<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63Q
Rx PI-naive
IncludeMixtures No
References 39
Patients 102
Isolates 104
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Hoelscher (2001)97TZ0797TZ07AF361877None   I13V, M36I, R41K, L63Q, I64VC
Gordon (2003)ZA060p01ZA060p01AY196510None   T12S, I15V, G16E, L19I, M36I, R41K, D60E, L63Q, H69K, V77I, L89M, I93LC
Bessong (2006)POB_02TS02ZA02TS02ZADQ222261None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, L89M, I93LC
Rousseau (2006)Pt6303PS119MB1DQ351238None   L10I, E35D, M36I, R41K, L63Q, H69K, L89MC
 Pt18104SK139B1AY878072None   T12S, L19V, M36I, R41K, K45R, L63Q, H69K, L89M, I93LC
 Pt22705SK244B1DQ369992None   T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
Kassu (2007)ETH-G-216G-216AB285824None   T12S, I15V, L19I, A22AV, L23LF, M36I, R41K, L63Q, H69K, I93LC
Martinson (2007)CHB231BCHB231BEU152425None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, L89M, I93LC
 CHB231MCHB231MEU152426None   T12S, I15V, M36IT, R41K, L63Q, H69K, L89M, I93LC
Soundararajan (2007)TRC5TRC5EF491927None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93LC
 TRC51TRC51EF491950None   T12S, I15V, L19I, E35D, M36I, N37D, R41K, L63Q, H69K, A71T, I93LC
Deho (2008)125125EU244687None   I15V, L19I, M36I, R41K, L63Q, H69K, I93LC
Jacobs (2008)16801680EF602186None   T12S, I15V, L19I, R41K, K45R, L63Q, I66L, H69K, V77I, L89I, I93LC
 18021802EF602235None   L10M, I15V, L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
Marconi (2008)ICH20ICH20EU308011None   W6V, T12S, I15V, L19I, E35D, M36I, R41K, R57K, L63Q, H69K, T74S, L89M, I93LC
 SW058sw058EU308069None   T12S, I15V, G16E, L19I, M36I, L63Q, H69K, L89M, I93LC
Matthews (2008)PS117PS117FJ199689None   T12S, I15V, L19I, K20R, M36I, P39T, R41K, R57K, Q61N, L63Q, H69K, I93LC
 SK139SK139FJ199916None   T12S, L19V, M36I, R41K, K45R, L63Q, H69K, L89M, I93LC
 SK244SK244FJ199989None   T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
Nyombi (2008)TMS133TMS133EU251831None   T12S, I15V, L19V, K20R, E35D, M36I, R41K, D60E, L63Q, H69K, L89M, I93LC
Hawkins (2009)R115ZZR115FJ931311None   T12S, I15V, L19V, K20R, M36I, R41K, L63Q, H69K, L89M, I93LC
 R347ZZR347FJ931374None   I13V, I15V, L19IV, K20R, M36I, R41K, L63Q, I64L, H69K, L89M, I93LC
Hosseinipour (2009)84558455GQ228212None   I15V, G16E, L19LI, E35D, M36I, N37E, K45R, R57RK, L63Q, H69K, I72EV, L89M, I93FLC
 93729372GQ228235None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
Kandathil (2009)CD06_402CD06_402EU683765None   I15V, G16A, L19I, E35G, M36V, N37D, L63Q, H69K, K70R, T74S, L89M, I93LC
Rajesh (2009)N58TRCNPR58FJ595421None   T12P, I15V, G16E, L19I, N37S, P39S, R41K, I62V, L63Q, H69K, A71T, I93LC
 F12TRCFPR12FJ595474None   L19I, M36MLV, N37ST, P39S, R41K, I62V, L63Q, H69K, A71T, I93LC
Vercauteren (2009)pt100uuruByGKbHGQ400924None  I47KK14R, I15V, E35D, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
Wallis (2009)GT00135141GT00135141 None   I15V, G16GE, L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
 23576622357662 None   K14R, I15V, M36I, R41K, L63Q, H69K, I93LC
 TJC2420050TJC2420050 None   T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, L63Q, H69K, L89M, I93LC
 22838712283871 None   I3F, T12S, L19I, K20R, M36I, R41K, L63Q, H69K, L89M, I93LC
Gonzalez (2010)KLesa5KLesa5GQ433823None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, L89M, I93LC
 SO6SO6GQ433890None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93LC
