Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	K20R
Rx	>= 1 PI
IncludeMixtures	No

References	23
Patients	77
Isolates	93

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Weidle (2001)	PW_UG477	PW_UG477a		SQV	24			K20R, M36I, R41K, Q61E, H69K, V82VI, L89M, I93L	C
		PW_UG477b		SQV	73			K20R, M36I, R41K, Q61E, H69K, K70KE, L89M, I93L	C
Kantor (2002)	TCDD-01	TCDD-01	AY090840	NFV	22			T12S, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63I, E65D, H69K, V82I, L89M, I93L	C
	TCDD-27	TCDD-27	AY090853	SQV	149			T12S, I13V, I15V, G16E, L19I, K20R, M36I, R41K, H69K, I93L	C
	TCDD-33	TCDD-33	AY090859	IDV	135			T12S, I15IV, L19I, K20R, M36I, R41K, H69K, L89M, I93L	C
Johnston (2003)	TC-71	TC-71		IDV	52	G48V, I54T, V82A		L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93L	C
Shafer (2003)	A384_3441	3441b	EF549036	NFV	32			T12S, I15V, L19T, K20R, M36L, R41K, L63P, H69K, I93L	C
Colonno (2004)	RC-008-060-076	060-07621	AY461494	ATV	80	I50L		T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
	RC-008-060-169	060-1691	AY461495	ATV		I50L		T12S, I15V, G16GE, L19I, K20R, E35D, M36I, R41K, H69KQ, L89M, I93L	C
Grossman (2004)	IL77	IL77b	AY529531	NFV	1	M46MI		G16X, K20R, M36I, N37D, R41K, H69K, L89M, I93L	C
		IL77a	AY529532	NFV	48			K20R, L24L*, M36I, N37D, R41K, H69K, L89M, I93L	C
	IL197	IL197a	AY529559	NFV	34			T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
	IL217	IL217	AY529576	NFV	104	D30N	N88D	L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93L	C
	IL433	IL433a	AY529600	IDV	117	M46ML, V82A, L90LM	Q58E	L10C, I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93L	C
		IL433b	AY529601	IDV	174	M46L, V82A, L90LM	L10F, Q58QE	I15V, K20R, M36I, L63PT, H69K, L89M, I93L	C
	IL708	IL708	AY529608	NFV	44	I84C		I15V, K20R, M36I, R41K, L63T, H69K, I72T, I93L	C
Non-B Workgroup (2005)	UK162	UK162	AY900762	RTV	57	M46I, V82A, L90M	K43T	T12S, I15V, L19I, K20R, D25E, M36I, R41K, K55R, Q61E, I62V, L63V, H69K, T74S, L89M, I93L	C
	UK538	UK538		SQV, RTV	4			V11X, T12S, I15V, L19T, K20R, M36I, R41K, D60E, L63P, H69K, V77I, L89M, I93L	C
	UK545	UK545		SQV				T12S, I15V, L19I, K20R, M36I, R41K, K55N, D60E, H69K, L89M, I93L	C
	UK624	UK624		PI	NA	I54V		T12S, I15V, L19I, K20R, M36I, R41K, L63P, H69K, I93L	C
	UK773a	UK773a		NFV				P9PL, T12S, I15IV, L19T, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	IL80	IL80	AY900811	RTV, NFV, SQV	114	I54V, V82A, I84V	K43T	W6WL, T12S, L19I, K20R, E21EG, M36I, G40E, R41K, L63P, H69K, A71V, T74A, I93L	C
	UK1447b	UK1447b	AY900833	IDV, NFV, SQV, RTV, APV, LPV	175	M46I, I50V, I54V, V82A, L90M	L10F, L23I, K43T	I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93L	C
	UK2069	UK2069	AY900845	NFV		D30N	N88D	T12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93L	C
	SA84_DR29	SA84_DR29	AY901107	NFV				T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69K, T74S, L89M, I93L	C
	TK1002	TK1002		RTV	225	M46I, I54V, V82A		L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93L	C
	TK1020	TK1020		SQV, RTV, IDV	211	I54V, V82C, L90M	F53L	L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93L	C
		TK1020a		SQV, RTV, IDV, LPV	229	M46L, I54V, V82C, L90M	L23I, F53L	L10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93L	C
		TK1020b		SQV, RTV, IDV, LPV	392	M46I, I47V, I54V, V82C, L90M	L23I, K43T, F53L	L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93L	C
	TK3009	TK3009		SQV, NFV	158	L90M		K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93L	C
		TK3009a		SQV, NFV, LPV	232	L90M		I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93L	C
		TK3009b		SQV, NFV, LPV	232	L90M		I13IV, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93L	C
