<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I50L
Rx >= 1 PI
IncludeMixtures No
References 2
Patients 46
Isolates 46
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Colonno (2004)RC-008-060-076060-07621AY461494ATV80I50L T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93LC
 RC-008-060-169060-1691AY461495ATV I50L T12S, I15V, G16GE, L19I, K20R, E35D, M36I, R41K, H69KQ, L89M, I93LC
 RC-008-060-510060-5101AY461496ATV I50LL89MVT12S, I15V, G16GE, L19I, K20KT, E35ED, M36I, R41K, K45R, D60E, L63LP, I64IV, H69K, A71AV, I85IV, I93LC
 RC-034-067-562067-5621AY461501ATV I50L K14R, I15V, L19I, K20T, E34EK, E35D, M36I, N37D, R41K, K55KN, D60E, I64IV, H69K, A71V, L89MT, I93LC
 RC-034-076-586076-5861AY461502ATV I50L T12S, I15V, L19I, M36I, R41K, K45N, L63P, H69K, L89M, I93LC
Diaz (2015)RenG17053RenG17053KT748081PINAI50L, L90ML33IL10Y, I13IV, I15V, K20T, E34EQ, E35N, M36I, N37E, R41N, K45R, D60N, I62IV, L63LP, C67CF, G68GE, H69KR, A71I, L89I, I93LC
 RenG15755RenG15755KT746783PINAI50L, L90ML33F, G73SI13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, L63P, H69K, K70E, A71I, I93LC
 RenG16014RenG16014KT747042PINAI50LT74PI15V, K20R, M36I, N37K, R41N, K45R, H69K, A71V, L89MT, I93LC
 RenG17176RenG17176KT748204PINAI50L, V82A, L90MG73SI15V, G16A, K20R, E34Q, E35D, M36I, N37K, R41N, K45R, L63P, I66L, H69K, A71V, I93ILC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG17413RenG17413KT748441PINAI50L I15V, E34KR, M36L, R41N, K45N, D60E, I62V, L63P, H69K, K70KQ, V82VI, L89M, I93LC
 RenG17106RenG17106KT748134PINAI50L, V82VA, N88SL33FI13V, K14R, I15V, K20KR, E35D, M36I, N37K, R41N, K45KR, Q61N, I64IV, H69K, A71IV, T74S, L89M, I93LC
 RenG15974RenG15974KT747002PINAM46MI, I50LL23LI, L33F, F53FL, N83NDL10LR, I13V, I15V, E35D, M36IL, N37K, R41N, I62V, L63V, H69K, A71V, T74A, L89IM, I93LC
 RenG15801RenG15801KT746829PINAI50L, V82L I15V, G16E, K20R, E35D, M36I, N37K, P39S, R41N, K45R, G68E, H69R, A71V, L89I, I93LC
 RenG16022RenG16022KT747050PINAI50L, V82ILL33FK14KR, I15V, K20T, M36I, N37K, R41N, H69K, A71V, L89I, I93LC
 RenG17080RenG17080KT748108PINAI50L, V82M, L90MQ58E, L89VI13V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, K70T, A71V, I93LC
 RenG15832RenG15832KT746860PINAI50LL10F, L23LI, L33FI13IV, I15V, E35D, M36L, N37K, R41N, K45Q, D60E, I62IV, L63P, H69K, A71AV, T74TR, L89M, I93LC
 RenG16794RenG16794KT747822PINAI50LL23LI, L89AMTVI15V, K20KR, E34ED, E35ED, M36I, N37K, R41N, L63V, H69K, A71V, T74TS, I93LC
 RenG15065RenG15065KT746093PINAM46I, I50L, L90MQ58EI13V, I15V, L19I, K20R, E35D, M36I, N37K, R41N, K55R, L63P, H69K, A71T, L89I, I93LC
 RenG14916RenG14916KT745944PINAI50L, V82M, L90ML23I, L33FI13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG15278RenG15278KT746306PINAM46L, I50L, V82ILM, L90LML24LI, L33F, Q58E, T74PI13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, L63AV, H69K, A71AV, L89M, I93LC
 RenG14545RenG14545KT745573PINAM46L, I50L, I54IV, V82VA, L90ML33LF, G73SL10V, I13IV, I15IV, K20KR, E35ED, N37K, R41N, K45R, L63P, H69K, A71AITV, T74S, V77VI, I85V, I93LC
