<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63H
Rx PI-naive
IncludeMixtures No
References 64
Patients 145
Isolates 145
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Pieniazek (1998)LE-15LE15AF025727None   I15V, G16E, L23S, M36I, R41K, L63H, H69K, L89MC
Novitsky (2002)99BW475499BW4754AF443086None   T12S, I15V, L19I, E35D, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
Yang (2002)DH020DH020AB078716None   T12S, K14R, I15V, L19I, M36I, R41K, L63H, H69K, I93LC
Gordon (2003)ZA037p01ZA037p01AY136990None   T12S, K14R, I15V, L19T, M36I, R41K, L63H, H69K, I93LC
Jorgensen (2003)JLB_Pat61HIM419487AJ419487None   I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
Maljkovic (2003)MI_Pat7599SE17921AY165220None   K14R, I15V, L19I, E35ED, N37S, R41RK, L63H, H69K, L89M, I93ILC
Deshpande (2004)in23in23AY515747None   T12S, L19I, K20R, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
Aulicino (2005)ARE195FLARE195FLAY968312None   L5V, K14R, I15V, G16E, N37K, R41N, L63H, H69K, L89M, I93LC
Balakrishnan (2005)YRG6YRG6AY787492None   T12P, I15V, G16E, L19I, M36I, N37S, R41K, L63H, H69K, P79PS, L89M, I93LC
Bellocchi (2005)859MT000859GU199534None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63H, H69K, K70Q, L89M, I93LC
Brown (2005)BB_02ET_28802ET_288AY713417None   K14R, M36I, R41K, L63H, H69K, I93LC
Bussmann (2005)01BW3381N01BW3381NAY829317None   T12S, I15V, L19I, M36I, N37S, R41K, L63H, H69K, L89M, I93LC
 01BW386S01BW386SAY829276None   T12Q, I15V, L19I, E35D, M36I, R41K, L63H, H69K, L89M, I93LC
Eshleman (2005)ESH7044ESH7044AY756866None   T12S, G16E, L19I, E35ED, M36I, R41K, Q61H, L63H, H69K, L89M, I93LC
Grossman (2005)1986819868PR181 None   I15V, Q18HY, L19I, R41K, L63H, H69K, I93LC
 1986919869PR182 None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93LC
Petch (2005)LP06MAL-06PRAY860458None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89LM, I93LC
Tovanabutra (2005)98US_MSC301898US_3018AY444800None   T12S, I15V, G16E, L19I, M36I, L63H, H69K, L89M, I93LC
Parreira (2006)PG216PG216AM071422None  N83DI3T, I15V, L19I, E35D, N37S, R41K, I62V, L63H, H69K, K70Q, V77I, L89M, I93LC
 PG217PG217AM071447None   I15V, L19I, N37S, R41K, I62V, L63H, H69K, K70Q, V77I, L89M, I93LC
 PG196PG196AM071452None   T12S, I15V, L19I, M36I, N37S, R41K, Q61H, L63H, H69K, L89M, I93L, T96AC
Razafindratsimandresy (2006)RR_MAD-MO105MAD-MO105DQ345031None   T12S, I15V, L19I, K20R, M36I, R41K, Q61H, L63H, H69K, K70Q, V77I, L89M, I93LC
Rodrigues (2006)BR04RS97BR04RS97DQ070538None   I15V, G16A, M36I, N37K, R41N, K45R, L63H, H69KC
Rousseau (2006)Pt7503PS143MB1DQ396391None   T12S, I15V, L19V, M36I, R41K, L63H, H69K, L89M, I93LC
 Pt11003SK078B1AY901971None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93LC
 Pt11903SK103B1DQ164106None   T12S, I15V, L19I, M36I, R41K, D60N, L63H, H69K, I93LC
Church (2007)70447044EF602614None   T12S, G16E, L19I, E35ED, M36I, R41K, Q61H, L63H, H69K, L89M, I93LC
