Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	M36T
Rx	PI-naive
IncludeMixtures	No

References	36
Patients	63
Isolates	63

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Handema (2002)	H00ZM4781	H00ZM4781	AB081167	None		I15V, L19I, M36T, R41K, H69K, L89M, I93L	C
Brindeiro (2003)	BRP2136	BRP2136	AY213431	None		M36T, N37K, R41N, D60E, L63P, H69K, L89M, I93L	C
	BRC1525	BRC1525	AY213520	None		I13V, I15V, M36T, N37K, R41N, H69K, L89I, I93L	C
Gordon (2003)	ZA066p01	ZA066p01	AY137004	None		T12S, I15V, G16E, L19I, M36T, N37S, R41K, L63T, H69K, L89M, I93L	C
Soares (2003)	BRP2022	BRP2022	AF527205	None		L10I, M36T, N37K, R41N, H69K, L89M, I93L	C
	BRP2073	BRP2073	AF527284	None		Q2K, I15V, G16A, M36T, N37K, R41N, H69K	C
	BRP2089	BRP2089	AF527305	None		L10V, I15V, M36T, N37K, R41N, L63V, H69K, L89M, N98K	C
Balakrishnan (2005)	YRG21	YRG21	AY787507	None		I13V, K14R, I15V, L19I, M36T, R41K, L63P, H69K, L89M, I93L	C
Non-B Workgroup (2005)	BR1001	BR1001	AY900898	None		L10I, M36T, N37K, R41N, H69K, L89M, I93L	C
	BR1018	BR1018	AY900912	None		Q2K, I15V, G16A, M36T, N37K, R41N, H69K	C
	BR1024	BR1024	AY900915	None		L10V, I15V, M36T, N37K, R41N, L63V, H69K, L89M, N98K	C
Bessong (2006)	POB_01PB16ZA	01PB16ZA	DQ222248	None		T12S, I15V, G16E, L19I, M36T, N37T, P39S, R41K, D60E, Q61E, L63S, H69K, T74A, L89M, I93L	C
Rousseau (2006)	Pt73	03PS136MB1	DQ351231	None		L19V, M36T, R41K, L63V, I64L, H69K, L89M, I93L	C
	Pt113	03SK086B1	DQ164124	None		T12P, K14R, L19I, M36T, G40R, R41K, L63P, H69K, K70R, G86R, L89M, I93L, G94R	C
Santos (2006)	058PR	058PR	AY275776	None		I15V, L19V, M36T, N37K, R41N, L63T, H69K, L89M, I93L	C
	C076PR	C076PR	DQ191012	None		I15V, M36T, N37K, R41N, L63T, H69K, L89M, I93L	C
	C077PR	C077PR	DQ191013	None		L10I, M36T, N37K, R41N, L63P, H69K, L89M, I93L	C
Sen (2007)	N029	RT29-PL	EF186939	None		T12S, I15V, L19T, M36T, R41K, L63P, H69K, I93L	C
Soundararajan (2007)	TRC24	TRC24	EF491938	None		T12TS, I15V, L19T, M36T, R41K, L63P, H69K, V77I, L89M, I93L	C
Vidal (2007)	U0702	02BU.U0702	AM260287	None		T12S, I15V, L19V, M36T, N37K, R41N, K45R, H69K, L89M, I93L	C
Arora (2008)	50	PI-50		None		I13V, I15V, L19I, M36T, R41K, L63P, H69K, L89M, I93L	C
Ibe (2008)	99	99	AB356162	None		I15V, G16E, M36T, N37K, R41N, H69K, L89I, I93L	C
Marconi (2008)	SW012	sw012	EU308030	None		T12S, I15V, G16E, L19V, M36T, N37D, R41K, D60E, L63T, I64L, H69K, I72V, V77I, L89M, I93L	C
	SW076	sw076	EU308087	None		T12S, I15V, L19T, M36T, R41K, D60E, H69K, L89M, I93L	C
Matthews (2008)	A373	A373	FJ199572	None		T12S, I15V, L19V, M36T, R41K, L63S, H69K, L89M, I93L	C
	PS037	PS037	FJ199618	None		T12S, I15V, L19I, M36T, R41K, H69K, L89M, I93L	C
	PS136	PS136	FJ199705	None		L19V, M36T, R41K, L63V, I64L, H69K, L89M, I93L	C
	PS368	PS368	FJ199787	None		T12S, I15V, G16E, L19I, M36T, P39S, R41K, D60E, I62V, H69K, L89M, I93L	C
	SK086	SK086	FJ199887	None		T12P, K14R, L19I, M36T, G40R, R41K, L63P, H69K, K70R, G86R, L89M, I93L, G94R	C
	SK135	SK135	FJ199912	None		I15V, L19I, E35D, M36T, R41K, H69K, L89M	C
	SK161	SK161	FJ199933	None		L19T, M36T, L63P, H69K, L89M, I93L	C
Pillay (2008)	DR69	DR69	AY589918	None		T12S, I15V, L19I, E35D, M36T, R41K, D60E, Q61E, L63P, H69K, V82I, L89M, I93L	C
