<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63T
Rx >= 1 PI
IncludeMixtures No
References 21
Patients 74
Isolates 86
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kantor (2002)TCDD-08TCDD-08_1AY090845SQV95  I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72IT, T74S, L89M, I93LC
Soares (2003)BR54BR54AY275730NFV56  T12A, I13V, G16E, L19I, M36I, N37K, R41N, L63T, H69K, L89M, I93LC
Gomez-Carrillo (2004)9610596105AY365516PINA  T12A, I15S, G16R, E35D, M36I, N37K, R41N, L63T, H69K, I72T, T74S, L89M, I93LC
Grossman (2004)IL49IL49AY529530NFV64N88NS, L90LM Q7QK, L10LI, I15V, G16E, K20RT, E35D, M36I, L38LM, R41RK, R57K, L63T, H69K, T74TS, L89M, I93LC
 IL160IL160AY529612SQV, NFV128D30NN88DT12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93LC
 IL287IL287AY529620SQV, RTV, IDV, NFV184I84V, L90M L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93LC
 IL433IL433aAY529600IDV117M46ML, V82A, L90LMQ58EL10C, I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93LC
 IL708IL708AY529608NFV44I84C I15V, K20R, M36I, R41K, L63T, H69K, I72T, I93LC
Non-B Workgroup (2005)UK973UK973AY900789NFV54  T12S, I15V, L19T, K20KT, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 IL273IL273 NFV, IDV, RTV137  I15V, M36I, R41K, L63T, H69K, V82I, L89M, I93LC
 TK3020TK3020a RTV, NFV, SQV120  T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93LC
 TK3022TK3022 SQV, NFV103  T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LIC
Rhee (2005)CA7907CA24813AY797580IDV, NFV260D30NL10F, N88DT12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93LC
Weber (2005)F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
Baxter (2006)12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt5FDB_Pt5 NFV N88SL10FI15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93LC
 Pt7FDB_Pt7 NFV D30NL33FL10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93LC
Sen (2007)T009NPT9EF186927SQV, RTV   T12S, K14R, I15V, G16E, L19I, M36IV, R41K, Q61H, L63T, H69K, L89M, I93LC
  NPT9-PLEF186959SQV, RTV   T12S, K14R, I15V, G16E, L19I, M36V, R41K, Q61H, L63T, H69K, L89M, I93LC
von Wyl (2007)19702313EF449901PINAI54IV, N88NS, L90M L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93LC
 374822080EF449879PINA  M36I, R41K, L63T, H69KN, T74S, L89M, I93LC
Marconi (2008)SW068SW068EU308079LPV23  I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
Pillay (2008)DR54DR54AY589907NFV, RTV   L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FLC
 DR9303ZA.DR93AY589932IDV, LPV M46I, L90M L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93LC
Riddler (2008)RG9485RG9485w19 LPV26  T12S, I15V, L19I, M36I, L63T, H69K, I93LC
Kandathil (2009)VL06_192VL06_192EU037774PINA  T12S, I15V, L19I, E35D, M36I, N37E, L63T, H69K, T74S, L76X, L89M, I93LC
 VL07_109VL07_109EU781834PINA  T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93LC
 VL07_108VL07_108EU781837PINA  T12S, K14R, I15V, G16E, L19I, M36V, R41K, D60E, Q61E, L63T, H69K, I93LC
Kassaye (2009)TCDD-08TC08_2003FJ445719SQV210  I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93LC
  TC08_2004FJ445726SQV239  I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93LC
Dau (2010)07762A07762AGU581866PINA  K14KR, I15V, K20KR, M36I, N37K, R41N, L63T, H69K, T74S, L89M, I93LC
El-Khatib (2010)Pat07911ZA_SAVE1255JF960529LPV   T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63T, H69K, T74S, V82VI, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
 331_07BR07SC331GQ401326NFV   I15V, L19Q, M36I, N37K, R41N, D60E, L63T, H69K, L89M, I93LC
Barber (2012)6957669576JQ361677LPV I54V, V82AL10FT12S, I15V, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
Van Zyl (2013)763762KC424271LPV M46I, I54V, V82A T12TS, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
  1445KC423150LPV M46I, I54V, V82A T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
 80642KC424197LPV   T12S, L19I, M36I, R41K, L63T, H69K, I93LC
 11311491KC423181LPV L90M G17D, L19I, M36I, L63T, H69K, L89M, I93LC
 11691618KC423273LPV   T12S, K14R, I15V, G16E, L19V, M36I, N37K, R41K, K43R, R57K, L63T, H69K, V82I, L89M, I93LC