Han (2007)LN5103CNLN51EF122531None   T12S, I15V, G16E, L19I, M36I, N37D, R41K, D60E, L63H, H69K, L89M, I93LC
Kassu (2007)ETH-G-001G-001AB285752None   K14R, I15V, L19I, M36I, N37D, R41K, I62V, L63H, H69K, V82I, L89M, I93LC
 ETH-G-046G-046AB285772None   I13V, I15IV, G16E, M36I, R41K, L63H, H69K, I93LC
Vidal (2007)U072702BU.U0727AM260291None   T12S, I15V, G16E, N37K, R41N, L63H, H69K, I72L, V82I, L89I, I93LC
 U080802BU.U0808AM260294None   T12S, I15V, G16E, L19I, K20R, M36I, N37K, R41N, R57K, L63H, H69K, K70R, L89I, I93LC
 U100502BU.U1005AM260302None   T12S, K14R, G16E, L19I, K20R, D25X, M36I, N37K, P39S, R41N, L63H, H69K, L89I, I93LC
Chang (2008)TW5191aTW5191a None   L10P, T12S, L19I, R41K, L63H, H69K, L89M, I93LC
 TW5192aTW5192a None   T12S, L19I, T31S, R41K, L63H, H69K, K70R, L89M, I93LC
Ferreira (2008)626BR06PR626EU340744None   T12P, I15V, G16E, E35D, N37K, R41H, L63H, I64V, H69K, V82I, I93LC
Jacobs (2008)17711771EF602211None   T12P, I15V, L19I, N37S, R41K, K45R, L63H, H69K, V77I, L89M, I93LC
Matthews (2008)SK078SK078FJ199882None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93LC
 SK103SK103FJ199893None   T12S, I15V, L19I, M36I, R41K, D60N, L63H, H69K, I93LC
Nyombi (2008)TMS128TMS128EU251826None   L19T, M36I, R41K, L63H, H69K, I93LC
Bartolo (2009)CSE12901AOCSE129EU068336None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
Kandathil (2009)VL05_146VL05_146EU110061None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 VL05_173VL05_173EU110066None   T12P, I13V, I15V, G16E, Q18X, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 VL07_060VL07_060EU110081None   I15V, L19T, D25X, M36I, R41K, L63H, H69K, I72T, L89M, I93LC
Kousiappa (2009)CY175CY175EU673406None   T12S, I15V, L19I, M36I, N37D, L63H, H69K, L89M, I93LC
 CY176CY176EU673407None   T12S, I15V, L19I, M36I, N37D, L63H, H69K, L89M, I93LC
Rajesh (2009)N34TRCNPR34FJ595397None   T12P, K14R, I15V, G16E, M36I, R41K, L63H, H69K, L89M, I93LC
 N57TRCNPR57FJ595420None   T12S, I15V, G16E, L19I, M36I, R41K, L63H, H69K, L89IM, I93LC
 N21TRCNPR21FJ595384None   T12S, I15V, G16E, L19I, M36V, R41K, I62V, L63H, I64M, H69K, V82I, L89M, I93LC
 N86TRCNPR86FJ595449None   T12P, K14R, I15V, G16E, M36I, R41K, L63H, H69K, L89M, I93LC
 F11TRCFPR11FJ595473None   T12S, I15V, G16E, L19I, M36I, R41K, L63H, H69K, L89I, I93LC
Vercauteren (2009)pt15274104583469GQ399497None   L10LV, I15V, L19I, M36I, R41K, L63H, C67CY, H69K, L89M, I93LC
 pt8817924235985GQ400143None   T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63H, H69K, L89M, I93LC
Gonzalez (2010)LV3LV3GQ433859None   T12S, I15V, L19I, M36I, R41K, Q61H, L63H, H69K, K70Q, L89M, I93LC
Papathanasopoulos (2010)1740907ZA17409GU253422None   T12S, I15V, G16E, L19I, N37S, L63H, H69K, L89M, I93LC
Rodrigues (2010)346_07BR07SC346GQ401328None   I15V, M36I, N37K, R41N, I62V, L63H, H69K, L89M, I93LC
Wright (2010)103SK103HM593110None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93LC
