Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	A71V
Rx	>= 1 PI
IncludeMixtures	No

References	13
Patients	55
Isolates	79

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kantor (2002)	TCDD-05	TCDD-05_1	AY090844	SQV	38	L90M		T12S, I15V, L19I, M36I, R41K, L63P, H69K, A71V, I93L	C
	TCDD-28	TCDD-28_1	AY090854	SQV	279	L90M	G73GS	I15V, L19I, M36I, R41K, L63P, H69K, A71V, I93L	C
Johnston (2003)	TC-71	TC-71		IDV	52	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93L	C
Colonno (2004)	RC-034-067-562	067-5621	AY461501	ATV		I50L		K14R, I15V, L19I, K20T, E34EK, E35D, M36I, N37D, R41K, K55KN, D60E, I64IV, H69K, A71V, L89MT, I93L	C
Grossman (2004)	IL266	IL266	AY529621	SQV, RTV, IDV, NFV	180	I54IL, I84V, L90M	T74TP	R8RG, L10I, I15V, K20KI, E35EG, M36I, R41RK, L63P, H69K, A71V, L89M, Q92QR, I93L	C
	IL280	IL280a	AY529617	SQV, IDV	180	I84V, L90M		T12S, I15V, K20KR, M36I, R41RK, L63P, H69K, A71V, T74S, L89M, I93L	C
		IL280b	AY529616	SQV, IDV	201	M46MI, I84V, L90M		T12S, I15V, Q18L, D29DG, M36I, R41RK, L63P, H69KR, A71V, T74S, R87RT, L89M, I93L	C
	IL287	IL287	AY529620	SQV, RTV, IDV, NFV	184	I84V, L90M		L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93L	C
	IL384	IL384a	AY529618	IDV, SQV, RTV, NFV	154	M46I, I54V, V82A, L90M	T74P	W6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93L	C
		IL384b	AY529622	IDV, SQV, RTV, NFV	239	M46I, I54V, V82A, L90M	T74P	L10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93L	C
Montes (2004)	MB_patCOU	02_COUL707	AJ577870	SQV, RTV, IDV, NFV	221	L90M	G73S	L10I, T12S, I15V, K20T, M36I, R41K, L63P, H69K, A71V, I93L	C
Non-B Workgroup (2005)	UK186b	UK186b	AY900763	SQV, RTV	183	I84V, L90M	V11VI, G73GS	L10I, I15V, G16E, L19I, R41K, L63H, H69K, A71V, V77I, I93L	C
	UK231	UK231	AY900765	RTV, NFV	26	L90M	L33I, K43T	Q18L, L19T, K20X, E35N, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, L89M, I93L	C
	UK456b	UK456b	AY900773	NFV, IDV, RTV		M46I, L90M		L10LI, T12S, L19I, K20I, M36I, R41K, L63P, I64V, H69K, A71V, T74S, L89M, I93L	C
	UK955	UK955	AY900786	SQV, RTV, IDV	137	I54V, I84V, L90M	G73S, L89V	L10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93L	C
	UK1447	UK1447	AY900803	IDV, SQV, RTV	83	G48GA, I54V, V82A, I84V, L90M	L23LI, K43KT	L10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93L	C
	IL80	IL80	AY900811	RTV, NFV, SQV	114	I54V, V82A, I84V	K43T	W6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93L	C
	UK1447b	UK1447b	AY900833	IDV, NFV, SQV, RTV, APV, LPV	175	M46I, I50V, I54V, V82A, L90M	L10F, L23I, K43T	I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93L	C
	BR6	BR6	AY900885	SQV, RTV, IDV	306	I54V, I84V, L90M	L89V	L10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93L	C
	TK3015	TK3015		SQV, IDV	204	I54V, V82A, L90M	K43T	L10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L	C
		TK3015a		SQV, IDV, LPV	264	I54V, V82A, L90M	L10F, K43T	T12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L	C
		TK3015b		SQV, IDV, LPV	283	I54V, V82A, L90M	L10F, K43T	T12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L	C
		TK3015c		SQV, IDV, LPV, RTV, TPV	375	I54V, V82T, I84IV, L90M	K43T	L10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93L	C
	TK3016	TK3016		SQV, NFV	167	I54V, L90M	T74P	L10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93L	C
	TK3019	TK3019		SQV, NFV, RTV	143	I54V, I84IV, L90M	V11VI, G73S	L10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93L	C
