<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63I
Rx PI-naive
IncludeMixtures No
References 47
Patients 88
Isolates 88
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Salminen (1996)C2220C2220U46016None   M36I, R41K, L63I, H69K, L89M, I93L, C95RC
Hammer (1997)ACTG320_27402740 None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93ILC
Dowling (2002)KER2010KER2010AF457054None   I13V, L19I, K20R, M36I, R41K, I62V, L63I, H69K, A71T, L89I, I93LC
Hierholzer (2002)SU227SU227AY102497None   L10I, M36I, R41K, L63I, H69Q, L89M, I93LC
Brindeiro (2003)BRSP1501BRSP1501AY213239None   L10I, G17GW, L19P, K20E, M36I, N37K, R41N, L63I, H69K, L89M, I93LC
Gordon (2003)ZA024p01ZA024p01AY136977None   I15V, L19I, N37S, R41K, L63I, H69K, V77I, I93LC
Yang (2004)98KE38498KE384AY492764None   T12S, L19I, M36I, R41K, I62V, L63I, H69K, L89MC
Bellocchi (2005)896MT000896GU199565None   T12S, I15V, L19I, E35ED, M36MIL, N37NS, R41K, L63I, H69K, L89M, I93LC
Eshleman (2005)ESH5070ESH5070AY756853None   I3V, T12S, I15V, L19V, T31TS, V32X, M36I, R41K, L63I, H69K, L89M, I93LC
 ESH5090ESH5090AY756856None   T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, D60E, L63I, H69K, L89M, I93LC
Grossman (2005)2104221042PR243 None   I13V, I15V, M36I, R41K, L63I, I64V, H69K, I72IV, L89M, I93LC
Parreira (2006)PG187PG187AM071431None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
Rodrigues (2006)BR04RS123BR04RS123DQ070617None   K20R, L33V, M36I, N37K, R41N, Q61N, L63I, H69K, L89MC
Rousseau (2006)Pt2803PS051MB1DQ396385None   T12S, K14R, I15V, L19V, M36I, R41K, L63I, H69K, L89M, I93LC
 Pt14604PS177MB1DQ396394None   T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
 Pt17104SK052MB2DQ396366None   T12S, I15V, L19T, R41K, D60E, L63I, H69K, L89M, I93LC
 Pt18704SK147B1DQ164114None   T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63I, H69K, L89M, I93LC
 Pt18904SK151B1AY901977None   T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
 Pt255C.J38MAAY463228None   I15V, L19I, E35D, M36I, R41K, D60E, L63I, H69K, L89M, I93LC
 03ZASK212B03SK212BDQ978981None   T12S, I15V, L19T, K20M, M36I, R41K, L63I, H69K, L89M, I93LC
Church (2007)50905090EF602606None   T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, D60E, L63I, H69K, L89M, I93LC
Kassu (2007)ETH-G-241G-241AB285836None  V32VAT12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
Deho (2008)127127EU244659None   L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, I62V, L63I, H69K, T74A, L89M, I93LC
Ferreira (2008)430BR05PR430EU340715None   L10M, I15V, E35D, N37K, R41N, I62V, L63I, H69K, T74A, L89M, I93LC
Jacobs (2008)17431743EF602189None   T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, L89M, I93LC
 18181818EF602246None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
Marconi (2008)SW088sw088EU308097None   T12S, I15V, L19I, M36I, N37D, R41K, D60E, L63I, H69K, L89M, I93LC
 SW100SW0100EU308108None   T12TA, I15V, L19I, M36I, N37NS, R41K, L63I, H69K, T74S, L89M, I93LC
Matthews (2008)11801180FJ199546None   T12S, K14R, I15V, L19V, E35D, M36I, R41K, L63I, H69K, L89M, I93LC
 J38J38FJ199579None   I15V, L19I, E35D, M36I, R41K, D60E, L63I, H69K, L89M, I93LC
 PS177PS177FJ199737None   T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
 PS426PS426FJ199825None   I15V, L19V, M36I, R41K, D60E, L63I, H69K, V77I, L89M, I93LC
 SK052SK052FJ199871None   T12S, I15V, L19T, R41K, D60E, L63I, H69K, L89M, I93LC
 SK147SK147FJ199923None   T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63I, H69K, L89M, I93LC
 SK151SK151FJ199926None   T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
Bartolo (2009)HDP7001AOHDP70EU068242None   T12S, I13L, I15V, L19V, M36I, N37S, R41K, L63I, H69K, L89M, I93LC
Orrell (2009)MD100816MD1008162005 None   I15V, L19V, M36I, R41K, L63I, H69K, V77I, L89M, I93LC
Vercauteren (2009)pt17702710515734GQ399254None   I13V, I15V, G16E, L19T, K20R, M36I, N37D, L63I, H69K, L89M, I93LC
Hattori (2010)C06-51110419C06-51110419AB864826None   T12S, K14R, I15V, L19T, R41K, L63I, H69K, T74S, V77I, L89M, I93LC
Tymchuck (2010)MW20MW20HM744729None   I15V, L19I, M36I, R41K, I62V, L63I, H69K, T74S, L89M, I93LC
Wright (2010)171SK171HM593179None   T12X, I15IV, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
 413SK413HM593421None   T12S, I15V, L19I, E35D, M36I, R41K, D60E, I62V, L63I, H69K, V82I, L89M, I93LC
 80SK80HM593494None   T12S, I15V, L19V, M36I, R41K, L63I, H69K, L89M, I93LC
Bussmann (2011)B0761B0761JQ617032None   I15V, L19I, N37S, R41K, L63I, H69K, T74S, L89M, I93LC
 B0589B0589JQ617082None   K14KR, I15V, L19I, N37S, R41K, L63I, H69K, V77I, L89M, I93LC
 B0603B0603JQ617093None   I15V, L19I, E35D, M36I, R41K, I62V, L63I, H69Q, T74S, L89M, I93LC
de Medeiros (2011)Pat022RS066JF487851None   T12S, I15V, L19I, E35N, M36I, N37K, R41N, L63I, H69K, L89MC
Graf (2011)SC39SC39JF774006None   M36I, N37K, R41N, L63I, H69K, L89M, I93LC
 SC53SC53JF774017None   T12P, K14R, I15V, M36I, N37K, R41N, L63I, H69K, L89M, I93LC
 SC97SC97JF774036None   I15V, M36T, N37K, R41I, L63I, H69K, T74S, L89I, I93LC
Green (2011)707PKE07F707PKE07FHM623499None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, V82I, L89M, I93LC
 707PKE18F707PKE18FHM623508None   L10M, T12S, I15V, L19V, E35D, M36I, R41K, I62V, L63I, H69K, T74S, L89M, I93LC
Hamers (2011)300129CP076300129HM119705None   I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
 CP076301594CP076301594HQ993632None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, V82I, L89M, I93LC
 CP076300386CP076300386HQ994393None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
 CP076300968CP076300968HQ994734None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
 CP076303112CP076303112HQ995288None   T12S, I15V, K20R, E35D, M36I, N37D, R41K, L63I, H69K, L89M, I93LC
Kasang (2011)2974229742HM572410None   T12S, I15V, L19I, E35D, M36I, R41K, L63I, H69K, L89MC
Manasa (2011)10035751003575JN664999None   T12S, L19I, M36L, L63I, H69K, L89M, I93LC
