<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L33F
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 97
Isolates 98
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kantor (2002)TCDD-30TCDD-30_1AY090856NFV, IDV14I54FLL33FL10I, T12S, I15V, L19I, E34D, M36I, R41K, Q58QP, D60E, L63P, H69K, T74E, P79PL, I85V, L89M, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)PL4725100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Baxter (2006)12-10071007-30519DQ875953PINAM46L, I54IV, V82A, L90ML33F, K43KTL10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93LC
 12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt10FDB_Pt10 NFV D30N, L90ML33FI15V, G17D, L19V, E35D, M36I, N37K, R41K, L63P, H69K, A71V, I93LC
 Pt7FDB_Pt7 NFV D30NL33FL10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93LC
 Pt8FDB_Pt8 NFV D30NL33F, N88DT12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89IC
 Pt9FDB_Pt9 NFV D30NL33F, N88DT12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Kouri (2012)CU522-10CU522-10JQ585402PINAM46I, I54L, V82A, L90ML33F, T74PI13V, N37S, R41K, K55R, I62V, L63P, H69K, L89M, I93LC
 CU1452-09CU1452-09JQ585296PINAD30N, I54M, L90ML33F, N88DT12S, I13V, K14R, I15V, E35D, M36I, N37S, R41K, L63P, H69K, T74S, L89I, I93LC
 CU728-10CU728-10JQ585411PINAM46I, I50V, L90ML33FW6G, L10V, N37S, R41K, K55R, Q61E, L63P, H69K, T74S, V77I, V82VI, I85V, L89M, I93LC
 CU2104-09CU2104-09JQ585341PINAG48GV, I54MV, I84V, L90LML33F, Q58QE, T74PS, N83NDL10I, E34K, E35D, M36I, N37S, R41K, L63LP, G68GE, H69K, A71AV, L89IM, I93LC
 CU1340-10CU1340-10JQ585423PINAM46I, I54AT, V82A, I84IVL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74TA, L89M, I93LC
Mollan (2012)MK142MK142w36 RTV, ATV36 L33FT12S, L19T, R41K, H69K, K70R, V77I, L89M, I93LC
Van Zyl (2013)504904KC424348LPV26I54V, V82AL10F, L33FT12S, I15V, L19T, K20KT, M36IL, R41K, L63P, H69K, L89IM, I93LC
 14602908KC423889LPV26M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 1576168KC423322LPV26M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 12001390KC423114LPV26M46L, I54V, V82AL10F, L24LI, L33FI15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, I62IV, H69K, L89M, I93LC
 16361248KC422997LPV26M46MI, I54V, V82A, L90ML10F, L33F, K43T, G73ST12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93LC
 16801795KC423414LPV26M46I, I50V, I54V, V82AL10F, L33FT12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
 11281379KC423106LPV26I54V, V82AL10F, L24I, L33F, N83DG16GA, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, I85V, L89I, T91S, I93LC
Grossman (2014)471471KF135082IDV, LPV52M46I, I54V, V82AL10F, L24I, L33FI13V, K14R, I15V, K20KT, M36I, R41K, L63P, H69K, T74TS, L89M, I93LC
 255255KF135032SQV, LPV90M46I, I54V, V82AL10F, L33F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93LC
 4949KF135089NFV, LPV52I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93LC
 101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
 217217KF135024NFV, LPV52D30N, I54V, V82AL33F, N88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, H69Q, V75I, L89I, I93LC
