<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K43T
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 19
Isolates 22
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG5959_w7 NFV7 K43TT12S, I15V, L19I, M36I, R41K, I62V, L63P, I64M, H69K, L89M, I93LC
Non-B Workgroup (2005)UK162UK162AY900762RTV57M46I, V82A, L90MK43TT12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93LC
 UK231UK231AY900765RTV, NFV26L90ML33I, K43TQ18L, L19T, K20X, E35N, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, L89M, I93LC
 UK1147UK1147AY900794IDV, NFV117M46IK43TT12S, I15V, L19I, K20T, E35D, M36I, N37D, D60E, Q61E, L63P, H69K, A71T, L89T, I93LC
 IL80IL80AY900811RTV, NFV, SQV114I54V, V82A, I84VK43TW6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 TK1020TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015c SQV, IDV, LPV, RTV, TPV375I54V, V82T, I84IV, L90MK43TL10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93LC
Baxter (2006)12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 48-14071407-30410DQ877803PINAI54V, V82A, L90ML10FI, K43TT12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93LC
 48-24052405-30826DQ877890PINAM46I, V82AL10F, K43T, T74PT12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
Kandathil (2009)VL07_040VL07_040EU030407PINAM46I, L90MK43TT12S, I15V, L19I, K20T, E35D, M36I, R41K, L63P, H69K, T74S, I93LC
Kouri (2012)CU2016-09CU2016-09JQ585331PINAM46I, I54M, V82A, L90MK43TL10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 CU1340-10CU1340-10JQ585423PINAM46I, I54AT, V82A, I84IVL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74TA, L89M, I93LC
 CU2035-09CU2035-09JQ585332PINAM46I, I54M, V82A, L90MK43TQ2H, L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91S, I93LC
Van Zyl (2013)16361248KC422997LPV26M46MI, I54V, V82A, L90ML10F, L33F, K43T, G73ST12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93LC
Grossman (2014)101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC