<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63C
Rx PI-naive
IncludeMixtures No
References 26
Patients 63
Isolates 65
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)UK740UK740AY900782None   T12S, L19I, M36I, P39Q, R41K, I62V, L63C, H69K, A71T, I72V, I93LC
Kassu (2007)ETH-G-068G-068AB285779None   L10V, I15V, G16E, K20KR, M36I, N37T, P39S, L63C, H69K, L89MC
Martinson (2007)KEH161BKEH161BEU152443None   T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63C, H69K, T74S, L89M, I93LC
 KEH161MKEH161MEU152444None   T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63C, H69K, T74S, V82VI, L89M, I93LC
Huang (2009)Blm_x1118Blm_x1118KT737198None   T12S, I15V, L19I, K20R, E35N, M36I, N37D, R41K, L63C, H69K, I93LC
Wallis (2009)22816722281672 None   L10LI, I13V, L19V, M36I, R41K, L63C, I64M, H69K, L89M, I93LC
 TJC2393652TJC2393652 None   L10LI, I13IV, L19IV, M36I, R41K, R57RK, L63C, I64M, H69K, L89M, I93LC
 TJC2413549TJC2413549 None   T12S, I15V, L19I, M36I, N37D, R41K, I62IV, L63C, H69K, A71T, I93LC
 23622102362210 None   I15V, G16E, L19I, E35D, M36I, N37D, D60E, L63C, H69K, L89M, I93LC
 TJC2388289TJC2388289 None   T12S, I15V, G16E, L19I, M36I, R41K, D60E, Q61E, L63C, H69K, L89IM, I93LC
Gonzalez (2010)LUC8LUC8GQ433849None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63C, H69K, V82I, L89M, I93LC
Wright (2010)297SK297HM593300None   T12S, I15V, Q18E, L19I, K20R, E35D, M36I, R41K, L63C, H69K, L89M, I93LC
 387SK387HM593393None   L10LI, I15IV, L19AITV, M36I, R41K, D60E, I62IV, L63C, E65ED, H69K, L89LM, I93LC
Hamers (2011)300104CP076300104HM119682None   T12S, I15V, G17D, L19I, K20R, E35D, M36I, R41K, L63C, H69K, T74S, L89M, I93LC
 300132CP076300132HM119708None   K14R, I15V, L19I, M36I, R41K, R57RK, L63C, H69K, I93LC
 300632CP076300632HM120029None   T12S, I15V, L19I, E35D, M36I, R41K, L63C, H69K, T74A, L89MC
 CP076300310CP076300310HQ994358None   L10V, T12S, L19I, R41K, L63C, H69K, T74S, V77I, L89MC
 CP076300993CP076300993HQ994562None   T12S, I15V, G16A, L19I, M36I, R41K, D60E, Q61E, L63C, H69K, L89M, I93LC
 CP076301066CP076301066HQ994590None   I15V, E35D, M36I, R41K, I62IV, L63C, H69K, T74SC
 CP763A03401CP763A03401HQ994659None   K14KN, I15IV, G16GE, L19I, M36I, L63C, H69K, L89M, I93LC
Nwobegahay (2011)08MB09ZA08MB09ZAGU188812None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63C, H69K, T74S, L89M, I93LC
van Zyl (2011)A183A183JN638108None   K14R, I15V, L19I, E35D, M36I, R41K, L63C, H69K, I93LC
Wright (2011)AS2-1325B2AS2-1325B2HQ696817None   T12S, I15V, G16E, L19I, M36I, R41K, L63C, H69K, L89M, I93LC
De Gascun (2012)IRL26145IRL26145JN622955None   T12S, I15V, L19I, M36I, R41K, L63C, H69Q, L89M, I93LC
 IRL55706IRL55706JN623024None   T12S, K14I, I15V, G16E, L19IV, E35D, M36I, R41K, K45R, D60E, L63C, H69K, L89M, I93LC
 IRL62145IRL62145JN623030None   T12S, K14I, I15V, G16E, L19I, E35D, M36I, R41RK, D60E, L63C, H69K, L89M, I93LC
Hunt (2012)GP09_0041GP09_0041KF736711None   T12S, I15V, G16E, L19I, E35D, M36I, R41K, R57K, L63C, H69K, T74S, I93LC
Ndase (2012)5204062252040622KC900739None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63C, H69K, T74A, L89M, I93LC
Nwobegahay (2012)BBCR38ZABBCR38ZAGU177484None   T12S, I15K, L19I, K20R, M36I, N37D, R41K, L63C, H69K, I93LC
Bila (2013)MZ09-083HIV-1KF927221None   T12S, I15V, L19I, E35D, M36I, R41K, D60E, L63C, H69K, L89M, I93LC
 MZ10-208HIV-1KF927307None   I15V, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, L63C, H69K, I93LC
