Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	C
Gene	PR
Mutation	A71V
Rx	>= 1 PI
IncludeMixtures	No

References	20
Patients	156
Isolates	181

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kantor (2002)	TCDD-05	TCDD-05_1	AY090844	SQV	38	L90M		T12S, I15V, L19I, M36I, R41K, L63P, H69K, A71V, I93L	C
Johnston (2003)	TC-71	TC-71		IDV	52	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93L	C
Colonno (2004)	RC-034-067-562	067-5621	AY461501	ATV		I50L		K14R, I15V, L19I, K20T, E34EK, E35D, M36I, N37D, R41K, K55KN, D60E, I64IV, H69K, A71V, L89MT, I93L	C
Grossman (2004)	IL266	IL266	AY529621	SQV, RTV, IDV, NFV	180	I54IL, I84V, L90M	T74TP	R8RG, L10I, I15V, K20KI, E35EG, M36I, R41RK, L63P, H69K, A71V, L89M, Q92QR, I93L	C
	IL280	IL280a	AY529617	SQV, IDV	180	I84V, L90M		T12S, I15V, K20KR, M36I, R41RK, L63P, H69K, A71V, T74S, L89M, I93L	C
		IL280b	AY529616	SQV, IDV	201	M46MI, I84V, L90M		T12S, I15V, Q18L, D29DG, M36I, R41RK, L63P, H69KR, A71V, T74S, R87RT, L89M, I93L	C
	IL287	IL287	AY529620	SQV, RTV, IDV, NFV	184	I84V, L90M		L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93L	C
	IL384	IL384a	AY529618	IDV, SQV, RTV, NFV	154	M46I, I54V, V82A, L90M	T74P	W6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93L	C
		IL384b	AY529622	IDV, SQV, RTV, NFV	239	M46I, I54V, V82A, L90M	T74P	L10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93L	C
Montes (2004)	MB_patCOU	02_COUL707	AJ577870	SQV, RTV, IDV, NFV	221	L90M	G73S	L10I, T12S, I15V, K20T, M36I, R41K, L63P, H69K, A71V, I93L	C
Non-B Workgroup (2005)	UK186b	UK186b	AY900763	SQV, RTV	183	I84V, L90M	V11VI, G73GS	L10I, I15V, G16E, L19I, R41K, L63H, H69K, A71V, V77I, I93L	C
	UK231	UK231	AY900765	RTV, NFV	26	L90M	L33I, K43T	Q18L, L19T, K20X, E35N, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, L89M, I93L	C
	UK456b	UK456b	AY900773	NFV, IDV, RTV		M46I, L90M		L10LI, T12S, L19I, K20I, M36I, R41K, L63P, I64V, H69K, A71V, T74S, L89M, I93L	C
	UK955	UK955	AY900786	SQV, RTV, IDV	137	I54V, I84V, L90M	G73S, L89V	L10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93L	C
	UK1447	UK1447	AY900803	IDV, SQV, RTV	83	G48GA, I54V, V82A, I84V, L90M	L23LI, K43KT	L10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93L	C
	IL80	IL80	AY900811	RTV, NFV, SQV	114	I54V, V82A, I84V	K43T	W6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93L	C
	UK1447b	UK1447b	AY900833	IDV, NFV, SQV, RTV, APV, LPV	175	M46I, I50V, I54V, V82A, L90M	L10F, L23I, K43T	I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93L	C
	BR6	BR6	AY900885	SQV, RTV, IDV	306	I54V, I84V, L90M	L89V	L10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93L	C
	TK3015	TK3015		SQV, IDV	204	I54V, V82A, L90M	K43T	L10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L	C
		TK3015a		SQV, IDV, LPV	264	I54V, V82A, L90M	L10F, K43T	T12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L	C
		TK3015b		SQV, IDV, LPV	283	I54V, V82A, L90M	L10F, K43T	T12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L	C
		TK3015c		SQV, IDV, LPV, RTV, TPV	375	I54V, V82T, I84IV, L90M	K43T	L10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93L	C