 333SK333HM593338None   T12PS, I15V, L19T, E35D, M36I, R41K, W42W*, L63H, G68GE, H69K, L89M, I93LC
 431SK431HM593441None   T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63H, H69K, L89M, I93LC
 45SK45HM593460None   T12S, I15V, G16E, L19I, R41K, D60E, L63H, H69K, L89M, I93LC
 78SK78HM593492None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93LC
Bussmann (2011)B0757B0757JQ617030None   I15V, G16E, L19IT, K20R, M36I, R41K, L63H, H69K, I72V, V77I, V82VI, L89M, I93LC
 B0552B0552JQ617047None   K14KE, I15V, L19I, E35D, M36I, I62V, L63H, H69K, K70E, A71V, L89M, I93LC
 B0557B0557JQ617051None   I15V, G16E, L19I, N37S, R41K, L63H, H69K, V77VI, I93LC
 B0586B0586JQ617079None   G16A, E35D, R41K, L63H, H69K, I72M, L89M, I93LC
 B0587B0587JQ617080None   I15V, L19I, M36I, N37S, R41K, L63H, H69K, I93LC
Deshpande (2011)Pat043in1131JF414427None   T12S, L19I, M36I, R41K, W42WR, K43R, L63H, H69K, L89M, I93LC
 Pat029in1109JF414441None   T12P, I15V, G16E, L19I, K20R, M36I, R41K, R57RK, L63H, H69K, V82I, L89M, I93LC
 Pat005in1031JF414465None   T12S, L19I, M36I, R41K, L63H, H69K, K70KR, V82I, L89M, I93LC
Ferreira (2011)BRMT2564BRMT2564HQ638713None   T12A, I15V, G16E, M36T, N37K, R41N, L63H, H69K, L89I, I93LC
Graf (2011)SC96SC96JF774035None   T12A, I13V, I15V, G16E, M36I, N37K, R41N, L63H, H69K, L89M, I93LC
Hamers (2011)300136CP076300136HM119712None   T12S, I15V, G16E, L19I, R41K, L63H, H69K, A71T, L89I, I93LC
 300169CP076300169HM119742None   T12S, I15V, L19I, M36I, N37S, R41K, Q61N, L63H, H69K, L89M, I93LC
 300451CP076300451HM119872None   L10I, T12S, I15V, L19I, M36I, R41K, I62IV, L63H, H69K, L89IC
 300474CP076300474HM119893None   T12S, K14R, I15V, G16E, L19I, K20R, M36I, R41K, K45KR, I62IV, L63H, H69K, I72IT, L89I, I93LC
 300529CP076300529HM119945None   T12S, K14R, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89M, I93LC
 300558CP076300558HM119967None   T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63H, H69K, L89M, I93LC
 300672CP076300672HM120063None   I15V, L19T, R41K, L63H, H69K, V77I, L89LM, I93LC
 300692CP076300692HM120077None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, I72IM, L89M, I93LC
 CP076303209CP076303209HQ994218None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 CP076303217CP076303217HQ994225None   I15V, L19M, K20R, M36I, R41K, K45KR, I62IV, L63H, H69K, L89I, I93LC
 CP076305108CP076305108HQ994332None   T12S, I13V, I15V, L19I, K20R, M36I, N37D, R41K, L63H, H69K, L89M, I93LC
 CP076305115CP076305115HQ994338None   T12S, I13V, I15V, L19I, K20R, M36I, N37D, R41K, L63H, H69K, L89M, I93LC
 CP076300396CP076300396HQ994400None   T12S, I15V, G16E, L19I, M36I, R41K, R57K, L63H, H69K, V82I, L89I, I93LC
 CP076302111CP076302111HQ994484None   T12S, I15V, L19T, M36I, R41K, L63H, H69K, V82VI, L89M, I93LC
 CP076302141CP076302141HQ994507None   I15V, L19I, M36I, R41K, I62V, L63H, H69K, I93LC
