Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L63T
Rx	>= 1 PI
IncludeMixtures	No

References	23
Patients	92
Isolates	108

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kantor (2002)	TCDD-08	TCDD-08_1	AY090845	SQV	95			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72IT, T74S, L89M, I93L	C
Soares (2003)	BR54	BR54	AY275730	NFV	56			T12A, I13V, G16E, L19I, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
Gomez-Carrillo (2004)	96105	96105	AY365516	PI	NA			T12A, I15S, G16R, E35D, M36I, N37K, R41N, L63T, H69K, I72T, T74S, L89M, I93L	C
Grossman (2004)	IL49	IL49	AY529530	NFV	64	N88NS, L90LM		Q7QK, L10LI, I15V, G16E, K20RT, E35D, M36I, L38LM, R41RK, R57K, L63T, H69K, T74TS, L89M, I93L	C
	IL160	IL160	AY529612	SQV, NFV	128	D30N	N88D	T12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93L	C
	IL287	IL287	AY529620	SQV, RTV, IDV, NFV	184	I84V, L90M		L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93L	C
	IL433	IL433a	AY529600	IDV	117	M46ML, V82A, L90LM	Q58E	L10C, I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93L	C
	IL708	IL708	AY529608	NFV	44	I84C		I15V, K20R, M36I, R41K, L63T, H69K, I72T, I93L	C
Non-B Workgroup (2005)	UK973	UK973	AY900789	NFV	54			T12S, I15V, L19T, K20KT, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	IL273	IL273		NFV, IDV, RTV	137			I15V, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	TK3020	TK3020a		RTV, NFV, SQV	120			T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93L	C
	TK3022	TK3022		SQV, NFV	103			T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LI	C
Rhee (2005)	CA7907	CA24813	AY797580	IDV, NFV	260	D30N	L10F, N88D	T12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93L	C
Weber (2005)	F36402	F36402	AY714443	IDV, SQV, Unknown	>65	M46I, I84V, L90M	L10F, T74P	I15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93L	C
Baxter (2006)	12-1716	1716-30421	DQ876854	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T	L10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93L	C
	12-3102	3102-30610	DQ877250	PI	NA	L90M	L23I, L33F, F53L, Q58E	L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L	C
Doualla-Bell (2006)	Pt5	FDB_Pt5		NFV		N88S	L10F	I15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93L	C
	Pt7	FDB_Pt7		NFV		D30N	L33F	L10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93L	C
Sen (2007)	T009	NPT9	EF186927	SQV, RTV				T12S, K14R, I15V, G16E, L19I, M36IV, R41K, Q61H, L63T, H69K, L89M, I93L	C
		NPT9-PL	EF186959	SQV, RTV				T12S, K14R, I15V, G16E, L19I, M36V, R41K, Q61H, L63T, H69K, L89M, I93L	C
von Wyl (2007)	19	702313	EF449901	PI	NA	I54IV, N88NS, L90M		L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93L	C
	37	4822080	EF449879	PI	NA			M36I, R41K, L63T, H69KN, T74S, L89M, I93L	C
Marconi (2008)	SW068	SW068	EU308079	LPV	23			I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
Pillay (2008)	DR54	DR54	AY589907	NFV, RTV				L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FL	C
	DR93	03ZA.DR93	AY589932	IDV, LPV		M46I, L90M		L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93L	C
Riddler (2008)	RG9485	RG9485w19		LPV	26			T12S, I15V, L19I, M36I, L63T, H69K, I93L	C
Kandathil (2009)	VL06_192	VL06_192	EU037774	PI	NA			T12S, I15V, L19I, E35D, M36I, N37E, L63T, H69K, T74S, L76X, L89M, I93L	C
	VL07_109	VL07_109	EU781834	PI	NA			T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93L	C
	VL07_108	VL07_108	EU781837	PI	NA			T12S, K14R, I15V, G16E, L19I, M36V, R41K, D60E, Q61E, L63T, H69K, I93L	C
Kassaye (2009)	TCDD-08	TC08_2003	FJ445719	SQV	210			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93L	C
		TC08_2004	FJ445726	SQV	239			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93L	C
Dau (2010)	07762A	07762A	GU581866	PI	NA			K14KR, I15V, K20KR, M36I, N37K, R41N, L63T, H69K, T74S, L89M, I93L	C
