<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation T74A
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 55
Isolates 66
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL198IL198aAY529561IDV7  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL198bAY529562IDV51  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL198cAY529563IDV69  W6L, T12S, I15V, G16R, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
 IL183IL183aAY529550NFV25  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL183bAY529549NFV30  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL183cAY529548NFV42  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
  IL183dAY529551NFV48  T12S, I15V, L19T, M36I, R41K, Q61QH, H69K, T74A, L89M, I93LC
  IL183eAY529552NFV66  W6WR, T12S, I13IK, I15V, L19T, K20KR, M36I, R41K, H69K, T74A, L89M, I93LPC
  IL183fAY529553NFV78 V11IQ7R, T12S, I15V, L19T, M36I, R41K, L63LP, H69K, T74A, L89M, I93LC
 IL184IL184aAY529554NFV39  T12S, I15V, L19T, M36I, L38LM, R41K, H69K, T74A, L89M, I93LC
  IL184bAY529555NFV56  T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93LC
 IL297IL297AY529583NFV58 N88NDT12S, I15V, L19I, M36I, R41K, H69K, T74A, L89M, I93LC
Non-B Workgroup (2005)UK704UK704AY900781RTV, IDV   T12S, I15V, L19I, M36I, R41K, Q61E, L63V, H69K, T74A, L89M, I93LC
 IL80IL80AY900811RTV, NFV, SQV114I54V, V82A, I84VK43TW6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93LC
 IL184IL184cAY901184NFV62 V11VIT12S, I13IM, I15V, Q18R, L19Q, M36I, R41K, H69K, T74A, L89M, I93LC
 TK1004TK1004 NFV, RTV, IDV131  I3IV, T12P, I15V, L19I, K20T, E21G, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74A, L89M, I93LC
 TK1020TK1020 SQV, RTV, IDV211I54V, V82C, L90MF53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
 TK3031TK3031 SQV, NFV203D30NN88DI15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93LC
 PL4706685002 IDV, NFV104D30NN88DT12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93LC
Weber (2005)M86744M86744AY714447IDV, RTV13  T12PS, I13V, I15V, L19T, K20R, M36I, N37D, R41K, D60E, Q61E, H69K, I72IR, T74A, L89M, I93LC
Baxter (2006)12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt9FDB_Pt9 NFV D30NL33F, N88DT12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93LC
Sanabani (2006)04BR01304BR013AY727522PINAM46I, G48V, V82AL24IL10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93LC
von Wyl (2007)19702313EF449901PINAI54IV, N88NS, L90M L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93LC
Pillay (2008)DR4202ZA.DR42AY589897IDV V82VA T12S, I15V, L19I, E35ED, M36I, R41K, I62IV, L63V, H69K, T74A, L89M, I93L, N98IC
Rosen-Zvi (2008)7106p71-2 LPV12  I15V, Q18E, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63V, H69K, T74A, L89M, I93LC
Kassaye (2009)TCDD-31TC31_2003FJ445704SQV, APV, IDV, LPV198M46MI, L76VV32VG, I47IMR41R*K, D60DE, L63P, H69K, T74A, I85V, L89M, I93LC
El-Khatib (2010)Pat09511ZA_SAVE2018JF960545LPV   T12S, I15V, L19I, N37K, R41N, L63P, H69K, T74A, L89M, I93LC
 Pat12711ZA_SAVE2466JF960577LPV   T12S, I15V, L19I, R41K, L63Q, H69K, T74A, V77I, L89M, I93LC
Rodrigues (2010)318_07BR07SC318GQ401302LPV   I15V, N37K, R41I, L63P, H69K, T74A, L89M, I93LC
Van Zyl (2013)15312747KC423812LPV26  T12S, I15V, L19V, M36I, N37D, L63V, H69K, I72V, T74A, L89M, I93LC
Grossman (2014)11751175KF134960LPV52  T12S, I15V, L19I, M36I, R41K, Q61QH, H69K, T74A, L89M, I93LC
 55KF135110RTV, LPV52M46L, I54V, V82AL24L*IR, N88NDL10V, I15V, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC
  5KF135111RTV, LPV265I54V, V82A L10IV, I15IV, G16GE, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC
 283283 SQV, RTV, IDV, LPV52I54V, V82AL10F, D30DET12S, I13IV, K14R, I15V, K20I, E35D, M36I, Q61H, H69K, T74A, L89I, I93LC
Steegen (2014)10ZAKS06210ZAKS062KJ176344LPV   R41K, K45R, H69K, T74A, L89M, I93LC
Diaz (2015)RenG15974RenG15974KT747002PINAM46MI, I50LL23LI, L33F, F53FL, N83NDL10LR, I13V, I15V, E35D, M36IL, N37K, R41N, I62V, L63V, H69K, A71V, T74A, L89IM, I93LC
 RenG16641RenG16641KT747669PINAM46I, I84V L10V, I15V, G16E, E35G, M36I, N37K, P39S, R41N, I62V, L63T, I64V, H69K, T74A, I85V, L89M, I93LC
 RenG13855RenG13855KT744883PINAL90ML23I, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71I, T74A, L89I, I93LC
 RenG14258RenG14258KT745286PINA  L10V, I15V, G16A, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93LC
 RenG15373RenG15373KT746401PINA  I13V, E35D, N37K, R41N, L63P, H69K, T74A, L89M, I93LC
 RenG14493RenG14493KT745521PINAI50LL33LFI15V, E35D, M36I, N37K, R41N, R57K, Q61QH, L63V, H69K, A71V, T74A, L89I, I93LC
 RenG12637RenG12637KT743665PINAM46I, N88SF53LL10Y, I15V, K20T, E35G, M36I, N37D, R41K, L63V, I64V, H69K, T74A, L89M, I93LC
 RenG11901RenG11901KT742929PINA  I13V, I15V, M36I, N37K, R41N, K43KR, I62V, L63Q, H69K, T74A, L89M, I93LC
 RenG13433RenG13433KT744461PINAI50L, V82ML24I, K43KTT12P, I15S, G16R, K20RT, E34KN, E35D, M36I, N37K, R41N, K45KR, L63T, G68E, H69K, A71V, I72IT, T74A, Q92K, I93LC
 RenG12626RenG12626KT743654PINA  I15V, K20R, M36I, N37K, R41N, I62V, H69K, T74A, L89M, I93LC
 RenG11129RenG11129KT742157PINA  I15V, N37K, R41N, H69K, T74A, L89MC
 RenG10989RenG10989KT742017PINAM46I, I54V, V82A I15V, K20R, E35ED, M36I, N37K, R41N, K55R, L63T, H69K, I72T, T74A, L89M, I93LC
 RenG11098RenG11098KT742126PINAD30NN88DI13V, K14KR, I15V, K20T, E35D, M36I, N37Q, R41NS, D60E, Q61N, L63Q, H69K, T74A, V77VI, L89M, I93LC
 RenG10417RenG10417KT741445PINA  I15V, L19I, N37K, R41N, L63T, H69K, T74A, V77I, L89M, I93LC
 RenG10624RenG10624KT741652PINAL90MQ58EI13V, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, Q61N, L63T, I64IV, H69K, A71T, T74A, V82I, L89I, I93LC
 RenG10600RenG10600KT741628PINA L33FT12TAP, I13V, K14KR, M36I, N37K, P39S, R41N, I62V, L63Q, I64M, H69K, T74A, L89M, I93LC
 RenG11227RenG11227KT742255PINAI50L, V82A, L90ML33FT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37E, R41N, K45R, L63P, H69K, A71V, T74A, L89I, I93LC
 RenG10176RenG10176KT741204PINA  T12E, I15V, L19I, M36I, N37K, R41N, D60E, H69K, T74A, L89M, I93LC
 RenG10527RenG10527KT741555PINA  L10V, I13V, I15V, K20R, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93LC
 RenG11250RenG11250KT742278PINAM46I, I50IL, I54V, V82F, L90M L10V, V11VL, K14R, I15V, Q18P, K20T, E35D, M36I, N37K, R41N, K55H, Q61QE, I62V, L63P, H69K, A71AV, T74A, L89I, I93ILC
Novitsky (2015)bcpp_245bcpp_245KR860706PINA  I15V, M36I, R41K, I62V, L63T, H69K, T74A, L89M, I93LC
 bcpp_395bcpp_395KR860753PINAM46I, N88S T12P, I15V, L19I, K20I, E35G, M36I, R41K, Q61E, L63P, H69K, T74A, L89M, I93LC
 bcpp_285bcpp_285KR860719PINA  T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74A, L89M, I93LC
 mpp_446mpp_446KR861208PINA  T12S, I15V, L19I, N37D, R41K, L63P, H69K, T74A, L89M, I93LC
 mpp_150mpp_150KR860933PINA  T12S, I15V, L19I, M36I, R41K, K43R, L63A, H69K, T74A, L89M, I93LC
Rossouw (2015)RP156RP156KT032056LPV122M46L, I54V, V82AL10FT12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74A, L89M, I93LC
 RP039RP039KT032010LPV148M46L, I54V, V82AL10FT12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55KR, I62IV, L63P, H69K, I72V, T74A, L89M, I93LC