<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 23
Patients 185
Isolates 208
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Snoeck (2002)BE16aBE16aAF339009IDV107M46I, V82AL24IL10IM, T12TS, I15V, L19T, M36I, R41K, K43KN, R57RS, D60E, Q61E, L63P, H69K, L89M, I93LC
Colonno (2004)RC-007-045-235045-2351AY461491ATV M46I, I50IL T12S, I15V, L19T, E35D, M36I, R41K, K45R, K55H, R57K, L63IT, H69K, I93LC
Grossman (2004)IL369IL369AY529591NFV111M46I, L90M T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93LC
 IL384IL384aAY529618IDV, SQV, RTV, NFV154M46I, I54V, V82A, L90MT74PW6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93LC
  IL384bAY529622IDV, SQV, RTV, NFV239M46I, I54V, V82A, L90MT74PL10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93LC
Snoeck (2004)BE13bBE13bAY900730IDV44M46IL24IT12S, I15V, L19I, M36I, N37K, R41N, K45R, L63P, H69K, L89T, I93LC
Non-B Workgroup (2005)UK162UK162AY900762RTV57M46I, V82A, L90MK43TT12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93LC
 UK456bUK456bAY900773NFV, IDV, RTV M46I, L90M L10LI, T12S, L19I, K20I, M36I, R41K, L63P, I64V, H69K, A71V, T74S, L89M, I93LC
 UK1147UK1147AY900794IDV, NFV117M46IK43TT12S, I15V, L19I, K20T, E35D, M36I, N37D, D60E, Q61E, L63P, H69K, A71T, L89T, I93LC
 UK1428aUK1428aAY900800SQV91M46I I15V, L19I, M36I, N37S, R41K, H69K, T74S, L89M, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 BR42BR42AY900895NFV97M46I, L90M L10V, E35D, M36I, N37K, R41N, L63P, I64V, H69K, L89MC
 TK1002TK1002 RTV225M46I, I54V, V82A L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93LC
 TK1020TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
 TK1021TK1021 IDV, RTV, LPV331M46I, I54V, V82AL10F, L24I, Q58ET12S, L19I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, L89M, I93LC
 TK3032TK3032 SQV, IDV239M46I, I54V, V82T, L90M L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63P, G68GE, H69K, L89M, I93L, C95FC
 TK4004TK4004 IDV, SQV, RTV, NFV, LPV278M46I, L90M L10R, I15V, L19I, K20M, M36I, R41K, L63P, H69K, K70R, L89M, I93LC
 K5009TK5009 RTV, IDV96M46I, L76V, V82AL10LFT12S, I15V, L19I, K20KR, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Weber (2005)F16446F16446AY677447SQV, NFV, APV, LPV208M46I, I54V, I84V, L90M L10I, T12S, L19I, K20M, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 12-30823082-30430DQ877155PINAM46I, I84V, L90MG73SL10I, T12S, I13N, I15V, L19I, M36I, R41RK, Q61H, L63P, H69K, A71V, I72L, I93LC
 48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-24052405-30826DQ877890PINAM46I, V82AL10F, K43T, T74PT12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
 48-50965096-30901DQ878592PINAM46I, I54V, V82A, L90MK43KT, T74PL10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93LC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
Doualla-Bell (2006)Pt11FDB_Pt11 NFV M46I, L90M T12S, I15V, L19I, M36I, R41K, L63V, H69K, V77I, L89M, I93LC
 Pt13FDB_Pt13 NFV D30N, M46IL10F, N88DI15V, M36I, R41K, L63P, H69K, I93LC
 Pt6FDB_Pt6 NFV M46I, N88SL10FT12S, I15V, L19V, K20I, M36I, R41K, L63V, I64V, H69K, T74V, L89M, I93LC