	TK3016	TK3016		SQV, NFV	167	I54V, L90M	T74P	L10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93L	C
	TK3019	TK3019		SQV, NFV, RTV	143	I54V, I84IV, L90M	V11VI, G73S	L10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93L	C
		TK3019a		SQV, NFV, RTV	149	L90M	G73S, T74AP	I15V, L19I, E35D, M36I, R41K, I62V, L63P, H69T, A71V, I72L, I93L	C
	TK3035	TK3035		IDV, NFV, RTV	202	I54A, V82A		L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K45KR, D60E, L63P, H69K, A71V, L89M, I93L	C
	TK4011	TK4011		SQV, RTV, NFV, IDV	261	V82A, L90M	Q58E, G73S	L10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93L	C
	PL34057	96049		NFV	82	L90M		I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93L	C
	PL42056	72786		IDV, RTV	275	V82A	L10F, L24I, I54C	T12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L	C
		91776		IDV, RTV, LPV	340	V82A	L10F, L24I, I54C	G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L	C
Baxter (2006)	12-3049	3049-30508	DQ876115	PI	NA	M46I, I54V, L76V, V82A, L90M	L10FI	W6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93L	C
	12-3082	3082-30430	DQ877155	PI	NA	M46I, I84V, L90M	G73S	L10I, T12S, I13N, I15V, L19I, M36I, R41RK, Q61H, L63P, H69K, A71V, I72L, I93L	C
	48-1407	1407-30410	DQ877803	PI	NA	I54V, V82A, L90M	L10FI, K43T	T12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93L	C
	48-9302	9302-30918	DQ877587	PI	NA	I54V, V82A, L90M	L10F, G73GS, L89IMV	I15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93L	C
Doualla-Bell (2006)	Pt10	FDB_Pt10		NFV		D30N, L90M	L33F	I15V, G17D, L19V, E35D, M36I, N37K, R41K, L63P, H69K, A71V, I93L	C
	Pt2	FDB_Pt2		NFV		L90M		T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93L	C
Sen (2007)	T093	NPT93	EF186929	RTV, IDV		M46I, I54L, L90M	L23LI, G73ST	L10Y, T12S, L19T, K20I, L24LF, R41K, K45KR, K55KR, L63P, H69K, A71V, I72IM, V77I, I93L	C
		NPT93-PL	EF186978	RTV, IDV		M46I, I54IL, L90M	G73ST	L10Y, T12S, L19T, K20I, L24F, R41K, K45R, K55R, L63P, H69K, A71V, V77I, I93L	C
	T076	NPT76	EF186928	NFV, RTV		M46L, V82A, L90M	T74P	L10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93L	C
		NPT76-PL	EF186980	NFV, RTV		M46L	T74P	L10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93L	C
Waleria-Aleixo (2008)	08PR060719	08PR060719	FJ591541	PI	NA	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, N37K, R41N, L63T, H69K, A71V, T74S, I93L	C
	08PR050398	08PR050398	FJ591423	PI	NA	I50L	L10F, K43KT, Q58QE, T74TP, N88T	I15V, G16Q, K20R, E35D, M36I, N37K, P39S, R41N, I62IV, I64V, H69K, A71V, L89M, I93L	C
	08PR050311	08PR050311	FJ591339	PI	NA	L90M	K43T	I13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63LP, H69K, A71V, T74S, V82I, L89I, I93L	C
	RES223	RES223	FJ591940	PI	NA	I54V, L90M	L23I	I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74S, L89I, I93L	C
	08PR050386	08PR050386	FJ591411	PI	NA	I54V, V82A, L90M	L10F, L33F, G73S	I15V, K20T, E35D, M36I, N37K, R41N, Q61H, L63P, C67F, H69K, A71V, I93L	C
	08PR050433	08PR050433	FJ591430	PI	NA	I54V, V82A, L90M	N88D	I15V, G16A, K20R, E35D, M36I, N37E, R41H, K45R, D60N, L63P, H69K, K70KT, A71V, L89I, I93L	C
