<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63H
Rx >= 1 PI
IncludeMixtures No
References 9
Patients 40
Isolates 42
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)UK186bUK186bAY900763SQV, RTV183I84V, L90MV11VI, G73GSL10I, I15V, G16E, L19I, R41K, L63H, H69K, A71V, V77I, I93LC
 UK598UK598AY900779IDV97L90M T12S, I15V, G16E, L19I, M36I, R41K, K45R, L63H, H69K, L89I, I93LC
 PL5249699430 IDV191  T12S, I15V, L19I, E35D, M36I, R41K, D60E, L63H, H69K, L89M, I93LC
Waleria-Aleixo (2008)RES185RES185FJ591922PINAM46L, I54V, V82AL24IQ2QR, L10V, I15V, G16E, K20R, E35D, M36I, N37E, R41K, K55KR, L63H, H69K, T74S, I85V, L89I, I93LC
Van Zyl (2013)391412.ZA.GT2217KC423889LPV M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 45011.ZA.WC191KC423708LPV  V11IT12S, I15V, G16E, L19I, R41K, K55R, D60E, L63H, H69K, V77I, L89I, I93LC
 74512.ZA.WC220KC423913LPV   T12A, I13V, I15V, G16E, L19I, K20R, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
 54811.ZA.EC064KC423577LPV M46L, I54V, L76V, V82AL10FI15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, L89I, I93LC
 438108.ZA.GT617KC424191LPV   T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61QHKN, L63H, H69K, L89M, I93LC
 40409.ZA.WC038KC424312LPV   T12S, I15V, G16E, L19I, N37S, L63H, H69K, V77I, I93ILC
 41712.ZA.EC172KC423811LPV   L5X, T12S, I15V, L19I, M36I, N37D, L63H, H69K, L89I, I93LC
 296110.ZA.GT1445KC423234LPV M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63H, H69K, A71V, I72IM, L89M, I93LC
Steegen (2014)11ZAKS08611ZAKS086KJ176368LPV   R41K, L63H, H69K, L89M, I93LC
 09ZAKS00209ZAKS002KJ176286LPV   R41K, L63H, H69K, L89M, I93LC
 10ZAKS06910ZAKS069KJ176351LPV   R41K, I62V, L63H, H69K, A71T, I93LC
 10ZAKS04310ZAKS043KJ176325LPV   R41K, L63H, H69K, L89M, I93LC
 12ZAKS26712ZAKS267KJ176546LPV   R41N, I62V, L63H, H69K, I72IV, V82I, L89I, I93LC
 12ZAKS34812ZAKS348KJ176627LPV M46L R41K, L63H, H69K, L89M, I93LC
Diaz (2015)RenG17457RenG17457KT748485PINA  T12TA, K14R, I15V, G16E, M36I, N37K, R41N, R57K, L63H, H69K, L89I, I93LC
 RenG15962RenG15962KT746990PINAI54V, V82AL10FV, L24II15IV, G16E, K20R, E35D, M36I, N37E, R41N, K43R, K45V, R57K, Q58R, L63H, I66V, H69K, L89I, I93LC
 RenG14917RenG14917KT745945PINAM46I, I47A, L90ML10FI15V, G16E, L19P, K20I, N37K, R41N, F53Y, D60E, Q61HN, L63H, H69K, V77I, I85V, L89I, I93LC
 RenG15384RenG15384KT746412PINA  T12P, K14R, I15V, G16E, M36L, N37K, R41N, D60DE, L63H, H69K, L89IM, I93LC
 RenG14023RenG14023KT745051PINA  T4TI, T12P, K14R, I15V, G16E, M36L, N37K, R41N, L63H, H69K, V82VI, L89IM, I93LC
 RenG15285RenG15285KT746313PINA  I15IV, G16E, M36I, N37K, R41N, L63H, H69K, L89I, I93LC
 RenG14927RenG14927KT745955PINAL90M I15V, G16E, L19I, K20T, N37K, R41H, K45R, L63H, H69K, V82I, I85V, L89LIM, I93LC
 RenG11849RenG11849KT742877PINA  I15V, M36I, N37K, R41N, K45R, L63H, H69K, L89M, I93LC
 RenG13056RenG13056KT744084PINA  K14R, I15V, G16E, M36T, N37K, R41N, R57K, L63H, H69K, L89I, I93LC
 RenG12987RenG12987KT744015PINA  T12A, K14R, I15V, G16E, N37KR, R41N, I62IV, L63H, I64L, H69K, L89I, I93LC
Chimukangara (2016)NC12NC12KU508554RTV, ATV21  T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, I62V, L63H, H69K, A71T, I93LC
Neogi (2016)715413.ZA.WC355KT592930LPV   T12Q, I15V, L19I, M36I, R41K, Q61N, L63H, H69K, K70Q, I72M, I93LC
 67013.ZA.EC722KT592865LPV M46I, I54V, V82A L10V, T12S, I15V, G16E, L19I, K20I, M36I, R41K, L63H, H69K, L89M, I93LC
 310513.ZA.GT3120KT593367LPV   T12S, K14R, L19I, M36I, R41K, D60E, L63H, H69K, L89M, I93L, C95CYC
 28013.ZA.NL075KT593448LPV   L10I, T12S, I15V, L19V, M36I, R41K, L63H, H69K, L89M, I93LC
Steegen (2016)GFGPB095GFGPB095KU127764LPV317  T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63H, H69K, L89I, I93LC
Posada Cespedes (2017)454815.ZA.WC597 LPV   T12S, K14R, I15V, L19I, M36I, R41K, L63H, H69K, L89M, I93LC
 32412.ZA.WC278KX542541LPV M46IL I15V, L19I, M36I, R41K, D60E, Q61E, L63H, H69K, L89M, I93LC
 120714.ZA.EC1061KX543698LPV   I15V, L19T, M36I, R41K, I62V, L63H, H69K, I93LC
 244614.ZA.GT3598 LPV   T12S, I15V, L19I, M36I, R41K, Q61H, L63H, H69K, L89M, I93LC
 296111.ZA.GT1507 LPV M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, A71V, I72IM, L89M, I93LC
 45113.ZA.WC284KX543554LPV   T12S, I15V, G16E, L19I, K20R, L23LF, M36I, R41K, L63H, H69K, V77I, L89I, I93LC
  14.ZA.WC407 LPV   T12S, I15V, G16E, L19I, K20R, M36I, R41K, L63H, H69K, V77I, L89I, I93LC
 304612.ZA.GT2494KX542307LPV M46MI, L76LV, V82ACGS T12S, I15V, G16E, L19I, K20KT, E35D, M36I, R41K, K45R, R57K, L63H, H69K, I72V, L89I, I93LC