<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I54L
Rx >= 1 PI
IncludeMixtures No
References 9
Patients 15
Isolates 15
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Baxter (2006)48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LC
Sen (2007)T093NPT93EF186929RTV, IDV M46I, I54L, L90ML23LI, G73STL10Y, T12S, L19T, K20I, L24LF, R41K, K45KR, K55KR, L63P, H69K, A71V, I72IM, V77I, I93LC
Kassaye (2009)TC-68TC68_2004FJ445724NFV, LPV17I54L, L90LML10LFI15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93LC
Knops (2010)ID2137ID2137-GT2GU271173IDV, LPV, DRV, RTV33V32I, I54L, L76V, V82AL89VL5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
Kouri (2012)CU522-10CU522-10JQ585402PINAM46I, I54L, V82A, L90ML33F, T74PI13V, N37S, R41K, K55R, I62V, L63P, H69K, L89M, I93LC
Saravanan (2013)YRG18YRG18KC016213PINAM46I, I54L, L76V, I84VL10F, L24I, L33F, N83DI13V, I15V, G16E, L19I, E35D, M36L, N37S, K45R, R57K, Q61N, L63T, H69K, T74S, L89MC
Diaz (2015)RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG16715RenG16715KT747743PINAD30N, I54LN88DL10Y, I15V, L19Q, K20T, E35D, M36I, N37K, R41N, L63V, H69K, A71T, L89T, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG15117RenG15117KT746145PINAI54L, L90MT74P, N88NTK14R, I15V, G16E, K20T, E35D, M36I, N37K, P39S, R41N, I62V, H69K, A71V, V82I, L89M, I93LC
 RenG12144RenG12144KT743172PINAV32I, I54L, I84VL10F, L33I, L89VI13V, I15V, K20T, M36I, N37K, R41N, Q61N, L63P, I66FV, H69K, A71V, T74S, V77I, Q92KC
 RenG11113RenG11113KT742141PINAI54L, I84IVT74P, L89MVI15V, K20T, E35D, M36MI, N37K, R41N, L63P, H69K, A71V, V82I, T91S, I93LC
 RenG10574RenG10574KT741602PINAI54L, L90ML33F, G73ST12Q, I13IV, I15V, G16A, K20R, E35D, M36I, N37K, R41N, K45R, L63P, H69K, I93LC
Rossouw (2015)RP125RP125KT032044RTV, LPV138I54LV82~L19I, K20R, E35D, M36I, R41K, L63A, H69K, K70Q, A71V, I93LC
Chimukangara (2016)NC16NC16KU508562RTV, ATV145I54LK43T, T74PI15V, G16A, L19I, K20T, E35D, M36I, D60E, L63P, H69K, A71I, L89T, I93LC