<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63V
Rx >= 1 PI
IncludeMixtures No
References 21
Patients 81
Isolates 91
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kantor (2002)TCDD-26TCDD-26AY090852SQV38  I15V, L19X, M36I, R41K, L63V, H69K, V82I, L89M, I93LC
 TCDD-32TCDD-32AY090858RTV18  T12S, I13LV, K14EQ, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
Snoeck (2002)BE8BE8AF338992IDV80  I15V, L19V, E35D, M36L, R41K, L63V, H69K, T74S, L89M, I93LC
Johnston (2003)TC-71TC-71 IDV52G48V, I54T, V82A L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93LC
Weber (2003)85H610185H-12AY140821RTV13  L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93LC
  610185H-48AY140823RTV48I54V, V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69R, T74S, V77I, L89M, I93LC
Grossman (2004)IL477IL477AY529602NFV208D30NL10F, N88DT12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)UK162UK162AY900762RTV57M46I, V82A, L90MK43TT12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93LC
 UK594UK594AY900778SQV184  I13V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 UK704UK704AY900781RTV, IDV   T12S, I15V, L19I, M36I, R41K, Q61E, L63V, H69K, T74A, L89M, I93LC
 UK773aUK773a NFV   P9PL, T12S, I15IV, L19T, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 UK1447UK1447AY900803IDV, SQV, RTV83G48GA, I54V, V82A, I84V, L90ML23LI, K43KTL10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 UK2064UK2064 IDV150  I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 UK2069UK2069AY900845NFV D30NN88DT12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93LC
 TK1002TK1002 RTV225M46I, I54V, V82A L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93LC
 TK2023TK2023 RTV, IDV, SQV173  L10I, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V75I, L89M, I93LC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
Weber (2005)F92963F92963-2AY714404NFV, Unknown>47  I15V, L19I, M36I, R41K, L63V, H69K, L89IM, I93LC
 M83284M83284AY677471SQV82  T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93LC
Baxter (2006)48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
Doualla-Bell (2006)Pt11FDB_Pt11 NFV M46I, L90M T12S, I15V, L19I, M36I, R41K, L63V, H69K, V77I, L89M, I93LC
 Pt6FDB_Pt6 NFV M46I, N88SL10FT12S, I15V, L19V, K20I, M36I, R41K, L63V, I64V, H69K, T74V, L89M, I93LC
Pillay (2008)DR55DR55AY589908RTV104M46L, I54V, V82AL23LIT12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 DR4202ZA.DR42AY589897IDV V82VA T12S, I15V, L19I, E35ED, M36I, R41K, I62IV, L63V, H69K, T74A, L89M, I93L, N98IC
Riddler (2008)RG19024RG19024w20 LPV16  L5LF, T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74TS, L89M, I93LC
Rosen-Zvi (2008)7106p71-2 LPV12  I15V, Q18E, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63V, H69K, T74A, L89M, I93LC
  09p71-3 LPV175I54V, V82A I15V, Q18E, K20R, E35D, M36I, R41K, K45I, D60E, I62V, L63V, H69K, L89M, I93LC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Cardoso (2009)3098BRGO3098FJ638445PINA  L10M, I15V, L19T, M36I, N37K, R41N, L63V, H69K, I93LC
Jones (2009)176988176988FJ659847PINA  I15V, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93LC
Kassaye (2009)TCDD-13TC13_2003FJ445709SQV, NFV178  I15V, L19LI, M36I, R41K, L63V, H69K, V82I, I93LC
Rodrigues (2010)40_08BR08SC040GQ401333LPV   T12S, I15V, L19I, M36I, N37K, R41N, L63V, H69K, L89M, I93LC
Jones (2012)176988176988JN670420PINA  I15V, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93LC
Van Zyl (2013)82619KC424181LPV26  T12S, L19I, K20R, M36I, N37D, L63V, H69K, L89M, I93LC
 40454KC424126LPV26  T12S, I15V, L19I, K20R, E35Q, M36I, N37D, R41K, L63V, H69K, I72V, T74S, L89M, I93LC
 14532172KC423667LPV26M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, M36I, R41K, K43R, L63V, H69K, L89I, I93LC
 14522906KC423888LPV26M46I, I54V, L76V, V82AL10FT12TS, I15V, L19T, K20R, M36I, R41K, L63V, H69K, L89I, I93LC
 982884KC424338LPV26  L10M, I15V, L19M, E35D, R41K, L63V, H69K, L89M, I93LC
 18112902KC423885LPV26  T12S, I15V, L19I, M36I, L63V, H69K, T74S, L89M, I93LC
 2401432KC423142LPV103  L10M, I15V, M36I, R41K, L63V, H69K, L89M, I93LC
