<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K43T
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 31
Isolates 34
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG5959_w7 NFV7 K43TT12S, I15V, L19I, M36I, R41K, I62V, L63P, I64M, H69K, L89M, I93LC
Non-B Workgroup (2005)UK162UK162AY900762RTV57M46I, V82A, L90MK43TT12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93LC
 UK231UK231AY900765RTV, NFV26L90ML33I, K43TQ18L, L19T, K20X, E35N, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, L89M, I93LC
 UK1147UK1147AY900794IDV, NFV117M46IK43TT12S, I15V, L19I, K20T, E35D, M36I, N37D, D60E, Q61E, L63P, H69K, A71T, L89T, I93LC
 IL80IL80AY900811RTV, NFV, SQV114I54V, V82A, I84VK43TW6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 TK1020TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015c SQV, IDV, LPV, RTV, TPV375I54V, V82T, I84IV, L90MK43TL10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93LC
Baxter (2006)12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 48-14071407-30410DQ877803PINAI54V, V82A, L90ML10FI, K43TT12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93LC
 48-24052405-30826DQ877890PINAM46I, V82AL10F, K43T, T74PT12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
Kandathil (2009)VL07_040VL07_040EU030407PINAM46I, L90MK43TT12S, I15V, L19I, K20T, E35D, M36I, R41K, L63P, H69K, T74S, I93LC
Kouri (2012)CU2016-09CU2016-09JQ585331PINAM46I, I54M, V82A, L90MK43TL10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 CU1340-10CU1340-10JQ585423PINAM46I, I54AT, V82A, I84IVL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74TA, L89M, I93LC
 CU2035-09CU2035-09JQ585332PINAM46I, I54M, V82A, L90MK43TQ2H, L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91S, I93LC
Van Zyl (2013)16361248KC422997LPV26M46MI, I54V, V82A, L90ML10F, L33F, K43T, G73ST12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93LC
Grossman (2014)101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
Steegen (2014)12ZAKS29112ZAKS291KJ176570LPV M46I, I47A, I54VK43TR41K, R57K, D60E, L63P, H69K, A71V, V82I, L89M, I93LC
Diaz (2015)RenG15719RenG15719KT746747PINAI54V, L90ML23I, K43T, F53LI13V, I15V, L19I, K20T, E35D, M36I, N37K, R41N, I62IV, L63P, H69K, A71IV, T74S, V77I, L89I, I93LC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG14286RenG14286KT745314PINAV32I, M46MIL33LI, K43T, T74PI15V, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, A71AV, I85V, L89I, I93LC
 RenG13568RenG13568KT744596PINAM46I, I54V, V82AK43T, T74PL10Y, I15V, L19LI, K20R, E35D, M36I, N37K, R41N, Q61N, I62IV, L63P, H69K, L89T, I93LC
 RenG11494RenG11494KT742522PINAI50L, V82L, L90ML33F, K43TT12S, I13V, I15V, K20R, E35D, M36IV, N37K, R41N, Q61HN, L63T, I64V, H69K, A71V, T74S, L89M, I93LC
 RenG11741RenG11741KT742769PINAM46MI, I54V, V82A, L90ML33F, K43T, N88DL10V, I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74KR, L89M, I93LC
 RenG11471RenG11471KT742499PINAI54V, V82AK43T, T74PL10I, I15V, L19LI, K20R, E35D, M36I, N37K, R41INS, R57K, I62V, L63V, I64V, H69K, A71V, L89M, I93LC
 RenG10474RenG10474KT741502PINAG48S, I54V, V82F, L90ML33F, K43T, T74P, N83DL10I, I13V, K14R, I15V, E35D, M36L, N37K, R41IN, Q61N, I62V, C67CR, H69Q, L89I, I93LC
 RenG10982RenG10982KT742010PINAM46I, I50V, I54V, V82A, L90MV11I, L33F, K43T, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37K, R41N, I62IV, L63P, H69R, A71V, L89LM, I93LC
 RenG10631RenG10631KT741659PINAM46L, I54V, V82A, I84VV11I, L24I, K43TL10I, T12E, I13V, L19I, K20I, M36I, Q61N, L63T, I64V, H69K, A71V, I72IV, T74S, I93LC
Rossouw (2015)RP167RP167KT032058LPV, RTV312M46I, I54V, V82AL10F, L24I, K43TI15V, L19I, K20R, E35D, M36V, N37E, R57K, I62V, L63P, H69K, V77I, L89I, I93LC