Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	T74A
Rx	>= 1 PI
IncludeMixtures	No

References	12
Patients	23
Isolates	33

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Grossman (2004)	IL198	IL198a	AY529561	IDV	7			T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
		IL198b	AY529562	IDV	51			T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
		IL198c	AY529563	IDV	69			W6L, T12S, I15V, G16R, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
	IL183	IL183a	AY529550	NFV	25			T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
		IL183b	AY529549	NFV	30			T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
		IL183c	AY529548	NFV	42			T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
		IL183d	AY529551	NFV	48			T12S, I15V, L19T, M36I, R41K, Q61QH, H69K, T74A, L89M, I93L	C
		IL183e	AY529552	NFV	66			W6WR, T12S, I13IK, I15V, L19T, K20KR, M36I, R41K, H69K, T74A, L89M, I93LP	C
		IL183f	AY529553	NFV	78		V11I	Q7R, T12S, I15V, L19T, M36I, R41K, L63LP, H69K, T74A, L89M, I93L	C
	IL184	IL184a	AY529554	NFV	39			T12S, I15V, L19T, M36I, L38LM, R41K, H69K, T74A, L89M, I93L	C
		IL184b	AY529555	NFV	56			T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L	C
	IL297	IL297	AY529583	NFV	58		N88ND	T12S, I15V, L19I, M36I, R41K, H69K, T74A, L89M, I93L	C
Non-B Workgroup (2005)	UK704	UK704	AY900781	RTV, IDV				T12S, I15V, L19I, M36I, R41K, Q61E, L63V, H69K, T74A, L89M, I93L	C
	IL80	IL80	AY900811	RTV, NFV, SQV	114	I54V, V82A, I84V	K43T	W6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93L	C
	IL184	IL184c	AY901184	NFV	62		V11VI	T12S, I13IM, I15V, Q18R, L19Q, M36I, R41K, H69K, T74A, L89M, I93L	C
	TK1004	TK1004		NFV, RTV, IDV	131			I3IV, T12P, I15V, L19I, K20T, E21G, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74A, L89M, I93L	C
	TK1020	TK1020		SQV, RTV, IDV	211	I54V, V82C, L90M	F53L	L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93L	C
		TK1020a		SQV, RTV, IDV, LPV	229	M46L, I54V, V82C, L90M	L23I, F53L	L10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93L	C
	TK3031	TK3031		SQV, NFV	203	D30N	N88D	I15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93L	C
	PL47066	85002		IDV, NFV	104	D30N	N88D	T12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93L	C
Weber (2005)	M86744	M86744	AY714447	IDV, RTV	13			T12PS, I13V, I15V, L19T, K20R, M36I, N37D, R41K, D60E, Q61E, H69K, I72IR, T74A, L89M, I93L	C
Baxter (2006)	12-3102	3102-30610	DQ877250	PI	NA	L90M	L23I, L33F, F53L, Q58E	L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L	C
	48-1229	1229-30428	DQ877762	PI	NA	M46I, I54A, V82F, L90M		L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93L	C
	48-8056	8056-30930	DQ879080	PI	NA	V32I, I47A	L33F, Q58E	L10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93L	C
Doualla-Bell (2006)	Pt9	FDB_Pt9		NFV		D30N	L33F, N88D	T12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93L	C
Sanabani (2006)	04BR013	04BR013	AY727522	PI	NA	M46I, G48V, V82A	L24I	L10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93L	C
von Wyl (2007)	19	702313	EF449901	PI	NA	I54IV, N88NS, L90M		L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93L	C
Pillay (2008)	DR42	02ZA.DR42	AY589897	IDV		V82VA		T12S, I15V, L19I, E35ED, M36I, R41K, I62IV, L63V, H69K, T74A, L89M, I93L, N98I	C
Rosen-Zvi (2008)	71	06p71-2		LPV	12			I15V, Q18E, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63V, H69K, T74A, L89M, I93L	C
Kassaye (2009)	TCDD-31	TC31_2003	FJ445704	SQV, APV, IDV, LPV	198	M46MI, L76V	V32VG, I47IM	R41R*K, D60DE, L63P, H69K, T74A, I85V, L89M, I93L	C
El-Khatib (2010)	Pat095	11ZA_SAVE2018	JF960545	LPV				T12S, I15V, L19I, N37K, R41N, L63P, H69K, T74A, L89M, I93L	C
	Pat127	11ZA_SAVE2466	JF960577	LPV				T12S, I15V, L19I, R41K, L63Q, H69K, T74A, V77I, L89M, I93L	C
Rodrigues (2010)	318_07	BR07SC318	GQ401302	LPV				I15V, N37K, R41I, L63P, H69K, T74A, L89M, I93L	C

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