Sanabani (2006)04BR01304BR013AY727522PINAM46I, G48V, V82AL24IL10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93LC
Sen (2007)T093NPT93EF186929RTV, IDV M46I, I54L, L90ML23LI, G73STL10Y, T12S, L19T, K20I, L24LF, R41K, K45KR, K55KR, L63P, H69K, A71V, I72IM, V77I, I93LC
  NPT93-PLEF186978RTV, IDV M46I, I54IL, L90MG73STL10Y, T12S, L19T, K20I, L24F, R41K, K45R, K55R, L63P, H69K, A71V, V77I, I93LC
 T002NPT2EF186926RTV, IDV M46I, I54V, V82VAL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93LC
  NPT2-PLEF186983RTV, IDV M46I, I54V, V82AL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
 DR44DR44AY589899RTV M46I, I54V, V82A L10I, I15V, L19I, K20R, M36I, N37S, H69K, L89M, I93LC
 DR60DR60AY589912RTV M46I, N88S T12S, I15V, L19I, K20I, E35D, M36I, N37D, R41RK, D60E, L63P, H69K, A71AT, I72L, I93LC
 DR68DR68AY589917RTV104M46I, I54V, V82A L10V, T12S, I15V, L19I, E35ED, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
 DR9303ZA.DR93AY589932IDV, LPV M46I, L90M L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93LC
 DR10003ZA.DR100AY589936RTV M46I, I54V, V82A I15E, G16GE, L19E, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Kandathil (2009)VL07_040VL07_040EU030407PINAM46I, L90MK43TT12S, I15V, L19I, K20T, E35D, M36I, R41K, L63P, H69K, T74S, I93LC
 VL07_103VL07_103EU781835PINAM46I, I54V, V82AL24IL10I, T12S, I15V, L19T, M36I, R41K, L63P, H69K, L89M, I93LC
Kassaye (2009)TCDD-28TC28_2004FJ445727SQV, LPV378M46I, I84V, L90MG73SI15V, L19I, K20I, M36I, L63P, H69K, A71V, I93LC
Dau (2010)06552A06552AGU581760PINAM46I, I54V, L76V, V82A L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93LC
Green (2011)707PKE19F707PKE19FHM623509RTV, LPV131M46I, I54V, L76V, V82AQ58EL10I, T12S, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Kouri (2012)CU522-10CU522-10JQ585402PINAM46I, I54L, V82A, L90ML33F, T74PI13V, N37S, R41K, K55R, I62V, L63P, H69K, L89M, I93LC
 CU728-10CU728-10JQ585411PINAM46I, I50V, L90ML33FW6G, L10V, N37S, R41K, K55R, Q61E, L63P, H69K, T74S, V77I, V82VI, I85V, L89M, I93LC
 CU2016-09CU2016-09JQ585331PINAM46I, I54M, V82A, L90MK43TL10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 CU1340-10CU1340-10JQ585423PINAM46I, I54AT, V82A, I84IVL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74TA, L89M, I93LC
 CU2035-09CU2035-09JQ585332PINAM46I, I54M, V82A, L90MK43TQ2H, L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91S, I93LC
Van Zyl (2013)11701077KC422863LPV26M46I, I54V, V82AF53FLL10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
  959KC424396LPV27M46I, I54V, V82A L5LF, L10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
  1420KC423137LPV27M46I, I54V, V82AF53FLL10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 763762KC424271LPV183M46I, I54V, V82A T12TS, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
  1445KC423150LPV235M46I, I54V, V82A T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
 16721580KC423245LPV26M46I, I54IL, L76V, I84V E35D, M36I, R41K, L63P, H69K, L89MC
