Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L63Q
Rx	PI-naive
IncludeMixtures	No

References	34
Patients	66
Isolates	68

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Hoelscher (2001)	97TZ07	97TZ07	AF361877	None		I13V, M36I, R41K, L63Q, I64V	C
Gordon (2003)	ZA060p01	ZA060p01	AY196510	None		T12S, I15V, G16E, L19I, M36I, R41K, D60E, L63Q, H69K, V77I, L89M, I93L	C
Bessong (2006)	POB_02TS02ZA	02TS02ZA	DQ222261	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, L89M, I93L	C
Rousseau (2006)	Pt63	03PS119MB1	DQ351238	None		L10I, E35D, M36I, R41K, L63Q, H69K, L89M	C
	Pt181	04SK139B1	AY878072	None		T12S, L19V, M36I, R41K, K45R, L63Q, H69K, L89M, I93L	C
	Pt227	05SK244B1	DQ369992	None		T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93L	C
Kassu (2007)	ETH-G-216	G-216	AB285824	None		T12S, I15V, L19I, A22AV, L23LF, M36I, R41K, L63Q, H69K, I93L	C
Martinson (2007)	CHB231B	CHB231B	EU152425	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, L89M, I93L	C
	CHB231M	CHB231M	EU152426	None		T12S, I15V, M36IT, R41K, L63Q, H69K, L89M, I93L	C
Soundararajan (2007)	TRC5	TRC5	EF491927	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93L	C
	TRC51	TRC51	EF491950	None		T12S, I15V, L19I, E35D, M36I, N37D, R41K, L63Q, H69K, A71T, I93L	C
Deho (2008)	125	125	EU244687	None		I15V, L19I, M36I, R41K, L63Q, H69K, I93L	C
Jacobs (2008)	1680	1680	EF602186	None		T12S, I15V, L19I, R41K, K45R, L63Q, I66L, H69K, V77I, L89I, I93L	C
	1802	1802	EF602235	None		L10M, I15V, L19V, M36I, R41K, L63Q, H69K, L89M, I93L	C
Marconi (2008)	ICH20	ICH20	EU308011	None		W6V, T12S, I15V, L19I, E35D, M36I, R41K, R57K, L63Q, H69K, T74S, L89M, I93L	C
	SW058	sw058	EU308069	None		T12S, I15V, G16E, L19I, M36I, L63Q, H69K, L89M, I93L	C
Matthews (2008)	PS117	PS117	FJ199689	None		T12S, I15V, L19I, K20R, M36I, P39T, R41K, R57K, Q61N, L63Q, H69K, I93L	C
	SK139	SK139	FJ199916	None		T12S, L19V, M36I, R41K, K45R, L63Q, H69K, L89M, I93L	C
	SK244	SK244	FJ199989	None		T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93L	C
Nyombi (2008)	TMS133	TMS133	EU251831	None		T12S, I15V, L19V, K20R, E35D, M36I, R41K, D60E, L63Q, H69K, L89M, I93L	C
Hawkins (2009)	R115	ZZR115	FJ931311	None		T12S, I15V, L19V, K20R, M36I, R41K, L63Q, H69K, L89M, I93L	C
	R347	ZZR347	FJ931374	None		I13V, I15V, L19IV, K20R, M36I, R41K, L63Q, I64L, H69K, L89M, I93L	C
Hosseinipour (2009)	8455	8455	GQ228212	None		I15V, G16E, L19LI, E35D, M36I, N37E, K45R, R57RK, L63Q, H69K, I72EV, L89M, I93FL	C
	9372	9372	GQ228235	None		T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63Q, H69K, T74S, L89M, I93L	C
Kandathil (2009)	CD06_402	CD06_402	EU683765	None		I15V, G16A, L19I, E35G, M36V, N37D, L63Q, H69K, K70R, T74S, L89M, I93L	C
Rajesh (2009)	N58	TRCNPR58	FJ595421	None		T12P, I15V, G16E, L19I, N37S, P39S, R41K, I62V, L63Q, H69K, A71T, I93L	C
	F12	TRCFPR12	FJ595474	None		L19I, M36MLV, N37ST, P39S, R41K, I62V, L63Q, H69K, A71T, I93L	C
Vercauteren (2009)	pt100	uuruByGKbH	GQ400924	None	I47K	K14R, I15V, E35D, M36I, R41K, L63Q, H69K, T74S, L89M, I93L	C
Wallis (2009)	GT00135141	GT00135141		None		I15V, G16GE, L19V, M36I, R41K, L63Q, H69K, L89M, I93L	C
	2357662	2357662		None		K14R, I15V, M36I, R41K, L63Q, H69K, I93L	C
	TJC2420050	TJC2420050		None		T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, L63Q, H69K, L89M, I93L	C
	2283871	2283871		None		I3F, T12S, L19I, K20R, M36I, R41K, L63Q, H69K, L89M, I93L	C
Gonzalez (2010)	KLesa5	KLesa5	GQ433823	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, L89M, I93L	C
	SO6	SO6	GQ433890	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93L	C
	MA4	MA4	GQ433865	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, A71T, I93L	C