  217KF135025NFV, LPV273M46I, I50V, I54V, V82A, L90ML33FL10I, I13V, K14R, I15V, K20R, E35D, M36I, N37DE, R41K, K55R, L63E, G68GE, H69Q, A71AV, L89I, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 781781KF135142IDV, LPV106I54V, V82AL10F, L33FG16E, M36I, R41K, H69K, L89M, I93LC
 852852KF135155SQV, LPV52M46I, I54V, V82AL10F, L33FL19Q, K20R, G27GR, E35D, M36I, N37ND, P39Q, R41K, I62IV, L63P, H69K, L89M, Q92QK, I93LC
Diaz (2015)RenG16337RenG16337KT747365PINAM46I, I54V, V82A, L90ML10LF, L33F, G73ST12TS, I13V, K14R, I15V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, I93LC
 RenG15755RenG15755KT746783PINAI50L, L90ML33F, G73SI13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, L63P, H69K, K70E, A71I, I93LC
 RenG16894RenG16894KT747922PINAD30N, M46I, I54V, V82AL10F, L24I, L33F, N88DT12P, I13IV, K14KR, I15V, L19LP, K20KM, E35D, M36L, N37K, R41N, K55KR, R57RK, L63P, H69K, Q92QKC
 RenG17353RenG17353KT748381PINAM46I, I54V, L76V, V82AL10F, L33FI13V, K14KR, K20R, E35D, M36I, R41N, I62V, L63T, H69K, A71V, I72V, T74TA, L89M, I93LC
 RenG16793RenG16793KT747821PINAM46MI, I54V, V82M, L90ML24LI, L33F, T74PL10V, I13IV, I15IV, K20R, E35D, M36I, N37Q, R41N, Q61DN, I62V, L63PT, H69K, V77I, L89M, I93LC
 RenG16730RenG16730KT747758PINAM46I, L90ML10F, L33FI15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, N88E, L89I, I93LC
 RenG16791RenG16791KT747819PINAM46I, I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, K20T, E35N, M36I, N37Q, R41N, I62IV, L63V, H69K, I72V, L89I, I93LC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG17106RenG17106KT748134PINAI50L, V82VA, N88SL33FI13V, K14R, I15V, K20KR, E35D, M36I, N37K, R41N, K45KR, Q61N, I64IV, H69K, A71IV, T74S, L89M, I93LC
 RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG15974RenG15974KT747002PINAM46MI, I50LL23LI, L33F, F53FL, N83NDL10LR, I13V, I15V, E35D, M36IL, N37K, R41N, I62V, L63V, H69K, A71V, T74A, L89IM, I93LC
 RenG16022RenG16022KT747050PINAI50L, V82ILL33FK14KR, I15V, K20T, M36I, N37K, R41N, H69K, A71V, L89I, I93LC
 RenG16982RenG16982KT748010PINAM46L, I54IV, V82AL10LFPS, L23I, L33F, F53FLP9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93LC
 RenG15832RenG15832KT746860PINAI50LL10F, L23LI, L33FI13IV, I15V, E35D, M36L, N37K, R41N, K45Q, D60E, I62IV, L63P, H69K, A71AV, T74TR, L89M, I93LC
 RenG15346RenG15346KT746374PINAM46MI, I54V, V82VA, I84V, L90ML10F, L23LI, L33F, F53FL, G73S, T74PS, L89VV11L, I13V, I15V, K20T, E34Q, E35D, M36IL, N37K, R41N, I62V, L63P, G68D, H69R, A71V, I93LC
 RenG14709RenG14709KT745737PINAD30N, M46MI, V82AL10F, L24I, L33F, N88DT12P, I15V, K20T, E35N, M36I, N37K, R41N, K45R, L63P, H69K, V75I, I93LC
 RenG14788RenG14788KT745816PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20R, E35D, M36I, N37K, R41Y, R57RK, Q61N, L63P, H69K, A71V, L89M, I93LC
 RenG15215RenG15215KT746243PINAM46L, I50IL, I54V, V82AL24I, L33FL10Y, E35D, M36L, N37EK, R41N, R57K, D60E, L63P, H69K, A71AT, L89I, Q92QK, I93LC
