<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K43R
Rx PI-naive
IncludeMixtures No
References 46
Patients 73
Isolates 75
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Lole (1999)IND21068ind21068AF067155None   T12S, K14R, I15V, L19I, M36V, N37S, R41K, K43R, D60E, Q61E, L63P, H69K, L89M, I93LC
Novitsky (1999)96BW1196BW11 None   T12S, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93LC
Rodenburg (2001)CR_97ZA012CR_97ZA012AF286227None   T12S, I15V, L19I, E35D, M36I, N37D, K43R, L63P, H69K, L89M, I93LC
Handema (2002)H00ZM4740H00ZM4740AB081156None   I15V, M36I, R41K, K43R, L63P, H69K, I93LC
Yang (2002)DH008DH008AB078707None   T12S, K14R, I15V, L19I, M36V, R41K, K43R, L63P, H69K, K70R, I93LC
Arroyo (2004)01TZA30601TZA306AY253318None   I13V, K14R, I15V, G16E, E35D, M36I, R41K, K43R, K45R, R57K, L63S, H69K, L89MC
Balakrishnan (2005)YRG2YRG2AY787488None   T12X, I15V, L19T, M36I, K43R, Q61E, L63T, I64M, H69K, L89M, I93LC
 YRG26YRG26AY787512None   T12S, K14R, I15V, L19X, M36I, R41K, K43R, I62IV, L63P, H69K, T74TS, L89M, I93LC
Bussmann (2005)01BW2796S01BW2796SAY829296None   T12S, I15V, L19I, M36I, R41K, K43R, L63T, H69K, T74A, L89M, I93LC
Weber (2005)F88026F88026AY677467None   T12S, I15V, L19I, M36I, N37D, K43R, L63S, H69K, I93LC
Bessong (2006)POB_01PB35ZA01PB35ZADQ222254None   T12S, I15V, L19T, K20R, R41K, K43R, L63P, H69K, V77I, I93LC
Rousseau (2006)Pt1503PS026MB1DQ369985None   T12S, K14R, I15V, L19I, E35D, M36I, R41K, K43R, H69K, L89M, I93LC
 Pt16204PS206B1DQ164126None   T12S, I15V, L19I, M36I, R41K, K43R, L63V, H69K, T74S, L89M, I93LC
 Pt2441192M3MAY463219None   I15V, L19I, E35D, M36I, R41K, K43R, H69K, I93LC
Kassu (2007)ETH-G-124G-124AB285804None   L10V, T12TA, I15V, L19Q, K20R, M36I, R41K, K43R, L63S, H69K, I93LC
Novitsky (2007)12821282_0280EF026202None   T12S, I15V, L19V, M36I, R41K, K43R, Q61E, L63P, H69K, L89M, I93LC
  1282_0525EF026201None   T12S, I15V, L19I, M36I, R41K, K43R, Q61E, L63P, H69K, T74TA, L89M, I93LC
Sen (2007)N028RT28-PLEF186942None   T12S, I15V, L19I, M36I, R41K, K43R, L63P, H69K, T74TA, L89LM, I93LC
 T102NPT102EF186932None   T12P, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93LC
  NPT102-PLEF186981None   T12P, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93LC
Arora (2008)9PI-9 None   T12S, K14R, I15V, L19I, M36I, R41K, K43R, L63P, H69K, K70R, L89M, I93LC
Kamoto (2008)MW51MW51JQ617166None   I15V, L19I, M36I, R41K, K43R, L63P, H69K, T74S, L89M, I93LC
Marconi (2008)SW023sw023EU308036None   I15V, L19V, M36I, N37K, R41K, K43R, L63T, H69K, L89M, I93LC
 SW097SW097EU308105None   L19I, M36I, R41K, K43R, Q61H, H69K, L89M, I93LC
Matthews (2008)11921192FJ199549None   I15V, L19I, E35D, M36I, R41K, K43R, H69K, I93LC
 PS026PS026FJ199607None   T12S, K14R, I15V, L19I, E35D, M36I, R41K, K43R, H69K, L89M, I93LC
Aghokeng (2009)CYN194CYN194GU191586None   I13V, E35N, M36I, N37D, R41K, K43R, L63P, H69K, L89MC
Kandathil (2009)VL06_100VL06_100EU110075None   T12X, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93LC
 CD06_419CD06_419EU683767None   I13V, L19T, K20R, M36I, K43R, Q61E, L63P, H69K, I93LC
Rajesh (2009)N69TRCNPR69FJ595432None   K14R, I15V, L19I, M36I, N37D, R41K, K43R, H69K, L89LM, I93LC
Vercauteren (2009)pt16783261721063GQ399346None   T12S, I15V, L19T, K20R, M36V, N37E, K43R, H69K, I93LC
Wallis (2009)23427082342708 None   I15V, G16A, L19T, K20R, M36I, R41K, K43R, L63P, H69K, V77I, L89I, I93LC
 GT00081904GT00081904 None   T12S, I15V, L19I, E35D, M36I, R41K, K43R, R57RK, L63P, H69K, T74S, L89M, I93LC
Papathanasopoulos (2010)1785407ZA17854GU253408None   T12S, K14R, I15V, L19I, N37NS, R41K, K43R, L63P, H69K, L89M, I93LC
Tymchuck (2010)MW10MW10HM744720None  Q58ET12S, I15V, G16E, L19I, M36I, R41K, K43R, D60E, Q61E, L63T, E65D, H69K, L89M, I93LC
Bussmann (2011)B0534B0534JQ616982None   I15V, Q18H, L19I, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
 B0538B0538JQ616985None   I15V, L19I, M36I, R41K, K43R, L63Q, H69K, L89M, I93LC
 B0748B0748JQ617025None   I15V, L19I, E35D, M36I, R41K, K43R, L63P, H69K, K70R, L89M, I93LC
Deshpande (2011)Pat064in1075JF414456None   T12TS, I15V, L19I, M36I, R41K, K43R, L63P, H69K, K70KR, I93LC
 Pat045in1133JF414425None   T12S, K14R, L19I, K20R, M36I, R41K, K43R, L63P, H69K, I93LC
 Pat043in1131JF414427None   T12S, L19I, M36I, R41K, W42WR, K43R, L63H, H69K, L89M, I93LC
 Pat027in1105JF414443None   T12S, L19I, M36I, R41K, K43R, I62V, L63P, H69K, T74A, L89M, I93LC
Graf (2011)SC93SC93JF774034None   K14R, L33V, N37S, R41N, K43R, D60E, L63P, H69K, L89M, I93LC
Hamers (2011)300021CP076300021HM119617None   T12S, I15V, L19V, K20R, M36I, R41K, K43R, L63T, I64L, H69K, L89M, I93LC
 300049CP076300049HM119641None   T12S, I15V, L19I, M36I, R41K, K43R, L63T, H69K, L89M, I93LC
 300494CP076300494HM119913None   I13V, I15V, L19I, M36I, R41K, K43R, L63LIPT, H69K, I72IV, L89M, I93LC
 CP076301461CP076301461HQ994431None   T12S, I15V, L19T, K20R, M36I, R41K, K43R, L63P, H69K, V77I, L89M, I93LC
 CP076302106CP076302106HQ994479None   T12S, I15V, L19I, M36I, R41IT, K43R, L63P, H69K, L89M, I93LC
 CP763A03428CP763A03428HQ994675None   I15V, G16E, L19I, M36I, R41K, K43R, L63AT, H69K, I93LC
 CP763A03374CP763A03374HQ994908None   T12S, I15V, L19T, M36I, N37D, K43R, L63P, H69K, I93LC
