Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L63H
Rx	PI-naive
IncludeMixtures	No

References	58
Patients	119
Isolates	119

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Pieniazek (1998)	LE-15	LE15	AF025727	None		I15V, G16E, L23S, M36I, R41K, L63H, H69K, L89M	C
Novitsky (2002)	99BW4754	99BW4754	AF443086	None		T12S, I15V, L19I, E35D, M36I, R41K, L63H, H69K, K70R, L89M, I93L	C
Yang (2002)	DH020	DH020	AB078716	None		T12S, K14R, I15V, L19I, M36I, R41K, L63H, H69K, I93L	C
Gordon (2003)	ZA037p01	ZA037p01	AY136990	None		T12S, K14R, I15V, L19T, M36I, R41K, L63H, H69K, I93L	C
Jorgensen (2003)	JLB_Pat61	HIM419487	AJ419487	None		I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
Maljkovic (2003)	MI_Pat75	99SE17921	AY165220	None		K14R, I15V, L19I, E35ED, N37S, R41RK, L63H, H69K, L89M, I93IL	C
Deshpande (2004)	in23	in23	AY515747	None		T12S, L19I, K20R, M36I, R41K, L63H, H69K, K70R, L89M, I93L	C
Aulicino (2005)	ARE195FL	ARE195FL	AY968312	None		L5V, K14R, I15V, G16E, N37K, R41N, L63H, H69K, L89M, I93L	C
Balakrishnan (2005)	YRG6	YRG6	AY787492	None		T12P, I15V, G16E, L19I, M36I, N37S, R41K, L63H, H69K, P79PS, L89M, I93L	C
Bellocchi (2005)	859	MT000859	GU199534	None		T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63H, H69K, K70Q, L89M, I93L	C
Brown (2005)	BB_02ET_288	02ET_288	AY713417	None		K14R, M36I, R41K, L63H, H69K, I93L	C
Bussmann (2005)	01BW3381N	01BW3381N	AY829317	None		T12S, I15V, L19I, M36I, N37S, R41K, L63H, H69K, L89M, I93L	C
	01BW386S	01BW386S	AY829276	None		T12Q, I15V, L19I, E35D, M36I, R41K, L63H, H69K, L89M, I93L	C
Eshleman (2005)	ESH7044	ESH7044	AY756866	None		T12S, G16E, L19I, E35ED, M36I, R41K, Q61H, L63H, H69K, L89M, I93L	C
Grossman (2005)	19868	19868PR181		None		I15V, Q18HY, L19I, R41K, L63H, H69K, I93L	C
	19869	19869PR182		None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93L	C
Petch (2005)	LP06	MAL-06PR	AY860458	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89LM, I93L	C
Tovanabutra (2005)	98US_MSC3018	98US_3018	AY444800	None		T12S, I15V, G16E, L19I, M36I, L63H, H69K, L89M, I93L	C
Parreira (2006)	PG216	PG216	AM071422	None	N83D	I3T, I15V, L19I, E35D, N37S, R41K, I62V, L63H, H69K, K70Q, V77I, L89M, I93L	C
	PG217	PG217	AM071447	None		I15V, L19I, N37S, R41K, I62V, L63H, H69K, K70Q, V77I, L89M, I93L	C
	PG196	PG196	AM071452	None		T12S, I15V, L19I, M36I, N37S, R41K, Q61H, L63H, H69K, L89M, I93L, T96A	C
Razafindratsimandresy (2006)	RR_MAD-MO105	MAD-MO105	DQ345031	None		T12S, I15V, L19I, K20R, M36I, R41K, Q61H, L63H, H69K, K70Q, V77I, L89M, I93L	C
Rodrigues (2006)	BR04RS97	BR04RS97	DQ070538	None		I15V, G16A, M36I, N37K, R41N, K45R, L63H, H69K	C
Rousseau (2006)	Pt75	03PS143MB1	DQ396391	None		T12S, I15V, L19V, M36I, R41K, L63H, H69K, L89M, I93L	C
	Pt110	03SK078B1	AY901971	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93L	C
	Pt119	03SK103B1	DQ164106	None		T12S, I15V, L19I, M36I, R41K, D60N, L63H, H69K, I93L	C
Church (2007)	7044	7044	EF602614	None		T12S, G16E, L19I, E35ED, M36I, R41K, Q61H, L63H, H69K, L89M, I93L	C
Han (2007)	LN51	03CNLN51	EF122531	None		T12S, I15V, G16E, L19I, M36I, N37D, R41K, D60E, L63H, H69K, L89M, I93L	C
