<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L63A
Rx >= 1 PI
IncludeMixtures No
References 24
Patients 79
Isolates 86
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M6M6AY010422SQV   T12S, I15V, G16E, L19Q, M36I, N37R, R41N, Q61N, L63A, H69K, V82I, L89M, I93LC
 NY_M62M62AY010425SQV   T12S, I15V, G16E, L19Q, M36I, N37R, R41N, Q61N, L63A, H69K, V82I, L89M, I93LC
Kantor (2002)TCDD-22TCDD-22AY090849SQV, IDV17  I15V, L19I, M36I, R41K, L63A, H69K, I93LC
Grossman (2004)IL369IL369AY529591NFV111M46I, L90M T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93LC
Montes (2004)MB_patNIB01_NIB710AJ577964NFV94  T12S, I13V, I15V, L19I, M36I, N37K, R41N, Q61E, L63A, I64M, H69K, L89M, I93LC
  01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
Weber (2005)F26249F26249AY677450NFV103 L89MVT12S, L19I, K20KR, M36I, R41K, L63A, H69K, I93LC
 M69708M69708AY677400NFV81  T12S, L19I, K20R, M36I, N37D, R41K, L63A, I64V, H69K, I93LC
Pillay (2008)DR71DR71AY589920RTV43V32VI, V82AM46MVI15IV, G16E, L19I, M36I, R41K, Q61H, L63A, E65D, H69K, I72V, L89M, I93LC
 DR1402ZA.DR14AY589876IDV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
Waleria-Aleixo (2008)08PR06054208PR060542FJ591458PINAL90M T12TP, I13IV, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, I62V, L63A, C67CY, H69K, A71I, T74S, I93LC
 08PR05036708PR050367FJ591392PINAG48A, I54V, V82AT74PL10I, I15V, K20R, E35D, M36I, N37K, R41N, Q61N, L63A, H69K, I72V, L89M, I93LC
 08PR05030308PR050303FJ591331PINAM46I, L90ML10FI13V, I15V, K20T, M36I, N37K, R41N, I62V, L63A, I64V, H69K, L89M, I93LC
El-Khatib (2010)Pat11211ZA_SAVE2283JF960562LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
Sigaloff (2011)HIV100072HIV100072JN132216LPV   I15V, M36I, R41K, L63A, H69K, I93LC
 HIV101090HIV101090JN132262LPV   G16E, L19I, M36I, P39T, R41K, D60E, L63A, H69K, V82VI, L89M, I93LC
Barber (2012)3324533245JQ361668LPV  Q58ET12S, L19I, M36I, R41K, D60E, L63A, H69K, L89M, I93LC
El Annaz (2012)25392539.PRJN185242IDV52V82A T12S, I15V, L19I, M36I, N37D, K45R, L63A, H69K, L89M, I93LC
Hoffmann (2013)491648_1491648_1KJ081337LPV   I15V, G16GE, M36L, L63A, H69K, T74S, L89M, I93LC
Saravanan (2013)YRG70YRG70KC016265PINAM46I, I54V, L90MG73SI15V, L19I, K20T, E35D, M36I, R41K, I62V, L63A, H69K, A71I, I93LC
 YRG51YRG51KC016246PINAI54V, V82AL76SL10I, T12S, I15V, L19I, K20R, M36I, R41K, K45R, I62V, L63A, H69K, A71VC
 YRG34YRG34KC016229PINAM46I, I54IV, L90MG73ST4TS, R8R*, I15V, L19I, K20T, E35ED, M36I, R41K, L63A, H69K, A71V, I93LC
Van Zyl (2013)4812.ZA.EC158KC423791LPV   T12S, G16E, L19I, E35D, W42W*, L63A, H69K, V77I, L89M, I93LC
 93011.ZA.WC153KC423497LPV  I84TT12S, G16E, L19I, M36I, R41K, D60E, L63A, H69K, L89M, I93LC
 87709.ZA.WC055KC422825LPV   T12S, I15V, G16E, L19T, K20R, L63A, H69K, V77I, L89M, I93LC
 69909.ZA.WC058KC422843LPV   T12S, I15V, G16E, L19I, K20R, M36I, R41K, L63A, H69K, V77I, L89M, I93LC