 14602908KC423889LPV26M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 14532172KC423667LPV26M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, M36I, R41K, K43R, L63V, H69K, L89I, I93LC
 14522906KC423888LPV26M46I, I54V, L76V, V82AL10FT12TS, I15V, L19T, K20R, M36I, R41K, L63V, H69K, L89I, I93LC
 1576168KC423322LPV26M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 4721371KC423100LPV26M46I, V82A L10C, I15V, L19V, D25DY, M36I, R41RK, L63P, H69K, L89MC
 751548KC424133LPV26M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63N, H69K, A71V, L89M, I93LC
  1563KC423234LPV26M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63H, H69K, A71V, I72IM, L89M, I93LC
 582996KC424424LPV26M46I, I54V, L76V, V82A L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, L63P, H69K, A71V, L89M, I93LC
  1287KC423030LPV78M46I, I54V, L76V, V82A L10I, T12S, L19I, K20R, M36I, R41K, K55R, D60E, I62V, L63P, H69K, A71V, L89M, I93LC
 12421442KC423147LPV26M46I, I54V, L76V, V82AQ58EI15V, L19I, K20R, L23LF, E35D, M36I, R41K, L63P, H69K, L89MC
 16441954KC423531LPV26M46I, I50V, I54V, V82A L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69R, K70Q, A71V, I93LC
 1002865KC424321LPV104M46I, I54V, V82AL10FT12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93LC
  2427KC423704LPV208M46I, I54V, L76V, V82AL10FT12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93LC
 402656KC423765LPV26M46I, I54V, V82C, I84VL10FT12S, I15V, L19T, K20R, A22T, M36I, H69K, L89M, I93L, N98KC
 202459KC423723LPV26M46I, I54V, L76V, I84VL10FI15V, L19I, K20R, M36I, R41K, Q61QH, L63PS, H69K, A71V, I93LC
 13931541KC423216LPV26M46I, I54V T12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
  3002KC423927LPV130M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
 1230965KC424400LPV52M46I T12S, I15V, L19I, E35ED, R41K, D60E, H69K, V77I, L89M, I93LC
  1294KC423036LPV105M46I T12S, I15V, L19I, R41K, D60E, H69K, V77I, L89M, I93LC
 13041121KC422895LPV26M46I, I50V T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63S, H69K, I93LC
 17502453KC423718LPV26M46I, I54V, L76V, V82AL10FI15V, L19IT, K20R, E35D, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, A71V, L89M, I93LC
 16801795KC423414LPV26M46I, I50V, I54V, V82AL10F, L33FT12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93LC
 15822753KC423813LPV26M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
Grossman (2014)609609KF135112LPV52M46I, I54V, V82A, L90MN83D, L89VL10I, V11L, I13A, K20R, A22V, E35N, M36I, N37D, R41K, I62V, L63P, H69K, A71V, I93LC
  609 LPV134M46I, I54V, V82A, L90MG73S, N83D, L89VL10I, V11L, I13V, K20R, A22V, E35N, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, T91S, I93LC
  609 LPV292M46I, I54V, V82A, L90MG73GS, N83D, L89VL10I, V11L, I13AV, K20R, A22V, E35N, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71IV, T91S, I93LC
 11141114KF134952LPV52M46I, I54V, L76V, V82A L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93LC
 471471KF135082IDV, LPV52M46I, I54V, V82AL10F, L24I, L33FI13V, K14R, I15V, K20KT, M36I, R41K, L63P, H69K, T74TS, L89M, I93LC
