<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation F53L
Rx >= 1 PI
IncludeMixtures No
References 6
Patients 13
Isolates 17
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)TK1020TK1020 SQV, RTV, IDV211I54V, V82C, L90MF53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
Baxter (2006)12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
Waleria-Aleixo (2008)08PR05044308PR050443FJ591440PINAM46I, I54V, L90ML10F, L33F, F53L, T74P, N83DI13V, I15V, G16A, K20R, M36I, R41K, K55KR, Q61D, I62V, L63PT, H69K, L89M, I93LC
Van Zyl (2013)362209.ZA.GT912KC424397LPV I47AF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71V, I93LC
  10.ZA.GT1366KC423174LPV I47A, N88NSF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93LC
  10.ZA.GT1471KC423256LPV I47AF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93LC
Steegen (2014)11ZAKS17211ZAKS172KJ176453LPV I54V, L76V, V82AF53LR41K, D60E, Q61H, L63P, H69K, A71V, L89M, I93LC
Diaz (2015)RenG15719RenG15719KT746747PINAI54V, L90ML23I, K43T, F53LI13V, I15V, L19I, K20T, E35D, M36I, N37K, R41N, I62IV, L63P, H69K, A71IV, T74S, V77I, L89I, I93LC
 RenG13855RenG13855KT744883PINAL90ML23I, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71I, T74A, L89I, I93LC
 RenG12637RenG12637KT743665PINAM46I, N88SF53LL10Y, I15V, K20T, E35G, M36I, N37D, R41K, L63V, I64V, H69K, T74A, L89M, I93LC
 RenG10325RenG10325KT741353PINAI50L, V82ML23LI, L33F, F53LT12TA, I13V, K14KR, I15V, K20R, E35D, M36L, N37K, R41N, L63P, H69K, A71V, T74S, L89M, I93LC
 RenG10554RenG10554KT741582PINAM46L, I54V, V82M, L90ML33F, F53LL10V, I15V, G16E, L19I, K20R, E35D, M36I, N37T, P39Q, R41N, K55R, I62V, L63AITV, H69K, A71V, T74S, V77I, L89M, I93L, C95LC
 RenG11612RenG11612KT742640PINAI54V, V82F, L90ML23LI, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, L63P, H69K, A71IV, T74S, L89I, I93LC
 RenG11086RenG11086KT742114PINAM46I, I47A, I84VF53LL10V, G16E, E35D, M36V, N37E, P39S, R41N, I62V, L63T, H69R, A71V, T74S, L89M, I93LC
 RenG10493RenG10493KT741521PINAL90ML23LI, F53L, G73GS, L89IVI13V, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71V, T74K, V77VI, I93LC