 105606.ZA.GT018KC423693LPV   T12S, I15V, G16E, L19T, K20M, D29A, E35D, M36I, L63A, H69K, T74S, L89M, I93LC
 388911.ZA.GT1897KC423669LPV   T12S, L19T, K20R, M36I, L63A, H69K, L89M, I93LC
 272807.ZA.GT149KC422953LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
  08.ZA.GT566KC423363LPV  L76LIT12S, I15V, L19I, M36I, R41K, R57RK, L63A, H69K, I93LC
  10.ZA.GT1114KC424251LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
  11.ZA.GT1577KC423970LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
 291011.ZA.GT1726KC423519LPV   K14R, L19I, M36I, N37S, R41K, L63A, H69K, V82I, L89M, I93LC
 297906.ZA.GT036KC424090LPV   T12S, I15V, L19T, M36I, N37S, R41K, L63A, H69K, L89M, I93LC
  07.ZA.GT221KC424058LPV   T12S, I15V, L19T, M36I, N37S, R41K, L63A, H69K, L89M, I93LC
Acharya (2014)DGP143DGP143KJ185313RTV, ATV   T12S, I15V, L19T, M36I, R41K, L63A, H69K, I93LC
 DGP113DGP113KJ185283RTV, ATV M46I, I54V, L90MT74PL10I, T12S, I15V, L19T, M36I, R41K, L63A, H69K, A71V, I93LC
 DGP091DGP091KJ185261LPV  D30GL19I, M36I, R41K, L63A, H69K, L89M, I93LC
Grossman (2014)987987KF135176LPV52  T12S, I15V, L19IV, E35E_X, M36IT, R41K, R57RK, L63A, H69K, I93LC
 589589KF135105LPV52  L19I, M36I, R41K, D60E, I62V, L63A, H69K, I93LC
Diaz (2015)RenG14404RenG14404KT745432PINA  K14R, I15V, E35D, N37K, R41N, L63A, H69K, V82I, L89LF, I93LC
 RenG15290RenG15290KT746318PINA  I15V, K20R, M36I, N37K, R41N, I62V, L63A, H69K, L89LM, I93LC
 RenG15445RenG15445KT746473PINAV82L G16AE, K20KR, M36I, N37K, R41N, L63A, H69K, L89M, I93LC
Novitsky (2015)mpp_349mpp_349KR861120PINA  T12S, I15V, G16E, L19I, N37S, R41K, L63A, H69K, V77I, I93LC
 bcpp_403bcpp_403KR860757PINA  T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63A, H69K, T74S, L89M, I93LC
 mpp_150mpp_150KR860933PINA  T12S, I15V, L19I, M36I, R41K, K43R, L63A, H69K, T74A, L89M, I93LC
Rossouw (2015)RP125RP125KT032044RTV, LPV138I54LV82~L19I, K20R, E35D, M36I, R41K, L63A, H69K, K70Q, A71V, I93LC
 RP080RP080KT032023LPV22  T12S, I15V, L19I, E35D, M36I, L38L_DL, I62V, L63A, H69K, L89M, I93LC
 RP174RP174KT032060RTV, LPV385M46I, I54V, V82AL10FT12P, I15V, L19LI, K20KR, E35ED, M36MI, N37NS, R41K, L63A, H69K, A71AV, T91TI, I93LVC
Chimukangara (2016)NC14NC14KU508558LPV62  I15V, L19V, M36I, R41K, L63A, H69K, I93LC
Neogi (2016)79513.ZA.WC292KT593494LPV   T12S, K14R, I15V, L19I, K20R, E35D, N37A, R41K, L63A, H69K, V77I, V82I, L89M, I93LC
 353913.ZA.GT2917KT593229LPV   I15V, G16E, L19T, M36ML, N37CS, L63A, H69K, I93LC
 179913.ZA.GT3143KT593386LPV   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63A, H69K, V82I, L89M, I93LC
 96713.ZA.WC367KT592939LPV   I15V, L19I, K20R, M36I, L63A, H69K, K70Q, I72V, V77I, L89M, I93LC
 383313.ZA.GT2999KT593291LPV   T12S, I15V, L19I, E35D, M36I, R41K, L63A, H69KC
Steegen (2016)GFNWB003GFNWB003KU127978LPV192  T12S, L19I, K20R, M36I, R41K, Q61DE, I62V, L63A, I64L, H69K, L89M, I93LC
Steegen (2016)ZA13GFWPC002ZA13GFWPC002KU252882LPV   I15V, L19I, E35D, M36I, R41K, L63A, H69K, L89M, I93LC
