<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation M46L
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 44
Isolates 46
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL433IL433bAY529601IDV174M46L, V82A, L90LML10F, Q58QEI15V, K20R, M36I, L63PT, H69K, L89M, I93LC
Non-B Workgroup (2005)TK1020TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
Baxter (2006)12-10071007-30519DQ875953PINAM46L, I54IV, V82A, L90ML33F, K43KTL10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93LC
 12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
Sen (2007)T076NPT76EF186928NFV, RTV M46L, V82A, L90MT74PL10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93LC
  NPT76-PLEF186980NFV, RTV M46LT74PL10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93LC
Pillay (2008)DR55DR55AY589908RTV104M46L, I54V, V82AL23LIT12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
Waleria-Aleixo (2008)RES185RES185FJ591922PINAM46L, I54V, V82AL24IQ2QR, L10V, I15V, G16E, K20R, E35D, M36I, N37E, R41K, K55KR, L63H, H69K, T74S, I85V, L89I, I93LC
 08PR04015708PR040157FJ591188PINAM46L, I54V, V82A, L90M L10R, L19LI, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, I93LC
 08PR06062808PR060628FJ591483PINAM46L, G48V, I54T, V82A L10V, I15V, K20R, E35D, M36I, N37T, R41N, L63P, H69K, A71V, V75I, L89I, I93LC
 08PR06065108PR060651FJ591506PINAM46L, G48V, I54V, V82AL24I, L33FL10V, I15V, K20R, E35D, M36I, N37Q, R41V, I62V, H69K, T74S, L89I, T91S, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Kouri (2012)CU1893-09CU1893-09JQ585316PINAM46L I15V, M36I, R41K, H69K, L89M, I93LC
Saravanan (2013)YRG21YRG21KC016216PINAM46L, I54V, V82A, L90MQ58E, T74PL10W, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
 YRG04YRG04KC016199PINAM46L, I54VL10F, L33FT12S, I15V, L19I, K20T, E35D, M36L, R41K, L63P, H69K, A71VC
 YRG02YRG02KC016197PINAM46L, V82A, L90ML10F, Q58E, T74PI15V, L19I, K20R, M36I, R41K, K55KR, I62V, L63P, I64V, H69K, L89M, I93LC
Van Zyl (2013)10112.ZA.NL018KC423804LPV M46L T12TI, I15V, L19I, M36I, N37D, R41K, D60E, Q61E, H69K, K70KR, L89M, I93LC
 352210.ZA.GT1284KC423114LPV M46L, I54V, V82AL10F, L24LI, L33FI15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, I62IV, H69K, L89M, I93LC
 54811.ZA.EC064KC423577LPV M46L, I54V, L76V, V82AL10FI15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, L89I, I93LC
Grossman (2014)101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
 5050KF135091SQV, LPV52M46L, I54V, V82AL10F, L23IT12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LC
 311311KF135048LPV148M46L, I47A T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93LC
 55KF135110RTV, LPV52M46L, I54V, V82AL24L*IR, N88NDL10V, I15V, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC
Steegen (2014)11ZAKS16811ZAKS168KJ176652LPV M46L, I54V, V82AL10FT12S, I15V, L19V, M36I, R41K, L63P, H69K, T74S, L89M, I93LC
Diaz (2015)RenG16982RenG16982KT748010PINAM46L, I54IV, V82AL10LFPS, L23I, L33F, F53FLP9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93LC
