<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63S
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 51
Isolates 52
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG5959_w32 NFV32 L76LFI13V, M36I, R41K, L63S, I64IL, H69K, L89M, I93LC
Grossman (2004)IL574IL574AY529605NFV56D30N Q7H, R8A, I15V, L19I, K20T, M36I, N37S, R41K, L63S, H69K, I93LC
Chantratita (2005)14-013014-0130DQ130495PINA  W6R, L10I, T12S, K14R, I15V, Q18P, L19I, M36I, R41K, L63S, H69K, L89MC
Non-B Workgroup (2005)UK449UK449 SQV, NFV, RTV L90ML23IT12S, L19I, E35D, M36I, R41K, D60E, L63S, H69K, V82I, L89M, I93L, L97XC
 TK3031TK3031 SQV, NFV203D30NN88DI15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93LC
 TK5010TK5010 RTV, IDV27  I13V, I15V, L19I, M36I, N37D, R57K, L63S, H69K, L89MC
 PL3670560970 IDV98V82A, L90LMT74PL10I, T12TS, I15V, L19I, K20KR, M36I, N37NS, R41K, K45R, Q61N, L63S, H69K, I72V, L89M, I93LC
Weber (2005)M36208M36208AY714457NFV, Unknown>69  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
von Wyl (2007)1017278778EF449991RTV, PINA  L10V, L19I, M36I, L63S, H69K, I72V, L89M, I93LC
Riddler (2008)RG49532RG49532w9 LPV2  T12S, I15V, L19I, M36I, R41K, D60E, L63S, H69K, L89I, I93LC
Waleria-Aleixo (2008)08PR05039108PR050391FJ591416PINAD30NN88DL10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, I62V, L63S, H69K, T74A, L89M, I93LC
 RES144RES144FJ591899PINA  T12S, I15V, L19I, K20R, M36I, N37K, R41N, L63S, H69K, K70R, L89M, I93LC
Alcantara (2013)BRGO4055BRGO4055JN114150PINA  I15V, M36I, N37K, R41N, K45R, L63S, H69K, L89M, I93LC
Van Zyl (2013)O675575KC424149LPV26  T12S, L19I, M36I, N37S, R41K, L63S, H69K, V82I, L89M, I93LC
 362309.ZA.GT778KC424291LPV   T12S, I15V, L19T, K20R, M36I, L63S, H69K, L89M, I93LC
 364910.ZA.GT1047KC422895LPV M46I, I50V T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63S, H69K, I93LC
 86311.ZA.WC140KC423414LPV M46I, I50V, I54V, V82AL10F, L33FT12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93LC
 399212.ZA.GT2058KC423768LPV   T12S, I15V, L19I, E35D, M36I, R41K, K45KR, D60E, Q61E, L63S, H69K, L89M, I93LC
 157908.ZA.GT511KC423735LPV   T12S, K14R, I15V, G16E, L19I, K20KR, M36I, R41K, I62IV, L63S, H69K, L89M, I93LC
 247510.ZA.GT1345KC423160LPV   T12S, I15V, L19T, K20R, E35D, M36I, L63S, H69K, L89M, I93LC
 59709.ZA.WC046KC424339LPV   M36I, R41K, Q61E, I62IV, L63S, H69K, L89M, I93LC
 386211.ZA.GT1500KC423286LPV   T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63S, H69K, L89M, I93LC
 21312.ZA.EC187KC423853LPV   T12S, I15V, L19T, K20R, E35D, M36I, R41K, K45R, L63S, H69K, L89M, I93LC
 352909.ZA.GT793KC424296LPV   M36I, R41K, K45R, L63S, H69K, L89I, I93LC
 371810.ZA.GT1063KC422908LPV   L19T, K20R, M36I, R41K, L63S, H69K, I72L, L89M, I93LC
 190411.ZA.GT1698KC423495LPV   I15V, L19T, M36I, R41K, L63S, H69K, I93LC
 65211.ZA.WC150KC423489LPV   I15V, L19I, M36I, R41K, L63S, H69K, L89M, I93LC
 356309.ZA.GT1002KC422861LPV   I15V, L19T, E35ED, M36I, L63S, H69K, V82I, L89M, I93LC
  10.ZA.GT1424KC423210LPV   I15V, L19T, E35D, M36I, L63S, H69K, V82I, L89M, I93LC
Grossman (2014)13261326KF134971LPV52V82A I15V, G16E, K20R, M36I, R41K, Q61H, L63S, H69K, K70R, L89M, I93LC
 20312031KF135015LPV52  I15V, M36I, R41K, L63S, H69K, I93LC
 15331533KF134985LPV52  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
Steegen (2014)10ZAKS02910ZAKS029KJ176311LPV   R41K, L63S, H69K, V77I, L89M, I93LC
 10ZAKS07210ZAKS072KJ176354LPV   R41K, L63S, H69K, I93LC
 12ZAKS31512ZAKS315KJ176594LPV   R41K, L63S, H69K, T74S, V77I, L89M, I93LC
 11ZAKS08711ZAKS087KJ176369LPV   R41K, I62IV, L63S, H69K, K70KR, V77I, L89M, I93LC
Diaz (2015)RenG17396RenG17396KT748424PINA  I15V, L19I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG14521RenG14521KT745549PINA  L10M, I15V, N37K, R41N, R57RK, L63S, C67E, H69K, V77I, L89M, I93LC
 RenG15314RenG15314KT746342PINA  I15V, L19I, M36I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG11822RenG11822KT742850PINA  K14R, I15V, L19I, M36I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG13499RenG13499KT744527PINA  K14R, I15V, M36I, N37K, R41T, L63S, H69K, V82I, L89M, I93LC
 RenG11976RenG11976KT743004PINAV82ILQ58QEI15V, L19IT, M36L, N37K, R41N, I62V, L63S, I64L, H69K, L89M, I93LC
 RenG10944RenG10944KT741972PINA  T12S, I15V, L19I, N37K, R41N, L63S, H69K, L89M, I93LC
 RenG10070RenG10070KT741098PINA  I15V, M36I, N37K, R41N, L63S, H69K, V82I, L89M, I93LC
Novitsky (2015)bcpp_121bcpp_121KR860651PINA  T12S, I15V, G16E, L19I, M36I, N37S, R41K, L63S, H69K, L89M, I93LC
 bcpp_042bcpp_042KR860619PINA  L19I, M36I, N37D, L63S, H69K, L89M, I93LC
 bcpp_136bcpp_136KR860655PINA  T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63S, H69K, I93LC
Neogi (2016)190313.ZA.GT3019KT593307LPV   I15V, L19T, M36I, R41K, L63S, H69KQ, I93LC
 214113.ZA.GT2836KT593173LPV M46I, I54VL10FT12S, I15V, L19I, M36I, R41K, L63S, H69K, I93LC
 315513.ZA.GT3003KT593295LPV   T12S, I15V, G16E, L19I, M36I, L63S, H69K, I72L, T74S, L89I, I93LC
 312413.ZA.GT2751KT593113LPV   T12AS, I15V, G16E, L19I, M36L, N37S, R41K, K45R, D60E, L63S, H69K, L89I, I93LC
Steegen (2016)GFGPB160GFGPB160KU128371LPV118V82AL10FI15V, L19I, K20R, M36I, R41K, I62V, L63S, H69K, I93LC