Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L63T
Rx	>= 1 PI
IncludeMixtures	No

References	33
Patients	184
Isolates	197

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kantor (2002)	TCDD-08	TCDD-08_1	AY090845	SQV	95			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72IT, T74S, L89M, I93L	C
Soares (2003)	BR54	BR54	AY275730	NFV	56			T12A, I13V, G16E, L19I, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
Gomez-Carrillo (2004)	96105	96105	AY365516	PI	NA			T12A, I15S, G16R, E35D, M36I, N37K, R41N, L63T, H69K, I72T, T74S, L89M, I93L	C
Grossman (2004)	IL49	IL49	AY529530	NFV	64	N88NS, L90LM		Q7QK, L10LI, I15V, G16E, K20RT, E35D, M36I, L38LM, R41RK, R57K, L63T, H69K, T74TS, L89M, I93L	C
	IL160	IL160	AY529612	SQV, NFV	128	D30N	N88D	T12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93L	C
	IL287	IL287	AY529620	SQV, RTV, IDV, NFV	184	I84V, L90M		L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93L	C
	IL433	IL433a	AY529600	IDV	117	M46ML, V82A, L90LM	Q58E	L10C, I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93L	C
	IL708	IL708	AY529608	NFV	44	I84C		I15V, K20R, M36I, R41K, L63T, H69K, I72T, I93L	C
Non-B Workgroup (2005)	UK973	UK973	AY900789	NFV	54			T12S, I15V, L19T, K20KT, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	IL273	IL273		NFV, IDV, RTV	137			I15V, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	TK3020	TK3020a		RTV, NFV, SQV	120			T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93L	C
	TK3022	TK3022		SQV, NFV	103			T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LI	C
Rhee (2005)	CA7907	CA24813	AY797580	IDV, NFV	260	D30N	L10F, N88D	T12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93L	C
Weber (2005)	F36402	F36402	AY714443	IDV, SQV, Unknown	>65	M46I, I84V, L90M	L10F, T74P	I15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93L	C
Baxter (2006)	12-1716	1716-30421	DQ876854	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T	L10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93L	C
	12-3102	3102-30610	DQ877250	PI	NA	L90M	L23I, L33F, F53L, Q58E	L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L	C
Doualla-Bell (2006)	Pt5	FDB_Pt5		NFV		N88S	L10F	I15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93L	C
	Pt7	FDB_Pt7		NFV		D30N	L33F	L10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93L	C
Sen (2007)	T009	NPT9	EF186927	SQV, RTV				T12S, K14R, I15V, G16E, L19I, M36IV, R41K, Q61H, L63T, H69K, L89M, I93L	C
		NPT9-PL	EF186959	SQV, RTV				T12S, K14R, I15V, G16E, L19I, M36V, R41K, Q61H, L63T, H69K, L89M, I93L	C
von Wyl (2007)	19	702313	EF449901	PI	NA	I54IV, N88NS, L90M		L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93L	C
	37	4822080	EF449879	PI	NA			M36I, R41K, L63T, H69KN, T74S, L89M, I93L	C
Marconi (2008)	SW068	SW068	EU308079	LPV	23			I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
