<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation M36L
Rx >= 1 PI
IncludeMixtures No
References 26
Patients 112
Isolates 124
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG7878_w9 NFV9D30DN, L90LML89MVT12S, I15V, L19I, E35D, M36L, N37E, D60E, L63P, I64IV, H69K, I93LC
  78_w30 NFV30D30NN88ND, L89MVT12S, I13IV, I15V, L19I, E35D, M36L, N37E, K45KQR, D60E, L63P, H69K, I93LC
 DMG8383_w4 NFV4  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
  83_w31 NFV31  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
  83_w49 NFV49  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
 DMG8686_w82 NFV65D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
 DMG9191_w22 NFV22D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
Snoeck (2002)BE8BE8AF338992IDV80  I15V, L19V, E35D, M36L, R41K, L63V, H69K, T74S, L89M, I93LC
Shafer (2003)A384_34413441bEF549036NFV32  T12S, I15V, L19T, K20R, M36L, R41K, L63P, H69K, I93LC
 A384_60006000bEF549368NFV10  T12S, K14R, I15V, L19I, M36L, N37S, R41K, H69K, L89M, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)UK356bUK356bAY900770NFV, RTV44  T12S, I15V, L19I, M36L, R41K, D60E, L63P, H69K, L89M, I93LC
 PL833877353 IDV, RTV304I54V, V82A L10I, I13IV, I15V, L19I, M36L, R41K, I62V, L63P, I64V, H69K, L89M, I93L, C95FC
Weber (2005)M83284M83284AY677471SQV82  T12S, I15V, L19I, M36L, L63V, H69K, T74S, V82I, L89M, I93LC
 M36208M36208AY714457NFV, Unknown>69  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
Baxter (2006)48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
Doualla-Bell (2006)Pt8FDB_Pt8 NFV D30NL33F, N88DT12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89IC
Sen (2007)T002NPT2EF186926RTV, IDV M46I, I54V, V82VAL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93LC
  NPT2-PLEF186983RTV, IDV M46I, I54V, V82AL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93LC
Pillay (2008)DR51DR51AY589904IDV78V82TL10FT12S, I15V, L19T, M36L, N37S, K45R, L63P, H69K, L89M, I93L, C95FC
 DR54DR54AY589907NFV, RTV   L19T, M36L, R41K, L63T, H69K, T74S, L89M, I93L, F99FLC
El-Khatib (2010)Pat08611ZA_SAVE1403JF960536LPV   T12S, I15V, L19I, M36L, N37S, L63LP, H69K, K70Q, L89M, I93LC
Rodrigues (2010)326_07BR07SC326GQ401321LPV   I15V, Q18L, M36L, N37K, R41N, L63P, H69K, L89M, I93LC
Hoffmann (2013)491648_1491648_1KJ081337LPV   I15V, G16GE, M36L, L63A, H69K, T74S, L89M, I93LC
Manasa (2013)RES356RES356KC951811LPV90  I15V, L19I, M36L, R41K, H69K, L89M, I93LC