 13542013KC423563LPV104  T12S, I15V, L19I, K20R, E35N, M36I, N37D, R41K, R57RK, D60E, L63V, H69K, T74S, L89M, I93LC
 2852979KC423915LPV26  T12S, I15V, G16E, L19V, M36L, L63V, H69K, T74S, L89M, I93LC
 1144265KC423761LPV26  K14N, I15V, L19I, M36I, L63V, H69K, V82I, L89M, I93LC
  767KC424273LPV78  K14N, I15V, L19I, M36I, L63V, H69K, V82I, L89M, I93LC
 10601844KC423454LPV52  L19T, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 11011078KC422864LPV26  I15V, L19I, M36I, R41K, L63V, E65D, H69K, T74S, L89M, I93LC
 15022120KC423633LPV26  T12S, I15V, L19I, K20KR, M36I, R41K, L63V, H69K, V82I, L89M, I93LC
 11862129KC423639LPV26  T12S, K14R, I15V, L19V, K20R, E35D, M36I, N37D, L63V, H69K, L89M, I93LC
 14341620KC423276LPV26  T12PS, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 1660584KC424152LPV26  T12S, I13V, I15V, G16A, L19T, K20R, M36I, R41K, L63V, H69K, I72IT, L89M, I93LC
  1015KC422807LPV78  T12S, I13V, I15V, G16A, L19T, K20R, M36I, R41K, Q61QH, L63V, H69K, I72IT, L89M, I93LC
 14761393KC423116LPV26  T12S, I15V, L19T, M36I, N37S, R41K, L63V, H69K, L89M, I93LC
 73339KC424033LPV26  T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, L89M, I93LC
 12059KC423591LPV26  L10I, T12S, K14KR, I15V, L19D, M36I, R41K, L63V, H69K, T74TA, L89M, I93LC
 14822669KC423774LPV26  T12S, I15V, L19I, E35D, M36V, R41K, L63V, H69K, T74S, L89M, I93LC
 74291KC424353LPV26  E35D, M36I, R41K, L63V, H69K, K70X, L89M, I93LC
 16812549KC423742LPV26  T12S, G16E, L19V, R41K, L63V, I64L, H69K, V77I, L89M, I93LC
 1104493KC424093LPV26  T12S, I15V, L19I, M36I, L63V, H69K, L89M, I93LC
  224KC423686LPV78  T12S, I15V, L19I, M36I, L63V, H69K, L89M, I93LC
  1022KC422813LPV130  M36I, L63V, H69K, L89M, I93LC
 9731802KC423420LPV26  T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74AS, L89M, I93LC
 11871699KC423334LPV26  T12S, I15V, G16E, L19I, E35D, M36I, L63V, H69K, T74S, L89M, I93LC
 622524KC424116LPV26  L10I, I15V, L19V, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 17392155KC423655LPV26  T12S, I15V, L19T, E35D, M36I, N37D, R41K, L63V, H69K, T74S, L89M, I93LC
 13131335KC423069LPV26  T12S, I15V, G16E, L19I, M36I, R41K, L63V, H69K, K70R, T74S, L89M, I93LC
 53936KC424009LPV26  T12S, I15V, L19I, K20R, E35Q, M36I, N37D, R41K, L63V, H69K, T74S, L89M, I93LC
 6471624KC423279LPV209  T12S, I15V, G16E, L19T, N37S, R57K, L63V, H69K, V77I, V82I, L89M, I93LC
 234127KC423018LPV26  T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 16341798KC423416LPV26  I15V, L19T, K20R, M36I, R41K, L63V, H69K, L89M, I93LC
 808993KC424422LPV1  T12S, K14R, I15V, L19I, M36I, R41K, L63V, H69K, V82I, L89M, I93LC
 15312747KC423812LPV26  T12S, I15V, L19V, M36I, N37D, L63V, H69K, I72V, T74A, L89M, I93LC
 1137706KC424236LPV26  T12P, I15V, G17D, L19I, M36I, N37S, L63V, H69K, L89M, I93LC
 12121653KC423300LPV26  T12E, I15V, L19V, M36I, R41K, D60E, L63V, H69K, L89M, I93LC
 10192144KC423648LPV26  T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 755835KC424306LPV26  T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
  1892KC423491LPV26  T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 16261072KC422859LPV26  L10M, K14N, L19I, M36I, R41K, L63V, H69K, L89M, I93LC
Grossman (2014)11431143KF134956LPV52  K20R, M36I, R41K, L63V, H69K, L89M, I93LC
 11141114KF134952LPV52M46I, I54V, L76V, V82A L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93LC
 325325KF135053SQV, NFV, IDV, LPV52  I15V, M36I, R41K, Q61E, L63V, H69K, T74S, L89M, I93LC
 285285KF135040IDV, LPV52  L10I, I13V, K14R, I15V, M36I, N37D, R41K, L63V, E65D, H69K, T74S, L89M, I93LC
 136136KF134973IDV, LPV52  T12S, I13IM, I15V, L19Q, M36I, N37ND, R41K, Q61E, L63V, H69K, L89M, I93LC
 766766KF135138NFV, LPV52 L10LFI15V, M36I, R41K, L63V, H69K, L89M, I93LC
 18871887KF135009LPV52  K14R, I15V, L19Q, M36I, R41K, L63V, H69K, V82I, L89M, I93LC
 18491849KF135006LPV52  I15V, L19I, M36I, R41K, L63V, H69K, K70R, I93LC
 789789KF135144NFV, RTV, IDV, LPV52I54IV, V82A, I84IV L10I, T12S, I15V, K20M, E34K, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 464464 NFV, IDV, LPV52V32I, I47V, I54MN83DL10I, M36I, R41K, I62V, L63V, T74S, V82I, I85V, L89I, I93LC
 942942 NFV, LPV52  T12S, I15V, L19V, M36I, R41K, L63V, H69K, T74S, L89M, I93LC