Pillay (2008)	DR54	DR54	AY589907	NFV, RTV				L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FL	C
	DR93	03ZA.DR93	AY589932	IDV, LPV		M46I, L90M		L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93L	C
Riddler (2008)	RG9485	RG9485w19		LPV	26			T12S, I15V, L19I, M36I, L63T, H69K, I93L	C
Waleria-Aleixo (2008)	08PR060719	08PR060719	FJ591541	PI	NA	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, N37K, R41N, L63T, H69K, A71V, T74S, I93L	C
	RES37	RES37	FJ591836	PI	NA			T12P, I15V, L19I, K20R, M36I, N37K, R41N, L63T, H69K, K70R, L89M, I93L	C
	08PR060652	08PR060652	FJ591507	PI	NA			T12A, K14R, I15V, G16E, M36I, N37K, R41N, L63T, H69K, I93L	C
	08PR050444	08PR050444	FJ591441	PI	NA	D30N, I50L	N88D	K14R, I15V, G16E, E35D, M36I, N37K, R41Y, K45R, K55N, L63T, H69K, A71V, L89I, I93L	C
Kandathil (2009)	VL06_192	VL06_192	EU037774	PI	NA			T12S, I15V, L19I, E35D, M36I, N37E, L63T, H69K, T74S, L76X, L89M, I93L	C
	VL07_109	VL07_109	EU781834	PI	NA			T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93L	C
	VL07_108	VL07_108	EU781837	PI	NA			T12S, K14R, I15V, G16E, L19I, M36V, R41K, D60E, Q61E, L63T, H69K, I93L	C
Kassaye (2009)	TCDD-08	TC08_2003	FJ445719	SQV	210			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93L	C
		TC08_2004	FJ445726	SQV	239			I15V, L19I, M36I, R41K, D60E, L63T, H69K, I72T, T74S, L89M, I93L	C
Dau (2010)	07762A	07762A	GU581866	PI	NA			K14KR, I15V, K20KR, M36I, N37K, R41N, L63T, H69K, T74S, L89M, I93L	C
El-Khatib (2010)	Pat079	11ZA_SAVE1255	JF960529	LPV				T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63T, H69K, T74S, V82VI, L89M, I93L	C
Rodrigues (2010)	301_07	BR07SC301	GQ401314	SQV, RTV, LPV		M46L, G48V, I54V, V82S	L24I, L33F, T74P	L10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93L	C
	331_07	BR07SC331	GQ401326	NFV				I15V, L19Q, M36I, N37K, R41N, D60E, L63T, H69K, L89M, I93L	C
Barber (2012)	69576	69576	JQ361677	LPV		I54V, V82A	L10F	T12S, I15V, L19I, M36I, R41K, L63T, H69K, L89M, I93L	C
Van Zyl (2013)	337	11.ZA.WC155	KC423504	LPV				L10I, T12S, I15V, L19I, M36I, R41K, L63T, H69Q, I72T, I93L	C
	3038	07.ZA.GT081	KC424144	LPV				L10I, T12S, I15V, L19T, K20R, M36I, R41RK, D60DE, Q61E, I62IV, L63T, E65D, H69K, L89M, I93L	C
	7043	11.ZA.EC098	KC423703	LPV				T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, K45R, D60E, Q61E, I62V, L63T, H69K, L89M, I93L	C
	3499	08.ZA.GT498	KC423694	LPV				L10I, I15V, L19I, M36I, P39PQ, R41K, L63T, H69Q, L89M, I93L	C
	4052	11.ZA.GT1874	KC423649	LPV				I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93L	C
	3604	09.ZA.GT633	KC424200	LPV				T12S, I15V, L19I, M36L, N37S, R41K, L63T, C67F, H69K, L89M, I93L	C
	3641	11.ZA.GT1597	KC423388	LPV				L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93L	C