	08PR060644	08PR060644	FJ591499	PI	NA	I54V, V82F, L90M		K14KR, I15V, G16A, K20R, E35D, M36I, N37K, R41N, R57RK, L63LP, H69K, A71V, I93L	C
	08PR060539	08PR060539	FJ591455	PI	NA	M46I, I50L, V82A	L24I	L10I, I15V, K20R, E35D, M36I, N37K, R41N, K45R, L63V, H69K, A71V, T74S, L89M, I93L	C
	08PR040157	08PR040157	FJ591188	PI	NA	M46L, I54V, V82A, L90M		L10R, L19LI, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, I93L	C
	RES246	RES246	FJ591953	PI	NA	I54IV		I13V, K20T, E35DG, M36I, N37K, R41N, I62L, H69K, A71V, T74S, L89I, I93L	C
	08PR050444	08PR050444	FJ591441	PI	NA	D30N, I50L	N88D	K14R, I15V, G16E, E35D, M36I, N37K, R41Y, K45R, K55N, L63T, H69K, A71V, L89I, I93L	C
	08PR060628	08PR060628	FJ591483	PI	NA	M46L, G48V, I54T, V82A		L10V, I15V, K20R, E35D, M36I, N37T, R41N, L63P, H69K, A71V, V75I, L89I, I93L	C
	08PR050239	08PR050239	FJ591268	PI	NA	I54V, I84V	L10F, L24I	T12P, K14KR, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71V, V77VI, P79L, L89M, I93L	C
	08PR060752	08PR060752	FJ591548	PI	NA	D30N	N88D	I13IV, I15V, K20T, M36I, N37K, R41N, L63P, H69K, A71V, I72IM, L89I, I93L	C
Kassaye (2009)	TCDD-05	TC05_2003	FJ445702	SQV	147	L90M		W6W*, P9PR, T12S, I15V, L19I, E35D, M36I, R41K, L63P, H69K, A71V, I93L	C
	TCDD-28	TC28_2003	FJ445707	SQV	361	L90M	G73S	I15V, L19I, K20I, M36I, L63P, H69K, A71V, I93L	C
		TC28_2004	FJ445727	SQV, LPV	378	M46I, I84V, L90M	G73S	I15V, L19I, K20I, M36I, L63P, H69K, A71V, I93L	C
Knops (2010)	ID2137	ID2137-GT1	GU271172	IDV, LPV		V32I, I47A, V82A		L10I, T12S, I15V, L19AP, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L	C
		ID2137-GT2	GU271173	IDV, LPV, DRV, RTV	33	V32I, I54L, L76V, V82A	L89V	L5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L	C
Kouri (2012)	CU1737-09	CU1737-09	JQ585309	PI	NA	M46MI, I54V, L76V, V82A	L10F, L24I, L33F	I13V, N37S, R41K, Q61QH, L63P, H69K, A71V, L89M, I93L	C
	CU2016-09	CU2016-09	JQ585331	PI	NA	M46I, I54M, V82A, L90M	K43T	L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91TS, I93L	C
	CU1124-09	CU1124-09	JQ585275	PI	NA	M46MI, I54V, L76V, V82A	L10F, L24I, L33F	I13V, N37S, R41K, L63P, H69K, A71V, L89M, I93L	C
	CU2035-09	CU2035-09	JQ585332	PI	NA	M46I, I54M, V82A, L90M	K43T	Q2H, L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91S, I93L	C
Van Zyl (2013)	504	09.ZA.WC054	KC422808	LPV		I54V, V82A, L90M	L33F	T12S, L19I, E34Q, R41K, D60E, L63P, H69K, A71V, I93L	C
	753	10.ZA.WC072	KC422997	LPV		M46MI, I54V, V82A, L90M	L10F, L33F, K43T, G73S	T12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93L	C
	174	11.ZA.WC194	KC423723	LPV		M46I, I54V, L76V, I84V	L10F	I15V, L19I, K20R, M36I, R41K, Q61QH, L63PS, H69K, A71V, I93L	C
	288	11.ZA.WC125	KC423356	LPV		M46I, I54V, L76V, V82M, L90M	V11VI, L33F	L10V, T12S, I13V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63V, I64L, H69K, A71V, T74S, L89M, I93L	C
	771	11.ZA.WC161	KC423531	LPV		M46I, I50V, I54V, V82A		L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69R, K70Q, A71V, I93L	C
	401	08.ZA.WC014	KC423987	LPV		I54V, L76V, V82A		L10V, T12TS, I15V, L19I, K20R, M36I, N37D, K55R, R57RK, D60E, I62V, L63P, H69K, A71V, L89M, I93L	C
