<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I54V
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 44
Isolates 54
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weber (2003)85H610185H-48AY140823RTV48I54V, V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69R, T74S, V77I, L89M, I93LC
Grossman (2004)IL384IL384aAY529618IDV, SQV, RTV, NFV154M46I, I54V, V82A, L90MT74PW6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93LC
  IL384bAY529622IDV, SQV, RTV, NFV239M46I, I54V, V82A, L90MT74PL10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93LC
Non-B Workgroup (2005)UK624UK624 PINAI54V T12S, I15V, L19I, K20R, M36I, R41K, L63P, H69K, I93LC
 UK955UK955AY900786SQV, RTV, IDV137I54V, I84V, L90MG73S, L89VL10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93LC
 UK1447UK1447AY900803IDV, SQV, RTV83G48GA, I54V, V82A, I84V, L90ML23LI, K43KTL10Y, I15V, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89LM, I93LC
 IL80IL80AY900811RTV, NFV, SQV114I54V, V82A, I84VK43TW6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 TK1002TK1002 RTV225M46I, I54V, V82A L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93LC
 TK1020TK1020 SQV, RTV, IDV211I54V, V82C, L90MF53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
 TK1021TK1021 IDV, RTV, LPV331M46I, I54V, V82AL10F, L24I, Q58ET12S, L19I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, L89M, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015c SQV, IDV, LPV, RTV, TPV375I54V, V82T, I84IV, L90MK43TL10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93LC
 TK3016TK3016 SQV, NFV167I54V, L90MT74PL10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93LC
 TK3019TK3019 SQV, NFV, RTV143I54V, I84IV, L90MV11VI, G73SL10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93LC
 TK3032TK3032 SQV, IDV239M46I, I54V, V82T, L90M L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63P, G68GE, H69K, L89M, I93L, C95FC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
  69936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
 PL833877353 IDV, RTV304I54V, V82A L10I, I13IV, I15V, L19I, M36L, R41K, I62V, L63P, I64V, H69K, L89M, I93L, C95FC
Weber (2005)F16446F16446AY677447SQV, NFV, APV, LPV208M46I, I54V, I84V, L90M L10I, T12S, L19I, K20M, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 F30356F30356AY677479Unknown, NFV>201I54V, V82A, L90M L10I, T12S, I15V, L19T, K20R, E35D, M36I, N37H, P39PS, R41K, K45R, L63P, H69KQ, A71I, I93LC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 48-14071407-30410DQ877803PINAI54V, V82A, L90ML10FI, K43TT12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
 48-50965096-30901DQ878592PINAM46I, I54V, V82A, L90MK43KT, T74PL10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93LC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
 48-93029302-30918DQ877587PINAI54V, V82A, L90ML10F, G73GS, L89IMVI15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93LC
Sen (2007)T002NPT2EF186926RTV, IDV M46I, I54V, V82VAL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93LC
  NPT2-PLEF186983RTV, IDV M46I, I54V, V82AL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93LC
Marconi (2008)SW070SW070EU308081LPV49I54V, V82AL33LFG16A, L19V, E35D, M36I, R41K, I62V, L63P, H69K, T74S, L89M, I93LC
Pillay (2008)DR44DR44AY589899RTV M46I, I54V, V82A L10I, I15V, L19I, K20R, M36I, N37S, H69K, L89M, I93LC
 DR55DR55AY589908RTV104M46L, I54V, V82AL23LIT12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 DR68DR68AY589917RTV104M46I, I54V, V82A L10V, T12S, I15V, L19I, E35ED, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
 DR10003ZA.DR100AY589936RTV M46I, I54V, V82A I15E, G16GE, L19E, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
 DR10203ZA.DR102AY589937RTV I54V, V82L, L90M I13IV, I15V, K20R, M36I, R41RK, L63LP, H69K, L89IC
Rosen-Zvi (2008)7109p71-3 LPV175I54V, V82A I15V, Q18E, K20R, E35D, M36I, R41K, K45I, D60E, I62V, L63V, H69K, L89M, I93LC
Kandathil (2009)VL07_103VL07_103EU781835PINAM46I, I54V, V82AL24IL10I, T12S, I15V, L19T, M36I, R41K, L63P, H69K, L89M, I93LC
Kassaye (2009)TCDD-30TC30_2003FJ445708NFV, IDV99I54V, I84V L10I, T12A, I15V, L19I, K20KR, E35D, M36I, R41K, L63P, H69Q, L89M, I93LC
Dau (2010)06552A06552AGU581760PINAM46I, I54V, L76V, V82A L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Green (2011)707PKE19F707PKE19FHM623509RTV, LPV131M46I, I54V, L76V, V82AQ58EL10I, T12S, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Barber (2012)5103051030JQ361665LPV I54V T12S, I15V, L19I, E35D, M36I, R41K, R57K, H69K, V82I, L89M, I93LC
 6957669576JQ361677LPV I54V, V82AL10FT12S, I15V, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
 6599465994JQ361682LPV M46MI, I54V, V82A L10I, T12S, I15V, L19V, M36I, R41K, K45KR, L63P, H69K, T74S, I93LC

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