	2885	08.ZA.GT573	KC423983	LPV				T12S, I15V, L19I, K20R, M36I, R41K, L63T, H69K, L89M, I93L	C
	3132	08.ZA.GT366	KC424143	LPV				L10I, K14S, I15V, L19I, M36I, R41K, L63T, I64M, H69K, I72V, L89M, I93L	C
	2971	08.ZA.GT605	KC424004	LPV				K14R, I15V, G17D, L19I, K20R, M36I, P39S, R41K, L63T, E65D, H69K, I72T, L89M, I93L	C
	3300	07.ZA.GT105	KC422971	LPV				I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	427	12.ZA.MP001	KC423906	LPV				L10V, T12TS, K14KR, I15V, G16E, L19I, M36I, K45R, L63T, H69K, L89M, I93L	C
	3781	11.ZA.GT1905	KC423695	LPV				T12S, K14R, I15V, L19I, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	3855	10.ZA.GT1227	KC423063	LPV				T12S, I15V, L19T, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, H69K, I93L	C
	540	07.ZA.WC004	KC424028	LPV				K14N, I15V, L19R, M36I, N37D, R41K, D60DE, Q61QE, L63T, H69K, L89M, I93L	C
	294	11.ZA.WC148	KC423474	LPV				I15V, L19LV, K20R, M36I, N37Q, R41N, D60N, I62V, L63T, H69K, L89M, I93L	C
	3272	11.ZA.GT1915	KC423704	LPV		M46I, I54V, L76V, V82A	L10F	T12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93L	C
	817	10.ZA.GT1294	KC423126	LPV				T12S, L19I, K20R, M36I, R41K, L63T, H69K, K70KR, L89M, I93L	C
	625	12.ZA.WC208	KC423813	LPV		M46I, I54V, L76V, V82A	L10F	I13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93L	C
	3486	11.ZA.GT1485	KC423273	LPV				T12S, K14R, I15V, G16E, L19V, M36I, N37K, R41K, K43R, R57K, L63T, H69K, V82I, L89M, I93L	C
	2965	07.ZA.GT186	KC424019	LPV				T12S, I15V, L19V, E35D, M36L, R41K, L63T, H69K, A71T, I93L	C
	3052	08.ZA.GT468	KC423603	LPV				K14KR, I15IV, L19IT, M36I, N37D, L63T, H69K, T74S, L89M, I93L	C
	966	11.ZA.WC171	KC423550	LPV				T12S, I15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, Q61E, I62V, L63T, G68E, H69K, L89M, I93L	C
	2085	11.ZA.GT1887	KC423660	LPV				T12S, I15V, G17D, L19T, K20R, M36I, R41K, L63T, H69K, I93L	C
	142	12.ZA.NL013	KC423795	LPV				L10I, K14T, I15V, L19V, M36I, R41K, L63T, E65D, H69K, L89M, I93L	C
	754	10.ZA.WC099	KC423201	LPV			V11VI	T12S, L19T, K20R, M36I, R41K, L63T, H69K, V82I, L89M, I93L	C
	3438	10.ZA.GT1370	KC423181	LPV		L90M		G17D, L19I, M36I, L63T, H69K, L89M, I93L	C
	2558	08.ZA.GT626	KC424197	LPV				T12S, L19I, M36I, R41K, L63T, H69K, I93L	C
	3271	09.ZA.GT819	KC424321	LPV		M46I, I54V, V82A	L10F	T12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93L	C
	1056	10.ZA.GT1333	KC423150	LPV		M46I, I54V, V82A		T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93L	C
	3326	09.ZA.GT717	KC424255	LPV				T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93L	C
		11.ZA.GT1508	KC423292	LPV				T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69K, L89M, I93L	C
	2731	11.ZA.GT1852	KC423634	LPV			V11I	L10I, I13V, G16E, Q18K, L19T, K20R, M36I, R41K, K43I, R57RK, L63T, H69K, L89M, I93L	C
