Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	D30N
Rx	>= 1 PI
IncludeMixtures	No

References	9
Patients	28
Isolates	29

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gibb (2002)	DMG78	78_w30		NFV	30	D30N	N88ND, L89MV	T12S, I13IV, I15V, L19I, E35D, M36L, N37E, K45KQR, D60E, L63P, H69K, I93L	C
	DMG86	86_w82		NFV	65	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
	DMG91	91_w22		NFV	22	D30N	L10F, N88D, L89V	T12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93L	C
Grossman (2004)	IL128	IL128b	AY529542	NFV	41	D30N		K14N, A22G, M36I, R41K, H69K, L89M, I93L	C
		IL128e	AY529545	NFV	74	D30N		K14N, E35D, M36I, R41K, L63LP, H69K, L89M, I93L	C
	IL160	IL160	AY529612	SQV, NFV	128	D30N	N88D	T12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93L	C
	IL185	IL185c	AY529558	NFV	132	D30N		T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NI	C
	IL217	IL217	AY529576	NFV	104	D30N	N88D	L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93L	C
	IL477	IL477	AY529602	NFV	208	D30N	L10F, N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L	C
	IL574	IL574	AY529605	NFV	56	D30N		Q7H, R8A, I15V, L19I, K20T, M36I, N37S, R41K, L63S, H69K, I93L	C
Non-B Workgroup (2005)	UK1518	UK1518	AY900807	NFV	68	D30N	N88D	T12S, I15V, L19V, K20T, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93L	C
	UK2069	UK2069	AY900845	NFV		D30N	N88D	T12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93L	C
	SA75_DR16	SA75_DR16	AY901099	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
	TK3027	TK3027		RTV, SQV, NFV	190	D30N, L90M	N88D	T12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93L	C
	TK3031	TK3031		SQV, NFV	203	D30N	N88D	I15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93L	C
	PL47066	85002		IDV, NFV	104	D30N	N88D	T12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93L	C
Rhee (2005)	CA7907	CA24813	AY797580	IDV, NFV	260	D30N	L10F, N88D	T12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93L	C
Weber (2005)	F56949	F56949	AY677453	NFV	154	D30N		T12S, I13V, I15V, L19I, K20T, M36I, R41K, K45T, L63P, H69K, I93L	C
Doualla-Bell (2006)	Pt1	FDB_Pt1		NFV		D30N		T12S, I15V, G16A, L19I, K20T, E35D, M36I, R41K, K45Q, D60E, C67E, H69K, L89IM, I93L	C
	Pt10	FDB_Pt10		NFV		D30N, L90M	L33F	I15V, G17D, L19V, E35D, M36I, N37K, R41K, L63P, H69K, A71V, I93L	C
	Pt13	FDB_Pt13		NFV		D30N, M46I	L10F, N88D	I15V, M36I, R41K, L63P, H69K, I93L	C
	Pt3	FDB_Pt3		NFV		D30N		T12S, I15V, L19V, K20T, E35D, M36I, R41K, K45Q, D60E, Q61E, L63P, H69K, V75I, I93L	C
	Pt7	FDB_Pt7		NFV		D30N	L33F	L10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93L	C
	Pt8	FDB_Pt8		NFV		D30N	L33F, N88D	T12S, I15V, G16E, L19I, M36L, R41K, L63Q, H69K, L89I	C
	Pt9	FDB_Pt9		NFV		D30N	L33F, N88D	T12S, I15V, L19I, M36I, R41K, I62V, L63P, H69K, T74A, L89IM, I93L	C
von Wyl (2007)	41	662849	EF449918	PI	NA	D30N	N88D	I15V, E35D, M36I, N37K, R41HN, L63P, H69K, A71AV, I85IV, I93L	C
Pillay (2008)	DR58	DR58	AY589910	NFV		D30N		T12S, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45Q, I64V, H69K, L89I, I93L	C
	DR16	02ZA.DR16	AY589877	NFV		D30N	L10F, V32VA, N88D	I15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98K	C
Kandathil (2009)	VL06_253	VL06_253	EU030406	PI	NA	D30N	N88D, L89V	L10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93L	C

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