<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K20T
Rx >= 1 PI
IncludeMixtures No
References 19
Patients 108
Isolates 116
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG104104_w66 NFV66N88SQ58QET12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, L89M, I93LC
Colonno (2004)RC-034-067-562067-5621AY461501ATV I50L K14R, I15V, L19I, K20T, E34EK, E35D, M36I, N37D, R41K, K55KN, D60E, I64IV, H69K, A71V, L89MT, I93LC
Grossman (2004)IL178IL178AY529547NFV65N88S L19KT, K20T, T31TK, E35D, M36I, R41K, K45KR, L63P, H69K, L89M, I93LC
 IL267IL267AY529619IDV, RTV, SQV, NFV229L90M I13IV, K14R, I15V, G16GE, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LC
 IL477IL477AY529602NFV208D30NL10F, N88DT12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93LC
 IL574IL574AY529605NFV56D30N Q7H, R8A, I15V, L19I, K20T, M36I, N37S, R41K, L63S, H69K, I93LC
Montes (2004)MB_patNIB01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
 MB_patCOU02_COUL707AJ577870SQV, RTV, IDV, NFV221L90MG73SL10I, T12S, I15V, K20T, M36I, R41K, L63P, H69K, A71V, I93LC
Non-B Workgroup (2005)UK276UK276AY900768IDV, SQV, NFV52L90M L10IV, T12S, I13V, I15V, L19I, K20T, M36I, Q61E, L63P, I64L, H69K, L89M, I93L, C95FC
 UK320UK320AY900769NFV57L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, H69K, T74S, L89I, I93LC
 UK496bUK496bAY900776NFV L90M T12S, I13V, L19I, K20T, M36I, R41K, D60E, L63P, I64V, H69K, L89M, I93LC
 UK1147UK1147AY900794IDV, NFV117M46IK43TT12S, I15V, L19I, K20T, E35D, M36I, N37D, D60E, Q61E, L63P, H69K, A71T, L89T, I93LC
 UK1154UK1154AY900795NFV L90M T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, D60E, L63P, I64V, H69K, V82I, L89M, I93LC
 UK1461UK1461AY900805NFV35 L23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 UK1518UK1518AY900807NFV68D30NN88DT12S, I15V, L19V, K20T, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93LC
 UK1461bUK1461b NFV35L90LML23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 TK1004TK1004 NFV, RTV, IDV131  I3IV, T12P, I15V, L19I, K20T, E21G, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74A, L89M, I93LC
  TK1004a NFV, RTV, IDV183  T12P, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93LC
  TK1004b NFV, RTV, IDV196  T12P, I15V, L19I, K20T, L24LF, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93LC
  TK1004c NFV, RTV, IDV268  T12P, I15V, L19IT, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93LC
 TK2018TK2018 IDV, RTV, NFV218M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93LC
 TK3010TK3010 SQV, NFV, RTV, IDV, LPV177  T12S, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89M, I93LC
  TK3010a SQV, NFV, RTV, IDV, LPV210  T12S, I15V, L19I, K20T, E35ED, M36I, R41K, L63P, H69K, L89M, I93LC
 TK3024TK3024 SQV, NFV205L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71I, T74S, I93LC
  TK3024a SQV, NFV, LPV246L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45KR, L63P, H69K, A71I, T74S, I93LC
 TK3026TK3026 RTV, SQV, NFV292L90M I15V, L19I, K20T, E35D, M36I, R41RK, L63P, H69K, A71I, T74S, L89I, I93LC
 TK3031TK3031 SQV, NFV203D30NN88DI15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93LC
 PL2421663450 NFV84D30DN, L90LM T12S, I13IV, I15V, L19T, K20T, E35EDG, M36I, N37E, L63LP, H69K, V82VI, L89I, I93ILC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
Weber (2005)F68541F68541AY677417NFV198M46MI, L90M T12S, I13V, I15V, L19I, K20T, E35X, M36I, R41K, H69K, T74AS, L89I, I93LC
