<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L23I
Rx >= 1 PI
IncludeMixtures No
References 6
Patients 14
Isolates 16
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patNIB01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
Non-B Workgroup (2005)UK243UK243AY900766IDV, NFV L90ML23IT12S, I15V, L19I, E35G, M36I, R41K, L63P, H69K, K70R, V82I, I93LC
 UK449UK449 SQV, NFV, RTV L90ML23IT12S, L19I, E35D, M36I, R41K, D60E, L63S, H69K, V82I, L89M, I93L, L97XC
 UK1461UK1461AY900805NFV35 L23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 UK1461bUK1461b NFV35L90LML23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 TK1020TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
Baxter (2006)12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Van Zyl (2013)16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
 751548KC424133LPV26M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63N, H69K, A71V, L89M, I93LC
  1563KC423234LPV26M46I, I50V, I54V, V82AL23IL10I, T12S, I15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61HN, L63H, H69K, A71V, I72IM, L89M, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
Grossman (2014)882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 5050KF135091SQV, LPV52M46L, I54V, V82AL10F, L23IT12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LC