<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation M36L
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 44
Isolates 52
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG7878_w9 NFV9D30DN, L90LML89MVT12S, I15V, L19I, E35D, M36L, N37E, D60E, L63P, I64IV, H69K, I93LC
  78_w30 NFV30D30NN88ND, L89MVT12S, I13IV, I15V, L19I, E35D, M36L, N37E, K45KQR, D60E, L63P, H69K, I93LC
 DMG8383_w4 NFV4  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
  83_w31 NFV31  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
  83_w49 NFV49  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
 DMG8686_w82 NFV65D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
 DMG9191_w22 NFV22D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
Snoeck (2002)BE8BE8AF338992IDV80  I15V, L19V, E35D, M36L, R41K, L63V, H69K, T74S, L89M, I93LC
Shafer (2003)A384_34413441bEF549036NFV32  T12S, I15V, L19T, K20R, M36L, R41K, L63P, H69K, I93LC
 A384_60006000bEF549368NFV10  T12S, K14R, I15V, L19I, M36L, N37S, R41K, H69K, L89M, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)UK356bUK356bAY900770NFV, RTV44  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
 PL833877353 IDV, RTV304I54V, V82A L10I, I13IV, I15V, L19I, M36L, R41K, I62V, L63P, I64V, H69K, L89M, I93L, C95FC
Weber (2005)M83284M83284AY677471SQV82  T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93LC
 M36208M36208AY714457NFV, Unknown>69  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
Baxter (2006)48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
Doualla-Bell (2006)Pt8FDB_Pt8 NFV D30NL33F, N88DT12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89IC
Sen (2007)T002NPT2EF186926RTV, IDV M46I, I54V, V82VAL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93LC
  NPT2-PLEF186983RTV, IDV M46I, I54V, V82AL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93LC
Pillay (2008)DR51DR51AY589904IDV78V82TL10FT12S, I15V, L19T, M36L, N37S, K45R, L63P, H69K, L89M, I93L, C95FC
 DR54DR54AY589907NFV, RTV   L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FLC
El-Khatib (2010)Pat08611ZA_SAVE1403JF960536LPV   T12S, I15V, L19I, M36L, N37S, L63LP, H69K, K70Q, L89M, I93LC
Rodrigues (2010)326_07BR07SC326GQ401321LPV   I15V, Q18L, M36L, N37K, R41N, L63P, H69K, L89M, I93LC
Hoffmann (2013)491648_1491648_1KJ081337LPV   I15V, G16GE, M36L, L63A, H69K, T74S, L89M, I93LC
Van Zyl (2013)85658KC424150LPV26  T12S, I15V, L19V, M36L, N37S, R41K, D60E, L63P, H69K, I93LC
  395KC424037LPV27  T12S, I15V, L19V, M36L, N37S, R41K, D60E, L63P, H69K, L89LM, I93LC
 7191250KC422999LPV26  T12S, I15V, L19I, M36L, R41K, D60E, L63P, C67G, H69K, L89M, I93LC
 15541662KC423308LPV26  I15V, L19I, E35D, M36L, N37E, R41K, I64V, H69K, A71T, I93LC
 729769KC424275LPV26  T12S, I15V, L19I, K20R, M36L, N37D, L63P, H69K, V77I, L89M, I93LC
 12811025KC422815LPV26  T12E, I15V, L19I, M36L, N37S, R41K, L63P, H69K, I93LC
  1076KC422862LPV27  T12E, I15V, L19I, M36L, N37S, R41K, L63P, H69K, I93LC
 16212755KC423815LPV26  I15IV, L19I, M36L, N37D, R41K, D60E, I62V, L63P, H69K, I72IV, L89M, I93LC
 16841723KC423355LPV26  T12S, L19I, E35D, M36L, R41K, L63P, H69K, V77I, L89M, I93LC
 2852979KC423915LPV26  T12S, I15V, G16E, L19V, M36L, L63V, H69K, T74S, L89M, I93LC
 14901727KC423358LPV26  I15V, L19I, E35D, M36L, R41K, D60E, L63P, H69K, I93LC
 16753039KC423939LPV26  I15V, L19I, M36L, N37S, R41K, L63P, H69K, I93LC
 2471537KC423212LPV104  K14R, I15V, L19I, M36L, N37S, R41K, L63P, H69K, L89M, I93LC
  1118KC422893LPV105  K14R, I15V, L19I, M36L, N37S, R41K, L63P, H69K, L89M, I93LC
 3481067KC422853LPV26  K14KR, I15V, G16GE, L19T, M36L, N37D, D60E, H69K, L89M, I93LC
 1273649KC424200LPV26  T12S, I15V, L19I, M36L, N37S, R41K, L63T, C67F, H69K, L89M, I93LC
 15062169KC423663LPV26  T12PS, I15V, L19I, M36L, N37S, L63P, H69K, R87RK, I93LC
 758374KC424019LPV26  T12S, I15V, L19V, E35D, M36L, R41K, L63T, H69K, A71T, I93LC
 624991KC424420LPV26  L10I, T12S, L19I, M36L, L63P, H69K, K70R, L89M, I93LC
 16352887KC423876LPV26  T12S, I15V, L19IV, K20R, E35D, M36L, R41K, L63P, H69K, V77I, L89M, I93LC
 7181328KC423062LPV26  T12S, I15V, L19T, M36L, R41K, L63P, H69K, I93LC
 980491KC424092LPV26  T12S, K14R, I15V, L19I, K20R, M36L, N37S, R41K, H69K, I72V, V77I, L89M, I93LC
 13481306KC423044LPV26 L10LFT12S, I15V, L19IT, M36L, N37Q, I62V, L63P, I64M, H69K, L89M, I93LC
 1297819KC424294LPV26  T12S, I15V, L19I, M36L, R41K, L63P, H69K, L89M, I93LC
Grossman (2014)16251625KF134990LPV52  K14R, I15V, G16A, L19I, K20R, E35D, M36L, N37A, R41K, L63M, H69K, V77I, L89M, I93LC
 15331533KF134985LPV52  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
  1533KF134986LPV76  I15V, L19I, M36L, N37NS, R41K, L63PS, H69K, L89M, I93LC