (2014)DGP162DGP162KJ185332RTV, ATV V32I, M46I, L76V, V82A, L90ML10F, K43TT12S, I15V, L19I, M36I, R41K, D60E, Q61E, L63T, H69K, A71V, I93LC
 DGP121DGP121KJ185291LPV M46I, I54V, L76V, V82AL10FT12S, K14R, I15V, L19T, M36V, N37D, L63P, H69K, A71V, I93LC
 DGP094DGP094KJ185264LPV M46I, L76V, I84VL10FT12S, I13V, I15V, L19T, M36I, R41K, L63P, H69K, K70R, A71V, L89MC
 DGP092DGP092KJ185262LPV M46I, L76V, V82FQ58EL10I, K14R, G17D, L19I, M36I, L63T, E65D, H69K, I72V, L89M, I93LC
 DGP089DGP089KJ185259RTV, ATV M46I, I54V, L76V, V82AL10F, F53LT12S, K14R, L19I, M36I, N37D, R41K, D60E, H69K, A71V, L89M, I93LC
Grossman (2014)11141114KF134952LPV52M46I, I54V, L76V, V82A L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93LC
 9797KF135174IDV, LPV133M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
  97KF135175IDV, LPV228M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
 946946KF135166NFV, LPV177M46MI, I54V, L76V, V82AL10FT12S, I15V, L19I, K20R, M36I, N37ND, R41K, K55R, R57RK, I62V, L63P, H69K, A71V, I93LC
 5252KF135094RTV, LPV52M46I, I54IV, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63PT, H69K, I72IT, L89M, I93LC
  52KF135095RTV, LPV115M46I, I54V, L76V, V82A, L90M L10V, K14KQ, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135096RTV, LPV194M46I, I54V, L76V, V82A, L90ML10FVI15V, L19V, K20R, M36I, N37D, R41K, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135097RTV, LPV210M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55KR, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135098RTV, LPV267M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, L89M, I93LC
  52KF135099RTV, LPV314M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, T74TS, L89M, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 805805KF135148SQV, LPV52M46I, I54IV, L76V, V82VAL10LFT12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93LC
 7878KF135145RTV, LPV52M46I, I54V, L76V, V82AL10F, L24II15V, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, I93LC
 952952 IDV, LPV52M46I, I54V, L76V, V82AL10FI15V, K20R, E35ED, M36I, N37D, R41K, R57K, I62V, L63P, I64M, H69K, K70KQ, A71AV, I72IV, L89M, I93LC
 610610 NFV, IDV, LPV69M46I, I54V, L76V, V82A, L90ML10FT12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95FC
Steegen (2014)12ZAKS20112ZAKS201KJ176481LPV M46I, I54V, L76V, V82A R41K, L63P, H69K, A71V, Q92R, I93LC
 10ZAKS03710ZAKS037KJ176319LPV M46MI, I54V, L76V, V82A, I84V R41RK, Q61QR, L63P, H69K, A71V, I93LC
 12ZAKS23512ZAKS235KJ176514LPV M46I, I54V, L76V, V82A I62V, L63V, H69K, T74S, L89M, I93LC
 12ZAKS22912ZAKS229KJ176509LPV I54V, L76V, V82A R41K, Q61H, L63P, H69K, A71V, I93LC
 09ZAKS00109ZAKS001KJ176285LPV M46I, I54V, L76V, V82A R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
 10ZAKS07110ZAKS071KJ176353LPV M46I, I54V, L76V, V82AQ58EK43R, I62IV, L63P, H69K, L89M, I93LC
