<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63A
Rx >= 1 PI
IncludeMixtures No
References 21
Patients 48
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M6M6AY010422SQV   T12S, I15V, G16E, L19Q, M36I, N37R, R41N, Q61N, L63A, H69K, V82I, L89M, I93LC
 NY_M62M62AY010425SQV   T12S, I15V, G16E, L19Q, M36I, N37R, R41N, Q61N, L63A, H69K, V82I, L89M, I93LC
Kantor (2002)TCDD-22TCDD-22AY090849SQV, IDV17  I15V, L19I, M36I, R41K, L63A, H69K, I93LC
Grossman (2004)IL369IL369AY529591NFV111M46I, L90M T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93LC
Montes (2004)MB_patNIB01_NIB710AJ577964NFV94  T12S, I13V, I15V, L19I, M36I, N37K, R41N, Q61E, L63A, I64M, H69K, L89M, I93LC
  01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
Weber (2005)F26249F26249AY677450NFV103 L89MVT12S, L19I, K20KR, M36I, R41K, L63A, H69K, I93LC
 M69708M69708AY677400NFV81  T12S, L19I, K20R, M36I, N37D, R41K, L63A, I64V, H69K, I93LC
Pillay (2008)DR71DR71AY589920RTV43V32VI, V82AM46MVI15IV, G16E, L19I, M36I, R41K, Q61H, L63A, E65D, H69K, I72V, L89M, I93LC
 DR1402ZA.DR14AY589876IDV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
Waleria-Aleixo (2008)08PR06054208PR060542FJ591458PINAL90M T12TP, I13IV, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, I62V, L63A, C67CY, H69K, A71I, T74S, I93LC
 08PR05036708PR050367FJ591392PINAG48A, I54V, V82AT74PL10I, I15V, K20R, E35D, M36I, N37K, R41N, Q61N, L63A, H69K, I72V, L89M, I93LC
 08PR05030308PR050303FJ591331PINAM46I, L90ML10FI13V, I15V, K20T, M36I, N37K, R41N, I62V, L63A, I64V, H69K, L89M, I93LC
El-Khatib (2010)Pat11211ZA_SAVE2283JF960562LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
Barber (2012)3324533245JQ361668LPV  Q58ET12S, L19I, M36I, R41K, D60E, L63A, H69K, L89M, I93LC
El Annaz (2012)25392539.PRJN185242IDV52V82A T12S, I15V, L19I, M36I, N37D, K45R, L63A, H69K, L89M, I93LC
Hoffmann (2013)491648_1491648_1KJ081337LPV   I15V, G16GE, M36L, L63A, H69K, T74S, L89M, I93LC
Van Zyl (2013)4812.ZA.EC158KC423791LPV   T12S, G16E, L19I, E35D, W42W*, L63A, H69K, V77I, L89M, I93LC
 93011.ZA.WC153KC423497LPV  I84TT12S, G16E, L19I, M36I, R41K, D60E, L63A, H69K, L89M, I93LC
 87709.ZA.WC055KC422825LPV   T12S, I15V, G16E, L19T, K20R, L63A, H69K, V77I, L89M, I93LC
 69909.ZA.WC058KC422843LPV   T12S, I15V, G16E, L19I, K20R, M36I, R41K, L63A, H69K, V77I, L89M, I93LC
 105606.ZA.GT018KC423693LPV   T12S, I15V, G16E, L19T, K20M, D29A, E35D, M36I, L63A, H69K, T74S, L89M, I93LC
 388911.ZA.GT1897KC423669LPV   T12S, L19T, K20R, M36I, L63A, H69K, L89M, I93LC
 272807.ZA.GT149KC422953LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
  08.ZA.GT566KC423363LPV  L76LIT12S, I15V, L19I, M36I, R41K, R57RK, L63A, H69K, I93LC