	7019	11.ZA.GT1594	KC423385	LPV				K14N, I15V, G16E, L19T, K20R, M36I, L63T, H69K, L89I, I93L	C
	1928	12.ZA.GT2293	KC423933	LPV		I54IV, V82VA	G48GE	T12S, I15IV, L19V, K20R, E35D, M36I, N37D, Q61E, I62IV, L63T, E65D, H69K, A71AV, I72V, T74S, L89M, I93L	C
	2658	11.ZA.GT1630	KC423425	LPV				T12P, I15V, L19I, K20R, E35D, M36I, N37D, R57RK, L63T, G68E, H69K, L89M, I93L	C
	2861	11.ZA.GT1606	KC423398	LPV				T12S, L19T, K20R, M36I, R41K, L63T, H69K, L89M, I93L	C
	3041	09.ZA.GT893	KC424387	LPV				T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93L	C
		12.ZA.GT2198	KC423873	LPV				T12S, I15V, G16E, L19I, M36I, N37NS, R41K, L63T, H69K, I72IT, L89M, I93L	C
		12.ZA.GT2277	KC423928	LPV				T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, L89M, I93L	C
	3460	08.ZA.GT623	KC424196	LPV				I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93L	C
		10.ZA.GT1207	KC423039	LPV				I15V, L19T, K20R, M36I, R41K, L63T, H69K, V75I, L89M, I93L	C
	835	09.ZA.GT716	KC424257	LPV				I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93L	C
		10.ZA.GT1198	KC423037	LPV				I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93L	C
		11.ZA.GT1750	KC423539	LPV				I15V, L19V, R41K, L63T, H69K, T74S, V77I, L89M, I93L	C
	3237	12.ZA.GT2309	KC423945	LPV				I13IV, L19T, K20R, M36I, R41K, L63T, H69K, I93L	C
	2046	07.ZA.GT228	KC424054	LPV				I15V, G16E, L19I, E35D, M36I, R41K, K45R, L63T, H69K, V82VI, L89M, I93L	C
		07.ZA.GT333	KC424130	LPV				I15V, G16E, L19I, E35DN, M36I, P39PT, R41K, K45R, L63T, H69K, L89M, I93L	C
	3223	09.ZA.GT1019	KC422873	LPV				T12S, I15V, L19I, M36I, R41K, K45R, L63T, H69K, L89M, I93L	C
Grossman (2014)	1628	1628	KF134991	LPV	52		V11I	R8T, P9T, L10I, I15V, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
	49	49	KF135089	NFV, LPV	52	I54V, V82A, L90M	L10F, L33F, T74P	I13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93L	C
	101	101	KF134929	IDV, LPV	52			W6MR, T12S, K14Y, I15V, L19T, K20R, M36I, R41K, L63T, H69K, I93L	C
		101	KF134930	IDV, LPV	156	M46L, V82A	L10F, L33F, K43T, F53FL, T74P	T12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93L	C
	762	762	KF135137	LPV	52			T12S, I15V, L19V, M36I, R41K, L63T, H69K, L89M, I93L	C
	1120	1120	KF134953	LPV	52			I15V, M36I, R41K, L63T, H69K, L89LM, I93L	C
	976	976	KF135172	LPV	52			K14R, I15V, L19I, M36I, N37D, R41K, L63T, H69K, L89M, I93L	C
	311	311	KF135047	LPV	52		T74TP	T12S, I15V, L19IT, K20KI, E35ED, M36I, Q61E, L63T, H69K, L89IM, I93L	C
		311	KF135048	LPV	148	M46L, I47A		T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93L	C
	805	805	KF135148	SQV, LPV	52	M46I, I54IV, L76V, V82VA	L10LF	T12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93L	C
	188	188	KF135010	IDV, LPV	52			K14T, I15V, K20R, M36I, R41RK, L63T, H69K, L89M, I93L	C
	13	13	KF134975	IDV, LPV	52			T12A, M36I, R41K, L63T, H69K, L89M, I93L	C
