<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation T74A
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 26
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL198IL198aAY529561IDV7  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL198bAY529562IDV51  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL198cAY529563IDV69  W6L, T12S, I15V, G16R, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
 IL183IL183aAY529550NFV25  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL183bAY529549NFV30  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL183cAY529548NFV42  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL183dAY529551NFV48  T12S, I15V, L19T, M36I, R41K, Q61QH, H69K, T74A, L89M, I93LC
  IL183eAY529552NFV66  W6WR, T12S, I13IK, I15V, L19T, K20KR, M36I, R41K, H69K, T74A, L89M, I93LPC
  IL183fAY529553NFV78 V11IQ7R, T12S, I15V, L19T, M36I, R41K, L63LP, H69K, T74A, L89M, I93LC
 IL184IL184aAY529554NFV39  T12S, I15V, L19T, M36I, L38LM, R41K, H69K, T74A, L89M, I93LC
  IL184bAY529555NFV56  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
 IL297IL297AY529583NFV58 N88NDT12S, I15V, L19I, M36I, R41K, H69K, T74A, L89M, I93LC
Non-B Workgroup (2005)UK704UK704AY900781RTV, IDV   T12S, I15V, L19I, M36I, R41K, Q61E, L63V, H69K, T74A, L89M, I93LC
 IL80IL80AY900811RTV, NFV, SQV114I54V, V82A, I84VK43TW6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93LC
 IL184IL184cAY901184NFV62 V11VIT12S, I13IM, I15V, Q18R, L19Q, M36I, R41K, H69K, T74A, L89M, I93LC
 TK1004TK1004 NFV, RTV, IDV131  I3IV, T12P, I15V, L19I, K20T, E21G, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74A, L89M, I93LC
 TK1020TK1020 SQV, RTV, IDV211I54V, V82C, L90MF53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
 TK3031TK3031 SQV, NFV203D30NN88DI15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93LC
 PL4706685002 IDV, NFV104D30NN88DT12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93LC
Weber (2005)M86744M86744AY714447IDV, RTV13  T12PS, I13V, I15V, L19T, K20R, M36I, N37D, R41K, D60E, Q61E, H69K, I72IR, T74A, L89M, I93LC
Baxter (2006)12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt9FDB_Pt9 NFV D30NL33F, N88DT12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93LC
Sanabani (2006)04BR01304BR013AY727522PINAM46I, G48V, V82AL24IL10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93LC
von Wyl (2007)19702313EF449901PINAI54IV, N88NS, L90M L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93LC
Pillay (2008)DR4202ZA.DR42AY589897IDV V82VA T12S, I15V, L19I, E35ED, M36I, R41K, I62IV, L63V, H69K, T74A, L89M, I93L, N98IC
Rosen-Zvi (2008)7106p71-2 LPV12  I15V, Q18E, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63V, H69K, T74A, L89M, I93LC
Kassaye (2009)TCDD-31TC31_2003FJ445704SQV, APV, IDV, LPV198M46MI, L76VV32VG, I47IMR41R*K, D60DE, L63P, H69K, T74A, I85V, L89M, I93LC
El-Khatib (2010)Pat09511ZA_SAVE2018JF960545LPV   T12S, I15V, L19I, N37K, R41N, L63P, H69K, T74A, L89M, I93LC
 Pat12711ZA_SAVE2466JF960577LPV   T12S, I15V, L19I, R41K, L63Q, H69K, T74A, V77I, L89M, I93LC
Rodrigues (2010)318_07BR07SC318GQ401302LPV   I15V, N37K, R41I, L63P, H69K, T74A, L89M, I93LC
Van Zyl (2013)15312747KC423812LPV26  T12S, I15V, L19V, M36I, N37D, L63V, H69K, I72V, T74A, L89M, I93LC
Grossman (2014)11751175KF134960LPV52  T12S, I15V, L19I, M36I, R41K, Q61QH, H69K, T74A, L89M, I93LC
 55KF135110RTV, LPV52M46L, I54V, V82AL24L*IR, N88NDL10V, I15V, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC
  5KF135111RTV, LPV265I54V, V82A L10IV, I15IV, G16GE, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC