<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K43R
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 13
Isolates 13
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)TK3022TK3022 SQV, NFV103  T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LIC
Weber (2005)00M387800M3878AY677436NFV74  I15V, L19IV, M36I, R41K, K43R, D60DE, Q61QE, L63P, H69K, L89M, I93LC
 F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
von Wyl (2007)1325062429EF449853PINA  I13IV, E35D, M36I, R41K, K43R, H69K, L89MC
El-Khatib (2010)Pat09911ZA_SAVE2062JF960549LPV   T12S, L19I, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
Van Zyl (2013)11691618KC423273LPV26  T12S, K14R, I15V, G16E, L19V, M36I, N37K, R41K, K43R, R57K, L63T, H69K, V82I, L89M, I93LC
 14221329KC423063LPV26  T12S, I15V, L19T, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, H69K, I93LC
 14532172KC423667LPV26M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, M36I, R41K, K43R, L63V, H69K, L89I, I93LC
 17252001KC423554LPV26  T12S, I15IV, G16E, L19I, M36MI, R41K, K43R, L63Q, H69K, V77I, V82I, L89I, I93LC
Grossman (2014)613613KF135114NFV, LPV52L90M Q7R, I15V, L19T, K20I, E35N, M36I, R41K, K43R, H69K, T74S, L89I, I93LC
Steegen (2014)09ZAKS01709ZAKS017KJ176299LPV M46I, I54V, V82A R41K, K43R, L63V, H69K, T74S, L89M, I93LC
 10ZAKS07110ZAKS071KJ176353LPV M46I, I54V, L76V, V82AQ58EK43R, I62IV, L63P, H69K, L89M, I93LC
Rossouw (2015)RP053RP053KT032014LPV63  L10V, I15V, L19I, E35D, M36I, R41K, K43R, H69K, T74S, L89M, I93LC