 882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 255255KF135032SQV, LPV90M46I, I54V, V82AL10F, L33F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93LC
 9797KF135173IDV, LPV52M46I, I54V, V82A, I84V, L90ML10FI13IV, I15V, K20R, M36I, R41K, L63P, H69K, A71V, L89LM, I93LC
  97KF135174IDV, LPV133M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
  97KF135175IDV, LPV228M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 217217KF135025NFV, LPV273M46I, I50V, I54V, V82A, L90ML33FL10I, I13V, K14R, I15V, K20R, E35D, M36I, N37DE, R41K, K55R, L63E, G68GE, H69Q, A71AV, L89I, I93LC
 943943 LPV379M46I, L90ML10F, N88DT12S, I15V, L19I, K20R, E35D, M36I, R41K, K55R, L63P, H69K, L89M, I93LC
 5252KF135094RTV, LPV52M46I, I54IV, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63PT, H69K, I72IT, L89M, I93LC
  52KF135095RTV, LPV115M46I, I54V, L76V, V82A, L90M L10V, K14KQ, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135096RTV, LPV194M46I, I54V, L76V, V82A, L90ML10FVI15V, L19V, K20R, M36I, N37D, R41K, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135097RTV, LPV210M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55KR, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135098RTV, LPV267M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, L89M, I93LC
  52KF135099RTV, LPV314M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, T74TS, L89M, I93LC
 201201KF135014IDV, LPV52M46IT74PL10I, T12S, I15V, L19T, M36I, R41K, K55R, L63I, H69K, L89M, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC
 805805KF135148SQV, LPV52M46I, I54IV, L76V, V82VAL10LFT12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93LC
 852852KF135155SQV, LPV52M46I, I54V, V82AL10F, L33FL19Q, K20R, G27GR, E35D, M36I, N37ND, P39Q, R41K, I62IV, L63P, H69K, L89M, Q92QK, I93LC
 155155KF134987IDV, LPV52M46I, I54V, V82AL10FI13X, I15V, K20T, M36I, R41K, I62IV, L63P, H69K, T74S, L89M, I93LC
 11341134KF134954LPV52M46I, I54V, V82A I15V, L19T, K20R, M36I, H69K, L89M, I93LC
 7878KF135145RTV, LPV52M46I, I54V, L76V, V82AL10F, L24II15V, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, I93LC
 20632063KF135018LPV52M46I, I54V, V82AL10F, G73S, L89VT12S, I15V, G16E, L19I, K20I, M36I, N37D, R41K, L63R, H69K, I85V, I93LC
 952952 IDV, LPV52M46I, I54V, L76V, V82AL10FI15V, K20R, E35ED, M36I, N37D, R41K, R57K, I62V, L63P, I64M, H69K, K70KQ, A71AV, I72IV, L89M, I93LC
 610610 NFV, IDV, LPV52M46I, I54V, V82A, L90ML10F, T74PST12S, I13V, I15V, L19Q, K20I, E35D, M36I, N37ND, R41K, Q61H, I62V, L63T, I64V, I66L, H69K, L89M, I93LC
  610 NFV, IDV, LPV69M46I, I54V, L76V, V82A, L90ML10FT12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95FC
Steegen (2014)12ZAKS26012ZAKS260KJ176539LPV M46I, I54V, V82S R41K, R57K, Q61H, I62V, L63V, H69K, A71V, T74S, L89M, I93LC
 09ZAKS01709ZAKS017KJ176299LPV M46I, I54V, V82A R41K, K43R, L63V, H69K, T74S, L89M, I93LC
 12ZAKS32312ZAKS323KJ176602LPV M46I, I54V, L76V, V82A Q61H, I62V, L63P, H69K, L89I, T91S, I93LC
