<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63T
Rx >= 1 PI
IncludeMixtures No
References 22
Patients 85
Isolates 100
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kantor (2002)TCDD-08TCDD-08_1AY090845SQV95  I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72IT, T74S, L89M, I93LC
Soares (2003)BR54BR54AY275730NFV56  T12A, I13V, G16E, L19I, M36I, N37K, R41N, L63T, H69K, L89M, I93LC
Gomez-Carrillo (2004)9610596105AY365516PINA  T12A, I15S, G16R, E35D, M36I, N37K, R41N, L63T, H69K, I72T, T74S, L89M, I93LC
Grossman (2004)IL49IL49AY529530NFV64N88NS, L90LM Q7QK, L10LI, I15V, G16E, K20RT, E35D, M36I, L38LM, R41RK, R57K, L63T, H69K, T74TS, L89M, I93LC
 IL160IL160AY529612SQV, NFV128D30NN88DT12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93LC
 IL287IL287AY529620SQV, RTV, IDV, NFV184I84V, L90M L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93LC
 IL433IL433aAY529600IDV117M46ML, V82A, L90LMQ58EL10C, I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93LC
 IL708IL708AY529608NFV44I84C I15V, K20R, M36I, R41K, L63T, H69K, I72T, I93LC
Non-B Workgroup (2005)UK973UK973AY900789NFV54  T12S, I15V, L19T, K20KT, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 IL273IL273 NFV, IDV, RTV137  I15V, M36I, R41K, L63T, H69K, V82I, L89M, I93LC
 TK3020TK3020a RTV, NFV, SQV120  T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93LC
 TK3022TK3022 SQV, NFV103  T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LIC
Rhee (2005)CA7907CA24813AY797580IDV, NFV260D30NL10F, N88DT12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93LC
Weber (2005)F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
Baxter (2006)12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt5FDB_Pt5 NFV N88SL10FI15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93LC
 Pt7FDB_Pt7 NFV D30NL33FL10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93LC
Sen (2007)T009NPT9EF186927SQV, RTV   T12S, K14R, I15V, G16E, L19I, M36IV, R41K, Q61H, L63T, H69K, L89M, I93LC
  NPT9-PLEF186959SQV, RTV   T12S, K14R, I15V, G16E, L19I, M36V, R41K, Q61H, L63T, H69K, L89M, I93LC
von Wyl (2007)19702313EF449901PINAI54IV, N88NS, L90M L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93LC
 374822080EF449879PINA  M36I, R41K, L63T, H69KN, T74S, L89M, I93LC
Marconi (2008)SW068SW068EU308079LPV23  I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
Pillay (2008)DR54DR54AY589907NFV, RTV   L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FLC
 DR9303ZA.DR93AY589932IDV, LPV M46I, L90M L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93LC
Riddler (2008)RG9485RG9485w19 LPV26  T12S, I15V, L19I, M36I, L63T, H69K, I93LC
Kandathil (2009)VL06_192VL06_192EU037774PINA  T12S, I15V, L19I, E35D, M36I, N37E, L63T, H69K, T74S, L76X, L89M, I93LC
 VL07_109VL07_109EU781834PINA  T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93LC
 VL07_108VL07_108EU781837PINA  T12S, K14R, I15V, G16E, L19I, M36V, R41K, D60E, Q61E, L63T, H69K, I93LC
Kassaye (2009)TCDD-08TC08_2003FJ445719SQV210  I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93LC
  TC08_2004FJ445726SQV239  I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93LC
Dau (2010)07762A07762AGU581866PINA  K14KR, I15V, K20KR, M36I, N37K, R41N, L63T, H69K, T74S, L89M, I93LC
El-Khatib (2010)Pat07911ZA_SAVE1255JF960529LPV   T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63T, H69K, T74S, V82VI, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
 331_07BR07SC331GQ401326NFV   I15V, L19Q, M36I, N37K, R41N, D60E, L63T, H69K, L89M, I93LC
Barber (2012)6957669576JQ361677LPV I54V, V82AL10FT12S, I15V, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
Van Zyl (2013)763762KC424271LPV183M46I, I54V, V82A T12TS, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
  1445KC423150LPV235M46I, I54V, V82A T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
 80642KC424197LPV52  T12S, L19I, M36I, R41K, L63T, H69K, I93LC
 11311491KC423181LPV52L90M G17D, L19I, M36I, L63T, H69K, L89M, I93LC
 11691618KC423273LPV26  T12S, K14R, I15V, G16E, L19V, M36I, N37K, R41K, K43R, R57K, L63T, H69K, V82I, L89M, I93LC
 16371520KC423201LPV26  T12S, L19T, K20R, M36I, R41K, L63T, H69K, V82I, L89M, I93LC
 14221329KC423063LPV26  T12S, I15V, L19T, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, H69K, I93LC
 13852410KC423695LPV26  T12S, K14R, I15V, L19I, M36I, R41K, L63T, H69K, V82I, L89M, I93LC
 17572422KC423703LPV26  T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, K45R, D60E, Q61E, I62V, L63T, H69K, L89M, I93LC
 950426KC424054LPV26  I15V, G16E, L19I, E35D, M36I, R41K, K45R, L63T, H69K, V82VI, L89M, I93LC
  544KC424130LPV27  I15V, G16E, L19I, E35DN, M36I, P39PT, R41K, K45R, L63T, H69K, L89M, I93LC