 RenG15215RenG15215KT746243PINAM46L, I50IL, I54V, V82AL24I, L33FL10Y, E35D, M36L, N37EK, R41N, R57K, D60E, L63P, H69K, A71AT, L89I, Q92QK, I93LC
 RenG15278RenG15278KT746306PINAM46L, I50L, V82ILM, L90LML24LI, L33F, Q58E, T74PI13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, L63AV, H69K, A71AV, L89M, I93LC
 RenG14186RenG14186KT745214PINAD30N, M46L, I54V, V82AQ58QE, N88DL10R, I15V, K20T, E35D, M36I, N37K, R41N, D60DE, Q61QH, L63P, I64IL, H69K, A71V, L89I, I93LC
 RenG15313RenG15313KT746341PINAM46L, G48A, I54V, V82A, L90ML33F, N83DL10V, K14KR, I15IV, G16E, K20R, E35D, M36I, N37K, R41N, R57K, Q61N, L63T, H69K, T74S, I85V, L89I, Q92K, I93LC
 RenG14545RenG14545KT745573PINAM46L, I50L, I54IV, V82VA, L90ML33LF, G73SL10V, I13IV, I15IV, K20KR, E35ED, N37K, R41N, K45R, L63P, H69K, A71AITV, T74S, V77VI, I85V, I93LC
 RenG13286RenG13286KT744314PINAM46L, V82A L10IV, K14R, I15V, K20R, L33F_E, M36I, N37K, R41N, K55R, R57K, I62V, H69K, T74S, L89M, I93LC
 RenG12084RenG12084KT743112PINAM46L, I54V, V82A, L90ML10F, L23I, Q58EI15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, L63P, H69K, I72IV, T74TS, L89IM, I93LC
 RenG10554RenG10554KT741582PINAM46L, I54V, V82M, L90ML33F, F53LL10V, I15V, G16E, L19I, K20R, E35D, M36I, N37T, P39Q, R41N, K55R, I62V, L63AITV, H69K, A71V, T74S, V77I, L89M, I93L, C95LC
Rossouw (2015)RP156RP156KT032056LPV122M46L, I54V, V82AL10FT12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74A, L89M, I93LC
 RP039RP039KT032010LPV148M46L, I54V, V82AL10FT12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55KR, I62IV, L63P, H69K, I72V, T74A, L89M, I93LC
 RP159RP159KT032057LPV200M46L, I54V, V82AL10F, L24I, L33F, T74API13IV, M36L, N37S, R41K, Q61N, I62V, L63V, H69K, L89M, I93ILC
Chimukangara (2016)NC1NC1KU508567RTV, ATV186M46L, I54V, V82AV32VA, L33FL10V, I13V, K14R, I15IV, G16E, L19V, K20R, E35D, M36I, N37D, R41K, K55R, L63T, H69K, T74S, L89I, I93LC
Neogi (2016)76813.ZA.WC354KT593539LPV M46L, I54V, I84V T12S, I15V, L19I, K20R, M36I, R41K, H69K, I85V, L89I, I93LC
Steegen (2016)ZA14GFKZC101ZA14GFKZC101KU253113LPV M46L, I54V, V82A L10V, T12TS, I15V, L19I, K20R, E35D, M36I, K55R, Q61H, L63V, H69K, T74S, L89M, I93LC
 ZA14GFKZC170ZA14GFKZC170KU253178LPV M46L I15V, M36I, R41K, D60E, Q61N, L63Q, H69K, L89M, I93LC
Posada Cespedes (2017)216409.ZA.GT860KX540333SQV, LPV M46L, G48V, I54V, V82A, L90M L10V, T12TS, I13V, G16E, L19T, K20R, M36I, N37ND, Q61H, L63T, H69K, T74S, L89M, I93LC
 718015.ZA.WC596 LPV M46L, I54V, V82AL10F, L23IT12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, L89M, I93LC
 25613.ZA.NL091 LPV M46L T12I, I15V, L19T, M36I, N37D, R41K, R57K, D60E, Q61E, H69K, K70R, L89M, I93LC
 130315.ZA.EC1698 LPV M46L, I54V, V82A L10I, K14T, G16E, L19I, M36I, N37K, R41K, Q61D, L63T, E65D, H69K, L89M, I93LC
 462714.ZA.GT3727KX544536LPV M46L, I54V, V82AL10FI15V, G16A, L19V, E35D, M36I, R41K, I62V, L63P, H69K, T74S, V77I, L89M, I93LC
 505915.ZA.GT4167 LPV M46L, G48V, I54V, V82A L10I, I15V, K20R, E35D, M36I, N37E, R41K, R57K, H69K, T74S, L89M, I93LC