<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K20T
Rx >= 1 PI
IncludeMixtures No
References 17
Patients 52
Isolates 60
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG104104_w66 NFV66N88SQ58QET12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, L89M, I93LC
Colonno (2004)RC-034-067-562067-5621AY461501ATV I50L K14R, I15V, L19I, K20T, E34EK, E35D, M36I, N37D, R41K, K55KN, D60E, I64IV, H69K, A71V, L89MT, I93LC
Grossman (2004)IL178IL178AY529547NFV65N88S L19KT, K20T, T31TK, E35D, M36I, R41K, K45KR, L63P, H69K, L89M, I93LC
 IL267IL267AY529619IDV, RTV, SQV, NFV229L90M I13IV, K14R, I15V, G16GE, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LC
 IL477IL477AY529602NFV208D30NL10F, N88DT12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93LC
 IL574IL574AY529605NFV56D30N Q7H, R8A, I15V, L19I, K20T, M36I, N37S, R41K, L63S, H69K, I93LC
Montes (2004)MB_patNIB01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
 MB_patCOU02_COUL707AJ577870SQV, RTV, IDV, NFV221L90MG73SL10I, T12S, I15V, K20T, M36I, R41K, L63P, H69K, A71V, I93LC
Non-B Workgroup (2005)UK276UK276AY900768IDV, SQV, NFV52L90M L10IV, T12S, I13V, I15V, L19I, K20T, M36I, Q61E, L63P, I64L, H69K, L89M, I93L, C95FC
 UK320UK320AY900769NFV57L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, H69K, T74S, L89I, I93LC
 UK496bUK496bAY900776NFV L90M T12S, I13V, L19I, K20T, M36I, R41K, D60E, L63P, I64V, H69K, L89M, I93LC
 UK1147UK1147AY900794IDV, NFV117M46IK43TT12S, I15V, L19I, K20T, E35D, M36I, N37D, D60E, Q61E, L63P, H69K, A71T, L89T, I93LC
 UK1154UK1154AY900795NFV L90M T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, D60E, L63P, I64V, H69K, V82I, L89M, I93LC
 UK1461UK1461AY900805NFV35 L23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 UK1518UK1518AY900807NFV68D30NN88DT12S, I15V, L19V, K20T, E35D, M36I, N37NS, R41K, H69K, T74S, L89M, I93LC
 UK1461bUK1461b NFV35L90LML23IT12S, I15V, L19I, K20T, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 TK1004TK1004 NFV, RTV, IDV131  I3IV, T12P, I15V, L19I, K20T, E21G, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74A, L89M, I93LC
  TK1004a NFV, RTV, IDV183  T12P, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93LC
  TK1004b NFV, RTV, IDV196  T12P, I15V, L19I, K20T, L24LF, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93LC
  TK1004c NFV, RTV, IDV268  T12P, I15V, L19IT, K20T, E35D, M36I, N37D, R41K, K45R, L63P, I64L, H69K, T74S, L89M, I93LC
 TK2018TK2018 IDV, RTV, NFV218M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93LC
 TK3010TK3010 SQV, NFV, RTV, IDV, LPV177  T12S, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89M, I93LC
  TK3010a SQV, NFV, RTV, IDV, LPV210  T12S, I15V, L19I, K20T, E35ED, M36I, R41K, L63P, H69K, L89M, I93LC
 TK3024TK3024 SQV, NFV205L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71I, T74S, I93LC
  TK3024a SQV, NFV, LPV246L90M T12S, I15V, L19I, K20T, E35D, M36I, R41K, K45KR, L63P, H69K, A71I, T74S, I93LC
 TK3026TK3026 RTV, SQV, NFV292L90M I15V, L19I, K20T, E35D, M36I, R41RK, L63P, H69K, A71I, T74S, L89I, I93LC