 9711093KC422873LPV104  T12S, I15V, L19I, M36I, R41K, K45R, L63T, H69K, L89M, I93LC
 1177240KC423694LPV26  L10I, I15V, L19I, M36I, P39PQ, R41K, L63T, H69Q, L89M, I93LC
 681320KC423983LPV26  T12S, I15V, L19I, K20R, M36I, R41K, L63T, H69K, L89M, I93LC
 905569KC424143LPV26  L10I, K14S, I15V, L19I, M36I, R41K, L63T, I64M, H69K, I72V, L89M, I93LC
 4502121KC423634LPV104 V11IL10I, I13V, G16E, Q18K, L19T, K20R, M36I, R41K, K43I, R57RK, L63T, H69K, L89M, I93LC
 82457KC424144LPV26  L10I, T12S, I15V, L19T, K20R, M36I, R41RK, D60DE, Q61E, I62IV, L63T, E65D, H69K, L89M, I93LC
 5212165KC423660LPV26  T12S, I15V, G17D, L19T, K20R, M36I, R41K, L63T, H69K, I93LC
 828946KC424387LPV52  T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93LC
  2883KC423873LPV52  T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93LC
  3005KC423928LPV53  T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
 1002865KC424321LPV104M46I, I54V, V82AL10FT12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93LC
  2427KC423704LPV208M46I, I54V, L76V, V82AL10FT12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93LC
 8681762KC423385LPV209  K14N, I15V, G16E, L19T, K20R, M36I, L63T, H69K, L89I, I93LC
 16391905KC423504LPV26  L10I, T12S, I15V, L19I, M36I, R41K, L63T, H69Q, I72T, I93LC
 15332947KC423906LPV26  L10V, T12TS, K14KR, I15V, G16E, L19I, M36I, K45R, L63T, H69K, L89M, I93LC
 1562834KC424305LPV26  T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 1273649KC424200LPV26  T12S, I15V, L19I, M36L, N37S, R41K, L63T, C67F, H69K, L89M, I93LC
 758374KC424019LPV26  T12S, I15V, L19V, E35D, M36L, R41K, L63T, H69K, A71T, I93LC
 762354KC424004LPV26  K14R, I15V, G17D, L19I, K20R, M36I, P39S, R41K, L63T, E65D, H69K, I72T, L89M, I93LC
 940739KC424257LPV104  I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
  1295KC423037LPV157  I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
  1978KC423539LPV209  I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
 9783050KC423945LPV209  I13IV, L19T, K20R, M36I, R41K, L63T, H69K, I93LC
 1565384KC424028LPV26  K14N, I15V, L19R, M36I, N37D, R41K, D60DE, Q61QE, L63T, H69K, L89M, I93LC
 15052145KC423649LPV26  I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93LC
 16511874KC423474LPV26  I15V, L19LV, K20R, M36I, N37Q, R41N, D60N, I62V, L63T, H69K, L89M, I93LC
 1026122KC422971LPV26  I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 17321998KC423550LPV26  T12S, I15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, Q61E, I62V, L63T, G68E, H69K, L89M, I93LC
 15822753KC423813LPV26M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
 844208KC423603LPV26  K14KR, I15IV, L19IT, M36I, N37D, L63T, H69K, T74S, L89M, I93LC
 1042736KC424255LPV26  T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93LC
  1643KC423292LPV130  T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93LC
 6531777KC423398LPV209  T12S, L19T, K20R, M36I, R41K, L63T, H69K, L89M, I93LC
 13001765KC423388LPV26  L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LC
 1147640KC424196LPV26  I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93LC
  1300KC423039LPV130  I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93LC
 1361404KC423126LPV26  T12S, L19I, K20R, M36I, R41K, L63T, H69K, K70KR, L89M, I93LC
 152711KC423795LPV26  L10I, K14T, I15V, L19V, M36I, R41K, L63T, E65D, H69K, L89M, I93LC
 4153026KC423933LPV209I54IV, V82VAG48GET12S, I15IV, L19V, K20R, E35D, M36I, N37D, Q61E, I62IV, L63T, E65D, H69K, A71AV, I72V, T74S, L89M, I93LC
Grossman (2014)16281628KF134991LPV52 V11IR8T, P9T, L10I, I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 4949KF135089NFV, LPV52I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93LC
 101101KF134929IDV, LPV52  W6MR, T12S, K14Y, I15V, L19T, K20R, M36I, R41K, L63T, H69K, I93LC
  101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
 762762KF135137LPV52  T12S, I15V, L19V, M36I, R41K, L63T, H69K, L89M, I93LC
 11201120KF134953LPV52  I15V, M36I, R41K, L63T, H69K, L89LM, I93LC
 976976KF135172LPV52  K14R, I15V, L19I, M36I, N37D, R41K, L63T, H69K, L89M, I93LC
 311311KF135047LPV52 T74TPT12S, I15V, L19IT, K20KI, E35ED, M36I, Q61E, L63T, H69K, L89IM, I93LC
  311KF135048LPV148M46L, I47A T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93LC
 805805KF135148SQV, LPV52M46I, I54IV, L76V, V82VAL10LFT12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93LC
 188188KF135010IDV, LPV52  K14T, I15V, K20R, M36I, R41RK, L63T, H69K, L89M, I93LC
 1313KF134975IDV, LPV52  T12A, M36I, R41K, L63T, H69K, L89M, I93LC
 160160KF134989SQV, LPV52D30NN88DT12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93LC
 260260KF135035IDV, LPV384I54V, V82A, L90ML10FI15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93LC