	863	11.ZA.WC140	KC423414	LPV		M46I, I50V, I54V, V82A	L10F, L33F	T12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93L	C
	736	10.ZA.WC092	KC423161	LPV		I54V, I84V	L10F, L23I, G73S, L89V	T4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93L	C
	1152	11.ZA.NL004	KC423718	LPV		M46I, I54V, L76V, V82A	L10F	I15V, L19IT, K20R, E35D, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, A71V, L89M, I93L	C
	3622	09.ZA.GT912	KC424397	LPV		I47A	F53L	T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71V, I93L	C
		10.ZA.GT1366	KC423174	LPV		I47A, N88NS	F53L	T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93L	C
		10.ZA.GT1471	KC423256	LPV		I47A	F53L	T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93L	C
	2961	08.ZA.GT353	KC424133	LPV		M46I, I50V, I54V, V82A	L23I	L10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63N, H69K, A71V, L89M, I93L	C
		10.ZA.GT1445	KC423234	LPV		M46I, I50V, I54V, V82A	L23I	L10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63H, H69K, A71V, I72IM, L89M, I93L	C
	2809	09.ZA.GT932	KC424424	LPV		M46I, I54V, L76V, V82A		L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, L63P, H69K, A71V, L89M, I93L	C
		10.ZA.GT1191	KC423030	LPV		M46I, I54V, L76V, V82A		L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, I62V, L63P, H69K, A71V, L89M, I93L	C
Acharya (2014)	DGP175	DGP175	KJ185345	RTV, ATV		M46I, I54V, V82A	L24I, K43T	L10V, T12S, K14R, I15V, L19I, M36I, R41K, L63P, H69K, A71V, L89M, I93L	C
	DGP165	DGP165	KJ185335	RTV, ATV		M46I, I54V, V82A, L90M	L33I	L10V, T12P, I15V, L19I, M36I, Q61E, L63P, H69K, A71V, I93L	C
	DGP162	DGP162	KJ185332	RTV, ATV		V32I, M46I, L76V, V82A, L90M	L10F, K43T	T12S, I15V, L19I, M36I, R41K, D60E, Q61E, L63T, H69K, A71V, I93L	C
	DGP142	DGP142	KJ185312	RTV, ATV		I54V, L90M	N88D	T12S, I15V, L19I, M36L, N37S, R41K, L63P, H69K, K70R, A71V, V82I, L89M, I93L	C
	DGP121	DGP121	KJ185291	LPV		M46I, I54V, L76V, V82A	L10F	T12S, K14R, I15V, L19T, M36V, N37D, L63P, H69K, A71V, I93L	C
	DGP113	DGP113	KJ185283	RTV, ATV		M46I, I54V, L90M	T74P	L10I, T12S, I15V, L19T, M36I, R41K, L63A, H69K, A71V, I93L	C
	DGP094	DGP094	KJ185264	LPV		M46I, L76V, I84V	L10F	T12S, I13V, I15V, L19T, M36I, R41K, L63P, H69K, K70R, A71V, L89M	C
	DGP093	DGP093	KJ185263	LPV		M46I, I84V, L90M		T12S, I15V, L19I, M36I, R41K, D60E, L63P, H69K, A71V, L89M, I93L	C
	DGP089	DGP089	KJ185259	RTV, ATV		M46I, I54V, L76V, V82A	L10F, F53L	T12S, K14R, L19I, M36I, N37D, R41K, D60E, H69K, A71V, L89M, I93L	C
	DGP072	DGP072	KJ185242	RTV, ATV		M46I, I54V, V82A	L24I, K43T	L10I, T12S, I15V, L19I, M36I, R41K, D60E, L63P, H69K, A71V, L89M, I93L	C
Grossman (2014)	609	609	KF135112	LPV	52	M46I, I54V, V82A, L90M	N83D, L89V	L10I, V11L, I13A, K20R, A22V, E35N, M36I, N37D, R41K, I62V, L63P, H69K, A71V, I93L	C
		609		LPV	134	M46I, I54V, V82A, L90M	G73S, N83D, L89V	L10I, V11L, I13V, K20R, A22V, E35N, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, T91S, I93L	C
	1114	1114	KF134952	LPV	52	M46I, I54V, L76V, V82A		L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93L	C
	255	255	KF135031	SQV, LPV	52	I54V, V82A	L10F, N88D, L89V	T12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93L	C
