Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	A71T
Rx	PI-naive
IncludeMixtures	No

References	38
Patients	62
Isolates	71

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	OtherMut	Subtype
Dowling (2002)	KER2010	KER2010	AF457054	None	I13V, L19I, K20R, M36I, R41K, I62V, L63I, H69K, A71T, L89I, I93L	C
Novitsky (2002)	00BW2127	00BW2127	AF443105	None	T12S, I15V, L19I, M36I, R41K, I62V, L63V, H69K, A71T, I85V, I93L	C
Yang (2002)	DH012	DH012	AB078710	None	T12S, I15V, E35D, M36I, N37D, L63P, A71T, I93L	C
Maljkovic (2003)	MI_Pat3	00SE18813	AY165226	None	T12S, I15V, L19I, M36I, R41K, I62V, L63AV, H69K, A71T, I72M, L89X, I93L	C
Deshpande (2004)	in134	in134	AY515841	None	T12S, I15V, L19T, M36V, R41K, L63T, H69K, A71T, I93L	C
	in104	in104	AY515814	None	T12P, I15V, L19I, M36V, N37S, R41K, L63P, H69K, A71T, L89M, I93L	C
	in119	in119	AY515829	None	I13V, K14R, I15V, L19V, N37S, R41K, L63P, H69K, A71T, L89M, C95CY	C
Bussmann (2005)	01BW2210N	01BW2210N	AY829309	None	L10I, T12S, I15V, L19I, M36I, R41K, R57K, I62V, L63G, H69K, A71T, L89M, I93L	C
	01BW3368N	01BW3368N	AY829315	None	T12S, I15V, L19I, E35D, M36I, R41K, I62V, L63A, H69K, A71T, I93L	C
Eshleman (2005)	16936	16936_BL	AY746376	None	T12S, I15V, G16E, L19I, M36L, N37E, P39S, I62V, L63P, H69K, A71T, I93L	C
		16936_1Y	AY746377	None	T12S, I15V, G16E, L19I, M36L, N37E, P39S, I62V, L63P, H69K, A71T, I93L	C
		16936_2Y	AY746378	None	T12S, I15V, G16E, L19I, M36L, N37E, P39S, I62V, L63P, H69K, A71T, I93L	C
Non-B Workgroup (2005)	UK740	UK740	AY900782	None	T12S, L19I, M36I, P39Q, R41K, I62V, L63C, H69K, A71T, I72V, I93L	C
	UK1988	UK1988	AY900830	None	T12S, I15V, L19I, E35D, R41K, K45R, I62V, L63T, I64L, H69K, A71T, V77VI, I93L	C
	UK2033	UK2033	AY900842	None	T12S, I15V, L19I, M36L, R41K, I62V, L63V, H69K, A71T, I93L	C
Rousseau (2006)	Pt182	04SK140B1	AY901973	None	T12S, I15V, L19I, M36I, R41K, Q61E, I62V, H69K, A71T, L89M, I93L	C
Dilernia (2007)	F349	F349	EF120244	None	T12P, I15V, L19I, M36I, N37K, R41I, R57K, L63T, H69K, A71T, I93L	C
	F098	F098	EF120337	None	L10V, T12S, I15V, L19I, M36MI, N37K, R41N, R57K, L63T, H69K, A71T, I93L	C
Martinson (2007)	CHB398M	CHB398M	EU152435	None	T12S, I15V, L19I, E35D, M36I, R41K, I62V, L63P, H69K, A71T, L89M, I93L	C
	CHB398B	CHB398B	EU152436	None	T12S, I15V, L19I, E35D, M36I, R41K, I62V, L63P, H69K, A71T, L89M, I93L	C
Novitsky (2007)	0898	0898_0019	EF026175	None	T12S, I15V, L19I, N37S, R41K, I62V, L63AS, H69K, A71T, V77I, I93L, G94E	C
		0898_7976	EF026176	None	T12S, I15V, L19I, N37S, R41K, I62V, L63A, H69K, A71T, V77I, I93L	C