Brown (2009)	CAS_1350_4_1257	CAS_1350_4_1257	FJ030696	None		L10V, I15V, M36T, N37K, R41N, H69K, L89M, I93L	C
Iqbal (2009)	100127	100127	EU449542	None		T12S, K14R, I15V, G16E, L19I, M36T, R41K, L63S, H69K, L89M, I93L	C
	100186	100186	EU449543	None		T12S, K14R, I15V, L19T, M36T, R41K, L63P, H69K, L89LM, I93L	C
Bonura (2010)	1223_116	1223_116	GU969560	None		L10V, I15V, G16GE, M36T, N37K, R41N, L63T, H69K, L89I, I93L	C
Djoko (2010)	625	CD2644	FR666625	None		T12S, I15IV, L19IM, M36T, N37D, R41K, L63T, H69K, V77I, L89M, I93L	C
Wright (2010)	300	SK300	HM593304	None		T12S, I15V, L19V, M36T, P39PS, R41K, L63LP, H69K, L89M, I93L	C
	372	SK372	HM593379	None		I15V, L19I, M36T, R41K, R57K, H69K, L89M, I93L	C
Ferreira (2011)	BRMT2564	BRMT2564	HQ638713	None		T12A, I15V, G16E, M36T, N37K, R41N, L63H, H69K, L89I, I93L	C
	BRMT2822	BRMT2822	HQ638727	None		I15V, M36T, N37K, R41N, K45R, H69K, L89I, I93L	C
Graf (2011)	SC02	SC02	JF773982	None		M36T, N37K, R41N, Q61D, L63E, H69K, I93L	C
	SC38	SC38	JF774005	None		L10I, I15V, M36T, N37K, R41N, L63T, C67G, H69K, L89I, I93L	C
	SC40	SC40	JF774007	None		L10V, I15V, M36T, N37K, R41N, H69K, L89M, I93L	C
	SC56	SC56	JF774019	None		G17E, Q18P, L19V, M36T, N37K, R41N, H69K, L89M, I93L	C
	SC97	SC97	JF774036	None		I15V, M36T, N37K, R41I, L63I, H69K, T74S, L89I, I93L	C
Hamers (2011)	CP763A03387	CP763A03387	HQ994646	None		I15V, L19V, E35D, M36T, N37E, L63P, H69K	C
Manasa (2011)	1000191	1000191	JN664971	None		T12S, I15V, L19I, M36T, L63T, E65D, H69K, V82I, L89M, I93L	C
Sanabani (2011)	BR2040	BR2040	JN692442	None		L10I, I15V, L19I, M36T, N37K, R41N, L63T, C67G, H69K, L89I, I93L	C
Santos (2011)	J151	J151_PR_RT	JN010536	None		L10V, I15V, M36T, N37K, R41N, H69K, L89LM	C
	J195	J195_PR	JN010601	None		L10V, I15V, M36T, N37K, R41S, H69K, L89M, I93L	C
	J211	J211_PR	JN010622	None		I13V, I15V, M36T, N37K, R41N, H69K, L89M, I93L	C
	J271	J271_PR	JN010673	None		T12K, I15V, G16E, L19I, M36T, N37K, P39S, R41N, H69K, L89M, I93L	C
	J332	J332_PR_RT	JN010707	None		T12K, I15V, G16E, M36T, N37K, R41N, H69K, L89M, I93L	C
	J342	J342_PR_RT_CN_RH	JN010722	None		I15V, L19LI, M36T, N37K, R41N, H69K, L89I, I93L	C
Thorat (2011)	Pat029	IN-NARI-HIVDR-5-029	HQ166867	None		T12S, I15V, L19M, M36T, N37A, R41K, L63P, C67Y, H69K, L89M, I93L	C
Chen (2012)	YN10DH0094	YN10DH0094	JQ658715	None		T12S, I15V, L19I, M36T, N37D, R41K, L63P, H69K, K70KR, I72V, I93L	C
da Silveira (2012)	BRMS47	BRMS47	JF342298	None		L10V, I13V, I15V, L19I, M36T, N37K, R41N, K43R, L63T, H69K, L89I, I93L	C
De Gascun (2012)	IRL20744	IRL20744	JN622999	None	Q58E	T12P, L19I, M36T, R41K, I62V, L63PS, H69K, T74A, L89M, I93L	C
Ssemwanga (2012)	5675HR	5675HR	JF800227	None		L10V, I15V, G16E, L19I, E35D, M36T, N37K, P39S, R41N, H69K, L89M, I93L	C
Alencar (2013)	SP2-0041	SP2-0041	JQ238082	None		I15V, M36T, N37K, R41N, K45KR, L63T, H69K, I72IV, T74S, L89I, I93L	C
Ferreira (2013)	BR09SP603	BR09SP603	HM534043	None		I13V, I15V, M36T, N37K, R41N, L63P, H69K, L89M, I93L	C
Frentz (2013)	EHR-41332	EHR-41332	JX300239	None		I15V, L19T, K20T, M36T, R41K, L63V, H69K, V82I, I93L	C

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