	160	160	KF134989	SQV, LPV	52	D30N	N88D	T12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93L	C
	260	260	KF135035	IDV, LPV	384	I54V, V82A, L90M	L10F	I15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93L	C
	504	504		IDV, LPV	52			T12TA, I13V, K14KR, I15V, M36I, R41K, L63T, I64M, H69K, L89M, I93L	C
	610	610		NFV, IDV, LPV	52	M46I, I54V, V82A, L90M	L10F, T74PS	T12S, I13V, I15V, L19Q, K20I, E35D, M36I, N37ND, R41K, Q61H, I62V, L63T, I64V, I66L, H69K, L89M, I93L	C
		610		NFV, IDV, LPV	69	M46I, I54V, L76V, V82A, L90M	L10F	T12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95F	C
Steegen (2014)	12ZAKS333	12ZAKS333	KJ176612	LPV				R41K, L63T, H69K, L89M, I93L	C
	11ZAKS111	11ZAKS111	KJ176393	LPV				R41K, L63T, I64IL, H69K, V82I, L89M, I93L	C
	12ZAKS271	12ZAKS271	KJ176550	LPV		V82A		R41K, K45R, L63T, H69K, T74S, L89M, I93L	C
	11ZAKS171	11ZAKS171	KJ176452	LPV		M46I, I50V, I54V, V82A		R41K, K55R, R57K, Q61H, L63T, H69K, A71V, I72K, T74S, L89M, I93L	C
	12ZAKS282	12ZAKS282	KJ176561	LPV		I47A, V82C		R41K, L63T, H69K, I93L	C
Diaz (2015)	RenG16936	RenG16936	KT747964	PI	NA			L10I, G16E, N37K, R41IT, R57K, D60E, L63T, H69K, L89M, I93L	C
	RenG17384	RenG17384	KT748412	PI	NA			I15V, L19LI, K20R, M36I, N37K, R41N, R57RK, L63T, H69K, L89M, I93L	C
	RenG17353	RenG17353	KT748381	PI	NA	M46I, I54V, L76V, V82A	L10F, L33F	I13V, K14KR, K20R, E35D, M36I, R41N, I62V, L63T, H69K, A71V, I72V, T74TA, L89M, I93L	C
	RenG15849	RenG15849	KT746877	PI	NA			I15V, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
	RenG17470	RenG17470	KT748498	PI	NA			L10V, T12I, I15V, G16E, E35D, M36I, N37K, R41N, L63T, H69K, I72V, L89M, I93L	C
	RenG16317	RenG16317	KT747345	PI	NA	M46I, I54V, V82A	L10F, Q58E, T74P, N88G	I15V, G16E, K20T, E21K, E35G, M36I, N37K, P39S, R41N, L63T, H69K, V77I, L89M	C
	RenG16825	RenG16825	KT747853	PI	NA			L10I, M36I, N37K, R41N, L63T, H69K, L89M, I93L, N98I	C
	RenG16641	RenG16641	KT747669	PI	NA	M46I, I84V		L10V, I15V, G16E, E35G, M36I, N37K, P39S, R41N, I62V, L63T, I64V, H69K, T74A, I85V, L89M, I93L	C
	RenG16982	RenG16982	KT748010	PI	NA	M46L, I54IV, V82A	L10LFPS, L23I, L33F, F53FL	P9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93L	C
	RenG14027	RenG14027	KT745055	PI	NA	I54V, V82A	K43KT	I15V, G16E, K20R, E35D, M36IV, N37KT, P39PS, R41KN, D60E, Q61N, L63T, H69K, T74TA, V77VI, L89M, I93L	C
	RenG14203	RenG14203	KT745231	PI	NA			I15V, L19IV, M36I, N37K, R41N, L63T, H69K, V82I, I93L	C
	RenG13952	RenG13952	KT744980	PI	NA			I15V, M36I, N37K, R41N, K45R, L63T, H69K, L89M, I93L	C
	RenG14874	RenG14874	KT745902	PI	NA	M46I, N88S		I15V, K20T, E35D, M36I, N37K, R41N, L63T, I64IV, H69K, T74S, L89M, I93L	C
	RenG15067	RenG15067	KT746095	PI	NA			T12A, I13V, K14R, I15V, G16E, M36I, N37K, R41N, K45R, D60E, Q61N, L63T, H69K, L89I, I93L	C