Saravanan (2013)YRG77YRG77KC016272PINAM46I, I54IVL23I, L33LF, K43KT, F53LI13V, K14R, I15V, L19I, E35D, M36L, N37S, R41K, L63P, H69K, A71X, L89T, I93LC
 YRG57YRG57KC016252PINAI54V, V82AK43KT, G73SL10I, I15V, L19I, M36L, N37S, I62V, L63P, H69K, A71V, I72IM, I85IV, I93LC
 YRG18YRG18KC016213PINAM46I, I54L, L76V, I84VL10F, L24I, L33F, N83DI13V, I15V, G16E, L19I, E35D, M36L, N37S, K45R, R57K, Q61N, L63T, H69K, T74S, L89MC
 YRG04YRG04KC016199PINAM46L, I54VL10F, L33FT12S, I15V, L19I, K20T, E35D, M36L, R41K, L63P, H69K, A71VC
Van Zyl (2013)333111.ZA.GT1572KC423358LPV   I15V, L19I, E35D, M36L, R41K, D60E, L63P, H69K, I93LC
 360409.ZA.GT633KC424200LPV   T12S, I15V, L19I, M36L, N37S, R41K, L63T, C67F, H69K, L89M, I93LC
 49911.ZA.WC112KC423308LPV   I15V, L19I, E35D, M36L, N37E, R41K, I64V, H69K, A71T, I93LC
 363709.ZA.GT791KC424294LPV   T12S, I15V, L19I, M36L, R41K, L63P, H69K, L89M, I93LC
 405411.ZA.GT1891KC423663LPV   T12PS, I15V, L19I, M36L, N37S, L63P, H69K, R87RK, I93LC
 292410.ZA.GT1232KC423062LPV   T12S, I15V, L19T, M36L, R41K, L63P, H69K, I93LC
 75212.ZA.EC198KC423876LPV   T12S, I15V, L19IV, K20R, E35D, M36L, R41K, L63P, H69K, V77I, L89M, I93LC
 324107.ZA.GT284KC424092LPV   T12S, K14R, I15V, L19I, K20R, M36L, N37S, R41K, H69K, I72V, V77I, L89M, I93LC
 292510.ZA.GT1162KC422999LPV   T12S, I15V, L19I, M36L, R41K, D60E, L63P, C67G, H69K, L89M, I93LC
 293109.ZA.GT750KC424275LPV   T12S, I15V, L19I, K20R, M36L, N37D, L63P, H69K, V77I, L89M, I93LC
 217909.ZA.GT944KC424420LPV   L10I, T12S, L19I, M36L, L63P, H69K, K70R, L89M, I93LC
 72412.ZA.WC209KC423815LPV   I15IV, L19I, M36L, N37D, R41K, D60E, I62V, L63P, H69K, I72IV, L89M, I93LC
 296507.ZA.GT186KC424019LPV   T12S, I15V, L19V, E35D, M36L, R41K, L63T, H69K, A71T, I93LC
 371710.ZA.GT1205KC423044LPV  L10LFT12S, I15V, L19IT, M36L, N37Q, I62V, L63P, I64M, H69K, L89M, I93LC
 80212.ZA.WC221KC423939LPV   I15V, L19I, M36L, N37S, R41K, L63P, H69K, I93LC
 11411.ZA.WC124KC423355LPV   T12S, L19I, E35D, M36L, R41K, L63P, H69K, V77I, L89M, I93LC
 361509.ZA.GT958KC422815LPV   T12E, I15V, L19I, M36L, N37S, R41K, L63P, H69K, I93LC
  09.ZA.GT1003KC422862LPV   T12E, I15V, L19I, M36L, N37S, R41K, L63P, H69K, I93LC
 306907.ZA.GT096KC424150LPV   T12S, I15V, L19V, M36L, N37S, R41K, D60E, L63P, H69K, I93LC
  07.ZA.GT188KC424037LPV   T12S, I15V, L19V, M36L, N37S, R41K, D60E, L63P, H69K, L89LM, I93LC
 183809.ZA.GT996KC422853LPV   K14KR, I15V, G16GE, L19T, M36L, N37D, D60E, H69K, L89M, I93LC
 175012.ZA.GT2261KC423915LPV   T12S, I15V, G16E, L19V, M36L, L63V, H69K, T74S, L89M, I93LC