 M72003M72003AY677426NFV, RTV, IDV212I54IV, L90ML10FI13V, K14N, I15V, L19I, K20T, E35N, M36I, R41K, K45R, I62IV, L63P, I64V, H69K, K70R, T74S, L89M, I93LC
 F56949F56949AY677453NFV154D30N T12S, I13V, I15V, L19I, K20T, M36I, R41K, K45T, L63P, H69K, I93LC
Baxter (2006)48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt1FDB_Pt1 NFV D30N T12S, I15V, G16A, L19I, K20T, E35D, M36I, R41K, K45Q, D60E, C67E, H69K, L89IM, I93LC
 Pt2FDB_Pt2 NFV L90M T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93LC
 Pt3FDB_Pt3 NFV D30N T12S, I15V, L19V, K20T, E35D, M36I, R41K, K45Q, D60E, Q61E, L63P, H69K, V75I, I93LC
 Pt4FDB_Pt4 NFV L90M K14R, I15V, L19I, K20T, E35D, M36I, R41K, D60E, Q61E, I64V, H69K, L89M, I93LC
 Pt5FDB_Pt5 NFV N88SL10FI15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
Kandathil (2009)VL06_253VL06_253EU030406PINAD30NN88D, L89VL10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93LC
 VL07_040VL07_040EU030407PINAM46I, L90MK43TT12S, I15V, L19I, K20T, E35D, M36I, R41K, L63P, H69K, T74S, I93LC
Kassaye (2009)TC-68TC68_2004FJ445724NFV, LPV17I54L, L90LML10LFI15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93LC
Rhee (2009)CA14714CA38172FJ983395NFV48L90M T12S, K14R, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63PS, I64V, H69K, L89M, I93LC
Dau (2010)07344A07344AGU581841PINAL90M T12S, I13V, I15V, L19I, K20T, M36I, N37ND, R41K, L63P, H69K, V82I, L89M, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Rodrigues (2010)305_07BR07SC305GQ401315NFV L90ML89VI13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93LC
Van Zyl (2013)16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
 14071550KC423222LPV26I54V, I84V T12S, I13V, I15V, G16E, L19I, K20T, M36I, R41K, K45V, D60E, Q61E, I66V, H69K, K70R, I72V, V82I, L89M, I93LC
 1288961KC424397LPV26I47AF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71V, I93LC
  1594KC423256LPV78I47AF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93LC
  1482KC423174LPV79I47A, N88NSF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93LC
 1002865KC424321LPV104M46I, I54V, V82AL10FT12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93LC
Grossman (2014)882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 638638KF135117IDV, LPV52L90M Q7T, L10V, I15V, K20T, M36I, N37NH, R41K, L63P, I64IV, H69K, I85IV, L89M, I93LC
 512512KF135092LPV52  I13V, K14R, I15V, K20T, M36I, R41K, H69K, V82I, L89M, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 805805KF135148SQV, LPV52M46I, I54IV, L76V, V82VAL10LFT12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93LC
 155155KF134987IDV, LPV52M46I, I54V, V82AL10FI13X, I15V, K20T, M36I, R41K, I62IV, L63P, H69K, T74S, L89M, I93LC
Diaz (2015)RenG17227RenG17227KT748255PINA L23IL10M, I13V, K20T, E35N, M36I, N37K, R41N, K45Q, I62V, L63P, H69K, T74K, V82VI, L89I, I93LC
 RenG17053RenG17053KT748081PINAI50L, L90ML33IL10Y, I13IV, I15V, K20T, E34EQ, E35N, M36I, N37E, R41N, K45R, D60N, I62IV, L63LP, C67CF, G68GE, H69KR, A71I, L89I, I93LC
 RenG16213RenG16213KT747241PINAI50IL, L90ML23LI, K43KTK20T, E35D, M36I, N37K, R41N, D60DE, I62IV, L63P, I64IV, H69K, A71AV, T74TS, V82VI, L89IM, I93LC
 RenG15719RenG15719KT746747PINAI54V, L90ML23I, K43T, F53LI13V, I15V, L19I, K20T, E35D, M36I, N37K, R41N, I62IV, L63P, H69K, A71IV, T74S, V77I, L89I, I93LC
 RenG16120RenG16120KT747148PINA  I15V, K20T, M36I, N37K, R41N, I62IMV, H69K, A71V, L89M, Q92R, I93LC
 RenG16791RenG16791KT747819PINAM46I, I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, K20T, E35N, M36I, N37Q, R41N, I62IV, L63V, H69K, I72V, L89I, I93LC
