<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation T74P
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 46
Isolates 49
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL384IL384aAY529618IDV, SQV, RTV, NFV154M46I, I54V, V82A, L90MT74PW6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93LC
  IL384bAY529622IDV, SQV, RTV, NFV239M46I, I54V, V82A, L90MT74PL10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93LC
Non-B Workgroup (2005)TK3016TK3016 SQV, NFV167I54V, L90MT74PL10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93LC
 PL3670560970 IDV98V82A, L90LMT74PL10I, T12TS, I15V, L19I, K20KR, M36I, N37NS, R41K, K45R, Q61N, L63S, H69K, I72V, L89M, I93LC
Weber (2005)F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
Baxter (2006)48-24052405-30826DQ877890PINAM46I, V82AL10F, K43T, T74PT12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93LC
 48-50965096-30901DQ878592PINAM46I, I54V, V82A, L90MK43KT, T74PL10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93LC
Sen (2007)T076NPT76EF186928NFV, RTV M46L, V82A, L90MT74PL10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93LC
  NPT76-PLEF186980NFV, RTV M46LT74PL10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93LC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Waleria-Aleixo (2008)08PR05036708PR050367FJ591392PINAG48A, I54V, V82AT74PL10I, I15V, K20R, E35D, M36I, N37K, R41N, Q61N, L63A, H69K, I72V, L89M, I93LC
 08RJ0407908RJ04079FJ591563PINAM46I, I54V, V82AL10F, L33F, T74PI15V, G16A, K20R, M36I, R41K, K55R, Q61D, I62V, L63P, H69K, L89M, I93LC
 08PR05044308PR050443FJ591440PINAM46I, I54V, L90ML10F, L33F, F53L, T74P, N83DI13V, I15V, G16A, K20R, M36I, R41K, K55KR, Q61D, I62V, L63PT, H69K, L89M, I93LC
 08PR06055308PR060553FJ591468PINA Q58E, T74PI15V, K20KT, E35ED, M36I, N37K, R41N, D60DE, I62IV, L63P, H69K, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Kouri (2012)CU522-10CU522-10JQ585402PINAM46I, I54L, V82A, L90ML33F, T74PI13V, N37S, R41K, K55R, I62V, L63P, H69K, L89M, I93LC
Van Zyl (2013)391412.ZA.GT2217KC423889LPV M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
Acharya (2014)DGP113DGP113KJ185283RTV, ATV M46I, I54V, L90MT74PL10I, T12S, I15V, L19T, M36I, R41K, L63A, H69K, A71V, I93LC
Grossman (2014)4949KF135089NFV, LPV52I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93LC
 101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
 201201KF135014IDV, LPV52M46IT74PL10I, T12S, I15V, L19T, M36I, R41K, K55R, L63I, H69K, L89M, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC
Diaz (2015)RenG16014RenG16014KT747042PINAI50LT74PI15V, K20R, M36I, N37K, R41N, K45R, H69K, A71V, L89MT, I93LC
 RenG16793RenG16793KT747821PINAM46MI, I54V, V82M, L90ML24LI, L33F, T74PL10V, I13IV, I15IV, K20R, E35D, M36I, N37Q, R41N, Q61DN, I62V, L63PT, H69K, V77I, L89M, I93LC
 RenG16791RenG16791KT747819PINAM46I, I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, K20T, E35N, M36I, N37Q, R41N, I62IV, L63V, H69K, I72V, L89I, I93LC
 RenG16317RenG16317KT747345PINAM46I, I54V, V82AL10F, Q58E, T74P, N88GI15V, G16E, K20T, E21K, E35G, M36I, N37K, P39S, R41N, L63T, H69K, V77I, L89MC
