Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L63I
Rx	PI-naive
IncludeMixtures	No

References	41
Patients	68
Isolates	68

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Salminen (1996)	C2220	C2220	U46016	None		M36I, R41K, L63I, H69K, L89M, I93L, C95R	C
Hammer (1997)	ACTG320_2740	2740		None		T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93IL	C
Dowling (2002)	KER2010	KER2010	AF457054	None		I13V, L19I, K20R, M36I, R41K, I62V, L63I, H69K, A71T, L89I, I93L	C
Hierholzer (2002)	SU227	SU227	AY102497	None		L10I, M36I, R41K, L63I, H69Q, L89M, I93L	C
Brindeiro (2003)	BRSP1501	BRSP1501	AY213239	None		L10I, G17GW, L19P, K20E, M36I, N37K, R41N, L63I, H69K, L89M, I93L	C
Gordon (2003)	ZA024p01	ZA024p01	AY136977	None		I15V, L19I, N37S, R41K, L63I, H69K, V77I, I93L	C
Yang (2004)	98KE384	98KE384	AY492764	None		T12S, L19I, M36I, R41K, I62V, L63I, H69K, L89M	C
Bellocchi (2005)	896	MT000896	GU199565	None		T12S, I15V, L19I, E35ED, M36MIL, N37NS, R41K, L63I, H69K, L89M, I93L	C
Eshleman (2005)	ESH5070	ESH5070	AY756853	None		I3V, T12S, I15V, L19V, T31TS, V32X, M36I, R41K, L63I, H69K, L89M, I93L	C
	ESH5090	ESH5090	AY756856	None		T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, D60E, L63I, H69K, L89M, I93L	C
Grossman (2005)	21042	21042PR243		None		I13V, I15V, M36I, R41K, L63I, I64V, H69K, I72IV, L89M, I93L	C
Parreira (2006)	PG187	PG187	AM071431	None		T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93L	C
Rodrigues (2006)	BR04RS123	BR04RS123	DQ070617	None		K20R, L33V, M36I, N37K, R41N, Q61N, L63I, H69K, L89M	C
Rousseau (2006)	Pt28	03PS051MB1	DQ396385	None		T12S, K14R, I15V, L19V, M36I, R41K, L63I, H69K, L89M, I93L	C
	Pt146	04PS177MB1	DQ396394	None		T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93L	C
	Pt171	04SK052MB2	DQ396366	None		T12S, I15V, L19T, R41K, D60E, L63I, H69K, L89M, I93L	C
	Pt187	04SK147B1	DQ164114	None		T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63I, H69K, L89M, I93L	C
	Pt189	04SK151B1	AY901977	None		T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93L	C
	Pt255	C.J38MA	AY463228	None		I15V, L19I, E35D, M36I, R41K, D60E, L63I, H69K, L89M, I93L	C
	03ZASK212B	03SK212B	DQ978981	None		T12S, I15V, L19T, K20M, M36I, R41K, L63I, H69K, L89M, I93L	C
Church (2007)	5090	5090	EF602606	None		T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, D60E, L63I, H69K, L89M, I93L	C
Kassu (2007)	ETH-G-241	G-241	AB285836	None	V32VA	T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93L	C
Deho (2008)	127	127	EU244659	None		L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, I62V, L63I, H69K, T74A, L89M, I93L	C
Ferreira (2008)	430	BR05PR430	EU340715	None		L10M, I15V, E35D, N37K, R41N, I62V, L63I, H69K, T74A, L89M, I93L	C
Jacobs (2008)	1743	1743	EF602189	None		T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, L89M, I93L	C
	1818	1818	EF602246	None		T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93L	C
Marconi (2008)	SW088	sw088	EU308097	None		T12S, I15V, L19I, M36I, N37D, R41K, D60E, L63I, H69K, L89M, I93L	C
	SW100	SW0100	EU308108	None		T12TA, I15V, L19I, M36I, N37NS, R41K, L63I, H69K, T74S, L89M, I93L	C
Matthews (2008)	1180	1180	FJ199546	None		T12S, K14R, I15V, L19V, E35D, M36I, R41K, L63I, H69K, L89M, I93L	C
	J38	J38	FJ199579	None		I15V, L19I, E35D, M36I, R41K, D60E, L63I, H69K, L89M, I93L	C
	PS177	PS177	FJ199737	None		T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93L	C
	PS426	PS426	FJ199825	None		I15V, L19V, M36I, R41K, D60E, L63I, H69K, V77I, L89M, I93L	C
	SK052	SK052	FJ199871	None		T12S, I15V, L19T, R41K, D60E, L63I, H69K, L89M, I93L	C
	SK147	SK147	FJ199923	None		T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63I, H69K, L89M, I93L	C
