<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation M46L
Rx >= 1 PI
IncludeMixtures No
References 9
Patients 15
Isolates 16
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL433IL433bAY529601IDV174M46L, V82A, L90LML10F, Q58QEI15V, K20R, M36I, L63PT, H69K, L89M, I93LC
Non-B Workgroup (2005)TK1020TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
Baxter (2006)12-10071007-30519DQ875953PINAM46L, I54IV, V82A, L90ML33F, K43KTL10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93LC
 12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
Sen (2007)T076NPT76EF186928NFV, RTV M46L, V82A, L90MT74PL10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93LC
  NPT76-PLEF186980NFV, RTV M46LT74PL10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93LC
Pillay (2008)DR55DR55AY589908RTV104M46L, I54V, V82AL23LIT12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Kouri (2012)CU1893-09CU1893-09JQ585316PINAM46L I15V, M36I, R41K, H69K, L89M, I93LC
Van Zyl (2013)15672032KC423577LPV26M46L, I54V, L76V, V82AL10FI15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, L89I, I93LC
 12001390KC423114LPV26M46L, I54V, V82AL10F, L24LI, L33FI15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, I62IV, H69K, L89M, I93LC
 72733KC423804LPV26M46L T12TI, I15V, L19I, M36I, N37D, R41K, D60E, Q61E, H69K, K70KR, L89M, I93LC
Grossman (2014)101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
 5050KF135091SQV, LPV52M46L, I54V, V82AL10F, L23IT12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LC
 311311KF135048LPV148M46L, I47A T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93LC
 55KF135110RTV, LPV52M46L, I54V, V82AL24L*IR, N88NDL10V, I15V, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC