<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L23I
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 30
Isolates 32
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patNIB01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
Non-B Workgroup (2005)UK243UK243AY900766IDV, NFV L90ML23IT12S, I15V, L19I, E35G, M36I, R41K, L63P, H69K, K70R, V82I, I93LC
 UK449UK449 SQV, NFV, RTV L90ML23IT12S, L19I, E35D, M36I, R41K, D60E, L63S, H69K, V82I, L89M, I93L, L97XC
 UK1461UK1461AY900805NFV35 L23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 UK1461bUK1461b NFV35L90LML23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 TK1020TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
Baxter (2006)12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Van Zyl (2013)16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
 751548KC424133LPV26M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63N, H69K, A71V, L89M, I93LC
  1563KC423234LPV26M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63H, H69K, A71V, I72IM, L89M, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
Grossman (2014)882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 5050KF135091SQV, LPV52M46L, I54V, V82AL10F, L23IT12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LC
Diaz (2015)RenG17227RenG17227KT748255PINA L23IL10M, I13V, K20T, E35N, M36I, N37K, R41N, K45Q, I62V, L63P, H69K, T74K, V82VI, L89I, I93LC
 RenG15719RenG15719KT746747PINAI54V, L90ML23I, K43T, F53LI13V, I15V, L19I, K20T, E35D, M36I, N37K, R41N, I62IV, L63P, H69K, A71IV, T74S, V77I, L89I, I93LC
 RenG15516RenG15516KT746544PINAI54V, V82VA, I84V, L90ML10F, L23I, Q58EI15V, K20R, E35D, M36I, N37K, R41N, R57RK, D60DE, I62IV, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 RenG16982RenG16982KT748010PINAM46L, I54IV, V82AL10LFPS, L23I, L33F, F53FLP9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93LC
 RenG14916RenG14916KT745944PINAI50L, V82M, L90ML23I, L33FI13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93LC
 RenG13855RenG13855KT744883PINAL90ML23I, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71I, T74A, L89I, I93LC
 RenG13600RenG13600KT744628PINAM46I, I50L, L90ML23II15V, K20T, E35D, M36I, N37K, R41N, L63PT, H69K, A71V, T74S, I85IV, L89I, I93LC
 RenG15500RenG15500KT746528PINAM46I, I47IV, I54V, V82F, L90ML23I, L33LI, F53FL, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, L89I, Q92QK, I93LC
 RenG15162RenG15162KT746190PINA L23II13IV, K20KR, E35D, M36MIV, N37K, R41N, K45R, L63P, H69K, A71IV, L89T, I93LC
 RenG12082RenG12082KT743110PINAM46I, I50V, V82A, L90ML10F, V11VI, L23I, L33F, Q58EI13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, G73V, T74S, L89T, I93LC
 RenG12084RenG12084KT743112PINAM46L, I54V, V82A, L90ML10F, L23I, Q58EI15V, L19I, K20R, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, L63P, H69K, I72IV, T74TS, L89IM, I93LC
 RenG12519RenG12519KT743547PINAM46I, I54V, V82A, L90ML10F, L23II13V, K14R, I15V, K20I, E35N, M36I, N37E, R41N, Q61H, I62V, L63P, H69K, A71T, T74S, L89I, I93LC
 RenG11141RenG11141KT742169PINAM46I, V82VA, I84VL10F, L23I, Q58QE, T74PSK14R, I15V, K20R, M36I, N37K, R41N, L63P, H69K, L89M, I93LC
 RenG10356RenG10356KT741384PINA L23II13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, L63P, H69K, T74S, L89T, I93LC
 RenG10952RenG10952KT741980PINA L23II13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, Q61H, L63P, H69K, A71T, L89T, I93LC
 RenG11076RenG11076KT742104PINAI54V, V82A, L90ML23I, G73S, L89VL10I, I15V, G16GW, L19LP, K20IM, E35D, M36I, N37K, R41N, K45R, K55KR, I62V, L63P, H69K, A71T, I85V, I93LC