 RenG15117RenG15117KT746145PINAI54L, L90MT74P, N88NTK14R, I15V, G16E, K20T, E35D, M36I, N37K, P39S, R41N, I62V, H69K, A71V, V82I, L89M, I93LC
 RenG15278RenG15278KT746306PINAM46L, I50L, V82ILM, L90LML24LI, L33F, Q58E, T74PI13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, L63AV, H69K, A71AV, L89M, I93LC
 RenG13551RenG13551KT744579PINAM46MI, I50V, I54V, V82M, N88SL33F, Q58E, T74PL10V, G16E, K20R, E35D, M36I, N37K, R41N, R57RK, L63T, H69K, L89F, I93LC
 RenG14286RenG14286KT745314PINAV32I, M46MIL33LI, K43T, T74PI15V, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, A71AV, I85V, L89I, I93LC
 RenG14901RenG14901KT745929PINAM46ML, G48GA, I54V, I84V, L90ML10F, T74P, L89VI15V, K20T, E35DN, M36I, N37K, R41H, Q61QH, I62IV, L63P, H69K, A71V, I85V, T91CS, I93LC
 RenG14949RenG14949KT745977PINA T74PL10I, T12S, I15V, L19I, M36I, N37K, R41N, D60DE, L63PT, H69K, L89M, I93LC
 RenG15206RenG15206KT746234PINAM46I, G48V, I54V, V82AQ58E, T74PL10V, I15V, K20R, E35D, M36I, N37K, R41N, F53Y, K55R, R57K, I62V, L63V, H69K, L89M, I93LC
 RenG13568RenG13568KT744596PINAM46I, I54V, V82AK43T, T74PL10Y, I15V, L19LI, K20R, E35D, M36I, N37K, R41N, Q61N, I62IV, L63P, H69K, L89T, I93LC
 RenG12371RenG12371KT743399PINAI50LT74PL10LIV, K14KR, I15V, Q18T, N37K, R41N, K45R, L63LP, H69K, A71V, V77I, L89M, I93LC
 RenG13175RenG13175KT744203PINAI54V, V82AL33F, T74PI13V, K20R, E35D, M36I, N37K, R41N, R57K, Q61H, H69K, L89I, I93LC
 RenG11113RenG11113KT742141PINAI54L, I84IVT74P, L89MVI15V, K20T, E35D, M36MI, N37K, R41N, L63P, H69K, A71V, V82I, T91S, I93LC
 RenG11100RenG11100KT742128PINAI50L, V82MT74PI15V, G16E, L19Q, K20R, E35D, M36I, N37K, P39PS, R41N, K45R, L63T, H69K, A71V, I72IV, I93LC
 RenG10097RenG10097KT741125PINAM46ML, I54V, V82ML24LI, L33F, T74P, N83DL10V, I13V, K14R, I15V, K20KR, E35D, M36IL, N37K, R41N, L63V, H69K, L89M, I93LC
 RenG10331RenG10331KT741359PINAM46I, I50L, V82AT74PL10I, I15V, L19I, K20R, M36I, N37K, R41N, I62IV, L63V, H69K, A71V, L89M, I93LC
 RenG11471RenG11471KT742499PINAI54V, V82AK43T, T74PL10I, I15V, L19LI, K20R, E35D, M36I, N37K, R41INS, R57K, I62V, L63V, I64V, H69K, A71V, L89M, I93LC
 RenG10615RenG10615KT741643PINAI50L, N88SL33F, T74PI13IV, I15V, K20R, E35D, M36I, N37K, R41N, L63LP, H69K, A71V, L89M, I93LC
 RenG10978RenG10978KT742006PINAI54V, V82AL33F, T74PL10I, I13V, G16E, K20R, M36I, N37K, R41N, L63T, H69Q, L89M, I93LC
 RenG11088RenG11088KT742116PINAI54V, V82C, L90ML10F, L33F, T74PT12S, I13V, I15V, G16E, L19AV, K20M, D25DN, E35DN, M36I, N37K, R41N, Q61H, L63T, I66IM, H69K, L89M, I93LC
 RenG10474RenG10474KT741502PINAG48S, I54V, V82F, L90ML33F, K43T, T74P, N83DL10I, I13V, K14R, I15V, E35D, M36L, N37K, R41IN, Q61N, I62V, C67CR, H69Q, L89I, I93LC
 RenG10982RenG10982KT742010PINAM46I, I50V, I54V, V82A, L90MV11I, L33F, K43T, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37K, R41N, I62IV, L63P, H69R, A71V, L89LM, I93LC
Chimukangara (2016)NC16NC16KU508562RTV, ATV145I54LK43T, T74PI15V, G16A, L19I, K20T, E35D, M36I, D60E, L63P, H69K, A71I, L89T, I93LC
 NC6NC6KU508590RTV, ATV113M46I, V82MT74PT12S, I15V, L19I, K20R, E35D, M36I, R41K, D60E, L63P, H69K, L89T, I93LC