 12ZAKS35512ZAKS355KJ176634LPV M46I, I54V, L76V, V82A R41K, K55R, R57K, I62V, L63P, H69K, L89I, I93LC
 12ZAKS20112ZAKS201KJ176481LPV M46I, I54V, L76V, V82A R41K, L63P, H69K, A71V, Q92R, I93LC
 11ZAKS13111ZAKS131KJ176413LPV M46I, I54V, V82A R41K, L63P, H69K, T74S, L89M, I93LC
 09ZAKS00509ZAKS005KJ176289LPV M46I, I54V, L76V, I84V G52X, D60E, Q61G, H69KN, A71V, L89M, I93LC
 10ZAKS07010ZAKS070KJ176352LPV M46I, I54V, L76V, V82A R41K, I62V, L63P, H69K, A71V, I72V, L89M, I93LC
 12ZAKS25812ZAKS258KJ176537LPV M46I, I54IV, V82A R41K, Q61QH, H69K, L89M, I93LC
 12ZAKS28812ZAKS288KJ176567LPV M46I, I54V, V82AQ58ED60E, L63P, H69K, L89M, Q92K, I93LC
 11ZAKS17111ZAKS171KJ176452LPV M46I, I50V, I54V, V82A R41K, K55R, R57K, Q61H, L63T, H69K, A71V, I72K, T74S, L89M, I93LC
 10ZAKS07110ZAKS071KJ176353LPV M46I, I54V, L76V, V82AQ58EK43R, I62IV, L63P, H69K, L89M, I93LC
 12ZAKS29112ZAKS291KJ176570LPV M46I, I47A, I54VK43TR41K, R57K, D60E, L63P, H69K, A71V, V82I, L89M, I93LC
 11ZAKS11611ZAKS116KJ176398LPV M46I, I54V, V82A R41K, L63P, H69K, L89M, I93LC
 10ZAKS03810ZAKS038KJ176320LPV M46I, I54V, L76V, V82A R41K, Q61H, L63P, H69K, L89IM, I93LC
 11ZAKS14011ZAKS140KJ176422LPV M46I, I54V, L76V, V82S R41K, K55R, L63P, H69K, A71V, I93LC
Diaz (2015)RenG17235RenG17235KT748263PINAM46I, L90MG73SI15V, E35D, M36I, N37E, R41K, K55R, I62V, L63P, H69K, I93LC
 RenG16337RenG16337KT747365PINAM46I, I54V, V82A, L90ML10LF, L33F, G73ST12TS, I13V, K14R, I15V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, I93LC
 RenG16729RenG16729KT747757PINAM46I I13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, R57K, L63P, H69K, K70KR, A71AT, L89T, I93LC
 RenG16894RenG16894KT747922PINAD30N, M46I, I54V, V82AL10F, L24I, L33F, N88DT12P, I13IV, K14KR, I15V, L19LP, K20KM, E35D, M36L, N37K, R41N, K55KR, R57RK, L63P, H69K, Q92QKC
 RenG17353RenG17353KT748381PINAM46I, I54V, L76V, V82AL10F, L33FI13V, K14KR, K20R, E35D, M36I, R41N, I62V, L63T, H69K, A71V, I72V, T74TA, L89M, I93LC
 RenG16330RenG16330KT747358PINAM46I, I54V, V82A, L90M L10V, I13A, L19LI, K20M, E21K, A22V, E35D, M36I, N37DE, R41N, I62V, L63P, I64V, H69K, T74S, L89M, I93L, C95VC
 RenG16730RenG16730KT747758PINAM46I, L90ML10F, L33FI15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, N88E, L89I, I93LC
 RenG16791RenG16791KT747819PINAM46I, I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, K20T, E35N, M36I, N37Q, R41N, I62IV, L63V, H69K, I72V, L89I, I93LC
 RenG15586RenG15586KT746614PINAM46I, I54V, I84V, L90M L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, D60E, I62V, L63P, H69K, A71V, L89I, I93LC
 RenG16317RenG16317KT747345PINAM46I, I54V, V82AL10F, Q58E, T74P, N88GI15V, G16E, K20T, E21K, E35G, M36I, N37K, P39S, R41N, L63T, H69K, V77I, L89MC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG16528RenG16528KT747556PINAM46I, I54V, V82AL10FI15S, G16R, G17GR, K20T, N37K, R41P, D60E, I62V, L63P, H69K, V77I, L89M, I93LC
 RenG17418RenG17418KT748446PINAM46I, I54V, V82F, L90M L10I, V11L, I13V, I15V, K20IT, E35G, M36I, N37K, P39Q, R41N, F53Y, L63P, I64IV, H69K, T74S, L89I, I93LC