	49	49	KF135089	NFV, LPV	52	I54V, V82A, L90M	L10F, L33F, T74P	I13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93L	C
	97	97	KF135173	IDV, LPV	52	M46I, I54V, V82A, I84V, L90M	L10F	I13IV, I15V, K20R, M36I, R41K, L63P, H69K, A71V, L89LM, I93L	C
		97	KF135174	IDV, LPV	133	M46I, I54V, L76V, V82C, I84V, L90M	L10F	T12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93L	C
		97	KF135175	IDV, LPV	228	M46I, I54V, L76V, V82C, I84V, L90M	L10F	T12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93L	C
	946	946	KF135166	NFV, LPV	177	M46MI, I54V, L76V, V82A	L10F	T12S, I15V, L19I, K20R, M36I, N37ND, R41K, K55R, R57RK, I62V, L63P, H69K, A71V, I93L	C
	389	389	KF135067	SQV, LPV	52	I54IV, V82A, L90M	L10F, N88ND	Q7X, R8~, I15V, L19I, K20KR, M36I, R41K, Q61H, I62V, L63P, H69K, A71V, L89IM, I93L	C
	488	488	KF135085	SQV, LPV	52	G48A, I54V, V82A	L10F, L24I, Q58E	K20R, M36I, R41K, L63P, H69K, A71V, I72V, N83S, L89I, I93L	C
	52	52	KF135095	RTV, LPV	115	M46I, I54V, L76V, V82A, L90M		L10V, K14KQ, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63P, H69K, A71V, I72IT, L89M, I93L	C
		52	KF135096	RTV, LPV	194	M46I, I54V, L76V, V82A, L90M	L10FV	I15V, L19V, K20R, M36I, N37D, R41K, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93L	C
		52	KF135097	RTV, LPV	210	M46I, I54V, L76V, V82A, L90M		L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55KR, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93L	C
		52	KF135098	RTV, LPV	267	M46I, I54V, L76V, V82A, L90M		L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, L89M, I93L	C
		52	KF135099	RTV, LPV	314	M46I, I54V, L76V, V82A, L90M		L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, T74TS, L89M, I93L	C
	581	581	KF135103	IDV, LPV	52	L90M		L10I, T12TA, L19I, K20I, E35ED, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93L	C
		581	KF135104	IDV, LPV	187	L90M		L10I, L19I, K20I, E35D, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93L	C
	160	160	KF134989	SQV, LPV	52	D30N	N88D	T12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93L	C
	260	260	KF135035	IDV, LPV	384	I54V, V82A, L90M	L10F	I15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93L	C
	78	78	KF135145	RTV, LPV	52	M46I, I54V, L76V, V82A	L10F, L24I	I15V, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, I93L	C
	401	401		NFV, LPV	52	I54V, V82A	L10F	I15IM, M36AV, R41K, L63P, H69K, A71V, I93L	C
Steegen (2014)	11ZAKS165	11ZAKS165	KJ176447	LPV		I50IV, I54V, V82A		R41K, H69K, A71V, T74S, L89I, I93L	C
	12ZAKS201	12ZAKS201	KJ176481	LPV		M46I, I54V, L76V, V82A		R41K, L63P, H69K, A71V, Q92R, I93L	C
	10ZAKS037	10ZAKS037	KJ176319	LPV		M46MI, I54V, L76V, V82A, I84V		R41RK, Q61QR, L63P, H69K, A71V, I93L	C
	12ZAKS319	12ZAKS319	KJ176598	LPV		I47A, V82A		R41K, R57K, L63P, H69Q, A71V, I93L	C
	12ZAKS229	12ZAKS229	KJ176509	LPV		I54V, L76V, V82A		R41K, Q61H, L63P, H69K, A71V, I93L	C
	11ZAKS140	11ZAKS140	KJ176422	LPV		M46I, I54V, L76V, V82S		R41K, K55R, L63P, H69K, A71V, I93L	C
Diaz (2015)	RenG16491	RenG16491	KT747519	PI	NA	M46MI, I54V, L76V, V82A, L90M	L10FI	I15V, L19V, K20R, E35D, M36I, N37K, R41P, I62V, L63P, H69K, A71V, I93L	C
