<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K20M
Rx PI-naive
IncludeMixtures No
References 33
Patients 84
Isolates 86
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Hoelscher (2001)97TZ0697TZ06AF361876None   T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93LC
Bellocchi (2005)157MC157GU199582None   T12TA, I15V, L19V, K20M, M36I, P39Q, R41K, R57RK, H69K, L89M, I93LC
Rousseau (2006)Pt903PS017MB1DQ351224None   T12S, I15V, L19T, K20M, E35D, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 03ZASK212B03SK212BDQ978981None   T12S, I15V, L19T, K20M, M36I, R41K, L63I, H69K, L89M, I93LC
Jacobs (2008)18141814EF602243None   T12S, I15V, L19T, K20M, M36I, R41K, H69K, L89M, I93LC
Matthews (2008)PS017PS017FJ199599None   T12S, I15V, L19T, K20M, E35D, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
Ayouba (2009)26582658HALDPRGQ351994None   T12S, I15V, K20M, M36I, R41K, L63P, H69K, L89M, I93LC
Bartolo (2009)LFA1501AOLFA15EU068265None   T12S, I15V, G16E, L19I, K20M, M36L, N37S, L63N, H69K, L89I, I93LC
 HM18001AOHM180EU068320None   T12S, I15V, G16E, L19I, K20M, M36IL, N37S, L63N, H69K, L89I, I93LC
Hosseinipour (2009)87608760GQ228214None   T12S, I15V, L19I, K20M, E35D, M36I, L63P, H69K, V82I, L89M, I93LC
Huang (2009)Blm_x0688Blm_x0688KT737130None   T12S, I15V, G16E, L19I, K20M, M36T, R41K, D60E, H69K, L89I, I93LC
 Blm_x0182Blm_x0182KT737033None   T12S, K14R, G17D, L19T, K20M, M36I, R41K, H69K, K70R, L89M, I93LC
Wallis (2009)23354852335485 None   T12S, I15V, L19I, K20M, E35D, M36I, R41K, D60E, H69K, V82I, L89M, I93LC
 22804152280415 None   T12S, I15V, L19I, K20M, M36I, N37T, L63V, H69K, T74S, L89M, I93LC
Gonzalez (2010)MO_1MO_1GQ433872None   T12A, I15V, L19I, K20M, E35N, M36I, N37D, R41K, L63V, H69K, T74S, L89MC
Papathanasopoulos (2010)1692306ZA16923GU253416None   T12S, I15V, G16E, L19T, K20M, E35D, M36I, I62V, L63A, H69K, A71T, I93LC
Wright (2010)113SK113HM593120None   T12TA, I13IV, I15V, G16E, L19I, K20M, M36I, R41K, D60E, G68GE, H69K, L89IM, T91TI, I93L, L97IC
Hamers (2011)300482CP076300482HM119901None   T12S, I15V, L19IR, K20M, M36I, R41K, L63V, H69K, L89M, I93LC
 300558CP076300558HM119967None   T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63H, H69K, L89M, I93LC
 302395CP076302395HM120103None   T12S, I15V, L19T, K20M, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 CP076301498CP076301498HQ994451None  V11VIL10M, T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63IV, H69K, L89M, I93LC
 CP076302166CP076302166HQ994518None   T12S, K14R, I15V, L19IT, K20M, N37S, R57K, I62V, L63S, H69K, L89M, I93LC
 CP076301100CP076301100HQ994782None   T12TS, K14R, I15V, L19T, K20M, E35D, M36I, R41K, H69K, T74A, L89M, I93LC
 CP763A03367CP763A03367HQ994903None   T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, K45KR, H69K, T74A, L89M, I93LC
Nwobegahay (2011)08MB47ZA08MB47ZAGU188829None   T12S, G16E, L19I, K20M, E35D, M36I, R41K, D60E, H69K, L89M, I93LC
van Zyl (2011)A142A142JN638086None   L10M, T12S, I15V, L19V, K20M, E35D, M36I, P39Q, R41K, L63V, H69K, L89M, I93LC