		0898_6451	EF026177	None	T12S, I15V, N37S, R41K, I62V, L63A, H69K, A71T, I72IV, V77I, I93L	C
	1898	1898_1854	EF026227	None	T12S, I15V, L19I, M36I, R41K, I62V, L63V, H69K, A71T, L89M, I93L	C
		1898_4401	EF026226	None	L10I, T12S, I13V, I15V, L19I, M36I, R41K, I62V, L63V, H69K, A71T, L89M, I93L	C
Soundararajan (2007)	TRC51	TRC51	EF491950	None	T12S, I15V, L19I, E35D, M36I, N37D, R41K, L63Q, H69K, A71T, I93L	C
Church (2008)	402788Z	402788Z	EU380753	None	K14R, N37K, R41N, R57K, L63P, H69K, A71T, L89M, I93L	C
Deho (2008)	140	140	EU244655	None	T12S, I15V, L19I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71T, I93L	C
Ibe (2008)	375	375	AB356365	None	K14KR, L19LI, N37E, L63AD, A71T, I72T	C
Kamoto (2008)	MW25	MW25	JQ617144	None	I15V, L19I, N37T, R41K, L63S, H69K, A71T, I93L	C
Lahuerta (2008)	P348405	p348405_04	EF407702	None	I15V, L19T, E35D, R41K, H69K, A71T, L89M, I93L	C
	P348426	P348426_04	EF407711	None	T12S, I15V, L19I, M36V, R41K, L63P, H69K, A71T, I93L	C
Matthews (2008)	SK140	SK140	FJ199917	None	T12S, I15V, L19I, M36I, R41K, Q61E, I62V, H69K, A71T, L89M, I93L	C
Somi (2008)	OY-05-390	OY-05-390	JQ616971	None	I15V, L19I, E35D, R41K, L63P, H69K, A71T, I93L	C
Hosseinipour (2009)	9430	9430	GQ228272	None	E35D, N37E, L63P, H69K, A71T, I93L	C
Kassaye (2009)	TC-47	TC47_2003	FJ445703	None	I15V, L19IT, M36I, R41K, I62V, L63S, H69K, A71T, I72E, L89M, I93L	C
		TC47_2004	FJ445723	None	I15V, L19T, M36I, R41K, I62V, L63S, H69K, A71T, I72E, I93L	C
Rajesh (2009)	N58	TRCNPR58	FJ595421	None	T12P, I15V, G16E, L19I, N37S, P39S, R41K, I62V, L63Q, H69K, A71T, I93L	C
	F12	TRCFPR12	FJ595474	None	L19I, M36MLV, N37ST, P39S, R41K, I62V, L63Q, H69K, A71T, I93L	C
Wallis (2009)	GT00367353	GT00367353		None	T12S, I15V, L19I, E35D, M36I, P39Q, R41K, R57K, L63A, H69K, A71T, I93L	C
	ReA2	GT02		None	T12S, I15V, L19T, E35D, M36I, R41K, L63P, H69K, A71T, I72V, I93L	C
	TJC2413549	TJC2413549		None	T12S, I15V, L19I, M36I, N37D, R41K, I62IV, L63C, H69K, A71T, I93L	C
	GT00366729	GT00366729		None	T12S, I15V, L19I, K20R, M36I, N37E, P39Q, R41K, K43KR, I62V, H69K, A71T, I93L	C
Gonzalez (2010)	914_M00m	914_M00m	GQ427114	None	L10V, I15V, Q18H, L19I, M36I, N37S, R41K, L63S, H69K, A71T, P79S, I93L	C
	MA4	MA4	GQ433865	None	T12S, I15V, L19I, M36I, R41K, L63Q, H69K, A71T, I93L	C
Hamers (2010)	300071	CP076300071	HM119658	None	T12S, I13X, I15V, L19I, E35D, M36MI, N37S, R41H, I62IV, L63LHQ, H69K, A71T, I93L	C
	300136	CP076300136	HM119712	None	T12S, I15V, G16E, L19I, R41K, L63H, H69K, A71T, L89I, I93L	C
	300504	CP076300504	HM119921	None	T12S, I15V, L19I, M36I, N37D, R57K, L63S, H69K, A71T, I93L	C