	RenG17238	RenG17238	KT748266	PI	NA			I15V, K20I, E35G, M36I, N37K, R41N, K45R, H69K, A71V, T74S, I85V, L89T, I93L	C
	RenG16014	RenG16014	KT747042	PI	NA	I50L	T74P	I15V, K20R, M36I, N37K, R41N, K45R, H69K, A71V, L89MT, I93L	C
	RenG17176	RenG17176	KT748204	PI	NA	I50L, V82A, L90M	G73S	I15V, G16A, K20R, E34Q, E35D, M36I, N37K, R41N, K45R, L63P, I66L, H69K, A71V, I93IL	C
	RenG17353	RenG17353	KT748381	PI	NA	M46I, I54V, L76V, V82A	L10F, L33F	I13V, K14KR, K20R, E35D, M36I, R41N, I62V, L63T, H69K, A71V, I72V, T74TA, L89M, I93L	C
	RenG16120	RenG16120	KT747148	PI	NA			I15V, K20T, M36I, N37K, R41N, I62IMV, H69K, A71V, L89M, Q92R, I93L	C
	RenG16730	RenG16730	KT747758	PI	NA	M46I, L90M	L10F, L33F	I15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, N88E, L89I, I93L	C
	RenG15586	RenG15586	KT746614	PI	NA	M46I, I54V, I84V, L90M		L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, D60E, I62V, L63P, H69K, A71V, L89I, I93L	C
	RenG15743	RenG15743	KT746771	PI	NA	M46I, I50L, V82A	L24I, L33F, K43T	L10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93L	C
	RenG17048	RenG17048	KT748076	PI	NA	M46I, I54L, L90M	L33F, Q58E, N88G, L89V	L10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93L	C
	RenG15557	RenG15557	KT746585	PI	NA	M46I, I54V, L76V, V82C, L90M		T12AS, I15V, G16E, L19P, K20T, E35G, M36I, N37K, R41N, K55R, R57RK, Q61N, L63N, H69K, A71V, I72R, L89I, I93L	C
	RenG16680	RenG16680	KT747708	PI	NA	I54V, L76V, V82A		L10V, I15V, K20R, D25DN, E35D, M36I, N37K, R41N, R57RK, Q61DN, I62V, L63P, H69K, A71V, L89M, I93L	C
	RenG15974	RenG15974	KT747002	PI	NA	M46MI, I50L	L23LI, L33F, F53FL, N83ND	L10LR, I13V, I15V, E35D, M36IL, N37K, R41N, I62V, L63V, H69K, A71V, T74A, L89IM, I93L	C
	RenG15801	RenG15801	KT746829	PI	NA	I50L, V82L		I15V, G16E, K20R, E35D, M36I, N37K, P39S, R41N, K45R, G68E, H69R, A71V, L89I, I93L	C
	RenG16022	RenG16022	KT747050	PI	NA	I50L, V82IL	L33F	K14KR, I15V, K20T, M36I, N37K, R41N, H69K, A71V, L89I, I93L	C
	RenG15516	RenG15516	KT746544	PI	NA	I54V, V82VA, I84V, L90M	L10F, L23I, Q58E	I15V, K20R, E35D, M36I, N37K, R41N, R57RK, D60DE, I62IV, L63P, H69K, K70KR, A71V, L89I, T91TS, I93L	C
	RenG17080	RenG17080	KT748108	PI	NA	I50L, V82M, L90M	Q58E, L89V	I13V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, K70T, A71V, I93L	C
	RenG16982	RenG16982	KT748010	PI	NA	M46L, I54IV, V82A	L10LFPS, L23I, L33F, F53FL	P9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93L	C
	RenG16794	RenG16794	KT747822	PI	NA	I50L	L23LI, L89AMTV	I15V, K20KR, E34ED, E35ED, M36I, N37K, R41N, L63V, H69K, A71V, T74TS, I93L	C
	RenG15346	RenG15346	KT746374	PI	NA	M46MI, I54V, V82VA, I84V, L90M	L10F, L23LI, L33F, F53FL, G73S, T74PS, L89V	V11L, I13V, I15V, K20T, E34Q, E35D, M36IL, N37K, R41N, I62V, L63P, G68D, H69R, A71V, I93L	C
	RenG14474	RenG14474	KT745502	PI	NA	M46I, I54V, V82A, I84V, L90M	L10F, K43KT	I15V, L19I, K20R, E35D, M36I, N37K, R41N, L63P, H69K, A71V, I85V, L89I, Q92K, I93L	C
	RenG14788	RenG14788	KT745816	PI	NA	M46I, I54V, L76V, V82F, L90M	L33F	L10I, I13V, K20R, E35D, M36I, N37K, R41Y, R57RK, Q61N, L63P, H69K, A71V, L89M, I93L	C