 RenG16802RenG16802KT747830PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, D60E, Q61D, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93LC
 RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG15557RenG15557KT746585PINAM46I, I54V, L76V, V82C, L90M T12AS, I15V, G16E, L19P, K20T, E35G, M36I, N37K, R41N, K55R, R57RK, Q61N, L63N, H69K, A71V, I72R, L89I, I93LC
 RenG16128RenG16128KT747156PINAM46I, I54V, I84VL10FI15V, K20T, E35DN, M36I, N37K, R41N, I62IV, L63V, H69K, T74E, I85V, L89M, I93LC
 RenG16641RenG16641KT747669PINAM46I, I84V L10V, I15V, G16E, E35G, M36I, N37K, P39S, R41N, I62V, L63T, I64V, H69K, T74A, I85V, L89M, I93LC
 RenG14474RenG14474KT745502PINAM46I, I54V, V82A, I84V, L90ML10F, K43KTI15V, L19I, K20R, E35D, M36I, N37K, R41N, L63P, H69K, A71V, I85V, L89I, Q92K, I93LC
 RenG14917RenG14917KT745945PINAM46I, I47A, L90ML10FI15V, G16E, L19P, K20I, N37K, R41N, F53Y, D60E, Q61HN, L63H, H69K, V77I, I85V, L89I, I93LC
 RenG14788RenG14788KT745816PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20R, E35D, M36I, N37K, R41Y, R57RK, Q61N, L63P, H69K, A71V, L89M, I93LC
 RenG15065RenG15065KT746093PINAM46I, I50L, L90MQ58EI13V, I15V, L19I, K20R, E35D, M36I, N37K, R41N, K55R, L63P, H69K, A71T, L89I, I93LC
 RenG15244RenG15244KT746272PINAM46I, I54V, I84VL10FI15V, G16A, K20Q, M36I, N37K, R41N, L63P, I66V, H69K, I85V, L89I, Q92K, I93LC
 RenG14874RenG14874KT745902PINAM46I, N88S I15V, K20T, E35D, M36I, N37K, R41N, L63T, I64IV, H69K, T74S, L89M, I93LC
 RenG14962RenG14962KT745990PINAM46I, I54V, V82AL10F, L24I, L33FI15V, G16E, L19Q, K20R, E35D, M36I, N37K, R41N, Q61H, L63T, H69K, L89I, Q92K, I93LC
 RenG14844RenG14844KT745872PINAM46I, I54V, V82A, N88SL10F, L33F, L89VI13V, I15V, K20T, E21EK, E35D, M36IL, N37K, R41N, I62V, L63P, H69K, G73D, T74S, I93ILC
 RenG15013RenG15013KT746041PINAM46I, I84VL10FI15V, G16A, K20I, E35G, M36I, N37K, R41N, K55R, R57K, D60E, Q61E, L63P, H69K, I85V, L89I, I93LC
 RenG14431RenG14431KT745459PINAM46I, I54V, V82C, L90ML10F, L24IT12P, L19MV, K20R, E35D, M36I, N37T, R41N, Q61HN, I62V, L63P, H69K, T74S, V77I, L89IM, T91S, I93LC
 RenG13600RenG13600KT744628PINAM46I, I50L, L90ML23II15V, K20T, E35D, M36I, N37K, R41N, L63PT, H69K, A71V, T74S, I85IV, L89I, I93LC
 RenG15500RenG15500KT746528PINAM46I, I47IV, I54V, V82F, L90ML23I, L33LI, F53FL, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, L89I, Q92QK, I93LC
 RenG15206RenG15206KT746234PINAM46I, G48V, I54V, V82AQ58E, T74PL10V, I15V, K20R, E35D, M36I, N37K, R41N, F53Y, K55R, R57K, I62V, L63V, H69K, L89M, I93LC
 RenG14834RenG14834KT745862PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, Q61N, L63P, G68GE, H69K, K70KR, A71V, L89IM, I93LC
 RenG13568RenG13568KT744596PINAM46I, I54V, V82AK43T, T74PL10Y, I15V, L19LI, K20R, E35D, M36I, N37K, R41N, Q61N, I62IV, L63P, H69K, L89T, I93LC
 RenG12445RenG12445KT743473PINAM46I, I54V, V82AL10FIV, L24II15V, K20R, E35D, M36I, N37K, R41N, R57K, I62IV, L63P, H69K, T74TS, L89IM, I93LC