 RenG16317RenG16317KT747345PINAM46I, I54V, V82AL10F, Q58E, T74P, N88GI15V, G16E, K20T, E21K, E35G, M36I, N37K, P39S, R41N, L63T, H69K, V77I, L89MC
 RenG16528RenG16528KT747556PINAM46I, I54V, V82AL10FI15S, G16R, G17GR, K20T, N37K, R41P, D60E, I62V, L63P, H69K, V77I, L89M, I93LC
 RenG16009RenG16009KT747037PINAI54V, L90M Q7QL, I13V, I15V, K20T, E35D, M36I, N37K, R41N, R57K, D60E, I62V, H69K, T74E, V77VI, V82I, L89M, I93LC
 RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG15557RenG15557KT746585PINAM46I, I54V, L76V, V82C, L90M T12AS, I15V, G16E, L19P, K20T, E35G, M36I, N37K, R41N, K55R, R57RK, Q61N, L63N, H69K, A71V, I72R, L89I, I93LC
 RenG16715RenG16715KT747743PINAD30N, I54LN88DL10Y, I15V, L19Q, K20T, E35D, M36I, N37K, R41N, L63V, H69K, A71T, L89T, I93LC
 RenG16128RenG16128KT747156PINAM46I, I54V, I84VL10FI15V, K20T, E35DN, M36I, N37K, R41N, I62IV, L63V, H69K, T74E, I85V, L89M, I93LC
 RenG16280RenG16280KT747308PINAD30N, I50ILN88D, L89AITVK14KR, I15V, L19I, K20T, M36IV, N37KR, R41NY, Q61H, H69K, A71IV, T74S, I85V, I93LC
 RenG16022RenG16022KT747050PINAI50L, V82ILL33FK14KR, I15V, K20T, M36I, N37K, R41N, H69K, A71V, L89I, I93LC
 RenG17445RenG17445KT748473PINAI50IL, L90ML23LI, L33LFI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, D60DE, I62V, L63LP, H69K, T74S, V82I, L89I, I93LC
 RenG15346RenG15346KT746374PINAM46MI, I54V, V82VA, I84V, L90ML10F, L23LI, L33F, F53FL, G73S, T74PS, L89VV11L, I13V, I15V, K20T, E34Q, E35D, M36IL, N37K, R41N, I62V, L63P, G68D, H69R, A71V, I93LC
 RenG14709RenG14709KT745737PINAD30N, M46MI, V82AL10F, L24I, L33F, N88DT12P, I15V, K20T, E35N, M36I, N37K, R41N, K45R, L63P, H69K, V75I, I93LC
 RenG14874RenG14874KT745902PINAM46I, N88S I15V, K20T, E35D, M36I, N37K, R41N, L63T, I64IV, H69K, T74S, L89M, I93LC
 RenG14050RenG14050KT745078PINAD30NL10F, N88DK14KR, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69Q, I72IV, V75I, L89M, I93LC
 RenG14536RenG14536KT745564PINAD30N, I54ILM, I84IVL10F, L33F, N88DI15V, G16E, K20T, E35D, M36I, N37EK, P39S, R41N, K45I, L63T, H69K, T74AS, I85V, L89M, I93ILC
 RenG14916RenG14916KT745944PINAI50L, V82M, L90ML23I, L33FI13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93LC
 RenG15117RenG15117KT746145PINAI54L, L90MT74P, N88NTK14R, I15V, G16E, K20T, E35D, M36I, N37K, P39S, R41N, I62V, H69K, A71V, V82I, L89M, I93LC
 RenG13868RenG13868KT744896PINAI54ILT74TPI15V, K20T, E35D, M36I, N37K, R41N, K45KR, L63LP, H69K, I85IV, L89M, I93LC
 RenG13855RenG13855KT744883PINAL90ML23I, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71I, T74A, L89I, I93LC
 RenG14841RenG14841KT745869PINAI54IL, V82VL, L90LMT74TPI15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71AV, L89M, I93LC
 RenG14844RenG14844KT745872PINAM46I, I54V, V82A, N88SL10F, L33F, L89VI13V, I15V, K20T, E21EK, E35D, M36IL, N37K, R41N, I62V, L63P, H69K, G73D, T74S, I93ILC
 RenG14186RenG14186KT745214PINAD30N, M46L, I54V, V82AQ58QE, N88DL10R, I15V, K20T, E35D, M36I, N37K, R41N, D60DE, Q61QH, L63P, I64IL, H69K, A71V, L89I, I93LC
 RenG14901RenG14901KT745929PINAM46ML, G48GA, I54V, I84V, L90ML10F, T74P, L89VI15V, K20T, E35DN, M36I, N37K, R41H, Q61QH, I62IV, L63P, H69K, A71V, I85V, T91CS, I93LC
 RenG14927RenG14927KT745955PINAL90M I15V, G16E, L19I, K20T, N37K, R41H, K45R, L63H, H69K, V82I, I85V, L89LIM, I93LC
 RenG13600RenG13600KT744628PINAM46I, I50L, L90ML23II15V, K20T, E35D, M36I, N37K, R41N, L63PT, H69K, A71V, T74S, I85IV, L89I, I93LC
