Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L33F
Rx	>= 1 PI
IncludeMixtures	No

References	5
Patients	15
Isolates	15

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Snoeck (2004)	BE59	BE59	AY900757	SQV, IDV, RTV, NFV	217	G48V, I54A, V82A	L33F, K43KT	L10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93L	C
Non-B Workgroup (2005)	PL4725	100703		Unknown, LPV, APV	>159	M46ML, G48V, I54V, V82S, L90M	V11VI, L33F, Q58E	L10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96S	C
Baxter (2006)	12-1007	1007-30519	DQ875953	PI	NA	M46L, I54IV, V82A, L90M	L33F, K43KT	L10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93L	C
	12-1716	1716-30421	DQ876854	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T	L10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93L	C
	12-3102	3102-30610	DQ877250	PI	NA	L90M	L23I, L33F, F53L, Q58E	L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L	C
	48-2254	2254-30930	DQ877888	PI	NA	G48V, I54V, V82S, L90M	L33F, Q58E	L10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TS	C
	48-3058	3058-30401	DQ877970	PI	NA	I54L, V82A, L90M	L33F, K43KT	L10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93L	C
	48-3229	3229-30523	DQ878136	PI	NA	M46I, I54V, V82A, I84V	L10F, L24I, L33F, K43T	T12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91S	C
	48-4134	4134-30317	DQ878365	PI	NA	G48V, I54V, V82A, I84V	L33F, K43T	L10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93L	C
	48-8056	8056-30930	DQ879080	PI	NA	V32I, I47A	L33F, Q58E	L10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93L	C
Doualla-Bell (2006)	Pt10	FDB_Pt10		NFV		D30N, L90M	L33F	I15V, G17D, L19V, E35D, M36I, N37K, R41K, L63P, H69K, A71V, I93L	C
	Pt7	FDB_Pt7		NFV		D30N	L33F	L10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93L	C
	Pt8	FDB_Pt8		NFV		D30N	L33F, N88D	T12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89I	C
	Pt9	FDB_Pt9		NFV		D30N	L33F, N88D	T12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93L	C
Rodrigues (2010)	301_07	BR07SC301	GQ401314	SQV, RTV, LPV		M46L, G48V, I54V, V82S	L24I, L33F, T74P	L10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93L	C

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