 266310.ZA.GT1044KC422893LPV   K14R, I15V, L19I, M36L, N37S, R41K, L63P, H69K, L89M, I93LC
  10.ZA.GT1426KC423212LPV   K14R, I15V, L19I, M36L, N37S, R41K, L63P, H69K, L89M, I93LC
Acharya (2014)DGP142DGP142KJ185312RTV, ATV I54V, L90MN88DT12S, I15V, L19I, M36L, N37S, R41K, L63P, H69K, K70R, A71V, V82I, L89M, I93LC
 DGP130DGP130KJ185300RTV, ATV   T12S, I15V, L19I, M36L, N37S, R41K, L63P, H69K, K70R, V82I, L89M, I93LC
 DGP119DGP119KJ185289RTV, ATV M46I, I50L, V82C, L90MQ58EL10I, T12S, I15V, L19I, M36L, N37S, R41K, L63P, H69K, K70R, L89M, I93LC
 DGP025DGP025KJ185195RTV, ATV M46I, I54A, V82A, L90ML10FT12S, I15V, G16A, L19I, M36L, N37C, L63T, H69K, L89M, I93LC
Grossman (2014)16251625KF134990LPV52  K14R, I15V, G16A, L19I, K20R, E35D, M36L, N37A, R41K, L63M, H69K, V77I, L89M, I93LC
 15331533KF134985LPV52  I15V, L19I, M36L, R41K, L63S, H69K, L89M, I93LC
  1533KF134986LPV76  I15V, L19I, M36L, N37NS, R41K, L63PS, H69K, L89M, I93LC
Diaz (2015)RenG16894RenG16894KT747922PINAD30N, M46I, I54V, V82AL10F, L24I, L33F, N88DT12P, I13IV, K14KR, I15V, L19LP, K20KM, E35D, M36L, N37K, R41N, K55KR, R57RK, L63P, H69K, Q92QKC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG17413RenG17413KT748441PINAI50L I15V, E34KR, M36L, R41N, K45N, D60E, I62V, L63P, H69K, K70KQ, V82VI, L89M, I93LC
 RenG16982RenG16982KT748010PINAM46L, I54IV, V82AL10LFPS, L23I, L33F, F53FLP9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93LC
 RenG15832RenG15832KT746860PINAI50LL10F, L23LI, L33FI13IV, I15V, E35D, M36L, N37K, R41N, K45Q, D60E, I62IV, L63P, H69K, A71AV, T74TR, L89M, I93LC
 RenG14890RenG14890KT745918PINA  I15V, M36L, N37K, R41N, H69K, L89M, I93LC
 RenG15215RenG15215KT746243PINAM46L, I50IL, I54V, V82AL24I, L33FL10Y, E35D, M36L, N37EK, R41N, R57K, D60E, L63P, H69K, A71AT, L89I, Q92QK, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG15384RenG15384KT746412PINA  T12P, K14R, I15V, G16E, M36L, N37K, R41N, D60DE, L63H, H69K, L89IM, I93LC
 RenG14023RenG14023KT745051PINA  T4TI, T12P, K14R, I15V, G16E, M36L, N37K, R41N, L63H, H69K, V82VI, L89IM, I93LC
 RenG12877RenG12877KT743905PINA  I15V, M36L, N37K, R41N, H69K, I72V, L89M, I93LC
 RenG12839RenG12839KT743867PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, L19I, K20KT, M36L, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG13361RenG13361KT744389PINA  I15V, M36L, N37K, R41N, L63P, H69K, L89M, I93LC
 RenG12798RenG12798KT743826PINA  M36L, N37K, R41N, L63P, H69K, L89M, I93LC
 RenG12853RenG12853KT743881PINA  I15V, M36L, N37K, R41N, L63T, H69K, T74S, L89M, I93LC
