Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	K43R
Rx	PI-naive
IncludeMixtures	No

References	41
Patients	61
Isolates	63

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Lole (1999)	IND21068	ind21068	AF067155	None		T12S, K14R, I15V, L19I, M36V, N37S, R41K, K43R, D60E, Q61E, L63P, H69K, L89M, I93L	C
Novitsky (1999)	96BW11	96BW11		None		T12S, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93L	C
Rodenburg (2001)	CR_97ZA012	CR_97ZA012	AF286227	None		T12S, I15V, L19I, E35D, M36I, N37D, K43R, L63P, H69K, L89M, I93L	C
Handema (2002)	H00ZM4740	H00ZM4740	AB081156	None		I15V, M36I, R41K, K43R, L63P, H69K, I93L	C
Yang (2002)	DH008	DH008	AB078707	None		T12S, K14R, I15V, L19I, M36V, R41K, K43R, L63P, H69K, K70R, I93L	C
Arroyo (2004)	01TZA306	01TZA306	AY253318	None		I13V, K14R, I15V, G16E, E35D, M36I, R41K, K43R, K45R, R57K, L63S, H69K, L89M	C
Balakrishnan (2005)	YRG2	YRG2	AY787488	None		T12X, I15V, L19T, M36I, K43R, Q61E, L63T, I64M, H69K, L89M, I93L	C
	YRG26	YRG26	AY787512	None		T12S, K14R, I15V, L19X, M36I, R41K, K43R, I62IV, L63P, H69K, T74TS, L89M, I93L	C
Bussmann (2005)	01BW2796S	01BW2796S	AY829296	None		T12S, I15V, L19I, M36I, R41K, K43R, L63T, H69K, T74A, L89M, I93L	C
Weber (2005)	F88026	F88026	AY677467	None		T12S, I15V, L19I, M36I, N37D, K43R, L63S, H69K, I93L	C
Bessong (2006)	POB_01PB35ZA	01PB35ZA	DQ222254	None		T12S, I15V, L19T, K20R, R41K, K43R, L63P, H69K, V77I, I93L	C
Rousseau (2006)	Pt15	03PS026MB1	DQ369985	None		T12S, K14R, I15V, L19I, E35D, M36I, R41K, K43R, H69K, L89M, I93L	C
	Pt162	04PS206B1	DQ164126	None		T12S, I15V, L19I, M36I, R41K, K43R, L63V, H69K, T74S, L89M, I93L	C
	Pt244	1192M3M	AY463219	None		I15V, L19I, E35D, M36I, R41K, K43R, H69K, I93L	C
Kassu (2007)	ETH-G-124	G-124	AB285804	None		L10V, T12TA, I15V, L19Q, K20R, M36I, R41K, K43R, L63S, H69K, I93L	C
Novitsky (2007)	1282	1282_0280	EF026202	None		T12S, I15V, L19V, M36I, R41K, K43R, Q61E, L63P, H69K, L89M, I93L	C
		1282_0525	EF026201	None		T12S, I15V, L19I, M36I, R41K, K43R, Q61E, L63P, H69K, T74TA, L89M, I93L	C
Sen (2007)	N028	RT28-PL	EF186942	None		T12S, I15V, L19I, M36I, R41K, K43R, L63P, H69K, T74TA, L89LM, I93L	C
	T102	NPT102	EF186932	None		T12P, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93L	C
		NPT102-PL	EF186981	None		T12P, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93L	C
Arora (2008)	9	PI-9		None		T12S, K14R, I15V, L19I, M36I, R41K, K43R, L63P, H69K, K70R, L89M, I93L	C
Kamoto (2008)	MW51	MW51	JQ617166	None		I15V, L19I, M36I, R41K, K43R, L63P, H69K, T74S, L89M, I93L	C
Marconi (2008)	SW023	sw023	EU308036	None		I15V, L19V, M36I, N37K, R41K, K43R, L63T, H69K, L89M, I93L	C
	SW097	SW097	EU308105	None		L19I, M36I, R41K, K43R, Q61H, H69K, L89M, I93L	C
Matthews (2008)	1192	1192	FJ199549	None		I15V, L19I, E35D, M36I, R41K, K43R, H69K, I93L	C
	PS026	PS026	FJ199607	None		T12S, K14R, I15V, L19I, E35D, M36I, R41K, K43R, H69K, L89M, I93L	C
Aghokeng (2009)	CYN194	CYN194	GU191586	None		I13V, E35N, M36I, N37D, R41K, K43R, L63P, H69K, L89M	C
Kandathil (2009)	VL06_100	VL06_100	EU110075	None		T12X, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93L	C
	CD06_419	CD06_419	EU683767	None		I13V, L19T, K20R, M36I, K43R, Q61E, L63P, H69K, I93L	C
Rajesh (2009)	N69	TRCNPR69	FJ595432	None		K14R, I15V, L19I, M36I, N37D, R41K, K43R, H69K, L89LM, I93L	C
Vercauteren (2009)	pt1678	3261721063	GQ399346	None		T12S, I15V, L19T, K20R, M36V, N37E, K43R, H69K, I93L	C
Wallis (2009)	2342708	2342708		None		I15V, G16A, L19T, K20R, M36I, R41K, K43R, L63P, H69K, V77I, L89I, I93L	C