	RenG14451	RenG14451	KT745479	PI	NA			L10I, L19I, N37K, R41N, L63T, H69K, L89M, I93L	C
	RenG14721	RenG14721	KT745749	PI	NA			W6G, L10I, M36I, N37E, R41N, D60N, L63T, H69K, L89M, I93L	C
	RenG14536	RenG14536	KT745564	PI	NA	D30N, I54ILM, I84IV	L10F, L33F, N88D	I15V, G16E, K20T, E35D, M36I, N37EK, P39S, R41N, K45I, L63T, H69K, T74AS, I85V, L89M, I93IL	C
	RenG14962	RenG14962	KT745990	PI	NA	M46I, I54V, V82A	L10F, L24I, L33F	I15V, G16E, L19Q, K20R, E35D, M36I, N37K, R41N, Q61H, L63T, H69K, L89I, Q92K, I93L	C
	RenG13551	RenG13551	KT744579	PI	NA	M46MI, I50V, I54V, V82M, N88S	L33F, Q58E, T74P	L10V, G16E, K20R, E35D, M36I, N37K, R41N, R57RK, L63T, H69K, L89F, I93L	C
	RenG15224	RenG15224	KT746252	PI	NA			M36I, N37K, R41N, L63T, H69K, I72T, T74S, L89M, I93L	C
	RenG14258	RenG14258	KT745286	PI	NA			L10V, I15V, G16A, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93L	C
	RenG15313	RenG15313	KT746341	PI	NA	M46L, G48A, I54V, V82A, L90M	L33F, N83D	L10V, K14KR, I15IV, G16E, K20R, E35D, M36I, N37K, R41N, R57K, Q61N, L63T, H69K, T74S, I85V, L89I, Q92K, I93L	C
	RenG14857	RenG14857	KT745885	PI	NA			I15V, G16E, M36T, N37K, R41N, L63T, H69K, L89I, I93L	C
	RenG14092	RenG14092	KT745120	PI	NA			T12P, K14KR, I15V, G16E, N37R, R41N, D60E, Q61D, L63T, H69K, I72K, L89M, I93L	C
	RenG14739	RenG14739	KT745767	PI	NA			M36I, R41H, D60E, L63T, H69K, L89M, I93L	C
	RenG15422	RenG15422	KT746450	PI	NA			L10M, I15IV, L19LI, N37K, R41N, L63T, H69K, I93L	C
	RenG15333	RenG15333	KT746361	PI	NA			L10V, G16E, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
	RenG12208	RenG12208	KT743236	PI	NA			I13V, M36I, N37K, R41N, D60E, Q61DN, L63T, H69K, L89M, I93L	C
	RenG13483	RenG13483	KT744511	PI	NA			T12N, I15V, N37K, R41N, D60E, L63T, H69K, L89M	C
	RenG13267	RenG13267	KT744295	PI	NA			T12A, K14R, I15V, G16E, M36I, N37K, R41N, Q61KN, L63T, H69K, L89I, I93L	C
	RenG13457	RenG13457	KT744485	PI	NA			L10V, I13IV, K14KNRS, L19I, K20KR, M36I, N37K, R41N, L63T, H69K, L89M	C
	RenG13229	RenG13229	KT744257	PI	NA			T12TA, I15S, G16R, M36I, N37K, R41N, Q61QH, L63T, H69K, I72IT, L89M, I93L	C
	RenG13433	RenG13433	KT744461	PI	NA	I50L, V82M	L24I, K43KT	T12P, I15S, G16R, K20RT, E34KN, E35D, M36I, N37K, R41N, K45KR, L63T, G68E, H69K, A71V, I72IT, T74A, Q92K, I93L	C
	RenG11819	RenG11819	KT742847	PI	NA			I15V, M36I, N37K, R41N, D60E, L63T, H69K, L89M, I93L	C
	RenG11807	RenG11807	KT742835	PI	NA			I15V, L19I, M36I, N37K, R41N, L63T, H69K, I93L	C
	RenG12853	RenG12853	KT743881	PI	NA			I15V, M36L, N37K, R41N, L63T, H69K, T74S, L89M, I93L	C
	RenG13284	RenG13284	KT744312	PI	NA			L10I, I13V, I15V, G16E, M36T, N37K, R41N, L63T, H69K, L89M, I93L	C
	RenG13127	RenG13127	KT744155	PI	NA			I15V, M36I, N37K, R41N, L63T, H69K, I93L	C