 ZA13GFWPC015ZA13GFWPC015KU252886LPV   T12S, Q18E, L19V, N37X, L63A, H69K, I93LC
 ZA13GFNCC002ZA13GFNCC002KU252895LPV   T12S, L19I, M36V, R41K, K45R, L63A, H69K, I72IV, T74S, L89MC
 ZA13GFGPC016ZA13GFGPC016KU252898LPV I54V, V82A T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57RK, L63A, H69K, A71AVC
 ZA13GFGPC055ZA13GFGPC055KU252954LPV   T12S, I15V, L19I, E35D, M36I, R41K, L63A, H69K, L89M, I93LC
 ZA13GFKZC011ZA13GFKZC011KU252979LPV   T12S, K14R, I15V, L19I, M36I, R41K, L63A, H69K, L89M, I93LC
 ZA13GFECC030ZA13GFECC030KU253008LPV   T12S, G17D, L19T, K20R, M36I, R41K, L63A, H69K, L89M, I93LC
 ZA13GFGPC082ZA13GFGPC082KU253015LPV   I15V, G16E, M36I, R41K, L63A, H69K, I93LC
 ZA14GFMPC025ZA14GFMPC025KU253037LPV   T12S, L19T, K20R, M36I, R41K, L63A, H69K, L89M, I93LC
 ZA14GFGPC094ZA14GFGPC094KU253044LPV   T12S, I15V, G16E, L19I, M36I, L63A, H69K, T74S, L89M, I93LC
 ZA14GFKZC098ZA14GFKZC098KU253107LPV   T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63A, H69K, T74S, L89M, I93LC
 ZA14GFKZC135ZA14GFKZC135KU253133LPV V32VI, M46I, I54V, V82VAL10LFL19V, K20KT, M36I, R41K, L63A, H69K, I93LC
 ZA14GFKZC159ZA14GFKZC159KU253154LPV  G48GRT12S, I15V, G16E, L19I, M36I, R41K, L63A, H69K, I93LC
 ZA14GFNWC028ZA14GFNWC028KU253172LPV   T12S, G16E, L19I, E35ED, N37S, R41K, L63A, H69K, T74S, V77I, L89M, I93LC
 ZA14GFKZC194ZA14GFKZC194KU253213LPV I54V, L76V, V82A L10I, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63A, H69K, A71V, I72IV, L89M, I93LC
Posada Cespedes (2017)219213.ZA.GT2654KX542997LPV   T4TI, T12S, I15V, L19I, K20R, E35D, M36I, N37E, R57K, D60E, L63A, H69K, L89M, I93LC
 433715.ZA.GT4415 LPV   T12S, L19I, K20R, M36I, R41K, L63A, H69K, L89M, I93LC
 315809.ZA.GT737KX540225LPV   T4P, I15V, L19I, M36I, R41K, D60E, Q61E, L63A, H69K, V82I, L89M, I93LC
 77710.ZA.WC064KX540875RTV   L10V, T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63A, H69K, I93LC
 185414.ZA.GT3474KX544333LPV   I15V, L19I, M36I, R41K, L63A, H69Q, I93LC
 78812.ZA.WC238KX542507LPV   T12S, I15V, L19I, E35D, M36I, L63A, H69K, T74S, V82I, L89M, I93LC
 69314.ZA.EC1251KX543864LPV   T12S, L19I, K20R, M36I, R41K, L63A, H69K, I93LC
 245715.ZA.GT4380 LPV   T12TS, K14I, I15V, L19T, K20R, M36I, R41K, L63A, H69K, L89M, I93LC
 499215.ZA.GT4066 LPV   T12S, I15V, L19I, M36I, R41K, D60E, L63A, I64M, H69K, L89M, I93LC
 42509.ZA.WC027KX540468LPV M46I, I54V, V82FL24IL10I, L19I, K20R, E35D, M36I, N37S, R41N, L63A, H69K, V77I, L89I, I93LC
 70814.ZA.EC1144KX543769LPV   T12S, I15V, L19V, M36I, R41K, L63A, H69K, I93LC
 431714.ZA.GT3476KX544334LPV   T12S, L19IV, K20R, M36I, R41K, L63A, H69K, L89M, I93LC
 388912.ZA.GT2158 LPV   T12S, L19T, K20R, M36I, L63A, H69K, L89M, I93LC
 96714.ZA.WC432 LPV   I15V, L19I, K20R, M36I, L63A, H69K, K70Q, I72V, V77I, L89M, I93LC
 200915.ZA.GT4226 LPV   T12S, I15V, L19I, M36IV, R41K, K45R, L63A, H69K, L89M, I93LC