 RenG14995RenG14995KT746023PINAI50LG73SI15V, G16A, K20KR, E35D, M36I, N37K, R41N, K45R, L63P, H69K, A71AITV, V82VI, I93LC
 RenG13600RenG13600KT744628PINAM46I, I50L, L90ML23II15V, K20T, E35D, M36I, N37K, R41N, L63PT, H69K, A71V, T74S, I85IV, L89I, I93LC
 RenG14776RenG14776KT745804PINAI50L I13V, K14R, I15V, L19I, K20KT, E34EQ, E35D, M36I, N37K, R41N, L63P, H69K, A71AV, L89M, I93LC
 RenG14024RenG14024KT745052PINAD30N, I50L, V82AL33F, N88DL10LR, I13V, I15IV, K20KRT, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, H69K, A71AV, T74S, V77VI, L89IM, I93LC
 RenG14493RenG14493KT745521PINAI50LL33LFI15V, E35D, M36I, N37K, R41N, R57K, Q61QH, L63V, H69K, A71V, T74A, L89I, I93LC
 RenG11998RenG11998KT743026PINAI50L I15V, G16A, K20R, E35D, M36I, N37K, R41N, K45R, L63P, H69K, A71T, V82VI, L89T, I93LC
 RenG12371RenG12371KT743399PINAI50LT74PL10LIV, K14KR, I15V, Q18T, N37K, R41N, K45R, L63LP, H69K, A71V, V77I, L89M, I93LC
 RenG13433RenG13433KT744461PINAI50L, V82ML24I, K43KTT12P, I15S, G16R, K20RT, E34KN, E35D, M36I, N37K, R41N, K45KR, L63T, G68E, H69K, A71V, I72IT, T74A, Q92K, I93LC
 RenG11850RenG11850KT742878PINAI50L I15V, E35D, M36I, N37Q, R41N, L63V, H69K, T74S, V82I, L89M, I93LC
 RenG12846RenG12846KT743874PINAI50LL33FI13V, K14R, I15V, M36A, N37K, R41N, K45KR, L63P, H69K, A71IV, V82I, L89IT, I93LC
 RenG12329RenG12329KT743357PINAM46ML, I50L, V82VA, N88NSL33F, T74TPL10LH, I15IV, E35D, M36I, N37K, R41N, D60E, I62IV, L63P, H69K, A71V, L89M, I93LC
 RenG13352RenG13352KT744380PINAI50LG73GCL10LV, K20R, E35D, M36I, N37K, R41N, K45KR, L63P, H69K, A71AT, L89LM, I93LC
 RenG10449RenG10449KT741477PINAI50LL33FI15V, E35D, M36L, N37K, R41N, R57RK, L63P, H69K, T74S, V82I, I85V, L89M, I93LC
 RenG10325RenG10325KT741353PINAI50L, V82ML23LI, L33F, F53LT12TA, I13V, K14KR, I15V, K20R, E35D, M36L, N37K, R41N, L63P, H69K, A71V, T74S, L89M, I93LC
 RenG11494RenG11494KT742522PINAI50L, V82L, L90ML33F, K43TT12S, I13V, I15V, K20R, E35D, M36IV, N37K, R41N, Q61HN, L63T, I64V, H69K, A71V, T74S, L89M, I93LC
 RenG11100RenG11100KT742128PINAI50L, V82MT74PI15V, G16E, L19Q, K20R, E35D, M36I, N37K, P39PS, R41N, K45R, L63T, H69K, A71V, I72IV, I93LC
 RenG10636RenG10636KT741664PINAI50LL10FK14R, I15V, N37K, R41I, K45KR, L63P, H69K, A71IV, V77I, L89M, I93LC
 RenG11227RenG11227KT742255PINAI50L, V82A, L90ML33FT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37E, R41N, K45R, L63P, H69K, A71V, T74A, L89I, I93LC
 RenG10331RenG10331KT741359PINAM46I, I50L, V82AT74PL10I, I15V, L19I, K20R, M36I, N37K, R41N, I62IV, L63V, H69K, A71V, L89M, I93LC
 RenG10585RenG10585KT741613PINAI50L W6S, Q7D, R8G, K14R, I15V, G16E, K20R, E34R, E35D, M36I, R41N, K45R, R57RK, H69KQ, A71IV, V77I, V82VI, L89T, I93LC
 RenG10615RenG10615KT741643PINAI50L, N88SL33F, T74PI13IV, I15V, K20R, E35D, M36I, N37K, R41N, L63LP, H69K, A71V, L89M, I93LC
 RenG10498RenG10498KT741526PINAD30N, I50L, V82VAL33F, N88DI13V, I15V, K20R, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, G68GE, H69K, A71AITV, T74S, L89M, I93LC
 RenG10491RenG10491KT741519PINAI50L, V82VA, N88S, L90LML33FL10M, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, K45R, H69K, A71V, L89I, I93LC