 TK3031TK3031 SQV, NFV203D30NN88DI15V, L19I, K20T, E35G, M36I, R41K, G51GR, L63S, H69K, T74A, L89M, I93LC
 PL2421663450 NFV84D30DN, L90LM T12S, I13IV, I15V, L19T, K20T, E35EDG, M36I, N37E, L63LP, H69K, V82VI, L89I, I93ILC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
Weber (2005)F68541F68541AY677417NFV198M46MI, L90M T12S, I13V, I15V, L19I, K20T, E35X, M36I, R41K, H69K, T74AS, L89I, I93LC
 M72003M72003AY677426NFV, RTV, IDV212I54IV, L90ML10FI13V, K14N, I15V, L19I, K20T, E35N, M36I, R41K, K45R, I62IV, L63P, I64V, H69K, K70R, T74S, L89M, I93LC
 F56949F56949AY677453NFV154D30N T12S, I13V, I15V, L19I, K20T, M36I, R41K, K45T, L63P, H69K, I93LC
Baxter (2006)48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Doualla-Bell (2006)Pt1FDB_Pt1 NFV D30N T12S, I15V, G16A, L19I, K20T, E35D, M36I, R41K, K45Q, D60E, C67E, H69K, L89IM, I93LC
 Pt2FDB_Pt2 NFV L90M T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93LC
 Pt3FDB_Pt3 NFV D30N T12S, I15V, L19V, K20T, E35D, M36I, R41K, K45Q, D60E, Q61E, L63P, H69K, V75I, I93LC
 Pt4FDB_Pt4 NFV L90M K14R, I15V, L19I, K20T, E35D, M36I, R41K, D60E, Q61E, I64V, H69K, L89M, I93LC
 Pt5FDB_Pt5 NFV N88SL10FI15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
Kandathil (2009)VL06_253VL06_253EU030406PINAD30NN88D, L89VL10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93LC
 VL07_040VL07_040EU030407PINAM46I, L90MK43TT12S, I15V, L19I, K20T, E35D, M36I, R41K, L63P, H69K, T74S, I93LC
Kassaye (2009)TC-68TC68_2004FJ445724NFV, LPV17I54L, L90LML10LFI15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93LC
Rhee (2009)CA14714CA38172FJ983395NFV48L90M T12S, K14R, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63PS, I64V, H69K, L89M, I93LC
Dau (2010)07344A07344AGU581841PINAL90M T12S, I13V, I15V, L19I, K20T, M36I, N37ND, R41K, L63P, H69K, V82I, L89M, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Rodrigues (2010)305_07BR07SC305GQ401315NFV L90ML89VI13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93LC
Van Zyl (2013)16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
 14071550KC423222LPV26I54V, I84V T12S, I13V, I15V, G16E, L19I, K20T, M36I, R41K, K45V, D60E, Q61E, I66V, H69K, K70R, I72V, V82I, L89M, I93LC
 1288961KC424397LPV26I47AF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, L63P, H69K, A71V, I93LC
  1594KC423256LPV78I47AF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93LC
  1482KC423174LPV79I47A, N88NSF53LT12S, I15V, L19I, K20T, E35D, M36I, R41K, K45R, D60E, L63P, H69K, A71V, I93LC
 1002865KC424321LPV104M46I, I54V, V82AL10FT12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93LC
Grossman (2014)882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 638638KF135117IDV, LPV52L90M Q7T, L10V, I15V, K20T, M36I, N37NH, R41K, L63P, I64IV, H69K, I85IV, L89M, I93LC
 512512KF135092LPV52  I13V, K14R, I15V, K20T, M36I, R41K, H69K, V82I, L89M, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 805805KF135148SQV, LPV52M46I, I54IV, L76V, V82VAL10LFT12TS, I15V, G16E, L19I, K20T, E35D, M36I, R41K, L63T, H69K, I85IV, L89I, I93LC
 155155KF134987IDV, LPV52M46I, I54V, V82AL10FI13X, I15V, K20T, M36I, R41K, I62IV, L63P, H69K, T74S, L89M, I93LC