 RenG13003RenG13003KT744031PINA  K14R, I15V, M36L, N37K, R41N, D60E, I62V, L63P, H69K, L89M, I93LC
 RenG11976RenG11976KT743004PINAV82ILQ58QEI15V, L19IT, M36L, N37K, R41N, I62V, L63S, I64L, H69K, L89M, I93LC
 RenG10449RenG10449KT741477PINAI50LL33FI15V, E35D, M36L, N37K, R41N, R57RK, L63P, H69K, T74S, V82I, I85V, L89M, I93LC
 RenG10325RenG10325KT741353PINAI50L, V82ML23LI, L33F, F53LT12TA, I13V, K14KR, I15V, K20R, E35D, M36L, N37K, R41N, L63P, H69K, A71V, T74S, L89M, I93LC
 RenG10474RenG10474KT741502PINAG48S, I54V, V82F, L90ML33F, K43T, T74P, N83DL10I, I13V, K14R, I15V, E35D, M36L, N37K, R41IN, Q61N, I62V, C67CR, H69Q, L89I, I93LC
Novitsky (2015)bcpp_261bcpp_261KR860709PINA  T12S, I15V, L19I, M36L, N37S, R41K, L63T, H69K, L89M, I93LC
 mpp_228mpp_228KR861008PINA  T12S, I15V, L19I, K20M, E35E_TN, M36L, L63T, H69K, I93LC
 bcpp_169bcpp_169KR860671PINA  I15V, L19I, E35D, M36L, N37S, R41K, H69K, L89M, I93LC
 bcpp_106bcpp_106KR860647PINA  T12S, L19I, E35E_TN, M36L, R41K, Q61E, L63P, H69K, L89M, I93LC
Rossouw (2015)RP112-3RP112-3KT032040RTV, LPV260I54IV, V82VAL10LFT12S, K14R, I15V, L19I, K20R, E35D, M36L, R41K, Q61H, L63P, H69K, V77I, L89M, I93LC
 RP099RP099KT032033LPV121M46I, I54V, V82AL10LF, L24LI, L33F, T74TPI13IV, K14KR, I15V, Q18E, L19IT, K20KR, M36L, R41K, Q61H, I62V, L63LP, H69K, L89I, I93L, L97LIC
 RP159RP159KT032057LPV200M46L, I54V, V82AL10F, L24I, L33F, T74API13IV, M36L, N37S, R41K, Q61N, I62V, L63V, H69K, L89M, I93ILC
Chimukangara (2016)NC27NC27KU508576LPV, RTV, ATV461  I15V, L19I, M36L, N37D, D60E, L63P, H69K, I93LC
 NC10NC10KU508550LPV586M46I, I54V, L76V, V82AL10F, L24I, Q58ET12S, I15V, G16E, L19I, K20M, M36L, N37D, L63N, H69K, L89I, I93L, L97IC
Ndahimana Jd Riedel (2016)21092109KT982501LPV   T12S, M36L, Q61N, L63PT, H69K, L89M, I93LC
Neogi (2016)94513.ZA.WC302KT593502LPV   I15V, G16E, L19I, K20R, M36L, R41K, H69K, V77I, L89M, I93LC
 20013.ZA.NL096KT593463LPV M46I I15V, M36L, R41K, D60E, Q61E, I62V, L63P, H69K, L89M, I93LC
 58913.ZA.EC749KT592881LPV   T12S, I15V, L19T, M36L, R41K, L63P, H69K, L89M, I93LC
 71913.ZA.GT2703KT593069LPV   T12TS, L19I, M36L, H69K, L89MC
 312413.ZA.GT2751KT593113LPV   T12AS, I15V, G16E, L19I, M36L, N37S, R41K, K45R, D60E, L63S, H69K, L89I, I93LC
Steegen (2016)ZA13GFKZC012ZA13GFKZC012KU252990LPV   I15V, L19T, K20T, E35E_TN, M36L, L63P, H69K, I93LC
 ZA13GFMPC004ZA13GFMPC004KU252991LPV M46I, I47IV, I54V, V82AL10FI13IV, K14KR, I15V, L19I, K20R, E35D, M36L, N37E, R41K, Q61H, H69K, V77I, L89IC