Hamers (2010)	300237	CP076300237	HM119800	None		T12S, I15V, L19I, E35D, M36I, R41K, K45KR, L63Q, H69K, T74S, L89M, I93L	C
	300477	CP076300477	HM119896	None		T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93L	C
	300547	CP076300547	HM119958	None		I15V, L19I, M36I, R41K, R57RK, L63Q, I64L, H69K, V82I, L89M, I93L	C
	302344	CP076302344	HM120086	None		T12PS, I15V, G16E, L19I, M36I, R41K, L63Q, H69K, L89I, I93L	C
	302383	CP076302383	HM120097	None		T12S, I15V, L19V, M36I, R41K, L63Q, H69K, L89M, I93L	C
	302408	CP076302408	HM120109	None		T12TS, I15V, G16E, L19I, M36L, N37AS, R41RK, L63Q, H69K, I72IV, L89M, I93L	C
Wright (2010)	244	SK244	HM593249	None		T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93L	C
	308	SK308	HM593312	None		L10I, T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63Q, H69K, L89M, I93L	C
	338	SK338	HM593343	None		T12S, I15V, L19I, M36I, R41K, Q61QH, L63Q, I64IM, H69K, L89LM, I93L	C
Bussmann (2011)	B0538	B0538	JQ616985	None		I15V, L19I, M36I, R41K, K43R, L63Q, H69K, L89M, I93L	C
	B0584	B0584	JQ617077	None		I15V, L19I, M36I, R41K, L63Q, H69K, I93L	C
Green (2011)	707PKE10F	707PKE10F	HM623501	None		T12S, I15V, L19I, M36I, R41K, K45R, D60DE, Q61QDEH, I62IV, L63Q, I64L, H69K, L89M, I93L	C
Hamers (2011)	CP076300339	CP076300339	HQ994374	None		T12S, I15V, L19I, K20R, M36I, R41K, L63Q, H69K, L89I, I93L	C
	CP076300398	CP076300398	HQ994401	None		T12S, I15V, L19T, K20R, M36I, R41K, D60E, Q61E, L63Q, E65ED, H69K, V77I, L89M, I93L	C
	CP076300929	CP076300929	HQ994545	None		T12S, I15V, L19T, M36I, N37D, R41K, L63Q, I64IL, H69K, L89LM, I93L	C
	CP076301071	CP076301071	HQ994593	None		T12S, I15V, L19I, K20R, M36I, N37S, R41K, L63Q, H69K, L89M, I93L	C
	CP076301041	CP076301041	HQ994773	None		T12S, I15V, L19I, M36I, N37T, R41K, L63Q, H69K, L89M, I93L	C
	CP076302656	CP076302656	HQ994800	None		T12S, K14R, I15V, L19I, M36I, R41K, L63Q, I64L, H69K, L89M, I93L	C
Manasa (2011)	1009100	1009100	JN665030	None		T12A, L19T, K20R, M36I, R41K, L63Q, H69K, L89M, I93L	C
Ndembi (2011)	NTCPS710	NTCPS710	HQ702660	None		T12S, I13V, I15V, K20R, M36I, R41K, I62V, L63Q, H69K, I72M, T74S, L89M	C
Nwobegahay (2011)	08MB69ZA	08MB69ZA	GU188847	None		I3V, L10M, I13V, I15K, G17S, L19I, K20R, M36I, P39Q, L63Q, H69K, L89M, I93L	C
Sigaloff (2011)	GT00135141	GT00135141_1	JN381569	None		I15V, G16GE, L19V, M36I, R41K, L63Q, H69K, L89M, I93L	C
		GT00135141_2	JN381570	None		I15V, G16GE, L19V, M36I, R41K, L63Q, H69K, L89M, I93L	C
Thorat (2011)	Pat013	IN-NARI-HIVDR-5-013	HQ166851	None		T12P, L19I, K20R, M36I, R41K, L63Q, H69K, K70R, I72V, T74TA, L89M, I93L	C
van Zyl (2011)	A275	A275	JN638166	None		I15V, L19I, M36I, R41K, Q61E, L63Q, H69K, I72V, L89M, I93L	C
	A279	A279	JN638170	None		T12S, I15V, L19T, M36I, N37S, R41K, K43R, L63Q, H69K, L89LM, I93L	C
	A59	A59	JN638216	None		I15V, L19T, N37S, R41K, L63Q, H69K, I93L	C
Wright (2011)	RB_052	RB_052	HQ696850	None		T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63Q, H69K, V82I, L89M, I93L	C
Musyoki (2012)	DGM.35	DGM.35	JN176297	None		T12S, I15V, L19V, M36I, N37D, R41K, K43R, L63Q, I64L, H69K, I93L	C
Nwobegahay (2012)	MC02ZA	MC02ZA	GU177502	None		T12S, I15V, L19I, K20R, M36I, P39Q, R41K, Q61N, L63Q, H69K, L89M, I93L	C
	MC11ZA	MC11ZA	GU177507	None		T12S, I15V, L19I, N37T, R41K, R57K, D60E, Q61E, L63Q, E65D, H69K, V77I, L89M, I93L	C
	MC35ZA	MC35ZA	GU177519	None		T12S, I15V, G16E, L19V, K20R, M36I, P39K, R41K, Q61H, L63Q, H69K, K70Q, L89I, I93L	C
Frentz (2013)	EHR-54810	EHR-54810	JX300450	None		T12S, I15V, L19I, M36I, R41K, I62IV, L63Q, H69K, T74A, L89M, I93L	C

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