 RenG12839RenG12839KT743867PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, L19I, K20KT, M36L, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG13401RenG13401KT744429PINAM46I, I54V, V82F, L90MT74PSL10V, I13V, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, Q61QHKN, H69K, L89I, I93LC
 RenG13449RenG13449KT744477PINAM46I, L90M N37K, R41N, K55KR, I62IV, L63P, H69K, V77I, I85IV, I93LC
 RenG12787RenG12787KT743815PINAV32I, M46I, I47AV, V82VAL10F, F53FLI15V, L19LV, K20KT, M36I, N37K, R41N, L63P, I64M, H69K, I85IV, L89M, I93LC
 RenG12082RenG12082KT743110PINAM46I, I50V, V82A, L90ML10F, V11VI, L23I, L33F, Q58EI13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, G73V, T74S, L89T, I93LC
 RenG13298RenG13298KT744326PINAM46I, I54V, L76V, L90M I15V, L19I, K20T, E35D, M36I, N37E, R41H, R57K, Q61R, I62V, L63LP, H69R, A71V, V82I, L89I, I93LC
 RenG12492RenG12492KT743520PINAV32VI, M46I, I47V, V82VA, L90ML10F, K43KT, I54CT12S, I15V, K20T, E21K, E35D, M36I, N37K, R41H, R57RK, D60DE, I62IV, L63P, C67F, H69K, A71IM, L89M, I93LC
 RenG12637RenG12637KT743665PINAM46I, N88SF53LL10Y, I15V, K20T, E35G, M36I, N37D, R41K, L63V, I64V, H69K, T74A, L89M, I93LC
 RenG12519RenG12519KT743547PINAM46I, I54V, V82A, L90ML10F, L23II13V, K14R, I15V, K20I, E35N, M36I, N37E, R41N, Q61H, I62V, L63P, H69K, A71T, T74S, L89I, I93LC
 RenG12354RenG12354KT743382PINAM46I, I54V, V82A, L90ML33LI, K43KT, G73SL10I, I15V, L19LP, K20KI, A22AV, E35DN, M36I, N37K, P39PQ, R41N, K45KR, I62V, L63P, C67F, H69K, A71IV, I72L, I85V, I93ILC
 RenG12228RenG12228KT743256PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, I15IV, K20M, E35D, M36I, N37K, R41H, I62V, L63P, H69K, L89I, T91TSC
 RenG12355RenG12355KT743383PINAM46I, L90ML89MVI13V, K14R, I15V, K20T, M36I, N37K, R41N, I62V, H69K, T74TS, V82VI, I93LC
 RenG11141RenG11141KT742169PINAM46I, V82VA, I84VL10F, L23I, Q58QE, T74PSK14R, I15V, K20R, M36I, N37K, R41N, L63P, H69K, L89M, I93LC
 RenG10989RenG10989KT742017PINAM46I, I54V, V82A I15V, K20R, E35ED, M36I, N37K, R41N, K55R, L63T, H69K, I72T, T74A, L89M, I93LC
 RenG11086RenG11086KT742114PINAM46I, I47A, I84VF53LL10V, G16E, E35D, M36V, N37E, P39S, R41N, I62V, L63T, H69R, A71V, T74S, L89M, I93LC
 RenG10972RenG10972KT742000PINAM46I I15V, E35D, M36I, N37K, R41N, L63P, H69K, T74S, L89T, I93LC
 RenG10789RenG10789KT741817PINAM46I, I54V, V82A, I84VL10F, Q58EI15V, L19I, K20R, M36I, N37K, R41N, K55KN, D60E, Q61DN, I62IV, L63P, I64IL, H69K, I85V, L89IM, I93ILC
 RenG10964RenG10964KT741992PINAM46I, I54V, V82C, I84V, L90ML10FT12R, I15V, L19LP, K20T, L33L_L, E35D, M36I, N37K, R41N, D60E, L63P, I66IV, H69K, A71AT, V77I, I85V, L89I, Q92K, I93L, C95FC
 RenG10161RenG10161KT741189PINAM46I, I54V, V82F, L90M L10IV, I13V, G16E, L19LI, K20R, E35D, M36I, N37Q, P39S, R41K, I62V, L63P, H69K, T74AE, L89M, I93L, N98ITC
 RenG10445RenG10445KT741473PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16A, N37K, R41N, K55R, R57K, L63P, H69K, L89IC
 RenG10518RenG10518KT741546PINAM46I, I47A L10V, I13V, I15V, G16A, L19P, K20I, M36MI, N37K, R41N, R57K, L63P, H69K, T74S, L89I, I93LC