	TK3019	TK3019		SQV, NFV, RTV	143	I54V, I84IV, L90M	V11VI, G73S	L10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93L	C
	TK3022	TK3022		SQV, NFV	103			T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LI	C
	TK3027	TK3027		RTV, SQV, NFV	190	D30N, L90M	N88D	T12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93L	C
		TK3027a		RTV, SQV, NFV, LPV	259			T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
		TK3027b		RTV, SQV, NFV, LPV	276	D30DN, L90LM	N88D	T12S, I13IV, I15V, L19I, K20R, E35D, M36I, N37ND, R41RK, L63P, H69K, T74S, L89IM, I93L	C
	TK3032	TK3032		SQV, IDV	239	M46I, I54V, V82T, L90M		L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63P, G68GE, H69K, L89M, I93L, C95F	C
	TK3035	TK3035		IDV, NFV, RTV	202	I54A, V82A		L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K45KR, D60E, L63P, H69K, A71V, L89M, I93L	C
	TK4011	TK4011		SQV, RTV, NFV, IDV	261	V82A, L90M	Q58E, G73S	L10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93L	C
	PL27956	60622		NFV, RTV, IDV	184	L90MR		L10V, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62IV, L63P, H69K, A71AV, T74S, V77VI, I93L	C
	PL42056	72786		IDV, RTV	275	V82A	L10F, L24I, I54C	T12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L	C
		91776		IDV, RTV, LPV	340	V82A	L10F, L24I, I54C	G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93L	C
	PL4725	58294		Unknown, LPV	>4	G48V, I54V, V82T, L90M	Q58E	L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L	C
		69936		Unknown, LPV	>51	G48V, I54V, V82S, L90M	Q58E	L10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CF	C
		80404		Unknown, LPV	>90	G48V, I54V, V82S, L90M	Q58E	L10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F	C
		100703		Unknown, LPV, APV	>159	M46ML, G48V, I54V, V82S, L90M	V11VI, L33F, Q58E	L10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96S	C
Weber (2005)	F77878	F77878	AY677381	Unknown, NFV	>133	L90M		G17D, K20R, E35D, M36I, L63Q, I64V, H69K, L89M, I93L	C
	M69708	M69708	AY677400	NFV	81			T12S, L19I, K20R, M36I, N37D, R41K, L63A, I64V, H69K, I93L	C
	F30356	F30356	AY677479	Unknown, NFV	>201	I54V, V82A, L90M		L10I, T12S, I15V, L19T, K20R, E35D, M36I, N37H, P39PS, R41K, K45R, L63P, H69KQ, A71I, I93L	C
	F62043	F62043	AY677411	NFV	85			T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
	M86744	M86744	AY714447	IDV, RTV	13			T12PS, I13V, I15V, L19T, K20R, M36I, N37D, R41K, D60E, Q61E, H69K, I72IR, T74A, L89M, I93L	C
Baxter (2006)	12-1007	1007-30519	DQ875953	PI	NA	M46L, I54IV, V82A, L90M	L33F, K43KT	L10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93L	C
	12-1716	1716-30421	DQ876854	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T	L10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93L	C
	12-3102	3102-30610	DQ877250	PI	NA	L90M	L23I, L33F, F53L, Q58E	L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L	C
	48-2254	2254-30930	DQ877888	PI	NA	G48V, I54V, V82S, L90M	L33F, Q58E	L10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TS	C
	48-2405	2405-30826	DQ877890	PI	NA	M46I, V82A	L10F, K43T, T74P	T12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93L	C
	48-3058	3058-30401	DQ877970	PI	NA	I54L, V82A, L90M	L33F, K43KT	L10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93L	C
	48-9201	9201-30911	DQ877578	PI	NA			K20R, M36I, N37K, R41N, H69K, L89M, I93L	C
Doualla-Bell (2006)	Pt7	FDB_Pt7		NFV		D30N	L33F	L10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93L	C
Sanabani (2006)	04BR013	04BR013	AY727522	PI	NA	M46I, G48V, V82A	L24I	L10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93L	C
McGrath (2007)	2	DMG_2a		RTV, ATV	48			T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