Kassu (2007)	ETH-G-001	G-001	AB285752	None		K14R, I15V, L19I, M36I, N37D, R41K, I62V, L63H, H69K, V82I, L89M, I93L	C
	ETH-G-046	G-046	AB285772	None		I13V, I15IV, G16E, M36I, R41K, L63H, H69K, I93L	C
Vidal (2007)	U0727	02BU.U0727	AM260291	None		T12S, I15V, G16E, N37K, R41N, L63H, H69K, I72L, V82I, L89I, I93L	C
	U0808	02BU.U0808	AM260294	None		T12S, I15V, G16E, L19I, K20R, M36I, N37K, R41N, R57K, L63H, H69K, K70R, L89I, I93L	C
	U1005	02BU.U1005	AM260302	None		T12S, K14R, G16E, L19I, K20R, D25X, M36I, N37K, P39S, R41N, L63H, H69K, L89I, I93L	C
Chang (2008)	TW5191a	TW5191a		None		L10P, T12S, L19I, R41K, L63H, H69K, L89M, I93L	C
	TW5192a	TW5192a		None		T12S, L19I, T31S, R41K, L63H, H69K, K70R, L89M, I93L	C
Ferreira (2008)	626	BR06PR626	EU340744	None		T12P, I15V, G16E, E35D, N37K, R41H, L63H, I64V, H69K, V82I, I93L	C
Jacobs (2008)	1771	1771	EF602211	None		T12P, I15V, L19I, N37S, R41K, K45R, L63H, H69K, V77I, L89M, I93L	C
Matthews (2008)	SK078	SK078	FJ199882	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93L	C
	SK103	SK103	FJ199893	None		T12S, I15V, L19I, M36I, R41K, D60N, L63H, H69K, I93L	C
Nyombi (2008)	TMS128	TMS128	EU251826	None		L19T, M36I, R41K, L63H, H69K, I93L	C
Bartolo (2009)	CSE129	01AOCSE129	EU068336	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
Kandathil (2009)	VL05_146	VL05_146	EU110061	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
	VL05_173	VL05_173	EU110066	None		T12P, I13V, I15V, G16E, Q18X, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
	VL07_060	VL07_060	EU110081	None		I15V, L19T, D25X, M36I, R41K, L63H, H69K, I72T, L89M, I93L	C
Kousiappa (2009)	CY175	CY175	EU673406	None		T12S, I15V, L19I, M36I, N37D, L63H, H69K, L89M, I93L	C
	CY176	CY176	EU673407	None		T12S, I15V, L19I, M36I, N37D, L63H, H69K, L89M, I93L	C
Rajesh (2009)	N34	TRCNPR34	FJ595397	None		T12P, K14R, I15V, G16E, M36I, R41K, L63H, H69K, L89M, I93L	C
	N57	TRCNPR57	FJ595420	None		T12S, I15V, G16E, L19I, M36I, R41K, L63H, H69K, L89IM, I93L	C
	N21	TRCNPR21	FJ595384	None		T12S, I15V, G16E, L19I, M36V, R41K, I62V, L63H, I64M, H69K, V82I, L89M, I93L	C
	N86	TRCNPR86	FJ595449	None		T12P, K14R, I15V, G16E, M36I, R41K, L63H, H69K, L89M, I93L	C
	F11	TRCFPR11	FJ595473	None		T12S, I15V, G16E, L19I, M36I, R41K, L63H, H69K, L89I, I93L	C
Vercauteren (2009)	pt1527	4104583469	GQ399497	None		L10LV, I15V, L19I, M36I, R41K, L63H, C67CY, H69K, L89M, I93L	C
	pt881	7924235985	GQ400143	None		T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63H, H69K, L89M, I93L	C
Gonzalez (2010)	LV3	LV3	GQ433859	None		T12S, I15V, L19I, M36I, R41K, Q61H, L63H, H69K, K70Q, L89M, I93L	C
Hamers (2010)	300136	CP076300136	HM119712	None		T12S, I15V, G16E, L19I, R41K, L63H, H69K, A71T, L89I, I93L	C
	300169	CP076300169	HM119742	None		T12S, I15V, L19I, M36I, N37S, R41K, Q61N, L63H, H69K, L89M, I93L	C
	300451	CP076300451	HM119872	None		L10I, T12S, I15V, L19I, M36I, R41K, I62IV, L63H, H69K, L89I	C
	300474	CP076300474	HM119893	None		T12S, K14R, I15V, G16E, L19I, K20R, M36I, R41K, K45KR, I62IV, L63H, H69K, I72IT, L89I, I93L	C
	300529	CP076300529	HM119945	None		T12S, K14R, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89M, I93L	C