  10.ZA.GT1114KC424251LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
  11.ZA.GT1577KC423970LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
 291011.ZA.GT1726KC423519LPV   K14R, L19I, M36I, N37S, R41K, L63A, H69K, V82I, L89M, I93LC
 297906.ZA.GT036KC424090LPV   T12S, I15V, L19T, M36I, N37S, R41K, L63A, H69K, L89M, I93LC
  07.ZA.GT221KC424058LPV   T12S, I15V, L19T, M36I, N37S, R41K, L63A, H69K, L89M, I93LC
Acharya (2014)DGP143DGP143KJ185313RTV, ATV   T12S, I15V, L19T, M36I, R41K, L63A, H69K, I93LC
 DGP113DGP113KJ185283RTV, ATV M46I, I54V, L90MT74PL10I, T12S, I15V, L19T, M36I, R41K, L63A, H69K, A71V, I93LC
 DGP091DGP091KJ185261LPV  D30GL19I, M36I, R41K, L63A, H69K, L89M, I93LC
Grossman (2014)987987KF135176LPV52  T12S, I15V, L19IV, E35E_X, M36IT, R41K, R57RK, L63A, H69K, I93LC
 589589KF135105LPV52  L19I, M36I, R41K, D60E, I62V, L63A, H69K, I93LC
Steegen (2014)10ZAKS05910ZAKS059KJ176341LPV I54V, V82A R41K, K45I, D60E, Q61D, I62V, L63A, H69K, L89M, I93LC
 12ZAKS30012ZAKS300KJ176579LPV I54V, V82A R41K, I62IV, L63A, H69K, V77I, L89M, I93LC
Diaz (2015)RenG14404RenG14404KT745432PINA  K14R, I15V, E35D, N37K, R41N, L63A, H69K, V82I, L89LF, I93LC
 RenG15290RenG15290KT746318PINA  I15V, K20R, M36I, N37K, R41N, I62V, L63A, H69K, L89LM, I93LC
 RenG15445RenG15445KT746473PINAV82L G16AE, K20KR, M36I, N37K, R41N, L63A, H69K, L89M, I93LC
Novitsky (2015)mpp_349mpp_349KR861120PINA  T12S, I15V, G16E, L19I, N37S, R41K, L63A, H69K, V77I, I93LC
 bcpp_403bcpp_403KR860757PINA  T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63A, H69K, T74S, L89M, I93LC
 mpp_150mpp_150KR860933PINA  T12S, I15V, L19I, M36I, R41K, K43R, L63A, H69K, T74A, L89M, I93LC
Rossouw (2015)RP125RP125KT032044RTV, LPV138I54LV82~L19I, K20R, E35D, M36I, R41K, L63A, H69K, K70Q, A71V, I93LC
 RP080RP080KT032023LPV22  T12S, I15V, L19I, E35D, M36I, L38L_DL, I62V, L63A, H69K, L89M, I93LC
 RP174RP174KT032060RTV, LPV385M46I, I54V, V82AL10FT12P, I15V, L19LI, K20KR, E35ED, M36MI, N37NS, R41K, L63A, H69K, A71AV, T91TI, I93LVC
Chimukangara (2016)NC14NC14KU508558LPV62  I15V, L19V, M36I, R41K, L63A, H69K, I93LC
Neogi (2016)79513.ZA.WC292KT593494LPV   T12S, K14R, I15V, L19I, K20R, E35D, N37A, R41K, L63A, H69K, V77I, V82I, L89M, I93LC
 353913.ZA.GT2917KT593229LPV   I15V, G16E, L19T, M36ML, N37CS, L63A, H69K, I93LC
 179913.ZA.GT3143KT593386LPV   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63A, H69K, V82I, L89M, I93LC
 96713.ZA.WC367KT592939LPV   I15V, L19I, K20R, M36I, L63A, H69K, K70Q, I72V, V77I, L89M, I93LC
 383313.ZA.GT2999KT593291LPV   T12S, I15V, L19I, E35D, M36I, R41K, L63A, H69KC
Steegen (2016)GFNWB003GFNWB003KU127978LPV192  T12S, L19I, K20R, M36I, R41K, Q61DE, I62V, L63A, I64L, H69K, L89M, I93LC