 CP076301048CP076301048HQ994580None   L10V, T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63H, H69K, L89M, I93LC
 CP076300943CP076300943HQ994719None   T12S, I15V, G16E, L19I, M36L, R41K, L63H, H69K, L89I, I93LC
 CP076300949CP076300949HQ994724None   T12P, K14R, I15V, G16E, L19LI, M36I, R41K, L63H, H69K, L89M, I93LC
 CP076301058CP076301058HQ994776None   T12P, K14R, G16E, L19I, K20KR, L63H, H69K, V75VI, V77I, L89M, I93LC
 CP076302636CP076302636HQ994783None  L10LFP1PS, T4TI, P9PL, T12S, I15V, L19I, E35D, M36I, R41K, L63H, H69K, I72IV, L89LM, I93LC
 CP076302691CP076302691HQ994830None   L19I, E35D, R41K, L63H, H69K, L89M, I93L, F99FLC
 CP076302730CP076302730HQ994866None   I15V, L19I, E35D, M36I, R41RK, L63H, H69K, L89M, I93LC
Manasa (2011)10018901001890JN664993None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 10053711005371JN665023None   L10M, T12S, I15V, L19I, M36I, N37A, R41K, R57K, L63H, H69K, L89M, I93LC
 10089731008973JN665027None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 10091621009162JN665034None   T12S, I15V, L19V, M36I, R41K, L63H, H69Q, V82I, I93LC
Ng (2011)FREE125FREE125HQ539035None   T12P, K14R, I15V, G16E, L19M, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
Parboosing (2011)Pat010HRS205HQ844616None   T12P, I15V, G16E, L19I, N37S, L63H, H69K, V77I, V82I, L89IM, I93LC
Sigaloff (2011)GP25416072GP25416072_1JN381561None   I15V, G16E, L19I, N37NHPT, P39PS, R41K, K45R, L63H, H69K, I72V, V77I, I93LC
Thorat (2011)Pat015IN-NARI-HIVDR-5-015HQ166853None   T12S, I15V, L19I, M36I, R41K, Q61H, L63H, H69K, P79A, L89M, I93LC
van Zyl (2011)A290A290JN638179None   I15V, G16E, L19I, M36I, R41K, L63H, H69K, I72V, I93LC
 A367A367JN638208None   T12S, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89I, I93LC
Wright (2011)AS1-0703B2AS1-0703B2HQ696792None   T12S, I15V, G16E, L19I, K20R, M36I, P39T, R41K, D60E, I62V, L63H, H69K, V82I, L89M, I93LC
 AS2-0110B2AS2-0110B2HQ696798None   I13V, G16E, L19T, K20R, E35D, M36I, R41I, L63H, H69K, K70R, L89I, I93LC
 G_004G_004HQ696827None   T12S, I15V, L19I, M36I, N37D, R41K, L63H, H69K, I93LC
 AS1-0703B7AS1-0703B7HQ696851None   T12S, I15V, G16E, L19I, K20R, M36I, P39S, R41K, D60E, I62V, L63H, H69K, V82I, L89M, I93LC
Zeng (2011)K54K54JF505512None   T12S, I15V, L19I, M36I, N37D, R41K, D60E, L63H, H69K, L89M, I93LC
Chen (2012)YN09DH0161YN09DH0161JQ658618None   K14R, I15V, L19I, M36I, R41K, I62V, L63H, H69K, L89M, I93LC
De Gascun (2012)IRL21211IRL21211JN622869None   T12S, L19IT, M36MI, R41K, I62V, L63H, H69K, T74TA, V77VIM, L89M, I93LC
 IRL31217IRL31217JN622876None   I15IV, L19I, N37NDGS, L38LM, R41RK, I62V, L63H, H69K, I72V, V77VIM, L89M, I93LC
Hingankar (2012)IN-NARI-4-102IN-NARI-4-102JN314977None   T12P, I15V, G16E, L19I, M36V, R41K, L63H, H69K, L89IM, I93LC
 IN-NARI-4-103IN-NARI-4-103JN314978None   T12PS, I15V, G16E, L19I, M36V, R41K, L63H, H69K, L89M, I93LC
Hunt (2012)GP06_194507GP06_194507KF736557None   T12S, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 GP07_218182GP07_218182KF736582None   T12S, L19I, K20R, M36I, R41K, L63H, H69K, L89M, I93LC
