<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L24I
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 36
Isolates 38
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Snoeck (2002)BE16aBE16aAF339009IDV107M46I, V82AL24IL10IM, T12TS, I15V, L19T, M36I, R41K, K43KN, R57RS, D60E, Q61E, L63P, H69K, L89M, I93LC
Snoeck (2004)BE13bBE13bAY900730IDV44M46IL24IT12S, I15V, L19I, M36I, N37K, R41N, K45R, L63P, H69K, L89T, I93LC
Non-B Workgroup (2005)TK1021TK1021 IDV, RTV, LPV331M46I, I54V, V82AL10F, L24I, Q58ET12S, L19I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, L89M, I93LC
 PL4205672786 IDV, RTV275V82AL10F, L24I, I54CT12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
  91776 IDV, RTV, LPV340V82AL10F, L24I, I54CG17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
Baxter (2006)12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
Sanabani (2006)04BR01304BR013AY727522PINAM46I, G48V, V82AL24IL10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93LC
Sen (2007)T002NPT2EF186926RTV, IDV M46I, I54V, V82VAL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93LC
  NPT2-PLEF186983RTV, IDV M46I, I54V, V82AL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93LC
Kandathil (2009)VL07_103VL07_103EU781835PINAM46I, I54V, V82AL24IL10I, T12S, I15V, L19T, M36I, R41K, L63P, H69K, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Kouri (2012)CU1340-10CU1340-10JQ585423PINAM46I, I54AT, V82A, I84IVL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74TA, L89M, I93LC
Van Zyl (2013)1576168KC423322LPV26M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 8441031KC422820LPV78I54V, V82AL10F, L24IT12S, I15V, L19I, E34Q, M36I, R41K, K45R, L63P, H69K, L89M, I93LC
 11281379KC423106LPV26I54V, V82AL10F, L24I, L33F, N83DG16GA, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, I85V, L89I, T91S, I93LC
Grossman (2014)471471KF135082IDV, LPV52M46I, I54V, V82AL10F, L24I, L33FI13V, K14R, I15V, K20KT, M36I, R41K, L63P, H69K, T74TS, L89M, I93LC
 488488KF135085SQV, LPV52G48A, I54V, V82AL10F, L24I, Q58EK20R, M36I, R41K, L63P, H69K, A71V, I72V, N83S, L89I, I93LC
 7878KF135145RTV, LPV52M46I, I54V, L76V, V82AL10F, L24II15V, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, I93LC
Diaz (2015)RenG16894RenG16894KT747922PINAD30N, M46I, I54V, V82AL10F, L24I, L33F, N88DT12P, I13IV, K14KR, I15V, L19LP, K20KM, E35D, M36L, N37K, R41N, K55KR, R57RK, L63P, H69K, Q92QKC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG15962RenG15962KT746990PINAI54V, V82AL10FV, L24II15IV, G16E, K20R, E35D, M36I, N37E, R41N, K43R, K45V, R57K, Q58R, L63H, I66V, H69K, L89I, I93LC
 RenG14709RenG14709KT745737PINAD30N, M46MI, V82AL10F, L24I, L33F, N88DT12P, I15V, K20T, E35N, M36I, N37K, R41N, K45R, L63P, H69K, V75I, I93LC
 RenG15215RenG15215KT746243PINAM46L, I50IL, I54V, V82AL24I, L33FL10Y, E35D, M36L, N37EK, R41N, R57K, D60E, L63P, H69K, A71AT, L89I, Q92QK, I93LC
 RenG14962RenG14962KT745990PINAM46I, I54V, V82AL10F, L24I, L33FI15V, G16E, L19Q, K20R, E35D, M36I, N37K, R41N, Q61H, L63T, H69K, L89I, Q92K, I93LC
 RenG14431RenG14431KT745459PINAM46I, I54V, V82C, L90ML10F, L24IT12P, L19MV, K20R, E35D, M36I, N37T, R41N, Q61HN, I62V, L63P, H69K, T74S, V77I, L89IM, T91S, I93LC
 RenG12445RenG12445KT743473PINAM46I, I54V, V82AL10FIV, L24II15V, K20R, E35D, M36I, N37K, R41N, R57K, I62IV, L63P, H69K, T74TS, L89IM, I93LC
 RenG12839RenG12839KT743867PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, L19I, K20KT, M36L, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG13433RenG13433KT744461PINAI50L, V82ML24I, K43KTT12P, I15S, G16R, K20RT, E34KN, E35D, M36I, N37K, R41N, K45KR, L63T, G68E, H69K, A71V, I72IT, T74A, Q92K, I93LC
 RenG12567RenG12567KT743595PINAM46ML, I54V, V82AL24I, Q58QEL10IV, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, L89MC
 RenG12228RenG12228KT743256PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, I15IV, K20M, E35D, M36I, N37K, R41H, I62V, L63P, H69K, L89I, T91TSC
 RenG10445RenG10445KT741473PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16A, N37K, R41N, K55R, R57K, L63P, H69K, L89IC
 RenG11404RenG11404KT742432PINAM46I, I54V, V82AV11I, L24I, L33FL10V, I13V, I15V, K20R, E35D, M36I, N37NK, R41P, K45KR, I62V, L63Q, G68DE, H69K, A71I, L89T, I93LC
 RenG10631RenG10631KT741659PINAM46L, I54V, V82A, I84VV11I, L24I, K43TL10I, T12E, I13V, L19I, K20I, M36I, Q61N, L63T, I64V, H69K, A71V, I72IV, T74S, I93LC
Rossouw (2015)RP167RP167KT032058LPV, RTV312M46I, I54V, V82AL10F, L24I, K43TI15V, L19I, K20R, E35D, M36V, N37E, R57K, I62V, L63P, H69K, V77I, L89I, I93LC
 RP145RP145KT032053PINAM46I, I54V, V82AL10F, L24I, L33F, Q58EI15V, G17D, L19V, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69K, P81PS, T91TN, I93LC
 RP159RP159KT032057LPV200M46L, I54V, V82AL10F, L24I, L33F, T74API13IV, M36L, N37S, R41K, Q61N, I62V, L63V, H69K, L89M, I93ILC