<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K20M
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 25
Isolates 26
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 TK4004TK4004 IDV, SQV, RTV, NFV, LPV278M46I, L90M L10R, I15V, L19I, K20M, M36I, R41K, L63P, H69K, K70R, L89M, I93LC
Weber (2005)F16446F16446AY677447SQV, NFV, APV, LPV208M46I, I54V, I84V, L90M L10I, T12S, L19I, K20M, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
Baxter (2006)48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
Pillay (2008)DR9303ZA.DR93AY589932IDV, LPV M46I, L90M L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93LC
Waleria-Aleixo (2008)08PR06064008PR060640FJ591495PINA  K14R, I15V, G16E, K20M, M36I, N37K, R41N, K45R, R57RK, L63V, H69K, L89M, I93LC
 RES79RES79FJ591853PINAM46I, L90MQ58EI15V, K20M, E35D, M36IV, N37K, R41N, L63P, H69K, L89M, I93LC
 08PR04021208PR040212FJ591242PINA M46MVK14R, I15V, G16E, K20M, M36I, N37K, R41N, K45R, R57RK, L63V, H69K, L89M, I93LC
Kassaye (2009)TCDD-23TC23_2003FJ445712SQV304L90M I15V, L19I, K20M, M36I, R41K, D60E, L63P, H69Q, V82I, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Van Zyl (2013)391412.ZA.GT2217KC423889LPV M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 363809.ZA.GT820KC424322LPV   T12S, I15V, L19V, K20M, E35D, M36I, R41K, H69K, T74S, L89M, I93LC
 327211.ZA.GT1915KC423704LPV M46I, I54V, L76V, V82AL10FT12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93LC
 111808.ZA.EC010KC423322LPV M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 105606.ZA.GT018KC423693LPV   T12S, I15V, G16E, L19T, K20M, D29A, E35D, M36I, L63A, H69K, T74S, L89M, I93LC
  10.ZA.GT1333KC423150LPV M46I, I54V, V82A T12S, I15V, G16E, L19I, K20M, E35D, M36I, L63T, H69K, T74S, L89M, I93LC
Grossman (2014)395395KF135068NFV, LPV52L90M K20M, M36I, R41K, L63P, H69K, L89M, I93LC
 789789KF135144NFV, RTV, IDV, LPV52I54IV, V82A, I84IV L10I, T12S, I15V, K20M, E34K, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 260260KF135035IDV, LPV384I54V, V82A, L90ML10FI15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93LC
Diaz (2015)RenG16330RenG16330KT747358PINAM46I, I54V, V82A, L90M L10V, I13A, L19LI, K20M, E21K, A22V, E35D, M36I, N37DE, R41N, I62V, L63P, I64V, H69K, T74S, L89M, I93L, C95VC
 RenG12879RenG12879KT743907PINA  T12TS, I13V, K14R, I15V, G16E, K20M, M36IT, N37K, R41N, R57K, Q61K, H69K, L89I, I93LC
 RenG12228RenG12228KT743256PINAM46I, I54V, V82AL10F, L24I, L33FI13IV, I15IV, K20M, E35D, M36I, N37K, R41H, I62V, L63P, H69K, L89I, T91TSC
 RenG11088RenG11088KT742116PINAI54V, V82C, L90ML10F, L33F, T74PT12S, I13V, I15V, G16E, L19AV, K20M, D25DN, E35DN, M36I, N37K, R41N, Q61H, L63T, I66IM, H69K, L89M, I93LC
Novitsky (2015)mpp_228mpp_228KR861008PINA  T12S, I15V, L19I, K20M, E35E_TN, M36L, L63T, H69K, I93LC
Chimukangara (2016)NC12NC12KU508554RTV, ATV21  T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, I62V, L63H, H69K, A71T, I93LC
 NC10NC10KU508550LPV586M46I, I54V, L76V, V82AL10F, L24I, Q58ET12S, I15V, G16E, L19I, K20M, M36L, N37D, L63N, H69K, L89I, I93L, L97IC