	GT00081904	GT00081904		None		T12S, I15V, L19I, E35D, M36I, R41K, K43R, R57RK, L63P, H69K, T74S, L89M, I93L	C
Hamers (2010)	300021	CP076300021	HM119617	None		T12S, I15V, L19V, K20R, M36I, R41K, K43R, L63T, I64L, H69K, L89M, I93L	C
	300049	CP076300049	HM119641	None		T12S, I15V, L19I, M36I, R41K, K43R, L63T, H69K, L89M, I93L	C
	300494	CP076300494	HM119913	None		I13V, I15V, L19I, M36I, R41K, K43R, L63LIPT, H69K, I72IV, L89M, I93L	C
Papathanasopoulos (2010)	17854	07ZA17854	GU253408	None		T12S, K14R, I15V, L19I, N37NS, R41K, K43R, L63P, H69K, L89M, I93L	C
Tymchuck (2010)	MW10	MW10	HM744720	None	Q58E	T12S, I15V, G16E, L19I, M36I, R41K, K43R, D60E, Q61E, L63T, E65D, H69K, L89M, I93L	C
Bussmann (2011)	B0534	B0534	JQ616982	None		I15V, Q18H, L19I, M36I, R41K, K43R, L63P, H69K, L89M, I93L	C
	B0538	B0538	JQ616985	None		I15V, L19I, M36I, R41K, K43R, L63Q, H69K, L89M, I93L	C
	B0748	B0748	JQ617025	None		I15V, L19I, E35D, M36I, R41K, K43R, L63P, H69K, K70R, L89M, I93L	C
Deshpande (2011)	Pat064	in1075	JF414456	None		T12TS, I15V, L19I, M36I, R41K, K43R, L63P, H69K, K70KR, I93L	C
	Pat045	in1133	JF414425	None		T12S, K14R, L19I, K20R, M36I, R41K, K43R, L63P, H69K, I93L	C
	Pat043	in1131	JF414427	None		T12S, L19I, M36I, R41K, W42WR, K43R, L63H, H69K, L89M, I93L	C
	Pat027	in1105	JF414443	None		T12S, L19I, M36I, R41K, K43R, I62V, L63P, H69K, T74A, L89M, I93L	C
Graf (2011)	SC93	SC93	JF774034	None		K14R, L33V, N37S, R41N, K43R, D60E, L63P, H69K, L89M, I93L	C
Hamers (2011)	CP076301461	CP076301461	HQ994431	None		T12S, I15V, L19T, K20R, M36I, R41K, K43R, L63P, H69K, V77I, L89M, I93L	C
	CP076302106	CP076302106	HQ994479	None		T12S, I15V, L19I, M36I, R41IT, K43R, L63P, H69K, L89M, I93L	C
	CP763A03428	CP763A03428	HQ994675	None		I15V, G16E, L19I, M36I, R41K, K43R, L63AT, H69K, I93L	C
	CP763A03374	CP763A03374	HQ994908	None		T12S, I15V, L19T, M36I, N37D, K43R, L63P, H69K, I93L	C
Nwobegahay (2011)	08MB43ZA	08MB43ZA	GU188826	None		L5F, T12S, L19I, M36I, R41K, K43R, D60E, I62V, L63A, H69K, L89M, I93L	C
Sigaloff (2011)	GT00366729	GT00366729_2	JN381608	None		T12S, I15V, L19I, K20R, M36I, N37E, P39Q, R41K, K43R, I62V, H69K, A71T, I93L	C
van Zyl (2011)	A279	A279	JN638170	None		T12S, I15V, L19T, M36I, N37S, R41K, K43R, L63Q, H69K, L89LM, I93L	C
	A33	A33	JN638195	None		I15V, L19I, M36I, R41K, K43R, L63P, C67CG, H69K, I93L	C
Wright (2011)	OW_013	OW_013	HQ696837	None		T12S, I15V, L19I, E35D, M36I, N37E, R41K, K43R, L63V, H69K, T74S, L89M, I93L	C
Zeng (2011)	K63	K63	JF505513	None		T12S, I15V, L19I, M36I, N37D, R41K, K43R, D60E, L63P, H69K, K70R, I93L	C
	K78	K78	JF505606	None		T12S, I15V, L19I, M36I, N37D, R41K, K43R, D60E, L63P, H69K, K70R, I93L	C
da Silveira (2012)	BRMS47	BRMS47	JF342298	None		L10V, I13V, I15V, L19I, M36T, N37K, R41N, K43R, L63T, H69K, L89I, I93L	C
Hingankar (2012)	IN-NARI-4-034	IN-NARI-4-034	JN314922	None		T12S, I15V, L19I, M36I, P39Q, R41K, K43R, I62IV, L63P, H69K, L89M, I93L	C
Musyoki (2012)	DGM.35	DGM.35	JN176297	None		T12S, I15V, L19V, M36I, N37D, R41K, K43R, L63Q, I64L, H69K, I93L	C
Nwobegahay (2012)	BBCR50ZA	BBCR50ZA	GU177492	None		T12S, I15V, L19T, K20R, E35D, M36I, R41K, K43R, L63P, H69K, I93L	C
Chen (2013)	11YNHH024	11YNHH024	JX412335	None		T12S, I15V, L19I, M36I, R41K, K43R, R57K, D60E, L63P, I64L, H69K, L89M, I93L	C
Frentz (2013)	EHR-85278	EHR-85278	JX300989	None		T12TS, I15IV, L19T, K20R, E35D, M36I, R41K, K43R, Q61QR, L63FS, H69K, K70KE, A71AT, T74TS, L89LM, I93L	C

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