 GP08_0391GP08_0391KF736649None   T12P, I15V, L19I, E35D, M36I, R41K, I62V, L63H, H69K, A71T, L89LM, I93LC
 GP08_1046GP08_1046KF736658None   T12S, I15V, L19I, E35D, M36I, N37S, R41K, L63H, H69K, I72V, L89M, I93LC
Manak (2012)25_LH0225_LH02JN687649None   T12S, I15V, L19V, M36I, R41K, D60E, L63H, H69K, L89I, I93LC
Bila (2013)MZBEI16HIV-1KF927405None   T12P, I15V, L19I, M36I, R41K, R57K, L63H, H69K, L89M, I93LC
 MZ10-161HIV-1KF927266None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 MzBei280HIV-1KF927370None   T12S, I15V, L19I, M36I, N37H, R41K, L63H, H69K, L89M, I93LC
Frentz (2013)EHR-33919EHR-33919JX300115None   T12S, I15V, G16E, L19I, K20R, M36I, R41K, R57K, L63H, H69K, L89I, I93LC
Han (2013)LC017ILC017IJX070483None   T12S, K14R, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
Hawke (2013)2991463 H2991463 HKC238110None   L19I, K20M, M36I, N37T, R41K, R57K, L63H, H69K, I93LC
 2991464 H2991464 HKC238111None   G16GE, L19IT, K20M, M36I, N37NT, R41RK, R57K, L63H, I64IV, H69KQ, I72IT, I93LC
Kiptoo (2013)KTL195KTL195KC517051None   T12S, I15V, L19I, M36I, R41K, K43KE, L63H, H69K, L89M, I93LC
Mulu (2013)ETH-G-5490ETH-G-5490KF026067None   T12S, I15V, L19T, K20R, M36I, R41K, K43R, Q61H, I62V, L63H, H69K, K70Q, L89M, I93LC
 ETH-G-5569ETH-G-5569KF026211None   I15V, L19I, M36I, R41K, L63H, H69K, L89I, I93LC
 ETH-G-5604ETH-G-5604KF026135None   T12P, K14R, I15V, G16E, M36I, R41K, L63H, H69Q, L89I, I93LC
 ETH-G-5545ETH-G-5545KF026105None   T12P, I13V, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
Van Zyl (2013)881161KC422926None   G16E, E35D, M36I, R41K, K45R, D60E, L63H, H69K, L89M, I93LC
 11081767KC423390None   I15V, L19I, M36I, N37D, R41K, L63H, H69K, I72V, V82I, I93LC
 1811323KC423058None   T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 1232899KC423882None   L10V, T12S, K14R, I15V, G16E, L19T, K20R, M36I, R41K, L63H, H69K, L89M, I93LC
 2101894KC423493None   L10M, T12E, I15V, L19T, K20I, M36I, R41K, Q61H, L63H, H69K, L89M, I93LC
 160499KC424097None   T12S, I15V, G16E, L19I, K20R, M36L, R41K, D60E, L63H, H69K, K70R, L89I, I93LC
 22965KC423909None   L10I, I13V, G16E, L19I, M36I, R41K, L63H, H69Q, I93LC
 14352732KC423803None   T12S, I15V, L19I, R41K, L63H, H69K, V77I, V82I, L89M, I93LC
 111622KC423277None   T12S, I13V, G16E, L19T, K20L, M36I, L63H, H69K, L89M, I93LC
 3911249KC422998None   T12S, I15V, G16E, L19I, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
 582106KC423622None   I15V, L19V, M36I, R41K, L63H, H69K, I93LC
 8351603KC423265None   T12S, I15V, G16E, L19I, E35D, M36I, R41K, K45R, R57K, L63H, H69K, I72V, L89M, I93LC
 610106KC422845None   T12P, I15V, G16E, L19V, M36I, R41K, L63H, H69K, L89I, I93LC
Steegen (2014)10ZAKS04510ZAKS045KJ176327None   R41K, L63H, H69K, L89M, I93LC
 11ZAKS13211ZAKS132KJ176414None   R41K, L63H, H69K, V77VI, L89I, I93LC