	RenG13007	RenG13007	KT744035	PI	NA			T12P, I15V, E35D, M36I, N37K, R41N, Q61E, L63T, H69K, V82I, L89M, I93L	C
	RenG11955	RenG11955	KT742983	PI	NA		V11VI	T12A, I13IV, K14R, I15V, G16E, M36I, N37K, R41N, Q61K, L63T, H69K, L89I, I93L	C
	RenG12462	RenG12462	KT743490	PI	NA	I54V, V82A		L10IV, K14R, I15V, K20R, E35D, M36I, N37K, R41N, I62V, L63T, H69K, A71V, T74S, L89M, I93L	C
	RenG11650	RenG11650	KT742678	PI	NA			I15V, K20R, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
	RenG10989	RenG10989	KT742017	PI	NA	M46I, I54V, V82A		I15V, K20R, E35ED, M36I, N37K, R41N, K55R, L63T, H69K, I72T, T74A, L89M, I93L	C
	RenG11616	RenG11616	KT742644	PI	NA			K14R, I15V, G16E, M36I, N37K, R41N, L63T, H69K, I72T, I93L	C
	RenG11086	RenG11086	KT742114	PI	NA	M46I, I47A, I84V	F53L	L10V, G16E, E35D, M36V, N37E, P39S, R41N, I62V, L63T, H69R, A71V, T74S, L89M, I93L	C
	RenG10417	RenG10417	KT741445	PI	NA			I15V, L19I, N37K, R41N, L63T, H69K, T74A, V77I, L89M, I93L	C
	RenG10565	RenG10565	KT741593	PI	NA			P39T, K43R, L63T, H69K, L89I, I93L	C
	RenG11494	RenG11494	KT742522	PI	NA	I50L, V82L, L90M	L33F, K43T	T12S, I13V, I15V, K20R, E35D, M36IV, N37K, R41N, Q61HN, L63T, I64V, H69K, A71V, T74S, L89M, I93L	C
	RenG11773	RenG11773	KT742801	PI	NA			I15V, K20R, M36I, N37K, R41N, K45KR, I62V, L63T, H69K, L89M, I93L	C
	RenG10624	RenG10624	KT741652	PI	NA	L90M	Q58E	I13V, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, Q61N, L63T, I64IV, H69K, A71T, T74A, V82I, L89I, I93L	C
	RenG11100	RenG11100	KT742128	PI	NA	I50L, V82M	T74P	I15V, G16E, L19Q, K20R, E35D, M36I, N37K, P39PS, R41N, K45R, L63T, H69K, A71V, I72IV, I93L	C
	RenG10144	RenG10144	KT741172	PI	NA			L10V, I13V, K14KR, G16E, K20R, M36I, N37K, R41N, D60DN, Q61QE, L63T, H69K, L89M, I93L	C
	RenG11254	RenG11254	KT742282	PI	NA			K14R, I15V, M36I, N37K, R41N, K45R, L63T, H69K, K70R, V82I, L89M, I93L	C
	RenG10137	RenG10137	KT741165	PI	NA			I15V, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
	RenG10527	RenG10527	KT741555	PI	NA			L10V, I13V, I15V, K20R, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93L	C
	RenG10978	RenG10978	KT742006	PI	NA	I54V, V82A	L33F, T74P	L10I, I13V, G16E, K20R, M36I, N37K, R41N, L63T, H69Q, L89M, I93L	C
	RenG11088	RenG11088	KT742116	PI	NA	I54V, V82C, L90M	L10F, L33F, T74P	T12S, I13V, I15V, G16E, L19AV, K20M, D25DN, E35DN, M36I, N37K, R41N, Q61H, L63T, I66IM, H69K, L89M, I93L	C
	RenG10631	RenG10631	KT741659	PI	NA	M46L, I54V, V82A, I84V	V11I, L24I, K43T	L10I, T12E, I13V, L19I, K20I, M36I, Q61N, L63T, I64V, H69K, A71V, I72IV, T74S, I93L	C
Giandhari (2015)	5079	2006_ZA_5079F	KP056179	RTV	39			L10M, T12S, I15V, L19I, N37K, R41I, L63T, H69K, K70R	C
Novitsky (2015)	bcpp_203	bcpp_203	KR860688	PI	NA			L10I, G16E, L19V, M36I, N37D, L63T, H69K, L89M, I93L	C
	bcpp_068	bcpp_068	KR860631	PI	NA			I15V, G17D, M36I, N37K, R41K, K45R, L63T, H69K, L89M, I93L	C