 RenG14536RenG14536KT745564PINAD30N, I54ILM, I84IVL10F, L33F, N88DI15V, G16E, K20T, E35D, M36I, N37EK, P39S, R41N, K45I, L63T, H69K, T74AS, I85V, L89M, I93ILC
 RenG14916RenG14916KT745944PINAI50L, V82M, L90ML23I, L33FI13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93LC
 RenG14962RenG14962KT745990PINAM46I, I54V, V82AL10F, L24I, L33FI15V, G16E, L19Q, K20R, E35D, M36I, N37K, R41N, Q61H, L63T, H69K, L89I, Q92K, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG15278RenG15278KT746306PINAM46L, I50L, V82ILM, L90LML24LI, L33F, Q58E, T74PI13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, L63AV, H69K, A71AV, L89M, I93LC
 RenG13551RenG13551KT744579PINAM46MI, I50V, I54V, V82M, N88SL33F, Q58E, T74PL10V, G16E, K20R, E35D, M36I, N37K, R41N, R57RK, L63T, H69K, L89F, I93LC
 RenG14844RenG14844KT745872PINAM46I, I54V, V82A, N88SL10F, L33F, L89VI13V, I15V, K20T, E21EK, E35D, M36IL, N37K, R41N, I62V, L63P, H69K, G73D, T74S, I93ILC
 RenG15313RenG15313KT746341PINAM46L, G48A, I54V, V82A, L90ML33F, N83DL10V, K14KR, I15IV, G16E, K20R, E35D, M36I, N37K, R41N, R57K, Q61N, L63T, H69K, T74S, I85V, L89I, Q92K, I93LC
 RenG14834RenG14834KT745862PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, Q61N, L63P, G68GE, H69K, K70KR, A71V, L89IM, I93LC
 RenG14024RenG14024KT745052PINAD30N, I50L, V82AL33F, N88DL10LR, I13V, I15IV, K20KRT, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, H69K, A71AV, T74S, V77VI, L89IM, I93LC
 RenG12839RenG12839KT743867PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, L19I, K20KT, M36L, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG12067RenG12067KT743095PINAI54ML24LI, L33FL10LI, I15V, G16E, K20R, E35D, M36I, N37T, P39S, R41N, I62V, L63V, I64L, G68GE, H69K, A71AV, I72V, T74S, V82VI, L89M, I93LC
 RenG13278RenG13278KT744306PINAI54IL, I84V, N88SL33F, Q58EL10Y, I13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, D60E, Q61E, I62V, L63P, H69K, A71T, L89M, I93LC
 RenG12082RenG12082KT743110PINAM46I, I50V, V82A, L90ML10F, V11VI, L23I, L33F, Q58EI13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, G73V, T74S, L89T, I93LC
 RenG13175RenG13175KT744203PINAI54V, V82AL33F, T74PI13V, K20R, E35D, M36I, N37K, R41N, R57K, Q61H, H69K, L89I, I93LC
 RenG12228RenG12228KT743256PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, I15IV, K20M, E35D, M36I, N37K, R41H, I62V, L63P, H69K, L89I, T91TSC
 RenG12846RenG12846KT743874PINAI50LL33FI13V, K14R, I15V, M36A, N37K, R41N, K45KR, L63P, H69K, A71IV, V82I, L89IT, I93LC
 RenG12329RenG12329KT743357PINAM46ML, I50L, V82VA, N88NSL33F, T74TPL10LH, I15IV, E35D, M36I, N37K, R41N, D60E, I62IV, L63P, H69K, A71V, L89M, I93LC
 RenG10449RenG10449KT741477PINAI50LL33FI15V, E35D, M36L, N37K, R41N, R57RK, L63P, H69K, T74S, V82I, I85V, L89M, I93LC
 RenG10325RenG10325KT741353PINAI50L, V82ML23LI, L33F, F53LT12TA, I13V, K14KR, I15V, K20R, E35D, M36L, N37K, R41N, L63P, H69K, A71V, T74S, L89M, I93LC
 RenG10554RenG10554KT741582PINAM46L, I54V, V82M, L90ML33F, F53LL10V, I15V, G16E, L19I, K20R, E35D, M36I, N37T, P39Q, R41N, K55R, I62V, L63AITV, H69K, A71V, T74S, V77I, L89M, I93L, C95LC