Iweriebor (2012)07V10ZA07V10ZAGU201824None   I15V, L19T, K20M, E35D, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
Manak (2012)08_LH0608_LH06JN687634None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0408_LH04JN687632None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0708_LH07JN687635None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0508_LH05JN687633None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0908_LH09JN687637None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0108_LH01JN687629None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0808_LH08JN687636None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH0308_LH03JN687631None   T12S, I13V, K14R, G17D, L19I, K20M, M36I, N37S, L63P, H69K, L89M, I93LC
 08_LH0208_LH02JN687630None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
 08_LH1008_LH10JN687638None   T12S, I13V, K14R, I15V, G17D, L19I, K20M, N37S, L63P, H69K, L89M, I93LC
Hawke (2013)2991463 H2991463HKC238110None   L19I, K20M, M36I, N37T, R41K, R57K, L63H, H69K, I93LC
 2991464 H2991464HKC238111None   G16GE, L19IT, K20M, M36I, N37NT, R41RK, R57K, L63H, I64IV, H69KQ, I72IT, I93LC
Manasa (2013)RES015RES015KC951641None   T12S, I15V, L19I, K20M, M36I, R41K, L63A, L89M, I93LC
 RES041RES041KC951662None   T4S, T12S, K14R, I15V, L19I, K20M, M36T_T, N37S, C67Y, H69K, L89I, I93LC
 RES171RES171KC951721None   T12S, I15V, Q18R, L19V, K20M, M36I, P39S, R41K, L63P, H69K, I93LC
 RES209RES209KC951727None   T12S, I15V, G16E, L19V, K20M, E35D, M36I, L63V, H69K, T74S, L89M, I93LC
 RES361RES361KC951815None   T12S, K14R, I15V, L19T, K20M, E35D, M36I, R41K, H69K, K70R, L89M, I93LC
Nzeyimana (2013)201_4438201_4438HG780632None   T12S, I13IV, I15V, G17E, L19I, K20M, E35D, M36I, N37K, R57RK, L63P, C67E, H69K, L89MC
 201_1781201_1781HG780736None   K14R, I15V, G16E, K20M, E34D, M36Q, P39Q, L63NT, H69K, I72T, I93LC
Van Zyl (2013)392011.ZA.GT1583KC423371None   L10M, I15V, L19T, K20M, E35D, M36I, R41K, Q61H, H69K, L89M, I93LC
 307107.ZA.GT226KC424055None   K14R, I15V, L19I, K20M, M36I, R41RK, H69K, I93LC
 170309.ZA.GT975KC422828None   T12S, I15V, L19I, K20M, E35D, M36I, R41K, L63P, H69K, T74S, L89M, I93LC
 292710.ZA.GT1372KC423183None   I15V, L19V, K20M, E35D, M36I, R41K, H69K, T74S, L89M, I93LC
 175707.ZA.GT254KC424066None   T12S, I13V, I15V, L19I, K20M, E34G, M36I, R41K, D60E, L63P, H69K, V82I, L89M, I93LC
 281410.ZA.GT1466KC423252None   L5LF, T12S, K14T, G16E, L19T, K20M, M36I, L63V, H69K, T74S, L89M, I93LC
 357610.ZA.GT1130KC422963None   I15V, G16E, L19T, K20M, E34A, M36I, R41K, L63S, H69K, I72M, V77I, I93LC
  12.ZA.GT2082KC423789None   I15V, G16E, L19T, K20M, E34AT, M36I, R41K, L63S, H69K, I72M, V77I, I93LC
 212011.ZA.GT1792KC423585None   T12S, I15IV, L19V, K20M, E35D, M36I, R41K, L63AITV, I64IM, H69K, K70R, I72IV, T74S, L89M, I93LC
 325506.ZA.GT051KC424288None   T12S, L19I, K20M, E35G, M36I, R41N, L63MV, H69K, L89M, I93LC
Abdissa (2014)243243_BLKJ561125None   T12A, I13V, I15V, G16E, L19LS, K20M, M36L, R41K, L63H, H69K, I72MV, L89M, I93LC
  243_FLKJ561139None   T12A, I13V, I15V, G16E, L19LS, K20M, M36L, R41K, L63H, H69K, I72MV, L89M, I93LC