	RenG14916	RenG14916	KT745944	PI	NA	I50L, V82M, L90M	L23I, L33F	I13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93L	C
	RenG15117	RenG15117	KT746145	PI	NA	I54L, L90M	T74P, N88NT	K14R, I15V, G16E, K20T, E35D, M36I, N37K, P39S, R41N, I62V, H69K, A71V, V82I, L89M, I93L	C
	RenG14615	RenG14615	KT745643	PI	NA	I54IV, L90M	L10F, T74TP	I15V, K20R, E35D, M36I, N37K, R41N, R57RK, I62V, L63P, H69K, A71V, L89M, I93L	C
	RenG14186	RenG14186	KT745214	PI	NA	D30N, M46L, I54V, V82A	Q58QE, N88D	L10R, I15V, K20T, E35D, M36I, N37K, R41N, D60DE, Q61QH, L63P, I64IL, H69K, A71V, L89I, I93L	C
	RenG14901	RenG14901	KT745929	PI	NA	M46ML, G48GA, I54V, I84V, L90M	L10F, T74P, L89V	I15V, K20T, E35DN, M36I, N37K, R41H, Q61QH, I62IV, L63P, H69K, A71V, I85V, T91CS, I93L	C
	RenG13600	RenG13600	KT744628	PI	NA	M46I, I50L, L90M	L23I	I15V, K20T, E35D, M36I, N37K, R41N, L63PT, H69K, A71V, T74S, I85IV, L89I, I93L	C
	RenG14834	RenG14834	KT745862	PI	NA	M46I, I54V, L76V, V82F, L90M	L33F	L10I, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, Q61N, L63P, G68GE, H69K, K70KR, A71V, L89IM, I93L	C
	RenG14493	RenG14493	KT745521	PI	NA	I50L	L33LF	I15V, E35D, M36I, N37K, R41N, R57K, Q61QH, L63V, H69K, A71V, T74A, L89I, I93L	C
	RenG12144	RenG12144	KT743172	PI	NA	V32I, I54L, I84V	L10F, L33I, L89V	I13V, I15V, K20T, M36I, N37K, R41N, Q61N, L63P, I66FV, H69K, A71V, T74S, V77I, Q92K	C
	RenG12731	RenG12731	KT743759	PI	NA			I15V, K20T, E35D, M36I, N37NK, R41N, K45R, L63C, H69K, A71V, T74TS, L89T, I93L	C
	RenG12371	RenG12371	KT743399	PI	NA	I50L	T74P	L10LIV, K14KR, I15V, Q18T, N37K, R41N, K45R, L63LP, H69K, A71V, V77I, L89M, I93L	C
	RenG13298	RenG13298	KT744326	PI	NA	M46I, I54V, L76V, L90M		I15V, L19I, K20T, E35D, M36I, N37E, R41H, R57K, Q61R, I62V, L63LP, H69R, A71V, V82I, L89I, I93L	C
	RenG12983	RenG12983	KT744011	PI	NA	I54V, V82A, L90M		L10I, K20R, E35D, M36I, N37K, R41P, Q61QK, L63P, H69K, A71V, I72V	C
	RenG13433	RenG13433	KT744461	PI	NA	I50L, V82M	L24I, K43KT	T12P, I15S, G16R, K20RT, E34KN, E35D, M36I, N37K, R41N, K45KR, L63T, G68E, H69K, A71V, I72IT, T74A, Q92K, I93L	C
	RenG11973	RenG11973	KT743001	PI	NA	D30N		I15V, K20T, E35D, M36I, N37K, R41N, G68E, H69K, A71V, I93L	C
	RenG12329	RenG12329	KT743357	PI	NA	M46ML, I50L, V82VA, N88NS	L33F, T74TP	L10LH, I15IV, E35D, M36I, N37K, R41N, D60E, I62IV, L63P, H69K, A71V, L89M, I93L	C
	RenG12462	RenG12462	KT743490	PI	NA	I54V, V82A		L10IV, K14R, I15V, K20R, E35D, M36I, N37K, R41N, I62V, L63T, H69K, A71V, T74S, L89M, I93L	C
	RenG10325	RenG10325	KT741353	PI	NA	I50L, V82M	L23LI, L33F, F53L	T12TA, I13V, K14KR, I15V, K20R, E35D, M36L, N37K, R41N, L63P, H69K, A71V, T74S, L89M, I93L	C
	RenG10554	RenG10554	KT741582	PI	NA	M46L, I54V, V82M, L90M	L33F, F53L	L10V, I15V, G16E, L19I, K20R, E35D, M36I, N37T, P39Q, R41N, K55R, I62V, L63AITV, H69K, A71V, T74S, V77I, L89M, I93L, C95L	C
	RenG11113	RenG11113	KT742141	PI	NA	I54L, I84IV	T74P, L89MV	I15V, K20T, E35D, M36MI, N37K, R41N, L63P, H69K, A71V, V82I, T91S, I93L	C
	RenG11086	RenG11086	KT742114	PI	NA	M46I, I47A, I84V	F53L	L10V, G16E, E35D, M36V, N37E, P39S, R41N, I62V, L63T, H69R, A71V, T74S, L89M, I93L	C