 MA4MA4GQ433865None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, A71T, I93LC
Wright (2010)244SK244HM593249None   T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
 308SK308HM593312None   L10I, T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63Q, H69K, L89M, I93LC
 338SK338HM593343None   T12S, I15V, L19I, M36I, R41K, Q61QH, L63Q, I64IM, H69K, L89LM, I93LC
Bussmann (2011)B0538B0538JQ616985None   I15V, L19I, M36I, R41K, K43R, L63Q, H69K, L89M, I93LC
 B0584B0584JQ617077None   I15V, L19I, M36I, R41K, L63Q, H69K, I93LC
Green (2011)707PKE10F707PKE10FHM623501None   T12S, I15V, L19I, M36I, R41K, K45R, D60DE, Q61QDEH, I62IV, L63Q, I64L, H69K, L89M, I93LC
Hamers (2011)300237CP076300237HM119800None   T12S, I15V, L19I, E35D, M36I, R41K, K45KR, L63Q, H69K, T74S, L89M, I93LC
 300477CP076300477HM119896None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93LC
 300547CP076300547HM119958None   I15V, L19I, M36I, R41K, R57RK, L63Q, I64L, H69K, V82I, L89M, I93LC
 302344CP076302344HM120086None   T12PS, I15V, G16E, L19I, M36I, R41K, L63Q, H69K, L89I, I93LC
 302383CP076302383HM120097None   T12S, I15V, L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
 302408CP076302408HM120109None   T12TS, I15V, G16E, L19I, M36L, N37AS, R41RK, L63Q, H69K, I72IV, L89M, I93LC
 CP076300339CP076300339HQ994374None   T12S, I15V, L19I, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 CP076300398CP076300398HQ994401None   T12S, I15V, L19T, K20R, M36I, R41K, D60E, Q61E, L63Q, E65ED, H69K, V77I, L89M, I93LC
 CP076300929CP076300929HQ994545None   T12S, I15V, L19T, M36I, N37D, R41K, L63Q, I64IL, H69K, L89LM, I93LC
 CP076301071CP076301071HQ994593None   T12S, I15V, L19I, K20R, M36I, N37S, R41K, L63Q, H69K, L89M, I93LC
 CP076301041CP076301041HQ994773None   T12S, I15V, L19I, M36I, N37T, R41K, L63Q, H69K, L89M, I93LC
 CP076302656CP076302656HQ994800None   T12S, K14R, I15V, L19I, M36I, R41K, L63Q, I64L, H69K, L89M, I93LC
Manasa (2011)10091001009100JN665030None   T12A, L19T, K20R, M36I, R41K, L63Q, H69K, L89M, I93LC
Ndembi (2011)NTCPS710NTCPS710HQ702660None   T12S, I13V, I15V, K20R, M36I, R41K, I62V, L63Q, H69K, I72M, T74S, L89MC
Nwobegahay (2011)08MB69ZA08MB69ZAGU188847None   I3V, L10M, I13V, I15K, G17S, L19I, K20R, M36I, P39Q, L63Q, H69K, L89M, I93LC
Sigaloff (2011)GT00135141GT00135141_1JN381569None   I15V, G16GE, L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
  GT00135141_2JN381570None   I15V, G16GE, L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
Thorat (2011)Pat013IN-NARI-HIVDR-5-013HQ166851None   T12P, L19I, K20R, M36I, R41K, L63Q, H69K, K70R, I72V, T74TA, L89M, I93LC
van Zyl (2011)A275A275JN638166None   I15V, L19I, M36I, R41K, Q61E, L63Q, H69K, I72V, L89M, I93LC
 A279A279JN638170None   T12S, I15V, L19T, M36I, N37S, R41K, K43R, L63Q, H69K, L89LM, I93LC
 A59A59JN638216None   I15V, L19T, N37S, R41K, L63Q, H69K, I93LC
Wright (2011)RB_052RB_052HQ696850None   T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63Q, H69K, V82I, L89M, I93LC
Hunt (2012)GP09_0092GP09_0092KF736713None   I13V, I15V, L19I, M36I, R41K, L63Q, I64L, H69K, L89M, I93LC
 GP07_219530GP07_219530KF736586None   T12S, G16E, L19T, E35D, M36I, L63Q, H69K, K70R, L89M, I93LC
 GP09_0137GP09_0137KF736714None   T12S, I15V, L19I, E35D, M36I, R41K, L63Q, H69K, V82I, L89M, I93LC
 GP09_1488GP09_1488KF736737None   I15V, G16A, M36I, R41K, L63Q, H69K, A71AT, I72IM, I93LC