 MZ10-191HIV-1KF927291None   T12S, L19I, K20R, M36I, N37S, R41K, L63C, H69K, L89M, I93LC
 MZ10-199HIV-1KF927299None   T12A, L19I, M36I, R41K, L63C, H69K, I93LC
Manasa (2013)RES366RES366KC951819None   T12S, I15V, L19I, M36I, N37S, R41K, L63C, H69K, I93LC
 RES024RES024KC951648None   I15V, K20R, E35N, M36I, N37ND, R41K, Q61QH, L63C, H69K, L89M, I93LC
Masimba (2013)TZ.HLM.020TZ.HLM.020KC537242None   T12S, I15V, L19I, M36I, R41K, L63C, I64L, H69K, L89MC
Rusine (2013)735H735HKC841756None   T12S, I15V, L19I, K20R, M36I, N37R, R41N, L63C, H69K, L89M, I93LC
 404H404HKC841663None   T12S, I15V, L19I, M36I, R41K, L63C, H69K, T74A, L89MC
Theys (2013)104770104770 None   I15V, L19I, M36I, R41K, D60E, Q61E, L63C, H69K, I93LC
Van Zyl (2013)O1129247KC423726None   T12S, I15V, G16E, L19I, M36I, R41K, D60E, L63C, H69K, I72V, L89I, I93LC
 294109.ZA.GT947KC422802None   T12S, I15V, G16E, L19I, M36L, R41K, L63C, H69K, V82I, L89M, I93LC
 363609.ZA.GT772KC424286None   K14N, I15V, G16E, L19I, K20R, M36I, N37NS, R41K, Q61E, L63C, H69K, L89M, I93LC
 404011.ZA.GT1808KC423598None   I15V, G16E, L19I, R41K, D60E, Q61K, L63C, I64L, H69K, I72M, L89M, I93LC
 377411.ZA.GT1531KC423314None   T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63C, H69K, T74S, L89M, I93LC
 299408.ZA.GT545KC423865None   T12S, I15V, G16E, L19I, K20R, M36I, P39S, D60E, Q61E, L63C, H69K, V82I, L89M, I93LC
 158108.ZA.GT550KC423890None   T12S, I15V, G16E, L19I, E35D, M36I, R41K, D60E, L63C, H69K, V77I, L89M, I93LC
  08.ZA.GT572KC423982None   T12S, I15V, G16E, L19I, E35D, M36I, R41K, D60E, L63C, H69K, V77I, L89M, I93LC
 5410.ZA.GT1199KC423038None   T12S, I15V, G16E, L19I, R41K, Q61E, L63C, H69K, V77I, I93LC
  10.ZA.GT1270KC423102None   T12S, I15V, G16E, L19I, R41K, Q61E, L63C, H69K, V77I, I93LC
 322112.ZA.GT2350KC423978None   T12S, I15V, L19T, M36I, R41K, D60E, Q61E, L63C, H69K, I93LC
Steegen (2014)11ZAKS12011ZAKS120KJ176402None   R41K, L63C, H69K, V82I, L89M, I93LC
Skhosana (2015)11ZALS01511ZALS015KM115800None   K14R, I15V, L19I, M36T_DV, N37Q, R41K, I47X, L63C, H69K, V77L, L89M, I93LC
 12ZALS14212ZALS142KM115785None   T12S, I15V, Q18E, L19I, K20R, E35D, M36I, R41K, Q61E, L63C, H69K, I93LC
Lam (2016)2002203020022030KR868100None   T12S, I15V, Q18H, L19I, K20R, M36I, R41K, L63C, H69K, I93LC
 2002203220022032KR868049None   T12S, I15V, G16E, L19I, M36I, R41K, L63C, H69K, I93LC
Neogi (2016)183513.ZA.GT2926KT593236None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63C, H69KC
 186613.ZA.GT2908KT593225None   T12S, K14R, I15V, L19I, M36I, R41K, L63C, H69K, V82I, L89M, I93LC
Steegen (2016)GFKZB045GFKZB045KU127897None   T12S, I15V, L19T, K20R, E35D, M36I, R41K, K45R, L63C, H69K, L89M, I93LC
 GFMPB010GFMPB010KU127864None   L10M, T12S, I13V, I15V, L19I, E35D, N37NS, R41K, L63C, H69K, A71T, I93LC
 GFGPB065GFGPB065KU127688None   T12S, I15V, L19I, K20R, E35D, M36I, R41K, D60E, L63C, H69K, K70R, L89M, I93LC
 GFGPB037GFGPB037KU127646None   L19V, K20R, M36I, R41K, Q61E, L63C, H69K, L89M, I93LC
 GFLPB009GFLPB009KU127879None   T4S, T12S, L19V, K20R, E35D, M36I, R41K, L63C, H69K, T74S, L89M, I93LC
 GFMPB050GFMPB050KU127975None   T12S, K14R, I15V, L19I, K20R, E35D, M36I, N37E, R41K, R57K, L63C, I64IM, E65ED, H69KC
 GFGPB078GFGPB078KU127734None   K14KR, L19IM, K20R, E35D, M36I, R41K, L63C, H69K, T74S, L89M, I93LC
 GFKZB228GFKZB228KU128120None   T12S, I13V, G16E, L19I, K20R, M36I, R41K, D60E, L63C, I64L, H69K, L89M, I93LC