	300558	CP076300558	HM119967	None		T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63H, H69K, L89M, I93L	C
	300672	CP076300672	HM120063	None		I15V, L19T, R41K, L63H, H69K, V77I, L89LM, I93L	C
	300692	CP076300692	HM120077	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, I72IM, L89M, I93L	C
Papathanasopoulos (2010)	17409	07ZA17409	GU253422	None		T12S, I15V, G16E, L19I, N37S, L63H, H69K, L89M, I93L	C
Rodrigues (2010)	346_07	BR07SC346	GQ401328	None		I15V, M36I, N37K, R41N, I62V, L63H, H69K, L89M, I93L	C
Wright (2010)	103	SK103	HM593110	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93L	C
	333	SK333	HM593338	None		T12PS, I15V, L19T, E35D, M36I, R41K, W42W*, L63H, G68GE, H69K, L89M, I93L	C
	431	SK431	HM593441	None		T12S, I15V, L19V, E35D, M36I, R41K, K45R, L63H, H69K, L89M, I93L	C
	45	SK45	HM593460	None		T12S, I15V, G16E, L19I, R41K, D60E, L63H, H69K, L89M, I93L	C
	78	SK78	HM593492	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, I93L	C
Bussmann (2011)	B0757	B0757	JQ617030	None		I15V, G16E, L19IT, K20R, M36I, R41K, L63H, H69K, I72V, V77I, V82VI, L89M, I93L	C
	B0552	B0552	JQ617047	None		K14KE, I15V, L19I, E35D, M36I, I62V, L63H, H69K, K70E, A71V, L89M, I93L	C
	B0557	B0557	JQ617051	None		I15V, G16E, L19I, N37S, R41K, L63H, H69K, V77VI, I93L	C
	B0586	B0586	JQ617079	None		G16A, E35D, R41K, L63H, H69K, I72M, L89M, I93L	C
	B0587	B0587	JQ617080	None		I15V, L19I, M36I, N37S, R41K, L63H, H69K, I93L	C
Deshpande (2011)	Pat043	in1131	JF414427	None		T12S, L19I, M36I, R41K, W42WR, K43R, L63H, H69K, L89M, I93L	C
	Pat029	in1109	JF414441	None		T12P, I15V, G16E, L19I, K20R, M36I, R41K, R57RK, L63H, H69K, V82I, L89M, I93L	C
	Pat005	in1031	JF414465	None		T12S, L19I, M36I, R41K, L63H, H69K, K70KR, V82I, L89M, I93L	C
Ferreira (2011)	BRMT2564	BRMT2564	HQ638713	None		T12A, I15V, G16E, M36T, N37K, R41N, L63H, H69K, L89I, I93L	C
Graf (2011)	SC96	SC96	JF774035	None		T12A, I13V, I15V, G16E, M36I, N37K, R41N, L63H, H69K, L89M, I93L	C
Hamers (2011)	CP076303209	CP076303209	HQ994218	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
	CP076303217	CP076303217	HQ994225	None		I15V, L19M, K20R, M36I, R41K, K45KR, I62IV, L63H, H69K, L89I, I93L	C
	CP076305108	CP076305108	HQ994332	None		T12S, I13V, I15V, L19I, K20R, M36I, N37D, R41K, L63H, H69K, L89M, I93L	C
	CP076305115	CP076305115	HQ994338	None		T12S, I13V, I15V, L19I, K20R, M36I, N37D, R41K, L63H, H69K, L89M, I93L	C
	CP076300396	CP076300396	HQ994400	None		T12S, I15V, G16E, L19I, M36I, R41K, R57K, L63H, H69K, V82I, L89I, I93L	C
	CP076302111	CP076302111	HQ994484	None		T12S, I15V, L19T, M36I, R41K, L63H, H69K, V82VI, L89M, I93L	C
	CP076302141	CP076302141	HQ994507	None		I15V, L19I, M36I, R41K, I62V, L63H, H69K, I93L	C
	CP076301048	CP076301048	HQ994580	None		L10V, T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63H, H69K, L89M, I93L	C
	CP076300943	CP076300943	HQ994719	None		T12S, I15V, G16E, L19I, M36L, R41K, L63H, H69K, L89I, I93L	C
	CP076300949	CP076300949	HQ994724	None		T12P, K14R, I15V, G16E, L19LI, M36I, R41K, L63H, H69K, L89M, I93L	C
	CP076301058	CP076301058	HQ994776	None		T12P, K14R, G16E, L19I, K20KR, L63H, H69K, V75VI, V77I, L89M, I93L	C