	bcpp_046	bcpp_046	KR860620	PI	NA			T12S, I15V, L19I, M36I, R41K, L63T, H69K, I93L	C
	bcpp_245	bcpp_245	KR860706	PI	NA			I15V, M36I, R41K, I62V, L63T, H69K, T74A, L89M, I93L	C
	bcpp_087	bcpp_087	KR860637	PI	NA			T12P, I15V, L19I, E35D, M36I, N37D, R41K, I62V, L63T, E65D, H69K, A71T, I93L	C
	bcpp_261	bcpp_261	KR860709	PI	NA			T12S, I15V, L19I, M36L, N37S, R41K, L63T, H69K, L89M, I93L	C
	mpp_228	mpp_228	KR861008	PI	NA			T12S, I15V, L19I, K20M, E35E_TN, M36L, L63T, H69K, I93L	C
	bcpp_413	bcpp_413	KR860760	PI	NA			T12S, I15V, L19I, E35D, M36I, R41K, K45R, R57K, D60E, L63T, H69K, V82I, L89M, I93L	C
	bcpp_027	bcpp_027	KR860614	PI	NA			T12S, I15V, L19I, E35D, M36I, L63T, H69K, L89M, I93L	C
Rossouw (2015)	RP030	RP030	KT032003	LPV	75			T12S, I15IV, Q18E, L19I, M36T, R41K, L63T, H69K, I93L	C
	RP117	RP117	KT032042	LPV	182			T12S, I15V, L19T, M36I, R41K, L63T, E65D, H69K, L89M, I93L	C
Sutherland (2015)	14	14_POST	KT351810	LPV				T12P, I15V, G16E, L19I, M36I, L63T, H69K, I72V, I93L	C
	18	18_POST	KT351818	LPV				T12S, L19I, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C
Chimukangara (2016)	NC9	NC9	KU508596	LPV	41			T12S, I15V, L19V, M36I, R41K, L63T, E65D, H69K, I93L	C
	NC1	NC1	KU508567	RTV, ATV	186	M46L, I54V, V82A	V32VA, L33F	L10V, I13V, K14R, I15IV, G16E, L19V, K20R, E35D, M36I, N37D, R41K, K55R, L63T, H69K, T74S, L89I, I93L	C
Ndahimana Jd Riedel (2016)	2142	2142	KT982494	LPV				T12S, I15V, M36I, R41K, R57K, L63T, I64L, H69K, T74S, V82I, L89M, I93L	C
	2036	2036	KT982525	LPV				I15V, K20R, M36I, N37K, R41N, L63T, H69K, I72V, I93L	C
Neogi (2016)	4190	13.ZA.GT3123	KT593370	LPV				I15V, L19I, M36I, N37T, R41K, L63T, H69K, V82I, L89M, I93L	C
	1572	13.ZA.GT3024	KT593311	LPV				T12S, L19I, M36I, N37S, R41K, L63T, H69K, T74S, L89M, I93L	C
	7143	13.ZA.EC707	KT592854	LPV		M46I, I54V, L76V, V82A	L10F, L24I, L33F	I13V, G16E, L19I, K20R, E35N, M36I, N37D, L63T, H69K, I72V, T74S, L89M, I93L	C
	621	13.ZA.NC005	KT593441	LPV				T12S, I15V, Q18E, L19I, K20R, E35D, M36I, R41K, R57RK, L63T, H69K, L89M, I93L	C
	4155	13.ZA.GT2809	KT593153	LPV				T12S, I15V, G16E, L19T, R41K, L63T, H69K, V77I, I93L	C
	4430	13.ZA.EC769	KT592897	LPV				T12S, I15V, L19V, N37NS, R57K, L63T, C67S, H69K, V77I, V82VI, L89M	C
	994	13.ZA.WC338	KT593529	LPV				I15V, L19I, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V77I, L89M, I93L	C
	112	13.ZA.EC772	KT592900	LPV				K14R, I15V, G17D, L19I, M36IL, N37S, L63T, H69K, L89M, I93L	C
	1986	13.ZA.GT3210	KT593436	LPV		M46I, I54V, V82A	L10F, Q58E	T12S, I15V, G16GE, L19V, K20R, E35D, M36I, L63T, H69K, T74S, L89M, I93L	C
Steegen (2016)	GFMPB084	GFMPB084	KU128175	LPV				T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93L	C

Protease Inhibitors

Database

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