Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	C
Gene	PR
Mutation	T74S
Rx	>= 1 PI
IncludeMixtures	No

References	23
Patients	77
Isolates	93

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kantor (2002)	TCDD-08	TCDD-08_1	AY090845	SQV	95			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72IT, T74S, L89M, I93L	C
	TCDD-32	TCDD-32	AY090858	RTV	18			T12S, I13LV, K14EQ, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
Snoeck (2002)	BE8	BE8	AF338992	IDV	80			I15V, L19V, E35D, M36L, R41K, L63V, H69K, T74S, L89M, I93L	C
Johnston (2003)	TC-71	TC-71		IDV	52	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93L	C
Weber (2003)	85H	610185H-12	AY140821	RTV	13			L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93L	C
		610185H-48	AY140823	RTV	48	I54V, V82A		L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69R, T74S, V77I, L89M, I93L	C
Gomez-Carrillo (2004)	96105	96105	AY365516	PI	NA			T12A, I15S, G16R, E35D, M36I, N37K, R41N, L63T, H69K, I72T, T74S, L89M, I93L	C
Grossman (2004)	IL267	IL267	AY529619	IDV, RTV, SQV, NFV	229	L90M		I13IV, K14R, I15V, G16GE, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93L	C
	IL280	IL280a	AY529617	SQV, IDV	180	I84V, L90M		T12S, I15V, K20KR, M36I, R41RK, L63P, H69K, A71V, T74S, L89M, I93L	C
		IL280b	AY529616	SQV, IDV	201	M46MI, I84V, L90M		T12S, I15V, Q18L, D29DG, M36I, R41RK, L63P, H69KR, A71V, T74S, R87RT, L89M, I93L	C
	IL287	IL287	AY529620	SQV, RTV, IDV, NFV	184	I84V, L90M		L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93L	C
	IL370	IL370	AY529592	NFV	55	D30DN, N88NDGS	L10F	T12S, L19V, K20KM, M36I, R41K, L63LP, H69K, T74S, L89IM, I93L	C
	IL428	IL428a	AY529598	NFV	50			T12S, I15V, L19V, M36I, R41K, H69K, T74S, L89M, I93L	C
		IL428b	AY529599	NFV, LPV	61			T12S, I15V, L19V, M36I, R41RK, H69K, T74S, L89M, I93L	C
Snoeck (2004)	BE42	BE42	AY900745	NFV	31			I15V, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93L	C
	BE59	BE59	AY900757	SQV, IDV, RTV, NFV	217	G48V, I54A, V82A	L33F, K43KT	L10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93L	C
Non-B Workgroup (2005)	UK107	UK107	AY900761	NFV	38			T12S, I15V, L19I, M36I, N37S, R41K, H69K, T74S, L89M, I93L	C
	UK162	UK162	AY900762	RTV	57	M46I, V82A, L90M	K43T	T12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93L	C
	UK320	UK320	AY900769	NFV	57	L90M		T12S, I15V, L19I, K20T, E35D, M36I, R41K, H69K, T74S, L89I, I93L	C
	UK456b	UK456b	AY900773	NFV, IDV, RTV		M46I, L90M		L10LI, T12S, L19I, K20I, M36I, R41K, L63P, I64V, H69K, A71V, T74S, L89M, I93L	C
	UK594	UK594	AY900778	SQV	184			I13V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	UK773a	UK773a		NFV				P9PL, T12S, I15IV, L19T, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	UK973	UK973	AY900789	NFV	54			T12S, I15V, L19T, K20KT, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	UK1428a	UK1428a	AY900800	SQV	91	M46I		I15V, L19I, M36I, N37S, R41K, H69K, T74S, L89M, I93L	C
	UK1447	UK1447	AY900803	IDV, SQV, RTV	83	G48GA, I54V, V82A, I84V, L90M	L23LI, K43KT	L10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93L	C
	UK1518	UK1518	AY900807	NFV	68	D30N	N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93L	C
	UK1447b	UK1447b	AY900833	IDV, NFV, SQV, RTV, APV, LPV	175	M46I, I50V, I54V, V82A, L90M	L10F, L23I, K43T	I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93L	C
	UK2064	UK2064		IDV	150			I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	UK2069	UK2069	AY900845	NFV		D30N	N88D	T12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93L	C
	SA75_DR16	SA75_DR16	AY901099	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