 ZA13GFMPC015ZA13GFMPC015KU253019LPV   K14R, I15V, L19I, K20R, E35D, M36L, N37D, R41K, I62V, L63V, H69K, T74S, V77I, L89M, I93LC
 ZA13GFFSC029ZA13GFFSC029KU253027LPV   E35E_TN, M36L, L63P, H69K, L89M, I93LC
 ZA14GFKZC050ZA14GFKZC050KU253068LPV   T12S, I15V, G16E, L19I, M36L, N37S, L63T, H69K, T74S, L89M, I93LC
 ZA14GFKZC051ZA14GFKZC051KU253074LPV   T12S, I15V, L19I, M36L, L38I, R41K, L63P, H69K, L89M, I93LC
 ZA14GFFSC031ZA14GFFSC031KU253095LPV   T12S, I15V, L19I, M36L, N37X, L38L_XL, R57K, D60E, Q61E, L63P, H69K, I93LC
 ZA14GFKZC133ZA14GFKZC133KU253139LPV   T12S, I15V, L19I, M36L, L63P, H69K, V82I, L89M, I93LC
 ZA14GFKZC134ZA14GFKZC134KU253140LPV   T12S, I15V, L19I, M36L, R41K, Q61E, L63V, H69K, T74S, L89M, I93LC
 ZA14GFNWC040ZA14GFNWC040KU253145LPV   T12S, L19V, M36L, N37S, R41K, L63P, H69K, K70KR, V82I, L89M, I93LC
 ZA14GFKZC216ZA14GFKZC216KU253160LPV   L19I, M36L, N37D, R41K, I62V, L63Q, H69K, A71T, L89M, I93LC
Posada Cespedes (2017)474014.ZA.GT3834 LPV   I15V, K20R, M36L, R41K, L63P, H69K, V77I, I93LC
 46314.ZA.WC395KX544668LPV I54V, V82AL33FT12S, L19T, K20R, M36L, L63P, H69K, L89M, I93LC
 71214.ZA.EC1090KX543724LPV   T12S, K14R, I15V, L19I, M36L, N37S, R41K, Q61N, L63S, H69K, V82I, L89M, I93LC
 101214.ZA.WC528KX544779LPV   T12S, I15V, L19T, K20R, M36L, N37S, R41K, L63P, H69K, V77I, L89M, I93LC
 717915.ZA.Pr218 LPV   I15V, L19I, K20R, M36L, R41K, I62V, L63P, C67CY, H69K, V77I, I93LC
 524314.ZA.EC1424KX544018LPV   I15V, L19T, K20R, M36L, N37S, H69K, L89M, I93LC
 170010.ZA.GT1354KX540771LPV   L10I, T12S, I15V, L19I, M36L, N37NS, P39PS, L63P, H69K, L89M, I93LC
 157614.ZA.GT3340KX544225LPV   K14I, I15V, G16E, L19I, M36L, L63T, H69K, T74S, L89M, I93LC
 93212.ZA.WC264KX542529LPV   I15V, L19I, M36L, N37S, H69K, L89M, I93LC
 451414.ZA.WC556 ATV   T12S, M36L, N37S, R41K, Q61N, H69K, L89M, I93LC
 48511.ZA.EC070KX540956LPV   T12TS, I15V, L19I, K20R, M36L, N37S, R41K, L63P, H69K, K70KR, V82I, L89M, I93LC
 438209.ZA.GT686KX540181LPV   L10V, T12S, I15V, G16E, L19I, M36L, N37AGST, R41RK, D60E, Q61N, L63T, H69K, I93LC
 246515.ZA.GT4468 LPV   I15V, L19T, M36L, N37S, L38LV, R41K, K45R, D60E, Q61E, I62IV, L63P, H69K, L89M, I93LC
 11413.ZA.WC358KX543624LPV M46I, I54V, V82AL10F, L24I, L33FT12S, L19I, E35D, M36L, R41K, L63P, H69K, L89LM, I93LC
 183815.ZA.GT4040 LPV   K14KR, I15IV, G16GE, L19T, M36L, N37D, D60E, L63PS, H69K, L89M, I93LC
 175014.ZA.GT3689 LPV   T12S, I15V, G16E, L19V, M36L, L63AITV, H69K, T74S, L89M, I93LC
 266311.ZA.GT1880KX541363LPV   K14R, I15V, L19I, M36L, N37S, R41K, L63P, H69K, L89M, I93LC