Nwobegahay (2011)BBVCT57ZABBVCT57ZAGU139631None   L19I, E35D, M36I, R41K, R57K, L63I, H69K, A71T, I72V, I93LC
Telan (2011)08R_01-35708R_01-357AB587103None   T12S, I15V, L19I, M36I, R41K, K45R, L63I, H69K, L89M, I93LC
van Zyl (2011)A314A314JN638191None   G17GD, L19I, K20R, M36I, R41K, K45R, L63I, H69K, L89M, I93LC
Wright (2011)AS2-1630B2AS2-1630B2HQ696815None   T12S, I15V, L19T, K20R, E35D, M36I, N37D, R41K, L63I, H69K, L89M, I93LC
De Gascun (2012)IRL40593IRL40593JN622886None   W6WL, L10I, V11VF, T12S, I15V, L19I, E35ED, M36MI, N37NS, R41K, L63I, H69K, V82I, L89M, I93LC
 IRL20589IRL20589JN622951None   T12S, I15V, L19I, M36I, R41K, R57RK, I62IV, L63I, H69K, T74S, L89M, I93LC
Hunt (2012)GP09_1636GP09_1636KF736740None   T12TS, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
 GP08_0234GP08_0234KF736645None   T12S, I15V, L19I, N37NT, R41K, K55R, L63I, H69K, V77I, L89M, I93LC
 GP08_0853GP08_0853KF736656None   I15V, L19I, M36IT, R41N, D60E, Q61N, L63I, H69K, L89M, I93LC
 GP07_214210GP07_214210KF736561None   T12S, I15V, L19I, K20R, E35D, M36I, N37D, K43KR, L63I, H69K, V82I, L89M, I93LC
Nwobegahay (2012)MC36ZAMC36ZAGU177520None   T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63I, H69K, V82I, L89M, I93LC
Bila (2013)MzNat148HIV-1KF927390None   T12S, I15V, L19I, E35D, M36I, R41K, I62V, L63I, H69K, T74S, V82I, L89M, I93LC
 MzMan244HIV-1KF927394None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
 MZMAN07HIV-1KF927416None   L19M, M36I, R41K, L63I, H69K, L89M, I93LC
 MZ09-040HIV-1KF927200None   T12S, I15V, L19I, M36I, R41K, L63I, H69K, L89M, I93LC
 MZQUE247HIV-1KF927431None  I50FT12S, I15V, L19T, E35D, M36I, R41K, L63I, H69K, L89M, I93LC
 MZ10-206HIV-1KF927305None   I15V, L19T, K20R, E35D, M36I, R41K, L63I, H69K, T74S, L89M, I93LC
 MZ10-247HIV-1KF927338None   T12A, I15V, L19I, E35D, M36I, R41K, L63I, H69K, L89M, I93LC
 MzQue280HIV-1KF927379None   T12P, I15V, M36I, N37D, L63I, H69K, L89M, I93LC
Frentz (2013)EHR-05673EHR-05673JX299633None   T12S, I15V, L19I, M36I, R41K, R57RK, I62IV, L63I, H69K, T74S, L89M, I93LC
 EHR-65902EHR-65902JX300649None   T12S, I15V, L19I, M36I, R41K, I62V, L63I, H69K, T74A, V82I, L89M, I93LC
Hoffmann (2013)032195_1032195_1KJ081311None   T12S, I15V, L19I, K20R, M36I, R41K, L63I, H69K, L89I, I93LC
 449813_2449813_2KJ081327None   M36I, R41K, L63I, H69K, L89I, I93LC
Kiptoo (2013)SNH041SNH041KC516987None   T12S, I13V, I15V, L19I, M36I, R41K, D60E, Q61QE, I62V, L63I, H69K, L89MC
 SNH074SNH074KC516954None   T12S, I13V, I15V, L19I, K20R, M36I, R41K, I62V, L63I, H69K, L89MC
Telan (2013)801357801357AB747376None   T12S, I15V, L19I, M36I, R41K, K45R, L63I, H69K, L89M, I93LC
Van Zyl (2013)476102KC422810None   L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, Q61E, L63I, H69K, T74K, L89M, I93LC
 9541832KC423445None   K14R, I15V, L19T, K20R, E35D, M36I, R41K, L63I, H69K, L89MC
Meixenberger (2014)11-0353411-03534KJ771605None   T12S, I13V, I15V, L19I, K20R, M36I, N37T, P39S, R41K, I62V, L63I, I64M, H69K, L89M, I93LC