	SA84_DR29	SA84_DR29	AY901107	NFV				T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69K, T74S, L89M, I93L	C
	TK1002	TK1002		RTV	225	M46I, I54V, V82A		L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93L	C
	TK1004	TK1004a		NFV, RTV, IDV	183			T12P, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93L	C
		TK1004b		NFV, RTV, IDV	196			T12P, I15V, L19I, K20T, L24LF, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93L	C
		TK1004c		NFV, RTV, IDV	268			T12P, I15V, L19IT, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93L	C
	TK2023	TK2023		RTV, IDV, SQV	173			L10I, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V75I, L89M, I93L	C
	TK3009	TK3009		SQV, NFV	158	L90M		K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93L	C
		TK3009a		SQV, NFV, LPV	232	L90M		I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93L	C
		TK3009b		SQV, NFV, LPV	232	L90M		I13IV, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93L	C
	TK3020	TK3020		RTV, NFV, SQV	120			T12S, I15V, L19I, E35D, M36I, R41K, L63AT, H69K, T74S, L89I, I93L	C
		TK3020a		RTV, NFV, SQV	120			T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93L	C
	TK3024	TK3024		SQV, NFV	205	L90M		T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71I, T74S, I93L	C
		TK3024a		SQV, NFV, LPV	246	L90M		T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45KR, L63P, H69K, A71I, T74S, I93L	C
	TK3026	TK3026		RTV, SQV, NFV	292	L90M		I15V, L19I, K20T, E35D, M36I, R41RK, L63P, H69K, A71I, T74S, L89I, I93L	C
	TK3027	TK3027		RTV, SQV, NFV	190	D30N, L90M	N88D	T12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93L	C
		TK3027b		RTV, SQV, NFV, LPV	276	D30DN, L90LM	N88D	T12S, I13IV, I15V, L19I, K20R, E35D, M36I, N37ND, R41RK, L63P, H69K, T74S, L89IM, I93L	C
	PL27956	60622		NFV, RTV, IDV	184	L90MR		L10V, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62IV, L63P, H69K, A71AV, T74S, V77VI, I93L	C
	PL34057	96049		NFV	82	L90M		I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93L	C
	PL4725	58294		Unknown, LPV	>4	G48V, I54V, V82T, L90M	Q58E	L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L	C
		69936		Unknown, LPV	>51	G48V, I54V, V82S, L90M	Q58E	L10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CF	C
		80404		Unknown, LPV	>90	G48V, I54V, V82S, L90M	Q58E	L10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F	C
		100703		Unknown, LPV, APV	>159	M46ML, G48V, I54V, V82S, L90M	V11VI, L33F, Q58E	L10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96S	C
Rhee (2005)	CA7907	CA24813	AY797580	IDV, NFV	260	D30N	L10F, N88D	T12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93L	C
Weber (2005)	M85073	M85073	AY677425	Unknown, NFV	>89			T12S, I15V, L19I, M36I, R41K, Q61E, H69K, T74S, L89M, I93L	C
	M72003	M72003	AY677426	NFV, RTV, IDV	212	I54IV, L90M	L10F	I13V, K14N, I15V, L19I, K20T, E35N, M36I, R41K, K45R, I62IV, L63P, I64V, H69K, K70R, T74S, L89M, I93L	C
	F92803	F92803	AY677402	IDV	24			I15V, M36I, R41K, H69K, T74S, L89M, I93L	C
	M83284	M83284	AY677471	SQV	82			T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93L	C
Baxter (2006)	12-1007	1007-30519	DQ875953	PI	NA	M46L, I54IV, V82A, L90M	L33F, K43KT	L10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93L	C
	12-3049	3049-30508	DQ876115	PI	NA	M46I, I54V, L76V, V82A, L90M	L10FI	W6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93L	C
	12-1716	1716-30421	DQ876854	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T	L10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93L	C
	48-2254	2254-30930	DQ877888	PI	NA	G48V, I54V, V82S, L90M	L33F, Q58E	L10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TS	C