	SK151	SK151	FJ199926	None		T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93L	C
Bartolo (2009)	HDP70	01AOHDP70	EU068242	None		T12S, I13L, I15V, L19V, M36I, N37S, R41K, L63I, H69K, L89M, I93L	C
Orrell (2009)	MD100816	MD1008162005		None		I15V, L19V, M36I, R41K, L63I, H69K, V77I, L89M, I93L	C
Vercauteren (2009)	pt1770	2710515734	GQ399254	None		I13V, I15V, G16E, L19T, K20R, M36I, N37D, L63I, H69K, L89M, I93L	C
Hamers (2010)	300129	CP076300129	HM119705	None		I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93L	C
Tymchuck (2010)	MW20	MW20	HM744729	None		I15V, L19I, M36I, R41K, I62V, L63I, H69K, T74S, L89M, I93L	C
Wright (2010)	171	SK171	HM593179	None		T12X, I15IV, L19I, M36I, R41K, L63I, H69K, L89M, I93L	C
	413	SK413	HM593421	None		T12S, I15V, L19I, E35D, M36I, R41K, D60E, I62V, L63I, H69K, V82I, L89M, I93L	C
	80	SK80	HM593494	None		T12S, I15V, L19V, M36I, R41K, L63I, H69K, L89M, I93L	C
Bussmann (2011)	B0761	B0761	JQ617032	None		I15V, L19I, N37S, R41K, L63I, H69K, T74S, L89M, I93L	C
	B0589	B0589	JQ617082	None		K14KR, I15V, L19I, N37S, R41K, L63I, H69K, V77I, L89M, I93L	C
	B0603	B0603	JQ617093	None		I15V, L19I, E35D, M36I, R41K, I62V, L63I, H69Q, T74S, L89M, I93L	C
de Medeiros (2011)	Pat022	RS066	JF487851	None		T12S, I15V, L19I, E35N, M36I, N37K, R41N, L63I, H69K, L89M	C
Graf (2011)	SC39	SC39	JF774006	None		M36I, N37K, R41N, L63I, H69K, L89M, I93L	C
	SC53	SC53	JF774017	None		T12P, K14R, I15V, M36I, N37K, R41N, L63I, H69K, L89M, I93L	C
	SC97	SC97	JF774036	None		I15V, M36T, N37K, R41I, L63I, H69K, T74S, L89I, I93L	C
Green (2011)	707PKE07F	707PKE07F	HM623499	None		T12S, I15V, L19I, M36I, R41K, L63I, H69K, V82I, L89M, I93L	C
	707PKE18F	707PKE18F	HM623508	None		L10M, T12S, I15V, L19V, E35D, M36I, R41K, I62V, L63I, H69K, T74S, L89M, I93L	C
Hamers (2011)	CP076301594	CP076301594	HQ993632	None		T12S, I15V, L19I, M36I, R41K, L63I, H69K, V82I, L89M, I93L	C
	CP076300386	CP076300386	HQ994393	None		T12S, I15V, L19I, M36I, R41K, L63I, H69K, T74S, L89M, I93L	C
	CP076300968	CP076300968	HQ994734	None		T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93L	C
	CP076303112	CP076303112	HQ995288	None		T12S, I15V, K20R, E35D, M36I, N37D, R41K, L63I, H69K, L89M, I93L	C
Kasang (2011)	29742	29742	HM572410	None		T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, L89M	C
Manasa (2011)	1003575	1003575	JN664999	None		T12S, L19I, M36L, L63I, H69K, L89M, I93L	C
Nwobegahay (2011)	BBVCT57ZA	BBVCT57ZA	GU139631	None		L19I, E35D, M36I, R41K, R57K, L63I, H69K, A71T, I72V, I93L	C
Telan (2011)	08R_01-357	08R_01-357	AB587103	None		T12S, I15V, L19I, M36I, R41K, K45R, L63I, H69K, L89M, I93L	C
van Zyl (2011)	A314	A314	JN638191	None		G17GD, L19I, K20R, M36I, R41K, K45R, L63I, H69K, L89M, I93L	C
Wright (2011)	AS2-1630B2	AS2-1630B2	HQ696815	None		T12S, I15V, L19T, K20R, E35D, M36I, N37D, R41K, L63I, H69K, L89M, I93L	C
De Gascun (2012)	IRL40593	IRL40593	JN622886	None		W6WL, L10I, V11VF, T12S, I15V, L19I, E35ED, M36MI, N37NS, R41K, L63I, H69K, V82I, L89M, I93L	C
	IRL20589	IRL20589	JN622951	None		T12S, I15V, L19I, M36I, R41K, R57RK, I62IV, L63I, H69K, T74S, L89M, I93L	C
Nwobegahay (2012)	MC36ZA	MC36ZA	GU177520	None		T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63I, H69K, V82I, L89M, I93L	C
Telan (2012)	801357	801357	AB747376	None		T12S, I15V, L19I, M36I, R41K, K45R, L63I, H69K, L89M, I93L	C
Frentz (2013)	EHR-05673	EHR-05673	JX299633	None		T12S, I15V, L19I, M36I, R41K, R57RK, I62IV, L63I, H69K, T74S, L89M, I93L	C
	EHR-65902	EHR-65902	JX300649	None		T12S, I15V, L19I, M36I, R41K, I62V, L63I, H69K, T74A, V82I, L89M, I93L	C

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