Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	M36L
Rx	>= 1 PI
IncludeMixtures	No

References	12
Patients	20
Isolates	24

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gibb (2002)	DMG78	78_w9		NFV	9	D30DN, L90LM	L89MV	T12S, I15V, L19I, E35D, M36L, N37E, D60E, L63P, I64IV, H69K, I93L	C
		78_w30		NFV	30	D30N	N88ND, L89MV	T12S, I13IV, I15V, L19I, E35D, M36L, N37E, K45KQR, D60E, L63P, H69K, I93L	C
	DMG83	83_w4		NFV	4			T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93L	C
		83_w31		NFV	31			T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93L	C
		83_w49		NFV	49			T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93L	C
	DMG86	86_w82		NFV	65	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
	DMG91	91_w22		NFV	22	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
Snoeck (2002)	BE8	BE8	AF338992	IDV	80			I15V, L19V, E35D, M36L, R41K, L63V, H69K, T74S, L89M, I93L	C
Shafer (2003)	A384_3441	3441b	EF549036	NFV	32			T12S, I15V, L19T, K20R, M36L, R41K, L63P, H69K, I93L	C
	A384_6000	6000b	EF549368	NFV	10			T12S, K14R, I15V, L19I, M36L, N37S, R41K, H69K, L89M, I93L	C
Snoeck (2004)	BE59	BE59	AY900757	SQV, IDV, RTV, NFV	217	G48V, I54A, V82A	L33F, K43KT	L10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93L	C
Non-B Workgroup (2005)	UK356b	UK356b	AY900770	NFV, RTV	44			T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93L	C
	PL8338	77353		IDV, RTV	304	I54V, V82A		L10I, I13IV, I15V, L19I, M36L, R41K, I62V, L63P, I64V, H69K, L89M, I93L, C95F	C
Weber (2005)	M83284	M83284	AY677471	SQV	82			T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93L	C
	M36208	M36208	AY714457	NFV, Unknown	>69			I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93L	C
Baxter (2006)	48-1229	1229-30428	DQ877762	PI	NA	M46I, I54A, V82F, L90M		L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93L	C
	48-5001	5001-30415	DQ878534	PI	NA	M46I, L76V, V82A	L10F, L33LF	I13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93IL	C
Doualla-Bell (2006)	Pt8	FDB_Pt8		NFV		D30N	L33F, N88D	T12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89I	C
Sen (2007)	T002	NPT2	EF186926	RTV, IDV		M46I, I54V, V82VA	L24I	L10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93L	C
		NPT2-PL	EF186983	RTV, IDV		M46I, I54V, V82A	L24I	L10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93L	C
Pillay (2008)	DR51	DR51	AY589904	IDV	78	V82T	L10F	T12S, I15V, L19T, M36L, N37S, K45R, L63P, H69K, L89M, I93L, C95F	C
	DR54	DR54	AY589907	NFV, RTV				L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FL	C
El-Khatib (2010)	Pat086	11ZA_SAVE1403	JF960536	LPV				T12S, I15V, L19I, M36L, N37S, L63LP, H69K, K70Q, L89M, I93L	C
Rodrigues (2010)	326_07	BR07SC326	GQ401321	LPV				I15V, Q18L, M36L, N37K, R41N, L63P, H69K, L89M, I93L	C

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