	48-3058	3058-30401	DQ877970	PI	NA	I54L, V82A, L90M	L33F, K43KT	L10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93L	C
	48-3229	3229-30523	DQ878136	PI	NA	M46I, I54V, V82A, I84V	L10F, L24I, L33F, K43T	T12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91S	C
	48-4134	4134-30317	DQ878365	PI	NA	G48V, I54V, V82A, I84V	L33F, K43T	L10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93L	C
	48-5001	5001-30415	DQ878534	PI	NA	M46I, L76V, V82A	L10F, L33LF	I13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93IL	C
Doualla-Bell (2006)	Pt2	FDB_Pt2		NFV		L90M		T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93L	C
	Pt5	FDB_Pt5		NFV		N88S	L10F	I15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93L	C
von Wyl (2007)	37	4822080	EF449879	PI	NA			M36I, R41K, L63T, H69KN, T74S, L89M, I93L	C
Marconi (2008)	SW055	sw055	EU308066	LPV	46			T12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, I72M, T74S, L89M, I93L	C
	SW068	SW068	EU308079	LPV	23			I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	SW070	SW070	EU308081	LPV	49	I54V, V82A	L33LF	G16A, L19V, E35D, M36I, R41K, I62V, L63P, H69K, T74S, L89M, I93L	C
Pillay (2008)	DR5	DR5	AY589870	SQV				T12S, I15V, L19I, M36I, R41K, L63P, H69K, T74S, I93L	C
	DR54	DR54	AY589907	NFV, RTV				L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FL	C
	DR55	DR55	AY589908	RTV	104	M46L, I54V, V82A	L23LI	T12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	DR16	02ZA.DR16	AY589877	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
	DR29	02ZA.DR29	AY589886	NFV				T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69K, T74S, L89M, I93L	C
Jones (2009)	176988	176988	FJ659847	PI	NA			I15V, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93L	C
Kandathil (2009)	VL06_253	VL06_253	EU030406	PI	NA	D30N	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93L	C
	VL07_040	VL07_040	EU030407	PI	NA	M46I, L90M	K43T	T12S, I15V, L19I, K20T, E35D, M36I, R41K, L63P, H69K, T74S, I93L	C
	VL06_192	VL06_192	EU037774	PI	NA			T12S, I15V, L19I, E35D, M36I, N37E, L63T, H69K, T74S, L76X, L89M, I93L	C
Kassaye (2009)	TCDD-08	TC08_2003	FJ445719	SQV	210			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93L	C
		TC08_2004	FJ445726	SQV	239			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93L	C
	TCDD-19	TC19_2003	FJ445710	IDV, RTV	26			I13V, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93L	C
Dau (2010)	06552A	06552A	GU581760	PI	NA	M46I, I54V, L76V, V82A		L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93L	C
	07762A	07762A	GU581866	PI	NA			K14KR, I15V, K20KR, M36I, N37K, R41N, L63T, H69K, T74S, L89M, I93L	C
El-Khatib (2010)	Pat079	11ZA_SAVE1255	JF960529	LPV				T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63T, H69K, T74S, V82VI, L89M, I93L	C
	Pat080	11ZA_SAVE1256	JF960530	LPV				T12S, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93L	C
	Pat092	11ZA_SAVE1489	JF960542	RTV, ATV		N88NS, L90M	L23I, F53FL	T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93L	C
	Pat109	11ZA_SAVE2228	JF960559	LPV				T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, H69K, T74S, L89M, I93L	C
Rodrigues (2010)	305_07	BR07SC305	GQ401315	NFV		L90M	L89V	I13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93L	C
	307_07	BR07SC307	GQ401316	NFV				L10IV, E35D, M36I, N37K, R41N, H69K, T74S, L89M, I93L	C
Barber (2012)	65994	65994	JQ361682	LPV		M46MI, I54V, V82A		L10I, T12S, I15V, L19V, M36I, R41K, K45KR, L63P, H69K, T74S, I93L	C
Jones (2012)	176988	176988	JN670420	PI	NA			I15V, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93L	C

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