 16371520KC423201LPV   T12S, L19T, K20R, M36I, R41K, L63T, H69K, V82I, L89M, I93LC
 14221329KC423063LPV   T12S, I15V, L19T, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, H69K, I93LC
 13852410KC423695LPV   T12S, K14R, I15V, L19I, M36I, R41K, L63T, H69K, V82I, L89M, I93LC
 17572422KC423703LPV   T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, K45R, D60E, Q61E, I62V, L63T, H69K, L89M, I93LC
 950426KC424054LPV   I15V, G16E, L19I, E35D, M36I, R41K, K45R, L63T, H69K, V82VI, L89M, I93LC
  544KC424130LPV   I15V, G16E, L19I, E35DN, M36I, P39PT, R41K, K45R, L63T, H69K, L89M, I93LC
 9711093KC422873LPV   T12S, I15V, L19I, M36I, R41K, K45R, L63T, H69K, L89M, I93LC
 1177240KC423694LPV   L10I, I15V, L19I, M36I, P39PQ, R41K, L63T, H69Q, L89M, I93LC
 681320KC423983LPV   T12S, I15V, L19I, K20R, M36I, R41K, L63T, H69K, L89M, I93LC
 905569KC424143LPV   L10I, K14S, I15V, L19I, M36I, R41K, L63T, I64M, H69K, I72V, L89M, I93LC
 4502121KC423634LPV  V11IL10I, I13V, G16E, Q18K, L19T, K20R, M36I, R41K, K43I, R57RK, L63T, H69K, L89M, I93LC
 82457KC424144LPV   L10I, T12S, I15V, L19T, K20R, M36I, R41RK, D60DE, Q61E, I62IV, L63T, E65D, H69K, L89M, I93LC
 5212165KC423660LPV   T12S, I15V, G17D, L19T, K20R, M36I, R41K, L63T, H69K, I93LC
 828946KC424387LPV   T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93LC
  2883KC423873LPV   T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93LC
  3005KC423928LPV   T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
 1002865KC424321LPV M46I, I54V, V82AL10FT12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93LC
  2427KC423704LPV M46I, I54V, L76V, V82AL10FT12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93LC
 8681762KC423385LPV   K14N, I15V, G16E, L19T, K20R, M36I, L63T, H69K, L89I, I93LC
 16391905KC423504LPV   L10I, T12S, I15V, L19I, M36I, R41K, L63T, H69Q, I72T, I93LC
 15332947KC423906LPV   L10V, T12TS, K14KR, I15V, G16E, L19I, M36I, K45R, L63T, H69K, L89M, I93LC
 1562834KC424305LPV   T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 1273649KC424200LPV   T12S, I15V, L19I, M36L, N37S, R41K, L63T, C67F, H69K, L89M, I93LC
 758374KC424019LPV   T12S, I15V, L19V, E35D, M36L, R41K, L63T, H69K, A71T, I93LC
 762354KC424004LPV   K14R, I15V, G17D, L19I, K20R, M36I, P39S, R41K, L63T, E65D, H69K, I72T, L89M, I93LC
 940739KC424257LPV   I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
  1295KC423037LPV   I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
  1978KC423539LPV   I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93LC
 9783050KC423945LPV   I13IV, L19T, K20R, M36I, R41K, L63T, H69K, I93LC
 1565384KC424028LPV   K14N, I15V, L19R, M36I, N37D, R41K, D60DE, Q61QE, L63T, H69K, L89M, I93LC
 15052145KC423649LPV   I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93LC
 16511874KC423474LPV   I15V, L19LV, K20R, M36I, N37Q, R41N, D60N, I62V, L63T, H69K, L89M, I93LC
 1026122KC422971LPV   I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93LC
 17321998KC423550LPV   T12S, I15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, Q61E, I62V, L63T, G68E, H69K, L89M, I93LC
 15822753KC423813LPV M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
 844208KC423603LPV   K14KR, I15IV, L19IT, M36I, N37D, L63T, H69K, T74S, L89M, I93LC
 1042736KC424255LPV   T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93LC
  1643KC423292LPV   T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93LC
 6531777KC423398LPV   T12S, L19T, K20R, M36I, R41K, L63T, H69K, L89M, I93LC
 13001765KC423388LPV   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LC
 1147640KC424196LPV   I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93LC
  1300KC423039LPV   I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93LC
 1361404KC423126LPV   T12S, L19I, K20R, M36I, R41K, L63T, H69K, K70KR, L89M, I93LC
 152711KC423795LPV   L10I, K14T, I15V, L19V, M36I, R41K, L63T, E65D, H69K, L89M, I93LC
 4153026KC423933LPV I54IV, V82VAG48GET12S, I15IV, L19V, K20R, E35D, M36I, N37D, Q61E, I62IV, L63T, E65D, H69K, A71AV, I72V, T74S, L89M, I93LC

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