Bartolo (2014)09AOHDP10209AOHDP102KF853754None   T12S, K14KE, I15V, G16E, L19I, K20M, E34A, M36I, P39PS, R41K, L63T, H69K, K70R, L89M, I93LC
Carvalho (2015)282282KM206112None  L10LFT12S, I15V, L19T, K20M, E35E_T, M36V, N37E, K43R, R57K, H69K, K70R, L89M, I93LC
 9090KM205988None   T12S, I15V, L19AT, K20M, E35E_T, M36V, N37E, K43R, R57K, H69K, L89M, I93LC
 255255KM206085None   T12S, I15V, L19T, K20M, E34D, E35E_T, M36I, N37E, K43R, L63A, E65D, H69K, I93LC
 267267KM206097None   T12S, I15V, L19T, K20M, E35E_T, M36V, N37E, P39S, K43R, R57K, E65D, H69K, L89M, I93LC
Hora (2015)DEMC07MW001DEMC07MW001KP109520None   T12S, I13V, I15V, L19V, K20M, E35D, M36I, R41K, D60E, I62V, H69K, A71T, L89M, I93LC
Novitsky (2015)mpp_077mpp_077KR860863None   T12S, I13V, I15V, G17D, L19V, K20M, M36I, N37K, R41K, D60E, Q61E, L63P, H69K, L89I, I93LC
Skhosana (2015)11ZALS01711ZALS017KM115762None   T12S, L19V, K20M, E35DN, M36I, R41K, L63P, H69K, T74S, L89M, I93LC
 10ZALS00510ZALS005KM115855None   T12S, I15V, G16E, L19I, K20M, M36I, R41K, K45R, D60E, I62V, L63H, H69K, I93LC
 12ZALS13512ZALS135KM115759None   T12S, I13IV, I15V, G16E, L19I, K20M, M36I, L63V, H69K, I72IL, T74AS, L89M, I93LC
 12ZALS14712ZALS147KM115726None   I15IL, L19T, K20M, E35G, M36I, R41K, L63P, H69K, L89M, I93LC
Baudi (2016)Zi13-036Zi13-036KX648676None   T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63H, H69K, L89M, I93LC
Lam (2016)2002200820022008KR868081None   T12S, I15V, L19I, K20M, E34A, E35D, M36I, P39S, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
 9902204099022040KR867996None   L10IM, T12S, I15V, G16E, L19I, K20M, E35D, M36I, P39L, L63T, H69K, L89M, I93LC
Neogi (2016)549813.ZA.EC525KT592733None   L10I, T12S, I13IV, G16E, L19IT, K20M, M36L, N37A, D60E, L63T, H69K, L89M, I93LC
 560613.ZA.EC812KT592918None   I15V, G16E, K20M, E35D, M36I, R41K, D60E, I62V, L63P, H69K, I72V, I93L, L97IC
 711613.ZA.EC536KT592739None   T12S, I15V, G16E, L19E, K20M, M36I, L63H, H69K, I72V, L89I, I93LC
 372613.ZA.GT2844KT593180None   T12P, I15V, G16E, L19T, K20M, M36IT, R41K, L63T, H69K, A71T, I72EV, L89LM, I93LC
Steegen (2016)GFKZB317GFKZB317KU128225None   I15V, L19V, K20M, M36I, R41K, D60E, Q61E, H69K, T74S, L89M, I93LC
 GFWCB037GFWCB037KU128190None   I13V, K20M, E35N, M36I, N37D, R41K, L63Q, I64VC
 GFMPB031GFMPB031KU127912None   K14R, I15V, G16E, L19T, K20M, E35D, M36I, L63S, H69K, V82I, L89I, I93LC
 GFKZB277GFKZB277KU128193None   L19V, K20M, M36L, R41K, H69K, L89M, I93LC
 GFKZB383GFKZB383KU128298None   T12S, K14R, I15V, L19R, K20M, M36I, R41K, L63P, H69K, K70T, T74A, L89M, I93LC
 GFFSB068GFFSB068KU128063None   T12S, L19V, K20M, N37T, R41K, L63T, H69K, T74S, L89M, I93LC
 GFFSB040GFFSB040KU127701None   T12S, K14KR, I15V, L19T, K20M, E34A, M36I, R41K, L63T, H69K, T74A, V77I, L89M, I93LC
Steegen (2016)GFMPA015GFMPA015KT893111None   T12S, I15V, G16E, L19T, K20M, E35D, M36I, R41K, K45KR, L63AV, H69K, I93LC
 GFECA010GFECA010KT893037None   T12S, I15V, L19T, K20M, E35D, M36L, K45R, L63P, H69K, K70KR, L89M, I93LC
 GFKZA045GFKZA045KT893115None   I15V, L19T, K20M, E35D, M36L, R41K, D60E, H69K, L89LM, I93LC