 RenG11404RenG11404KT742432PINAM46I, I54V, V82AV11I, L24I, L33FL10V, I13V, I15V, K20R, E35D, M36I, N37NK, R41P, K45KR, I62V, L63Q, G68DE, H69K, A71I, L89T, I93LC
 RenG10299RenG10299KT741327PINAM46I, I54V, L76V, V82A L10V, I15V, L19V, K20R, M36I, N37K, R41N, I62V, L63P, H69K, A71V, L89M, I93LC
 RenG10331RenG10331KT741359PINAM46I, I50L, V82AT74PL10I, I15V, L19I, K20R, M36I, N37K, R41N, I62IV, L63V, H69K, A71V, L89M, I93LC
 RenG10242RenG10242KT741270PINAM46I, I54V, V82A, L90M I13V, I15V, K20T, L33L_L, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG11250RenG11250KT742278PINAM46I, I50IL, I54V, V82F, L90M L10V, V11VL, K14R, I15V, Q18P, K20T, E35D, M36I, N37K, R41N, K55H, Q61QE, I62V, L63P, H69K, A71AV, T74A, L89I, I93ILC
 RenG10661RenG10661KT741689PINAM46I, I54V, V82A, L90ML33F, Q58E, G73SL10I, I13V, L19I, K20R, E35D, M36I, N37K, R41K, K55N, L63P, H69K, A71T, T74S, Q92K, I93LC
 RenG10982RenG10982KT742010PINAM46I, I50V, I54V, V82A, L90MV11I, L33F, K43T, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37K, R41N, I62IV, L63P, H69R, A71V, L89LM, I93LC
Novitsky (2015)bcpp_395bcpp_395KR860753PINAM46I, N88S T12P, I15V, L19I, K20I, E35G, M36I, R41K, Q61E, L63P, H69K, T74A, L89M, I93LC
Rossouw (2015)RP020RP020KT032001LPV42M46I, I54V, V82AL10FT12S, I15IV, L19I, K20R, E35D, M36I, R41K, R57K, L63P, H69K, L89IM, I93LC
 RP123-1RP123-1KT032043PINAM46I, I47V, I54V, L76V, V82AQ58EL10V, I15V, L19I, K20R, M36I, K55KR, D60E, L63P, H69K, A71V, L89M, I93LC
 RP154RP154KT032055LPV, RTV228M46I, I54V, V82AQ58EL10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K55KR, L63LP, H69K, K70R, L89IM, I93LC
 RP126RP126KT032045RTV, LPV348M46I, I54V, L76V, V82L Q7E, K14R, I15V, G16E, L19I, K20T, E35D, M36I, Q61N, L63C, H69K, L89I, I93LC
 RP167RP167KT032058LPV, RTV312M46I, I54V, V82AL10F, L24I, K43TI15V, L19I, K20R, E35D, M36V, N37E, R57K, I62V, L63P, H69K, V77I, L89I, I93LC
 RP145RP145KT032053PINAM46I, I54V, V82AL10F, L24I, L33F, Q58EI15V, G17D, L19V, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69K, P81PS, T91TN, I93LC
 RP099RP099KT032033LPV121M46I, I54V, V82AL10LF, L24LI, L33F, T74TPI13IV, K14KR, I15V, Q18E, L19IT, K20KR, M36L, R41K, Q61H, I62V, L63LP, H69K, L89I, I93L, L97LIC
 RP138RP138KT032050LPV, RTV231M46I, I54V, L76V, V82AL10FI15V, L19V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, I62V, H69K, A71V, L89M, I93LC
 RP104RP104KT032036LPV124M46I, I50V, I54V, V82A L10I, T12S, I15V, L19V, K20R, T31TI, E35D, M36I, R41K, L63P, H69K, K70R, A71V, V77I, L89M, I93LC
 RP045RP045KT032012LPV133M46I, I54V, L76V, V82AQ58EL10I, I15V, L19I, K20R, E35D, M36I, R41K, D60E, Q61D, L63P, C67E, H69K, L89MC
 RP061RP061KT032017PINAM46I, I54V, V82AL10FT12S, I15V, L19V, K20R, E35D, M36I, R41K, R57K, Q61DE, H69K, L89M, I93LC
 RP102-1RP102-1KT032034PINAM46I, I54V, L76V, V82A L10V, I15V, L19I, K20R, M36I, R41K, D60E, Q61E, I62V, L63P, H69K, I72IV, L89M, I93LC
 RP174RP174KT032060RTV, LPV385M46I, I54V, V82AL10FT12P, I15V, L19LI, K20KR, E35ED, M36MI, N37NS, R41K, L63A, H69K, A71AV, T91TI, I93LVC