 RenG12144RenG12144KT743172PINAV32I, I54L, I84VL10F, L33I, L89VI13V, I15V, K20T, M36I, N37K, R41N, Q61N, L63P, I66FV, H69K, A71V, T74S, V77I, Q92KC
 RenG13401RenG13401KT744429PINAM46I, I54V, V82F, L90MT74PSL10V, I13V, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, Q61QHKN, H69K, L89I, I93LC
 RenG12731RenG12731KT743759PINA  I15V, K20T, E35D, M36I, N37NK, R41N, K45R, L63C, H69K, A71V, T74TS, L89T, I93LC
 RenG13419RenG13419KT744447PINAL90M I13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG13298RenG13298KT744326PINAM46I, I54V, L76V, L90M I15V, L19I, K20T, E35D, M36I, N37E, R41H, R57K, Q61R, I62V, L63LP, H69R, A71V, V82I, L89I, I93LC
 RenG12492RenG12492KT743520PINAV32VI, M46I, I47V, V82VA, L90ML10F, K43KT, I54CT12S, I15V, K20T, E21K, E35D, M36I, N37K, R41H, R57RK, D60DE, I62IV, L63P, C67F, H69K, A71IM, L89M, I93LC
 RenG12637RenG12637KT743665PINAM46I, N88SF53LL10Y, I15V, K20T, E35G, M36I, N37D, R41K, L63V, I64V, H69K, T74A, L89M, I93LC
 RenG13467RenG13467KT744495PINA  I13V, I15V, K20T, E35D, M36I, N37K, R41N, L63V, H69K, T74S, V82I, I93LC
 RenG11973RenG11973KT743001PINAD30N I15V, K20T, E35D, M36I, N37K, R41N, G68E, H69K, A71V, I93LC
 RenG12355RenG12355KT743383PINAM46I, L90ML89MVI13V, K14R, I15V, K20T, M36I, N37K, R41N, I62V, H69K, T74TS, V82VI, I93LC
 RenG10128RenG10128KT741156PINA L23LIL10V, I13V, K14KR, I15V, K20T, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, H69K, A71AT, T74S, L89I, I93LC
 RenG11113RenG11113KT742141PINAI54L, I84IVT74P, L89MVI15V, K20T, E35D, M36MI, N37K, R41N, L63P, H69K, A71V, V82I, T91S, I93LC
 RenG10627RenG10627KT741655PINAL90M I13V, I15V, K20T, M36I, N37R, R41N, D60E, I62V, L63P, I64V, H69K, A71AV, V82VI, L89M, I93LC
 RenG11612RenG11612KT742640PINAI54V, V82F, L90ML23LI, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, L63P, H69K, A71IV, T74S, L89I, I93LC
 RenG11098RenG11098KT742126PINAD30NN88DI13V, K14KR, I15V, K20T, E35D, M36I, N37Q, R41NS, D60E, Q61N, L63Q, H69K, T74A, V77VI, L89M, I93LC
 RenG11346RenG11346KT742374PINAM46MI, L90M I13V, I15V, G16E, K20T, M36I, N37K, P39S, R41N, I62V, H69K, T74KR, V82I, L89M, I93LC
 RenG10964RenG10964KT741992PINAM46I, I54V, V82C, I84V, L90ML10FT12R, I15V, L19LP, K20T, L33L_L, E35D, M36I, N37K, R41N, D60E, L63P, I66IV, H69K, A71AT, V77I, I85V, L89I, Q92K, I93L, C95FC
 RenG10624RenG10624KT741652PINAL90MQ58EI13V, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, Q61N, L63T, I64IV, H69K, A71T, T74A, V82I, L89I, I93LC
 RenG11084RenG11084KT742112PINAL90LML10FR8RH, I13V, I15V, K20T, E35D, M36I, N37AEKT, R41N, H69K, T74S, L89I, I93LC
 RenG11040RenG11040KT742068PINAV82VA, L90LML10F, T74PSK14R, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63V, H69K, L89I, I93LC
 RenG10079RenG10079KT741107PINAL90M I15V, L19I, K20T, E35DN, M36I, N37E, R41N, K45R, L63LP, H69K, T74S, L89I, I93LC
 RenG10242RenG10242KT741270PINAM46I, I54V, V82A, L90M I13V, I15V, K20T, L33L_L, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG11250RenG11250KT742278PINAM46I, I50IL, I54V, V82F, L90M L10V, V11VL, K14R, I15V, Q18P, K20T, E35D, M36I, N37K, R41N, K55H, Q61QE, I62V, L63P, H69K, A71AV, T74A, L89I, I93ILC
 RenG10493RenG10493KT741521PINAL90ML23LI, F53L, G73GS, L89IVI13V, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71V, T74K, V77VI, I93LC
Rossouw (2015)RP126RP126KT032045RTV, LPV348M46I, I54V, L76V, V82L Q7E, K14R, I15V, G16E, L19I, K20T, E35D, M36I, Q61N, L63C, H69K, L89I, I93LC