		TK3019a		SQV, NFV, RTV	149	L90M	G73S, T74AP	I15V, L19I, E35D, M36I, R41K, I62V, L63P, H69T, A71V, I72L, I93L	C
	TK3035	TK3035		IDV, NFV, RTV	202	I54A, V82A		L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K45KR, D60E, L63P, H69K, A71V, L89M, I93L	C
	TK4011	TK4011		SQV, RTV, NFV, IDV	261	V82A, L90M	Q58E, G73S	L10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93L	C
	PL34057	96049		NFV	82	L90M		I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93L	C
	PL42056	72786		IDV, RTV	275	V82A	L10F, L24I, I54C	T12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L	C
		91776		IDV, RTV, LPV	340	V82A	L10F, L24I, I54C	G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L	C
Baxter (2006)	12-3049	3049-30508	DQ876115	PI	NA	M46I, I54V, L76V, V82A, L90M	L10FI	W6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93L	C
	12-3082	3082-30430	DQ877155	PI	NA	M46I, I84V, L90M	G73S	L10I, T12S, I13N, I15V, L19I, M36I, R41RK, Q61H, L63P, H69K, A71V, I72L, I93L	C
	48-1407	1407-30410	DQ877803	PI	NA	I54V, V82A, L90M	L10FI, K43T	T12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93L	C
	48-9302	9302-30918	DQ877587	PI	NA	I54V, V82A, L90M	L10F, G73GS, L89IMV	I15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93L	C
Doualla-Bell (2006)	Pt10	FDB_Pt10		NFV		D30N, L90M	L33F	I15V, G17D, L19V, E35D, M36I, N37K, R41K, L63P, H69K, A71V, I93L	C
	Pt2	FDB_Pt2		NFV		L90M		T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93L	C
Sen (2007)	T093	NPT93	EF186929	RTV, IDV		M46I, I54L, L90M	L23LI, G73ST	L10Y, T12S, L19T, K20I, L24LF, R41K, K45KR, K55KR, L63P, H69K, A71V, I72IM, V77I, I93L	C
		NPT93-PL	EF186978	RTV, IDV		M46I, I54IL, L90M	G73ST	L10Y, T12S, L19T, K20I, L24F, R41K, K45R, K55R, L63P, H69K, A71V, V77I, I93L	C
	T076	NPT76	EF186928	NFV, RTV		M46L, V82A, L90M	T74P	L10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93L	C
		NPT76-PL	EF186980	NFV, RTV		M46L	T74P	L10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93L	C
Kassaye (2009)	TCDD-05	TC05_2003	FJ445702	SQV	147	L90M		W6W*, P9PR, T12S, I15V, L19I, E35D, M36I, R41K, L63P, H69K, A71V, I93L	C
	TCDD-28	TC28_2003	FJ445707	SQV	361	L90M	G73S	I15V, L19I, K20I, M36I, L63P, H69K, A71V, I93L	C
		TC28_2004	FJ445727	SQV, LPV	378	M46I, I84V, L90M	G73S	I15V, L19I, K20I, M36I, L63P, H69K, A71V, I93L	C
Knops (2010)	ID2137	ID2137-GT1	GU271172	IDV, LPV		V32I, I47A, V82A		L10I, T12S, I15V, L19AP, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L	C
		ID2137-GT2	GU271173	IDV, LPV, DRV, RTV	33	V32I, I54L, L76V, V82A	L89V	L5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L	C
Van Zyl (2013)	1627	1466	KC423161	LPV	26	I54V, I84V	L10F, L23I, G73S, L89V	T4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93L	C
	1288	961	KC424397	LPV	26	I47A	F53L	T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71V, I93L	C
		1594	KC423256	LPV	78	I47A	F53L	T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93L	C
		1482	KC423174	LPV	79	I47A, N88NS	F53L	T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93L	C
	751	548	KC424133	LPV	26	M46I, I50V, I54V, V82A	L23I	L10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63N, H69K, A71V, L89M, I93L	C
		1563	KC423234	LPV	26	M46I, I50V, I54V, V82A	L23I	L10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63H, H69K, A71V, I72IM, L89M, I93L	C
	582	996	KC424424	LPV	26	M46I, I54V, L76V, V82A		L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, L63P, H69K, A71V, L89M, I93L	C
		1287	KC423030	LPV	78	M46I, I54V, L76V, V82A		L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, I62V, L63P, H69K, A71V, L89M, I93L	C