	CP076302636	CP076302636	HQ994783	None	L10LF	P1PS, T4TI, P9PL, T12S, I15V, L19I, E35D, M36I, R41K, L63H, H69K, I72IV, L89LM, I93L	C
	CP076302691	CP076302691	HQ994830	None		L19I, E35D, R41K, L63H, H69K, L89M, I93L, F99FL	C
	CP076302730	CP076302730	HQ994866	None		I15V, L19I, E35D, M36I, R41RK, L63H, H69K, L89M, I93L	C
Kousiappa (2011)	CY205	CY205	JF683757	None		I15V, M36I, N37D, R57RK, L63H, I64M, H69K, I72V, L89M, I93L	C
	CY227	CY227	JF683776	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
	CY228	CY228	JF683777	None		T12S, I15V, L19I, M36I, N37ND, R41RK, L63H, H69K, L89M, I93L	C
Manasa (2011)	1001890	1001890	JN664993	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
	1005371	1005371	JN665023	None		L10M, T12S, I15V, L19I, M36I, N37A, R41K, R57K, L63H, H69K, L89M, I93L	C
	1008973	1008973	JN665027	None		T12S, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93L	C
	1009162	1009162	JN665034	None		T12S, I15V, L19V, M36I, R41K, L63H, H69Q, V82I, I93L	C
Ng (2011)	FREE125	FREE125	HQ539035	None		T12P, K14R, I15V, G16E, L19M, M36I, R41K, L63H, H69K, K70R, L89M, I93L	C
Parboosing (2011)	Pat010	HRS205	HQ844616	None		T12P, I15V, G16E, L19I, N37S, L63H, H69K, V77I, V82I, L89IM, I93L	C
Sigaloff (2011)	GP25416072	GP25416072_1	JN381561	None		I15V, G16E, L19I, N37NHPT, P39PS, R41K, K45R, L63H, H69K, I72V, V77I, I93L	C
Thorat (2011)	Pat015	IN-NARI-HIVDR-5-015	HQ166853	None		T12S, I15V, L19I, M36I, R41K, Q61H, L63H, H69K, P79A, L89M, I93L	C
van Zyl (2011)	A290	A290	JN638179	None		I15V, G16E, L19I, M36I, R41K, L63H, H69K, I72V, I93L	C
	A367	A367	JN638208	None		T12S, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89I, I93L	C
Wright (2011)	AS1-0703B2	AS1-0703B2	HQ696792	None		T12S, I15V, G16E, L19I, K20R, M36I, P39T, R41K, D60E, I62V, L63H, H69K, V82I, L89M, I93L	C
	AS2-0110B2	AS2-0110B2	HQ696798	None		I13V, G16E, L19T, K20R, E35D, M36I, R41I, L63H, H69K, K70R, L89I, I93L	C
	G_004	G_004	HQ696827	None		T12S, I15V, L19I, M36I, N37D, R41K, L63H, H69K, I93L	C
	AS1-0703B7	AS1-0703B7	HQ696851	None		T12S, I15V, G16E, L19I, K20R, M36I, P39S, R41K, D60E, I62V, L63H, H69K, V82I, L89M, I93L	C
Zeng (2011)	K54	K54	JF505512	None		T12S, I15V, L19I, M36I, N37D, R41K, D60E, L63H, H69K, L89M, I93L	C
Chen (2012)	YN09DH0161	YN09DH0161	JQ658618	None		K14R, I15V, L19I, M36I, R41K, I62V, L63H, H69K, L89M, I93L	C
De Gascun (2012)	IRL21211	IRL21211	JN622869	None		T12S, L19IT, M36MI, R41K, I62V, L63H, H69K, T74TA, V77VIM, L89M, I93L	C
	IRL31217	IRL31217	JN622876	None		I15IV, L19I, N37NDGS, L38LM, R41RK, I62V, L63H, H69K, I72V, V77VIM, L89M, I93L	C
Hingankar (2012)	IN-NARI-4-102	IN-NARI-4-102	JN314977	None		T12P, I15V, G16E, L19I, M36V, R41K, L63H, H69K, L89IM, I93L	C
	IN-NARI-4-103	IN-NARI-4-103	JN314978	None		T12PS, I15V, G16E, L19I, M36V, R41K, L63H, H69K, L89M, I93L	C
Frentz (2013)	EHR-33919	EHR-33919	JX300115	None		T12S, I15V, G16E, L19I, K20R, M36I, R41K, R57K, L63H, H69K, L89I, I93L	C
Hawke (2013)	2991463 H	2991463 H	KC238110	None		L19I, K20M, M36I, N37T, R41K, R57K, L63H, H69K, I93L	C
	2991464 H	2991464 H	KC238111	None		G16GE, L19IT, K20M, M36I, N37NT, R41RK, R57K, L63H, I64IV, H69KQ, I72IT, I93L	C

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