Musyoki (2012)DGM.35DGM.35JN176297None   T12S, I15V, L19V, M36I, N37D, R41K, K43R, L63Q, I64L, H69K, I93LC
Nwobegahay (2012)MC02ZAMC02ZAGU177502None   T12S, I15V, L19I, K20R, M36I, P39Q, R41K, Q61N, L63Q, H69K, L89M, I93LC
 MC11ZAMC11ZAGU177507None   T12S, I15V, L19I, N37T, R41K, R57K, D60E, Q61E, L63Q, E65D, H69K, V77I, L89M, I93LC
 MC35ZAMC35ZAGU177519None   T12S, I15V, G16E, L19V, K20R, M36I, P39K, R41K, Q61H, L63Q, H69K, K70Q, L89I, I93LC
Bila (2013)MZ10-203_XAHIV-1KF927302None   T12S, I15V, L19T, N37S, R41K, D60E, L63Q, C67Y, H69K, T80TP, L89M, I93LC
Frentz (2013)EHR-54810EHR-54810JX300450None   T12S, I15V, L19I, M36I, R41K, I62IV, L63Q, H69K, T74A, L89M, I93LC
Hoffmann (2013)5652456524KJ081300None   T12S, I15V, G17GD, Q18E, L19I, K20R, E35D, M36I, R41K, R57RK, L63Q, H69K, L89M, I93LC
Mulu (2013)ETH-G-5726ETH-G-5726KF026173None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, I93LC
 ETH-G-5596ETH-G-5596KF026131None   T12S, I15V, L19V, M36I, R41K, D60E, Q61QH, L63Q, H69K, L89M, I93LC
 ETH-G-5573ETH-G-5573KF026121None   L10I, T12A, I15V, L19I, E35D, M36I, R41K, V56VL, L63Q, H69Q, L89M, I93LC
 ETH-G-5622ETH-G-5622KF026141None   T12S, I15V, L19I, E35D, M36I, R41K, L63Q, H69K, L89M, I93LC
 ETH-G-5786ETH-G-5786KF026191None   T12S, I15V, K20R, E35K, M36I, R41K, L63Q, I66IS, H69K, I72K, L89M, I93LC
Van Zyl (2013)10351267KC423015None   T12S, I15V, L19I, M36T, R41K, L63Q, H69K, L89M, I93LC
 1162541KC424128None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, V82I, L89M, I93LC
 5371627KC423282None   T12S, I15V, G16E, L19I, E35D, M36I, R41K, K45KN, R57RK, D60E, L63Q, H69K, V82I, L89M, I93LC
 17682455KC423720None   T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K43KR, R57RK, Q61QH, L63Q, H69K, T74S, L89M, I93LC
 161314KC423980None   T12S, I15V, L19I, K20R, M36I, N37S, R41K, L63Q, H69K, T74S, V77I, L89M, I93LC
 13091667KC423312None   T12S, I15V, L19I, E35D, M36I, N37D, R57K, Q61D, L63Q, H69K, A71T, I93LC
 17292935KC423899None   T12S, I15V, G16E, L19I, M36I, R41K, L63Q, H69K, L89M, I93LC
 3301810KC423426None   L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
 846645KC424198None   T12S, I15V, L19V, K20R, M36I, N37S, R41K, L63Q, H69K, K70Q, I72V, V77I, L89M, I93LC
 1881936KC423521None   I15V, G16E, L19T, E35D, M36I, N37D, L63Q, H69K, L89M, I93LC
 441113KC422900None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63Q, H69K, L89M, I93LC
 53599KC424419None   K14R, I15V, L19I, K20R, E35D, M36I, R41K, D60E, I62V, L63Q, H69K, K70M, L89M, I93LC
 15723063KC423950None   T12S, I15V, L19V, M36I, R41K, L63Q, I64L, H69K, V82I, L89M, I93LC
 12441349KC423080None   T12S, I15V, L19I, M36T, R41K, L63Q, H69K, L89M, I93LC
 11351217KC422968None   I15V, M36I, R41K, L63Q, H69K, I93LC
 12482088KC423609None   I15V, L19V, E35D, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
 652469KC424077None   T12S, I15V, L19I, M36I, R41K, L63Q, H69K, T74S, L89M, I93LC
Steegen (2014)12ZAKS36212ZAKS362KJ176641None   R41K, L63Q, H69K, I93LC
 12ZAKS30812ZAKS308KJ176587None   R41K, L63Q, H69K, I93LC
 11ZAKS18911ZAKS189KJ176470None   D60E, L63Q, I64L, H69K, L89M, I93LC
 12ZAKS35612ZAKS356KJ176635None   R41K, R57K, D60E, L63Q, H69K, L89MC
 11ZAKS19111ZAKS191KJ176472None   R41K, L63Q, H69K, L89M, I93LC
 11ZAKS18011ZAKS180KJ176461None   R41K, L63Q, I64L, H69K, L89M, I93LC
 12ZAKS30612ZAKS306KJ176585None   R41K, L63Q, H69K, I93LC
 12ZAKS30312ZAKS303KJ176582None  Q58ER57RK, L63Q, H69K, L89M, I93LC