<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K43R
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 25
Isolates 25
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)TK3022TK3022 SQV, NFV103  T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LIC
Weber (2005)00M387800M3878AY677436NFV74  I15V, L19IV, M36I, R41K, K43R, D60DE, Q61QE, L63P, H69K, L89M, I93LC
 F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
von Wyl (2007)1325062429EF449853PINA  I13IV, E35D, M36I, R41K, K43R, H69K, L89MC
El-Khatib (2010)Pat09911ZA_SAVE2062JF960549LPV   T12S, L19I, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
Van Zyl (2013)93111.ZA.WC173KC423554LPV   T12S, I15IV, G16E, L19I, M36MI, R41K, K43R, L63Q, H69K, V77I, V82I, L89I, I93LC
 385510.ZA.GT1227KC423063LPV   T12S, I15V, L19T, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, E65D, H69K, I93LC
 348611.ZA.GT1485KC423273LPV   T12S, K14R, I15V, G16E, L19V, M36I, N37K, R41K, K43R, R57K, L63T, H69K, V82I, L89M, I93LC
 389511.ZA.GT1894KC423667LPV M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, M36I, R41K, K43R, L63V, H69K, L89I, I93LC
Grossman (2014)613613KF135114NFV, LPV52L90M Q7R, I15V, L19T, K20I, E35N, M36I, R41K, K43R, H69K, T74S, L89I, I93LC
Steegen (2014)09ZAKS01709ZAKS017KJ176299LPV M46I, I54V, V82A R41K, K43R, L63V, H69K, T74S, L89M, I93LC
 10ZAKS07110ZAKS071KJ176353LPV M46I, I54V, L76V, V82AQ58EK43R, I62IV, L63P, H69K, L89M, I93LC
Diaz (2015)RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG15962RenG15962KT746990PINAI54V, V82AL10FV, L24II15IV, G16E, K20R, E35D, M36I, N37E, R41N, K43R, K45V, R57K, Q58R, L63H, I66V, H69K, L89I, I93LC
 RenG14790RenG14790KT745818PINA  I15V, E35D, N37DE, R41N, K43R, D60N, I62IV, L63P, H69K, A71T, I72V, L89LI, I93LC
 RenG13590RenG13590KT744618PINA  T12S, K14R, I15V, L19T, E35E_T, M36V, N37E, K43R, H69K, L89M, I93LC
 RenG10565RenG10565KT741593PINA  P39T, K43R, L63T, H69K, L89I, I93LC
Novitsky (2015)mpp_102mpp_102KR860885PINA  T12S, I15V, L19T, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
 mpp_209mpp_209KR860989PINA  T12S, I15V, L19I, M36I, R41N, K43R, D60E, L63P, H69K, K70R, L89M, I93LC
 mpp_163mpp_163KR860946PINA  T12S, I15V, G16A, L19I, M36I, R41N, K43R, L63P, H69K, K70R, L89M, I93LC
 bcpp_192bcpp_192KR860682PINA  L19I, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
 bcpp_298bcpp_298KR860724PINA  T12S, I15V, L19I, N37S, R41K, K43R, L63I, H69K, L89M, I93LC
 bcpp_060bcpp_060KR860627PINA  T12S, L19I, K20R, M36I, R41K, K43R, L63P, H69K, L89M, I93LC
 mpp_150mpp_150KR860933PINA  T12S, I15V, L19I, M36I, R41K, K43R, L63A, H69K, T74A, L89M, I93LC
Rossouw (2015)RP053RP053KT032014LPV63  L10V, I15V, L19I, E35D, M36I, R41K, K43R, H69K, T74S, L89M, I93LC