Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L63V
Rx	>= 1 PI
IncludeMixtures	No

References	19
Patients	32
Isolates	36

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kantor (2002)	TCDD-26	TCDD-26	AY090852	SQV	38			I15V, L19X, M36I, R41K, L63V, H69K, V82I, L89M, I93L	C
	TCDD-32	TCDD-32	AY090858	RTV	18			T12S, I13LV, K14EQ, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
Snoeck (2002)	BE8	BE8	AF338992	IDV	80			I15V, L19V, E35D, M36L, R41K, L63V, H69K, T74S, L89M, I93L	C
Johnston (2003)	TC-71	TC-71		IDV	52	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93L	C
Weber (2003)	85H	610185H-12	AY140821	RTV	13			L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93L	C
		610185H-48	AY140823	RTV	48	I54V, V82A		L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69R, T74S, V77I, L89M, I93L	C
Grossman (2004)	IL477	IL477	AY529602	NFV	208	D30N	L10F, N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L	C
Snoeck (2004)	BE59	BE59	AY900757	SQV, IDV, RTV, NFV	217	G48V, I54A, V82A	L33F, K43KT	L10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93L	C
Non-B Workgroup (2005)	UK162	UK162	AY900762	RTV	57	M46I, V82A, L90M	K43T	T12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93L	C
	UK594	UK594	AY900778	SQV	184			I13V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	UK704	UK704	AY900781	RTV, IDV				T12S, I15V, L19I, M36I, R41K, Q61E, L63V, H69K, T74A, L89M, I93L	C
	UK773a	UK773a		NFV				P9PL, T12S, I15IV, L19T, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	UK1447	UK1447	AY900803	IDV, SQV, RTV	83	G48GA, I54V, V82A, I84V, L90M	L23LI, K43KT	L10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93L	C
	UK1447b	UK1447b	AY900833	IDV, NFV, SQV, RTV, APV, LPV	175	M46I, I50V, I54V, V82A, L90M	L10F, L23I, K43T	I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93L	C
	UK2064	UK2064		IDV	150			I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	UK2069	UK2069	AY900845	NFV		D30N	N88D	T12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93L	C
	TK1002	TK1002		RTV	225	M46I, I54V, V82A		L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93L	C
	TK2023	TK2023		RTV, IDV, SQV	173			L10I, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V75I, L89M, I93L	C
	PL34057	96049		NFV	82	L90M		I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93L	C
Weber (2005)	F92963	F92963-2	AY714404	NFV, Unknown	>47			I15V, L19I, M36I, R41K, L63V, H69K, L89IM, I93L	C
	M83284	M83284	AY677471	SQV	82			T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93L	C
Baxter (2006)	48-3229	3229-30523	DQ878136	PI	NA	M46I, I54V, V82A, I84V	L10F, L24I, L33F, K43T	T12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91S	C
Doualla-Bell (2006)	Pt11	FDB_Pt11		NFV		M46I, L90M		T12S, I15V, L19I, M36I, R41K, L63V, H69K, V77I, L89M, I93L	C
	Pt6	FDB_Pt6		NFV		M46I, N88S	L10F	T12S, I15V, L19V, K20I, M36I, R41K, L63V, I64V, H69K, T74V, L89M, I93L	C
Pillay (2008)	DR55	DR55	AY589908	RTV	104	M46L, I54V, V82A	L23LI	T12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	DR42	02ZA.DR42	AY589897	IDV		V82VA		T12S, I15V, L19I, E35ED, M36I, R41K, I62IV, L63V, H69K, T74A, L89M, I93L, N98I	C
Riddler (2008)	RG19024	RG19024w20		LPV	16			L5LF, T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74TS, L89M, I93L	C
Rosen-Zvi (2008)	71	06p71-2		LPV	12			I15V, Q18E, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63V, H69K, T74A, L89M, I93L	C
		09p71-3		LPV	175	I54V, V82A		I15V, Q18E, K20R, E35D, M36I, R41K, K45I, D60E, I62V, L63V, H69K, L89M, I93L	C
Sylla (2008)	B7173	B7173_C1	EF525661	IDV		M46I, I84V	L10F, T74P	T12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93L	C
		B7173_C2	EF525662	IDV		M46I, I84V	L10F, T74P	T12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93L	C
Cardoso (2009)	3098	BRGO3098	FJ638445	PI	NA			L10M, I15V, L19T, M36I, N37K, R41N, L63V, H69K, I93L	C
Jones (2009)	176988	176988	FJ659847	PI	NA			I15V, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93L	C
Kassaye (2009)	TCDD-13	TC13_2003	FJ445709	SQV, NFV	178			I15V, L19LI, M36I, R41K, L63V, H69K, V82I, I93L	C
Rodrigues (2010)	40_08	BR08SC040	GQ401333	LPV				T12S, I15V, L19I, M36I, N37K, R41N, L63V, H69K, L89M, I93L	C
Jones (2012)	176988	176988	JN670420	PI	NA			I15V, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93L	C

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