	7	DMG_7a		ATV	48			L10I, I13V, G16GE, L19T, K20R, M36I, R41K, L63AITV, I64IM, E65D, H69K, T74TA, L89M, I93L	C
Sen (2007)	T076	NPT76	EF186928	NFV, RTV		M46L, V82A, L90M	T74P	L10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93L	C
		NPT76-PL	EF186980	NFV, RTV		M46L	T74P	L10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93L	C
von Wyl (2007)	19	702313	EF449901	PI	NA	I54IV, N88NS, L90M		L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93L	C
Marconi (2008)	SW055	sw055	EU308066	LPV	46			T12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, I72M, T74S, L89M, I93L	C
	SW083	sw083	EU308093	LPV	91	V82A		T12S, I15V, L19I, K20R, M36I, R41K, L63P, H69K, L89M, I93L	C
Pillay (2008)	DR32	DR32	AY589889	LPV				T12S, I15V, Q18E, L19I, K20R, M36I, R41K, L63P, H69K, V77I, L89M, I93L	C
	DR44	DR44	AY589899	RTV		M46I, I54V, V82A		L10I, I15V, L19I, K20R, M36I, N37S, H69K, L89M, I93L	C
	DR55	DR55	AY589908	RTV	104	M46L, I54V, V82A	L23LI	T12S, I15V, G16GE, L19I, K20R, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	DR58	DR58	AY589910	NFV		D30N		T12S, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45Q, I64V, H69K, L89I, I93L	C
	DR61	DR61	AY589913	NFV, RTV		V82VL, L90LM		T12TS, I13IV, I15V, L19M, K20R, M36I, N37D, R41K, H69K, L89M, I93L	C
	DR29	02ZA.DR29	AY589886	NFV				T12S, I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69K, T74S, L89M, I93L	C
	DR92	03ZA.DR92	AY589931	IDV, LPV		V82A, L90M		T12S, I13IV, I15V, L19IT, K20R, M36I, L38LV, R41K, D60E, Q61E, I62IV, L63P, H69K, L89M, I93L	C
	DR100	03ZA.DR100	AY589936	RTV		M46I, I54V, V82A		I15E, G16GE, L19E, K20R, E35D, M36I, R41K, H69K, L89I, I93L	C
	DR102	03ZA.DR102	AY589937	RTV		I54V, V82L, L90M		I13IV, I15V, K20R, M36I, R41RK, L63LP, H69K, L89I	C
Rosen-Zvi (2008)	71	06p71-2		LPV	12			I15V, Q18E, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63V, H69K, T74A, L89M, I93L	C
		09p71-3		LPV	175	I54V, V82A		I15V, Q18E, K20R, E35D, M36I, R41K, K45I, D60E, I62V, L63V, H69K, L89M, I93L	C
Kandathil (2009)	VL07_337	VL07_337	EU781838	PI	NA			L19T, K20R, M36V, R41K, L63P, H69K, L89M, I93L	C
Dau (2010)	06552A	06552A	GU581760	PI	NA	M46I, I54V, L76V, V82A		L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93L	C
El-Khatib (2010)	Pat076	11ZA_SAVE1046	JF960526	LPV				T12S, I15V, L19IT, K20R, M36I, R41K, H69K, I72V, L89M, I93L	C
	Pat078	11ZA_SAVE1172	JF960528	LPV				L10V, I15V, L19V, K20R, M36I, R41K, H69K, L89M, I93L	C
	Pat085	11ZA_SAVE1382	JF960535	SQV, LPV				T12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
	Pat104	11ZA_SAVE2119	JF960554	LPV				I15V, L19I, K20R, E35D, N37A, P39T, R41K, D60E, L63P, H69K, V77I, L89M	C
	Pat109	11ZA_SAVE2228	JF960559	LPV				T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, H69K, T74S, L89M, I93L	C
	Pat113	11ZA_SAVE2319	JF960563	LPV				T12S, I15V, L19I, K20R, M36I, R41K, D60E, Q61E, L63P, H69K, V77I, L89M, I93L	C
	Pat126	11ZA_SAVE2455	JF960576	LPV				T12S, I15V, L19M, K20R, M36I, R41K, L63P, H69K, V77I, L89LM, I93L	C
Knops (2010)	ID2137	ID2137-GT1	GU271172	IDV, LPV		V32I, I47A, V82A		L10I, T12S, I15V, L19AP, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L	C
		ID2137-GT2	GU271173	IDV, LPV, DRV, RTV	33	V32I, I54L, L76V, V82A	L89V	L5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L	C
Rodrigues (2010)	320_07	BR07SC320	GQ401304	LPV				L10V, T12S, I15V, K20R, E35D, M36I, N37K, R41N, H69K, L89M, I93L	C
	327_07	BR07SC327	GQ401322	LPV				K20R, M36I, N37K, R41N, H69K, L89M, I93L	C
Green (2011)	707PKE19F	707PKE19F	HM623509	RTV, LPV	131	M46I, I54V, L76V, V82A	Q58E	L10I, T12S, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93L	C

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