<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation Q58E
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 45
Isolates 49
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL433IL433aAY529600IDV117M46ML, V82A, L90LMQ58EL10C, I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93LC
Non-B Workgroup (2005)TK1021TK1021 IDV, RTV, LPV331M46I, I54V, V82AL10F, L24I, Q58ET12S, L19I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, L89M, I93LC
 TK4011TK4011 SQV, RTV, NFV, IDV261V82A, L90MQ58E, G73SL10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93LC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
  69936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Baxter (2006)12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
El-Khatib (2010)Pat10511ZA_SAVE2126JF960555LPV  Q58ET12S, I15V, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
Green (2011)707PKE19F707PKE19FHM623509RTV, LPV131M46I, I54V, L76V, V82AQ58EL10I, T12S, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Barber (2012)3324533245JQ361668LPV  Q58ET12S, L19I, M36I, R41K, D60E, L63A, H69K, L89M, I93LC
Van Zyl (2013)222915KC423893LPV26I84VQ58ET12S, I15V, L19I, M36I, R41K, D60K, Q61E, L63P, H69K, I93LC
 12421442KC423147LPV26M46I, I54V, L76V, V82AQ58EI15V, L19I, K20R, L23LF, E35D, M36I, R41K, L63P, H69K, L89MC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
 2181269KC423017LPV183 Q58ET12S, I15V, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
Grossman (2014)354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 488488KF135085SQV, LPV52G48A, I54V, V82AL10F, L24I, Q58EK20R, M36I, R41K, L63P, H69K, A71V, I72V, N83S, L89I, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC
Steegen (2014)11ZAKS11311ZAKS113KJ176395LPV  Q58ER41K, Q61E, L63P, H69K, V82I, L89M, I93LC
 12ZAKS28812ZAKS288KJ176567LPV M46I, I54V, V82AQ58ED60E, L63P, H69K, L89M, Q92K, I93LC
 10ZAKS07110ZAKS071KJ176353LPV M46I, I54V, L76V, V82AQ58EK43R, I62IV, L63P, H69K, L89M, I93LC
Diaz (2015)RenG16317RenG16317KT747345PINAM46I, I54V, V82AL10F, Q58E, T74P, N88GI15V, G16E, K20T, E21K, E35G, M36I, N37K, P39S, R41N, L63T, H69K, V77I, L89MC
 RenG16802RenG16802KT747830PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, D60E, Q61D, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93LC
 RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG15516RenG15516KT746544PINAI54V, V82VA, I84V, L90ML10F, L23I, Q58EI15V, K20R, E35D, M36I, N37K, R41N, R57RK, D60DE, I62IV, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 RenG17080RenG17080KT748108PINAI50L, V82M, L90MQ58E, L89VI13V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, K70T, A71V, I93LC
 RenG13840RenG13840KT744868PINAI54A, V82M, L90MQ58EL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62IV, L63P, H69K, A71IV, I72IT, I85V, L89M, Q92QK, I93LC
 RenG15065RenG15065KT746093PINAM46I, I50L, L90MQ58EI13V, I15V, L19I, K20R, E35D, M36I, N37K, R41N, K55R, L63P, H69K, A71T, L89I, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG15278RenG15278KT746306PINAM46L, I50L, V82ILM, L90LML24LI, L33F, Q58E, T74PI13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, L63AV, H69K, A71AV, L89M, I93LC
 RenG13551RenG13551KT744579PINAM46MI, I50V, I54V, V82M, N88SL33F, Q58E, T74PL10V, G16E, K20R, E35D, M36I, N37K, R41N, R57RK, L63T, H69K, L89F, I93LC
 RenG15500RenG15500KT746528PINAM46I, I47IV, I54V, V82F, L90ML23I, L33LI, F53FL, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, L89I, Q92QK, I93LC
 RenG15206RenG15206KT746234PINAM46I, G48V, I54V, V82AQ58E, T74PL10V, I15V, K20R, E35D, M36I, N37K, R41N, F53Y, K55R, R57K, I62V, L63V, H69K, L89M, I93LC
 RenG13278RenG13278KT744306PINAI54IL, I84V, N88SL33F, Q58EL10Y, I13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, D60E, Q61E, I62V, L63P, H69K, A71T, L89M, I93LC
 RenG13275RenG13275KT744303PINAN88SL10F, Q58EI13V, I15V, E35D, M36I, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG12082RenG12082KT743110PINAM46I, I50V, V82A, L90ML10F, V11VI, L23I, L33F, Q58EI13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, G73V, T74S, L89T, I93LC
 RenG12084RenG12084KT743112PINAM46L, I54V, V82A, L90ML10F, L23I, Q58EI15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, L63P, H69K, I72IV, T74TS, L89IM, I93LC
 RenG10789RenG10789KT741817PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, K55KN, D60E, Q61DN, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93ILC
 RenG10624RenG10624KT741652PINAL90MQ58EI13V, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, Q61N, L63T, I64IV, H69K, A71T, T74A, V82I, L89I, I93LC
 RenG10661RenG10661KT741689PINAM46I, I54V, V82A, L90ML33F, Q58E, G73SL10I, I13V, L19I, K20R, E35D, M36I, N37K, R41K, K55N, L63P, H69K, A71T, T74S, Q92K, I93LC
Rossouw (2015)RP123-1RP123-1KT032043PINAM46I, I47V, I54V, L76V, V82AQ58EL10V, I15V, L19I, K20R, M36I, K55KR, D60E, L63P, H69K, A71V, L89M, I93LC
 RP033RP033KT032006LPV164 Q58EL19T, K20R, M36I, R41K, D60E, H69K, L89M, I93LC
 RP154RP154KT032055LPV, RTV228M46I, I54V, V82AQ58EL10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K55KR, L63LP, H69K, K70R, L89IM, I93LC
 RP145RP145KT032053PINAM46I, I54V, V82AL10F, L24I, L33F, Q58EI15V, G17D, L19V, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69K, P81PS, T91TN, I93LC
 RP089RP089KT032030RTV, LPV152V82M, L90MQ58EI15V, L19T, K20R, M36I, R41K, D60E, L63P, H69K, P79H, L89M, I93LC
 RP045RP045KT032012LPV133M46I, I54V, L76V, V82AQ58EL10I, I15V, L19I, K20R, E35D, M36I, R41K, D60E, Q61D, L63P, C67E, H69K, L89MC