	1644	1954	KC423531	LPV	26	M46I, I50V, I54V, V82A		L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69R, K70Q, A71V, I93L	C
	20	2459	KC423723	LPV	26	M46I, I54V, L76V, I84V	L10F	I15V, L19I, K20R, M36I, R41K, Q61QH, L63PS, H69K, A71V, I93L	C
	1636	1248	KC422997	LPV	26	M46MI, I54V, V82A, L90M	L10F, L33F, K43T, G73S	T12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93L	C
	1750	2453	KC423718	LPV	26	M46I, I54V, L76V, V82A	L10F	I15V, L19IT, K20R, E35D, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, A71V, L89M, I93L	C
	1680	1795	KC423414	LPV	26	M46I, I50V, I54V, V82A	L10F, L33F	T12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93L	C
	1523	326	KC423987	LPV	26	I54V, L76V, V82A		L10V, T12TS, I15V, L19I, K20R, M36I, N37D, K55R, R57RK, D60E, I62V, L63P, H69K, A71V, L89M, I93L	C
Grossman (2014)	609	609	KF135112	NFV, RTV, LPV	52	M46I, I54V, V82A, L90M	N83D, L89V	L10I, V11L, I13A, K20R, A22V, E35N, M36I, N37D, R41K, I62V, L63P, H69K, A71V, I93L	C
	1114	1114	KF134952	LPV	52	M46I, I54V, L76V, V82A		L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93L	C
	255	255	KF135031	SQV, LPV	52	I54V, V82A	L10F, N88D, L89V	T12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93L	C
	49	49	KF135089	NFV, LPV	52	I54V, V82A, L90M	L10F, L33F, T74P	I13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93L	C
	97	97	KF135173	IDV, LPV	52	M46I, I54V, V82A, I84V, L90M	L10F	I13IV, I15V, K20R, M36I, R41K, L63P, H69K, A71V, L89LM, I93L	C
		97	KF135174	IDV, LPV	133	M46I, I54V, L76V, V82C, I84V, L90M	L10F	T12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93L	C
		97	KF135175	IDV, LPV	228	M46I, I54V, L76V, V82C, I84V, L90M	L10F	T12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93L	C
	946	946	KF135166	NFV, LPV	177	M46MI, I54V, L76V, V82A	L10F	T12S, I15V, L19I, K20R, M36I, N37ND, R41K, K55R, R57RK, I62V, L63P, H69K, A71V, I93L	C
	389	389	KF135067	SQV, LPV	52	I54IV, V82A, L90M	L10F, N88ND	Q7X, R8~, I15V, L19I, K20KR, M36I, R41K, Q61H, I62V, L63P, H69K, A71V, L89IM, I93L	C
	488	488	KF135085	SQV, LPV	52	G48A, I54V, V82A	L10F, L24I, Q58E	K20R, M36I, R41K, L63P, H69K, A71V, I72V, N83S, L89I, I93L	C
	52	52	KF135095	RTV, LPV	115	M46I, I54V, L76V, V82A, L90M		L10V, K14KQ, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63P, H69K, A71V, I72IT, L89M, I93L	C
		52	KF135096	RTV, LPV	194	M46I, I54V, L76V, V82A, L90M	L10FV	I15V, L19V, K20R, M36I, N37D, R41K, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93L	C
		52	KF135097	RTV, LPV	210	M46I, I54V, L76V, V82A, L90M		L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55KR, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93L	C
		52	KF135098	RTV, LPV	267	M46I, I54V, L76V, V82A, L90M		L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, L89M, I93L	C
		52	KF135099	RTV, LPV	314	M46I, I54V, L76V, V82A, L90M		L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, T74TS, L89M, I93L	C
	581	581	KF135103	IDV, LPV	52	L90M		L10I, T12TA, L19I, K20I, E35ED, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93L	C
		581	KF135104	IDV, LPV	187	L90M		L10I, L19I, K20I, E35D, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93L	C
	160	160	KF134989	SQV, LPV	52	D30N	N88D	T12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93L	C
	260	260	KF135035	IDV, LPV	384	I54V, V82A, L90M	L10F	I15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93L	C

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