 10ZAKS03810ZAKS038KJ176320LPV M46I, I54V, L76V, V82A R41K, Q61H, L63P, H69K, L89IM, I93LC
 11ZAKS14011ZAKS140KJ176422LPV M46I, I54V, L76V, V82S R41K, K55R, L63P, H69K, A71V, I93LC
Diaz (2015)RenG16491RenG16491KT747519PINAM46MI, I54V, L76V, V82A, L90ML10FII15V, L19V, K20R, E35D, M36I, N37K, R41P, I62V, L63P, H69K, A71V, I93LC
 RenG17353RenG17353KT748381PINAM46I, I54V, L76V, V82AL10F, L33FI13V, K14KR, K20R, E35D, M36I, R41N, I62V, L63T, H69K, A71V, I72V, T74TA, L89M, I93LC
 RenG15557RenG15557KT746585PINAM46I, I54V, L76V, V82C, L90M T12AS, I15V, G16E, L19P, K20T, E35G, M36I, N37K, R41N, K55R, R57RK, Q61N, L63N, H69K, A71V, I72R, L89I, I93LC
 RenG16680RenG16680KT747708PINAI54V, L76V, V82A L10V, I15V, K20R, D25DN, E35D, M36I, N37K, R41N, R57RK, Q61DN, I62V, L63P, H69K, A71V, L89M, I93LC
 RenG14788RenG14788KT745816PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20R, E35D, M36I, N37K, R41Y, R57RK, Q61N, L63P, H69K, A71V, L89M, I93LC
 RenG14834RenG14834KT745862PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, Q61N, L63P, G68GE, H69K, K70KR, A71V, L89IM, I93LC
 RenG13298RenG13298KT744326PINAM46I, I54V, L76V, L90M I15V, L19I, K20T, E35D, M36I, N37E, R41H, R57K, Q61R, I62V, L63LP, H69R, A71V, V82I, L89I, I93LC
 RenG10445RenG10445KT741473PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16A, N37K, R41N, K55R, R57K, L63P, H69K, L89IC
 RenG10299RenG10299KT741327PINAM46I, I54V, L76V, V82A L10V, I15V, L19V, K20R, M36I, N37K, R41N, I62V, L63P, H69K, A71V, L89M, I93LC
Rossouw (2015)RP123-1RP123-1KT032043PINAM46I, I47V, I54V, L76V, V82AQ58EL10V, I15V, L19I, K20R, M36I, K55KR, D60E, L63P, H69K, A71V, L89M, I93LC
 RP126RP126KT032045RTV, LPV348M46I, I54V, L76V, V82L Q7E, K14R, I15V, G16E, L19I, K20T, E35D, M36I, Q61N, L63C, H69K, L89I, I93LC
 RP138RP138KT032050LPV, RTV231M46I, I54V, L76V, V82AL10FI15V, L19V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, I62V, H69K, A71V, L89M, I93LC
 RP045RP045KT032012LPV133M46I, I54V, L76V, V82AQ58EL10I, I15V, L19I, K20R, E35D, M36I, R41K, D60E, Q61D, L63P, C67E, H69K, L89MC
 RP102-1RP102-1KT032034PINAM46I, I54V, L76V, V82A L10V, I15V, L19I, K20R, M36I, R41K, D60E, Q61E, I62V, L63P, H69K, I72IV, L89M, I93LC
 RP169RP169KT032059LPV, RTV286I54V, L76V, V82A E35D, M36I, N37ND, R41K, R57K, L63P, H69K, A71V, T74S, L89IM, T91TI, I93LC
Chimukangara (2016)NC10NC10KU508550LPV586M46I, I54V, L76V, V82AL10F, L24I, Q58ET12S, I15V, G16E, L19I, K20M, M36L, N37D, L63N, H69K, L89I, I93L, L97IC
Neogi (2016)558113.ZA.EC755KT592886LPV M46I, I54V, L76V, V82AL10F, K43TI15V, L19I, M36MI, I62V, L63P, H69K, A71V, L89M, I93LC
 714313.ZA.EC707KT592854LPV M46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16E, L19I, K20R, E35N, M36I, N37D, L63T, H69K, I72V, T74S, L89M, I93LC
 409313.ZA.GT2842KT593178LPV M46I, I54V, L76V, V82AL10FK14R, I15V, Q18QE, L19I, K20R, M36I, N37D, R41K, L63P, H69K, L89M, I93LC