<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63S
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 46
Isolates 48
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG5959_w32 NFV32 L76LFI13V, M36I, R41K, L63S, I64IL, H69K, L89M, I93LC
Grossman (2004)IL574IL574AY529605NFV56D30N Q7H, R8A, I15V, L19I, K20T, M36I, N37S, R41K, L63S, H69K, I93LC
Non-B Workgroup (2005)UK449UK449 SQV, NFV, RTV L90ML23IT12S, L19I, E35D, M36I, R41K, D60E, L63S, H69K, V82I, L89M, I93L, L97XC
 TK3031TK3031 SQV, NFV203D30NN88DI15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93LC
 TK5010TK5010 RTV, IDV27  I13V, I15V, L19I, M36I, N37D, R57K, L63S, H69K, L89MC
 PL3670560970 IDV98V82A, L90LMT74PL10I, T12TS, I15V, L19I, K20KR, M36I, N37NS, R41K, K45R, Q61N, L63S, H69K, I72V, L89M, I93LC
Weber (2005)M36208M36208AY714457NFV, Unknown>69  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
von Wyl (2007)1017278778EF449991RTV, PINA  L10V, L19I, M36I, L63S, H69K, I72V, L89M, I93LC
Riddler (2008)RG49532RG49532w9 LPV2  T12S, I15V, L19I, M36I, R41K, D60E, L63S, H69K, L89I, I93LC
Van Zyl (2013)89684KC424309LPV26  F53FS, L63S, H69K, V82I, L89M, I93LC
 12371075KC422861LPV26  I15V, L19T, E35ED, M36I, L63S, H69K, V82I, L89M, I93LC
  1535KC423210LPV78  I15V, L19T, E35D, M36I, L63S, H69K, V82I, L89M, I93LC
 14932661KC423768LPV26  T12S, I15V, L19I, E35D, M36I, R41K, K45KR, D60E, Q61E, L63S, H69K, L89M, I93LC
 3991896KC423495LPV26  I15V, L19T, M36I, R41K, L63S, H69K, I93LC
 122252KC423735LPV26  T12S, K14R, I15V, G16E, L19I, K20KR, M36I, R41K, I62IV, L63S, H69K, L89M, I93LC
 12411465KC423160LPV26  T12S, I15V, L19T, K20R, E35D, M36I, L63S, H69K, L89M, I93LC
 1202824KC424297LPV52  I15V, M36I, N37S, R41K, L63S, H69K, L89M, I93LC
 302843KC423853LPV26  T12S, I15V, L19T, K20R, E35D, M36I, R41K, K45R, L63S, H69K, L89M, I93LC
 1208820KC424296LPV26  M36I, R41K, K45R, L63S, H69K, L89I, I93LC
 65885KC424339LPV26  M36I, R41K, Q61E, I62IV, L63S, H69K, L89M, I93LC
 284916KC424359LPV26  I15V, L19I, N37S, R41K, L63S, H69K, V77I, I93LC
 13041121KC422895LPV26M46I, I50V T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63S, H69K, I93LC
 14261635KC423286LPV26  T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63S, H69K, L89M, I93LC
 15951444KC423149LPV26  I15V, L19I, M36I, R41K, L63S, H69K, L89M, I93LC
  1889KC423489LPV78  I15V, L19I, M36I, R41K, L63S, H69K, L89M, I93LC
 16801795KC423414LPV26M46I, I50V, I54V, V82AL10F, L33FT12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93LC
 675575KC424149LPV26  T12S, L19I, M36I, N37S, R41K, L63S, H69K, V82I, L89M, I93LC
 1291813KC424291LPV26  T12S, I15V, L19T, K20R, M36I, L63S, H69K, L89M, I93LC
 13491140KC422908LPV26  L19T, K20R, M36I, R41K, L63S, H69K, I72L, L89M, I93LC
Grossman (2014)13261326KF134971LPV52V82A I15V, G16E, K20R, M36I, R41K, Q61H, L63S, H69K, K70R, L89M, I93LC
 20312031KF135015LPV52  I15V, M36I, R41K, L63S, H69K, I93LC
 15331533KF134985LPV52  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
Steegen (2014)10ZAKS02910ZAKS029KJ176311LPV   R41K, L63S, H69K, V77I, L89M, I93LC
 10ZAKS07210ZAKS072KJ176354LPV   R41K, L63S, H69K, I93LC
 12ZAKS31512ZAKS315KJ176594LPV   R41K, L63S, H69K, T74S, V77I, L89M, I93LC
 11ZAKS08711ZAKS087KJ176369LPV   R41K, I62IV, L63S, H69K, K70KR, V77I, L89M, I93LC
Diaz (2015)RenG17396RenG17396KT748424PINA  I15V, L19I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG14521RenG14521KT745549PINA  L10M, I15V, N37K, R41N, R57RK, L63S, C67E, H69K, V77I, L89M, I93LC
 RenG15314RenG15314KT746342PINA  I15V, L19I, M36I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG11822RenG11822KT742850PINA  K14R, I15V, L19I, M36I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG13499RenG13499KT744527PINA  K14R, I15V, M36I, N37K, R41T, L63S, H69K, V82I, L89M, I93LC
 RenG11976RenG11976KT743004PINAV82ILQ58QEI15V, L19IT, M36L, N37K, R41N, I62V, L63S, I64L, H69K, L89M, I93LC
 RenG10944RenG10944KT741972PINA  T12S, I15V, L19I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG10070RenG10070KT741098PINA  I15V, M36I, N37K, R41N, L63S, H69K, V82I, L89M, I93LC
Novitsky (2015)bcpp_121bcpp_121KR860651PINA  T12S, I15V, G16E, L19I, M36I, N37S, R41K, L63S, H69K, L89M, I93LC
 bcpp_042bcpp_042KR860619PINA  L19I, M36I, N37D, L63S, H69K, L89M, I93LC
 bcpp_136bcpp_136KR860655PINA  T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63S, H69K, I93LC
 bcpp_477bcpp_477KR860787PINA  L19I, M36I, N37D, W42*, L63S, H69K, G86R, L89M, I93LC