 RenG10574RenG10574KT741602PINAI54L, L90ML33F, G73ST12Q, I13IV, I15V, G16A, K20R, E35D, M36I, N37K, R41N, K45R, L63P, H69K, I93LC
 RenG11494RenG11494KT742522PINAI50L, V82L, L90ML33F, K43TT12S, I13V, I15V, K20R, E35D, M36IV, N37K, R41N, Q61HN, L63T, I64V, H69K, A71V, T74S, L89M, I93LC
 RenG10445RenG10445KT741473PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16A, N37K, R41N, K55R, R57K, L63P, H69K, L89IC
 RenG10600RenG10600KT741628PINA L33FT12TAP, I13V, K14KR, M36I, N37K, P39S, R41N, I62V, L63Q, I64M, H69K, T74A, L89M, I93LC
 RenG10097RenG10097KT741125PINAM46ML, I54V, V82ML24LI, L33F, T74P, N83DL10V, I13V, K14R, I15V, K20KR, E35D, M36IL, N37K, R41N, L63V, H69K, L89M, I93LC
 RenG11404RenG11404KT742432PINAM46I, I54V, V82AV11I, L24I, L33FL10V, I13V, I15V, K20R, E35D, M36I, N37NK, R41P, K45KR, I62V, L63Q, G68DE, H69K, A71I, L89T, I93LC
 RenG11227RenG11227KT742255PINAI50L, V82A, L90ML33FT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37E, R41N, K45R, L63P, H69K, A71V, T74A, L89I, I93LC
 RenG10774RenG10774KT741802PINAV82F, I84V, L90ML33FI13V, I15V, K20AT, E35D, M36I, R41N, K45V, I62V, L63P, H69K, T74S, L89M, I93LC
 RenG11741RenG11741KT742769PINAM46MI, I54V, V82A, L90ML33F, K43T, N88DL10V, I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74KR, L89M, I93LC
 RenG10615RenG10615KT741643PINAI50L, N88SL33F, T74PI13IV, I15V, K20R, E35D, M36I, N37K, R41N, L63LP, H69K, A71V, L89M, I93LC
 RenG10498RenG10498KT741526PINAD30N, I50L, V82VAL33F, N88DI13V, I15V, K20R, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, G68GE, H69K, A71AITV, T74S, L89M, I93LC
 RenG10491RenG10491KT741519PINAI50L, V82VA, N88S, L90LML33FL10M, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, K45R, H69K, A71V, L89I, I93LC
 RenG10661RenG10661KT741689PINAM46I, I54V, V82A, L90ML33F, Q58E, G73SL10I, I13V, L19I, K20R, E35D, M36I, N37K, R41K, K55N, L63P, H69K, A71T, T74S, Q92K, I93LC
 RenG10978RenG10978KT742006PINAI54V, V82AL33F, T74PL10I, I13V, G16E, K20R, M36I, N37K, R41N, L63T, H69Q, L89M, I93LC
 RenG11088RenG11088KT742116PINAI54V, V82C, L90ML10F, L33F, T74PT12S, I13V, I15V, G16E, L19AV, K20M, D25DN, E35DN, M36I, N37K, R41N, Q61H, L63T, I66IM, H69K, L89M, I93LC
 RenG10474RenG10474KT741502PINAG48S, I54V, V82F, L90ML33F, K43T, T74P, N83DL10I, I13V, K14R, I15V, E35D, M36L, N37K, R41IN, Q61N, I62V, C67CR, H69Q, L89I, I93LC
 RenG10982RenG10982KT742010PINAM46I, I50V, I54V, V82A, L90MV11I, L33F, K43T, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37K, R41N, I62IV, L63P, H69R, A71V, L89LM, I93LC
Rossouw (2015)RP145RP145KT032053PINAM46I, I54V, V82AL10F, L24I, L33F, Q58EI15V, G17D, L19V, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69K, P81PS, T91TN, I93LC
 RP099RP099KT032033LPV121M46I, I54V, V82AL10LF, L24LI, L33F, T74TPI13IV, K14KR, I15V, Q18E, L19IT, K20KR, M36L, R41K, Q61H, I62V, L63LP, H69K, L89I, I93L, L97LIC
 RP159RP159KT032057LPV200M46L, I54V, V82AL10F, L24I, L33F, T74API13IV, M36L, N37S, R41K, Q61N, I62V, L63V, H69K, L89M, I93ILC