El-Khatib (2010)	Pat079	11ZA_SAVE1255	JF960529	LPV				T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63T, H69K, T74S, V82VI, L89M, I93L	C
Rodrigues (2010)	301_07	BR07SC301	GQ401314	SQV, RTV, LPV		M46L, G48V, I54V, V82S	L24I, L33F, T74P	L10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93L	C
	331_07	BR07SC331	GQ401326	NFV				I15V, L19Q, M36I, N37K, R41N, D60E, L63T, H69K, L89M, I93L	C
Barber (2012)	69576	69576	JQ361677	LPV		I54V, V82A	L10F	T12S, I15V, L19I, M36I, R41K, L63T, H69K, L89M, I93L	C
Van Zyl (2013)	763	762	KC424271	LPV	183	M46I, I54V, V82A		T12TS, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93L	C
		1445	KC423150	LPV	235	M46I, I54V, V82A		T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93L	C
	80	642	KC424197	LPV	52			T12S, L19I, M36I, R41K, L63T, H69K, I93L	C
	1131	1491	KC423181	LPV	52	L90M		G17D, L19I, M36I, L63T, H69K, L89M, I93L	C
	1169	1618	KC423273	LPV	26			T12S, K14R, I15V, G16E, L19V, M36I, N37K, R41K, K43R, R57K, L63T, H69K, V82I, L89M, I93L	C
	1637	1520	KC423201	LPV	26			T12S, L19T, K20R, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	1422	1329	KC423063	LPV	26			T12S, I15V, L19T, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, H69K, I93L	C
	1385	2410	KC423695	LPV	26			T12S, K14R, I15V, L19I, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	1757	2422	KC423703	LPV	26			T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, K45R, D60E, Q61E, I62V, L63T, H69K, L89M, I93L	C
	950	426	KC424054	LPV	26			I15V, G16E, L19I, E35D, M36I, R41K, K45R, L63T, H69K, V82VI, L89M, I93L	C
		544	KC424130	LPV	27			I15V, G16E, L19I, E35DN, M36I, P39PT, R41K, K45R, L63T, H69K, L89M, I93L	C
	971	1093	KC422873	LPV	104			T12S, I15V, L19I, M36I, R41K, K45R, L63T, H69K, L89M, I93L	C
	1177	240	KC423694	LPV	26			L10I, I15V, L19I, M36I, P39PQ, R41K, L63T, H69Q, L89M, I93L	C
	681	320	KC423983	LPV	26			T12S, I15V, L19I, K20R, M36I, R41K, L63T, H69K, L89M, I93L	C
	905	569	KC424143	LPV	26			L10I, K14S, I15V, L19I, M36I, R41K, L63T, I64M, H69K, I72V, L89M, I93L	C
	450	2121	KC423634	LPV	104		V11I	L10I, I13V, G16E, Q18K, L19T, K20R, M36I, R41K, K43I, R57RK, L63T, H69K, L89M, I93L	C
	824	57	KC424144	LPV	26			L10I, T12S, I15V, L19T, K20R, M36I, R41RK, D60DE, Q61E, I62IV, L63T, E65D, H69K, L89M, I93L	C
	521	2165	KC423660	LPV	26			T12S, I15V, G17D, L19T, K20R, M36I, R41K, L63T, H69K, I93L	C
	828	946	KC424387	LPV	52			T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93L	C
		2883	KC423873	LPV	52			T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93L	C
		3005	KC423928	LPV	53			T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, L89M, I93L	C
	1002	865	KC424321	LPV	104	M46I, I54V, V82A	L10F	T12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93L	C
		2427	KC423704	LPV	208	M46I, I54V, L76V, V82A	L10F	T12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93L	C
	868	1762	KC423385	LPV	209			K14N, I15V, G16E, L19T, K20R, M36I, L63T, H69K, L89I, I93L	C
	1639	1905	KC423504	LPV	26			L10I, T12S, I15V, L19I, M36I, R41K, L63T, H69Q, I72T, I93L	C
	1533	2947	KC423906	LPV	26			L10V, T12TS, K14KR, I15V, G16E, L19I, M36I, K45R, L63T, H69K, L89M, I93L	C
	1562	834	KC424305	LPV	26			T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	1273	649	KC424200	LPV	26			T12S, I15V, L19I, M36L, N37S, R41K, L63T, C67F, H69K, L89M, I93L	C
	758	374	KC424019	LPV	26			T12S, I15V, L19V, E35D, M36L, R41K, L63T, H69K, A71T, I93L	C
	762	354	KC424004	LPV	26			K14R, I15V, G17D, L19I, K20R, M36I, P39S, R41K, L63T, E65D, H69K, I72T, L89M, I93L	C
	940	739	KC424257	LPV	104			I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93L	C
		1295	KC423037	LPV	157			I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93L	C
		1978	KC423539	LPV	209			I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93L	C
	978	3050	KC423945	LPV	209			I13IV, L19T, K20R, M36I, R41K, L63T, H69K, I93L	C