Nwobegahay (2011)08MB43ZA08MB43ZAGU188826None   L5F, T12S, L19I, M36I, R41K, K43R, D60E, I62V, L63A, H69K, L89M, I93LC
Sigaloff (2011)GT00366729GT00366729_2JN381608None   T12S, I15V, L19I, K20R, M36I, N37E, P39Q, R41K, K43R, I62V, H69K, A71T, I93LC
van Zyl (2011)A279A279JN638170None   T12S, I15V, L19T, M36I, N37S, R41K, K43R, L63Q, H69K, L89LM, I93LC
 A33A33JN638195None   I15V, L19I, M36I, R41K, K43R, L63P, C67CG, H69K, I93LC
Wright (2011)OW_013OW_013HQ696837None   T12S, I15V, L19I, E35D, M36I, N37E, R41K, K43R, L63V, H69K, T74S, L89M, I93LC
Zeng (2011)K63K63JF505513None   T12S, I15V, L19I, M36I, N37D, R41K, K43R, D60E, L63P, H69K, K70R, I93LC
 K78K78JF505606None   T12S, I15V, L19I, M36I, N37D, R41K, K43R, D60E, L63P, H69K, K70R, I93LC
da Silveira (2012)BRMS47BRMS47JF342298None   L10V, I13V, I15V, L19I, M36T, N37K, R41N, K43R, L63T, H69K, L89I, I93LC
Hingankar (2012)IN-NARI-4-034IN-NARI-4-034JN314922None   T12S, I15V, L19I, M36I, P39Q, R41K, K43R, I62IV, L63P, H69K, L89M, I93LC
Hunt (2012)KZN08_329619KZN08_329619KF736684None   L19V, M36I, R41K, K43R, L63S, H69K, V82I, L89M, I93LC
 KZN08_346242KZN08_346242KF736706None   T12S, I15V, G16E, L19I, K20R, E35D, M36I, K43R, L63T, H69K, T74S, L89M, I93LC
Musyoki (2012)DGM.35DGM.35JN176297None   T12S, I15V, L19V, M36I, N37D, R41K, K43R, L63Q, I64L, H69K, I93LC
Nwobegahay (2012)BBCR50ZABBCR50ZAGU177492None   T12S, I15V, L19T, K20R, E35D, M36I, R41K, K43R, L63P, H69K, I93LC
Bila (2013)MZ10-205HIV-1KF927304None  V11VII15V, L19V, M36I, R41K, K43R, L63S, H69K, L89M, I93LC
Chen (2013)11YNHH02411YNHH024JX412335None   T12S, I15V, L19I, M36I, R41K, K43R, R57K, D60E, L63P, I64L, H69K, L89M, I93LC
Frentz (2013)EHR-85278EHR-85278JX300989None   T12TS, I15IV, L19T, K20R, E35D, M36I, R41K, K43R, Q61QR, L63FS, H69K, K70KE, A71AT, T74TS, L89LM, I93LC
Kiertiburanakul (2013)R51TS065R51TS065KF059702None   T12S, I13V, K14R, I15V, G16E, L19I, M36I, R41K, K43R, L63CS, H69K, K70R, V82I, L89IM, I93LC
Mulu (2013)ETH-G-5490ETH-G-5490KF026067None   T12S, I15V, L19T, K20R, M36I, R41K, K43R, Q61H, I62V, L63H, H69K, K70Q, L89M, I93LC
 ETH-G-5740ETH-G-5740KF026180None   I15V, E35D, M36L, R41K, K43R, Q61N, L63A, H69K, T74A, L89M, I93LC
Van Zyl (2013)3502726KC423800None   T12S, L19I, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
 7811695KC423331None   T12S, K14R, I15V, L19T, M36I, N37S, R41K, K43R, L63P, H69K, L89I, I93LC
 12401125KC422897None   T12S, L19V, K20R, M36I, R41K, K43R, L63P, H69K, L89I, I93LC
Steegen (2014)11ZAKS16311ZAKS163KJ176445None   R41K, K43R, L63P, H69K, I93LC
 11ZAKS17411ZAKS174KJ176455None   R41K, K43R, H69K, T74S, L89M, I93LC
 11ZAKS18511ZAKS185KJ176466None   R41K, K43R, I62V, L63S, H69K, A71T, I93LC