	300577	CP076300577	HM119981	None	L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, A71T, I72T, I93L	C
	302381	CP076302381	HM120095	None	T12S, I15V, L19I, M36I, R41K, R57RK, I62V, L63V, H69K, A71T, I72IEKV, I93L	C
Papathanasopoulos (2010)	16923	06ZA16923	GU253416	None	T12S, I15V, G16E, L19T, K20M, E35D, M36I, I62V, L63A, H69K, A71T, I93L	C
Rodrigues (2010)	322_07	BR07SC322	GQ401306	None	I15V, L19T, M36I, N37K, R41I, L63P, H69K, K70R, A71T, I93L	C
Wright (2010)	140	SK140	HM593148	None	L10LV, T12S, I15V, L19I, M36I, R41K, Q61E, I62IV, L63LP, H69K, A71T, L89M, I93L	C
Bussmann (2011)	B0690	B0690	JQ616996	None	I15V, L19I, M36I, R41K, I62V, L63A, H69K, A71T, L89M, I93L	C
	B0781	B0781	JQ617043	None	I15V, L19T, M36I, R41K, I62V, L63A, H69K, A71T, I93L	C
	B0564	B0564	JQ617058	None	I15V, L19IV, M36MI, N37NS, R41K, I62V, L63V, I64L, H69K, A71T, L89M, I93L	C
	B0566	B0566	JQ617060	None	L19V, E34G, M36I, R41K, L63P, H69K, A71T, L89M, I93L	C
	B0672	B0672	JQ617127	None	I15V, L19I, E35D, M36I, N37E, R41K, R57K, D60E, L63T, H69K, A71T, I72T, I93L	C
Deshpande (2011)	Pat023	in1100	JF414447	None	T12S, L19I, M36I, R41K, L63P, H69Q, A71T, I72IM, I93L	C
Hamers (2011)	CP076304264	CP076304264	HQ993952	None	T12S, I15V, L19I, M36I, P39PS, R41K, I62V, L63V, H69K, A71T, I93L	C
	CP076303179	CP076303179	HQ994195	None	T12S, I15IV, L19T, M36I, R41K, R57K, L63T, H69K, A71T, I93L	C
	CP076303222	CP076303222	HQ994228	None	T12S, I15V, L19I, M36I, R41K, L63P, H69K, A71T, I72T, L89I, I93L	C
	CP076305120	CP076305120	HQ994341	None	T12S, I15V, L19I, E35D, M36I, R41K, R57RK, I62V, L63ST, H69K, A71T, I93L	C
	CP763A03301	CP763A03301	HQ994622	None	T12S, I15V, L19T, E35D, M36I, R41K, K45R, I62V, L63V, H69K, A71T, I72V, I93L	C
Nwobegahay (2011)	BBVCT57ZA	BBVCT57ZA	GU139631	None	L19I, E35D, M36I, R41K, R57K, L63I, H69K, A71T, I72V, I93L	C
Sigaloff (2011)	GT00366729	GT00366729_1	JN381607	None	T12S, I15V, L19I, K20R, M36I, N37E, P39Q, R41K, K43KR, I62V, H69K, A71T, I93L	C
		GT00366729_2	JN381608	None	T12S, I15V, L19I, K20R, M36I, N37E, P39Q, R41K, K43R, I62V, H69K, A71T, I93L	C
De Gascun (2012)	IRL26089	IRL26089	JN622914	None	R8RG, T12S, K14KI, I15V, L19I, M36I, R41K, K55KT, I62IV, L63LIPT, H69K, A71T, I72V, I93L	C
Iweriebor (2012)	07B1ZA	07B1ZA	GU201798	None	I15V, G17D, L19V, M36I, N37T, L63P, H69K, A71T, L89I, I93L	C
Sigaloff (2012)	KELKN220	KELKN220	JN628493	None	T12S, I15V, L19I, M36I, R41K, I62V, L63S, H69K, A71T, I93L	C
Ferreira (2013)	BR09SP242	BR09SP242	HM534027	None	T12P, K14R, I15V, M36I, N37K, R41N, L63V, H69K, A71T, I93L	C

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