	RenG11410	RenG11410	KT742438	PI	NA	I54V, V82A, L90M		L10V, I13A, K20V, A22V, E35N, M36I, N37K, R41H, R57RK, D60E, I62V, L63P, I64V, H69K, A71V, I93M	C
	RenG11494	RenG11494	KT742522	PI	NA	I50L, V82L, L90M	L33F, K43T	T12S, I13V, I15V, K20R, E35D, M36IV, N37K, R41N, Q61HN, L63T, I64V, H69K, A71V, T74S, L89M, I93L	C
	RenG11100	RenG11100	KT742128	PI	NA	I50L, V82M	T74P	I15V, G16E, L19Q, K20R, E35D, M36I, N37K, P39PS, R41N, K45R, L63T, H69K, A71V, I72IV, I93L	C
	RenG10299	RenG10299	KT741327	PI	NA	M46I, I54V, L76V, V82A		L10V, I15V, L19V, K20R, M36I, N37K, R41N, I62V, L63P, H69K, A71V, L89M, I93L	C
	RenG11227	RenG11227	KT742255	PI	NA	I50L, V82A, L90M	L33F	T12S, I13V, I15V, L19I, K20R, E35D, M36I, N37E, R41N, K45R, L63P, H69K, A71V, T74A, L89I, I93L	C
	RenG10331	RenG10331	KT741359	PI	NA	M46I, I50L, V82A	T74P	L10I, I15V, L19I, K20R, M36I, N37K, R41N, I62IV, L63V, H69K, A71V, L89M, I93L	C
	RenG11741	RenG11741	KT742769	PI	NA	M46MI, I54V, V82A, L90M	L33F, K43T, N88D	L10V, I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74KR, L89M, I93L	C
	RenG11471	RenG11471	KT742499	PI	NA	I54V, V82A	K43T, T74P	L10I, I15V, L19LI, K20R, E35D, M36I, N37K, R41INS, R57K, I62V, L63V, I64V, H69K, A71V, L89M, I93L	C
	RenG10615	RenG10615	KT741643	PI	NA	I50L, N88S	L33F, T74P	I13IV, I15V, K20R, E35D, M36I, N37K, R41N, L63LP, H69K, A71V, L89M, I93L	C
	RenG10491	RenG10491	KT741519	PI	NA	I50L, V82VA, N88S, L90LM	L33F	L10M, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, K45R, H69K, A71V, L89I, I93L	C
	RenG10982	RenG10982	KT742010	PI	NA	M46I, I50V, I54V, V82A, L90M	V11I, L33F, K43T, T74P	L10I, I13V, I15V, K20R, E35D, M36I, N37K, R41N, I62IV, L63P, H69R, A71V, L89LM, I93L	C
	RenG10394	RenG10394	KT741422	PI	NA	G48V, I54T, V82A		L10I, I15V, K20R, E35D, M36I, N37K, R41N, Q61H, L63V, H69K, A71V, I72IR, T74S, I85V, L89I, I93L	C
	RenG10493	RenG10493	KT741521	PI	NA	L90M	L23LI, F53L, G73GS, L89IV	I13V, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71V, T74K, V77VI, I93L	C
Rossouw (2015)	RP123-1	RP123-1	KT032043	PI	NA	M46I, I47V, I54V, L76V, V82A	Q58E	L10V, I15V, L19I, K20R, M36I, K55KR, D60E, L63P, H69K, A71V, L89M, I93L	C
	MIV001	MIV001	KT032063	LPV, RTV	159	I54V, V82A, L90M	Q58E, G73T	I15V, L19I, K20R, M36I, R41K, I62V, L63P, H69K, A71V, I93L	C
	RP125	RP125	KT032044	RTV, LPV	138	I54L	V82~	L19I, K20R, E35D, M36I, R41K, L63A, H69K, K70Q, A71V, I93L	C
	RP138	RP138	KT032050	LPV, RTV	231	M46I, I54V, L76V, V82A	L10F	I15V, L19V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, I62V, H69K, A71V, L89M, I93L	C
	RP104	RP104	KT032036	LPV	124	M46I, I50V, I54V, V82A		L10I, T12S, I15V, L19V, K20R, T31TI, E35D, M36I, R41K, L63P, H69K, K70R, A71V, V77I, L89M, I93L	C
	RP169	RP169	KT032059	LPV, RTV	286	I54V, L76V, V82A		E35D, M36I, N37ND, R41K, R57K, L63P, H69K, A71V, T74S, L89IM, T91TI, I93L	C
Neogi (2016)	7114	13.ZA.EC517	KT592727	LPV		M46I, I50IV, I54V, V82A	L10F, L23LI, L24LI, L33F	T12S, L19I, N37S, R41K, L63P, H69K, A71V, I93L	C
	5581	13.ZA.EC755	KT592886	LPV		M46I, I54V, L76V, V82A	L10F, K43T	I15V, L19I, M36MI, I62V, L63P, H69K, A71V, L89M, I93L	C

Protease Inhibitors

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