	1565	384	KC424028	LPV	26			K14N, I15V, L19R, M36I, N37D, R41K, D60DE, Q61QE, L63T, H69K, L89M, I93L	C
	1505	2145	KC423649	LPV	26			I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93L	C
	1651	1874	KC423474	LPV	26			I15V, L19LV, K20R, M36I, N37Q, R41N, D60N, I62V, L63T, H69K, L89M, I93L	C
	1026	122	KC422971	LPV	26			I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	1732	1998	KC423550	LPV	26			T12S, I15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, Q61E, I62V, L63T, G68E, H69K, L89M, I93L	C
	1582	2753	KC423813	LPV	26	M46I, I54V, L76V, V82A	L10F	I13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93L	C
	844	208	KC423603	LPV	26			K14KR, I15IV, L19IT, M36I, N37D, L63T, H69K, T74S, L89M, I93L	C
	1042	736	KC424255	LPV	26			T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93L	C
		1643	KC423292	LPV	130			T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93L	C
	653	1777	KC423398	LPV	209			T12S, L19T, K20R, M36I, R41K, L63T, H69K, L89M, I93L	C
	1300	1765	KC423388	LPV	26			L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93L	C
	1147	640	KC424196	LPV	26			I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93L	C
		1300	KC423039	LPV	130			I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93L	C
	136	1404	KC423126	LPV	26			T12S, L19I, K20R, M36I, R41K, L63T, H69K, K70KR, L89M, I93L	C
	15	2711	KC423795	LPV	26			L10I, K14T, I15V, L19V, M36I, R41K, L63T, E65D, H69K, L89M, I93L	C
	415	3026	KC423933	LPV	209	I54IV, V82VA	G48GE	T12S, I15IV, L19V, K20R, E35D, M36I, N37D, Q61E, I62IV, L63T, E65D, H69K, A71AV, I72V, T74S, L89M, I93L	C
Grossman (2014)	1628	1628	KF134991	LPV	52		V11I	R8T, P9T, L10I, I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	49	49	KF135089	NFV, LPV	52	I54V, V82A, L90M	L10F, L33F, T74P	I13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93L	C
	101	101	KF134929	IDV, LPV	52			W6MR, T12S, K14Y, I15V, L19T, K20R, M36I, R41K, L63T, H69K, I93L	C
		101	KF134930	IDV, LPV	156	M46L, V82A	L10F, L33F, K43T, F53FL, T74P	T12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93L	C
	762	762	KF135137	LPV	52			T12S, I15V, L19V, M36I, R41K, L63T, H69K, L89M, I93L	C
	1120	1120	KF134953	LPV	52			I15V, M36I, R41K, L63T, H69K, L89LM, I93L	C
	976	976	KF135172	LPV	52			K14R, I15V, L19I, M36I, N37D, R41K, L63T, H69K, L89M, I93L	C
	311	311	KF135047	LPV	52		T74TP	T12S, I15V, L19IT, K20KI, E35ED, M36I, Q61E, L63T, H69K, L89IM, I93L	C
		311	KF135048	LPV	148	M46L, I47A		T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93L	C
	805	805	KF135148	SQV, LPV	52	M46I, I54IV, L76V, V82VA	L10LF	T12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93L	C
	188	188	KF135010	IDV, LPV	52			K14T, I15V, K20R, M36I, R41RK, L63T, H69K, L89M, I93L	C
	13	13	KF134975	IDV, LPV	52			T12A, M36I, R41K, L63T, H69K, L89M, I93L	C
	160	160	KF134989	SQV, LPV	52	D30N	N88D	T12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93L	C
	260	260	KF135035	IDV, LPV	384	I54V, V82A, L90M	L10F	I15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93L	C
	504	504		IDV, LPV	52			T12TA, I13V, K14KR, I15V, M36I, R41K, L63T, I64M, H69K, L89M, I93L	C
	610	610		NFV, IDV, LPV	52	M46I, I54V, V82A, L90M	L10F, T74PS	T12S, I13V, I15V, L19Q, K20I, E35D, M36I, N37ND, R41K, Q61H, I62V, L63T, I64V, I66L, H69K, L89M, I93L	C
		610		NFV, IDV, LPV	69	M46I, I54V, L76V, V82A, L90M	L10F	T12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95F	C
Steegen (2014)	12ZAKS333	12ZAKS333	KJ176612	LPV				R41K, L63T, H69K, L89M, I93L	C
	11ZAKS111	11ZAKS111	KJ176393	LPV				R41K, L63T, I64IL, H69K, V82I, L89M, I93L	C
	12ZAKS271	12ZAKS271	KJ176550	LPV		V82A		R41K, K45R, L63T, H69K, T74S, L89M, I93L	C
	11ZAKS171	11ZAKS171	KJ176452	LPV		M46I, I50V, I54V, V82A		R41K, K55R, R57K, Q61H, L63T, H69K, A71V, I72K, T74S, L89M, I93L	C
	12ZAKS282	12ZAKS282	KJ176561	LPV		I47A, V82C		R41K, L63T, H69K, I93L	C

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