<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation K20I
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 31
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL160IL160AY529612SQV, NFV128D30NN88DT12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93LC
Non-B Workgroup (2005)UK456bUK456bAY900773NFV, IDV, RTV M46I, L90M L10LI, T12S, L19I, K20I, M36I, R41K, L63P, I64V, H69K, A71V, T74S, L89M, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
Baxter (2006)12-30493049-30508DQ876115PINAM46I, I54V, L76V, V82A, L90ML10FIW6W*, I15V, L19T, K20I, E35DN, M36I, R41K, Q61H, L63P, H69K, A71V, T74S, I85V, L89I, T91S, I93LC
 48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-14071407-30410DQ877803PINAI54V, V82A, L90ML10FI, K43TT12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93LC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
 48-93029302-30918DQ877587PINAI54V, V82A, L90ML10F, G73GS, L89IMVI15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93LC
Doualla-Bell (2006)Pt6FDB_Pt6 NFV M46I, N88SL10FT12S, I15V, L19V, K20I, M36I, R41K, L63V, I64V, H69K, T74V, L89M, I93LC
Sen (2007)T093NPT93EF186929RTV, IDV M46I, I54L, L90ML23LI, G73STL10Y, T12S, L19T, K20I, L24LF, R41K, K45KR, K55KR, L63P, H69K, A71V, I72IM, V77I, I93LC
  NPT93-PLEF186978RTV, IDV M46I, I54IL, L90MG73STL10Y, T12S, L19T, K20I, L24F, R41K, K45R, K55R, L63P, H69K, A71V, V77I, I93LC
Pillay (2008)DR60DR60AY589912RTV M46I, N88S T12S, I15V, L19I, K20I, E35D, M36I, N37D, R41RK, D60E, L63P, H69K, A71AT, I72L, I93LC
Kassaye (2009)TCDD-28TC28_2003FJ445707SQV361L90MG73SI15V, L19I, K20I, M36I, L63P, H69K, A71V, I93LC
  TC28_2004FJ445727SQV, LPV378M46I, I84V, L90MG73SI15V, L19I, K20I, M36I, L63P, H69K, A71V, I93LC
 TCDD-35TC35_2003FJ445701NFV, IDV143  T12S, I15V, L19I, K20I, M36I, R41K, D60E, Q61E, L63P, H69K, I93LC
Grossman (2014)613613KF135114NFV, LPV52L90M Q7R, I15V, L19T, K20I, E35N, M36I, R41K, K43R, H69K, T74S, L89I, I93LC
 581581KF135103IDV, LPV52L90M L10I, T12TA, L19I, K20I, E35ED, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93LC
  581KF135104IDV, LPV187L90M L10I, L19I, K20I, E35D, M36I, R41K, Q61H, L63P, I64L, H69K, A71V, T74S, I85V, L89M, I93LC
 311311KF135048LPV148M46L, I47A T12S, I13IV, I15V, L19K, K20I, M36I, Q61E, L63T, H69K, T74S, L89I, I93LC
 160160KF134989SQV, LPV52D30NN88DT12V, L19I, K20I, M36I, R41K, K45R, L63T, H69K, A71V, I93LC
 20632063KF135018LPV52M46I, I54V, V82AL10F, G73S, L89VT12S, I15V, G16E, L19I, K20I, M36I, N37D, R41K, L63R, H69K, I85V, I93LC
 283283 SQV, RTV, IDV, LPV52I54V, V82AL10F, D30DET12S, I13IV, K14R, I15V, K20I, E35D, M36I, Q61H, H69K, T74A, L89I, I93LC
 610610 NFV, IDV, LPV52M46I, I54V, V82A, L90ML10F, T74PST12S, I13V, I15V, L19Q, K20I, E35D, M36I, N37ND, R41K, Q61H, I62V, L63T, I64V, I66L, H69K, L89M, I93LC
  610 NFV, IDV, LPV69M46I, I54V, L76V, V82A, L90ML10FT12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95FC
Diaz (2015)RenG17238RenG17238KT748266PINA  I15V, K20I, E35G, M36I, N37K, R41N, K45R, H69K, A71V, T74S, I85V, L89T, I93LC
 RenG14917RenG14917KT745945PINAM46I, I47A, L90ML10FI15V, G16E, L19P, K20I, N37K, R41N, F53Y, D60E, Q61HN, L63H, H69K, V77I, I85V, L89I, I93LC
 RenG15013RenG15013KT746041PINAM46I, I84VL10FI15V, G16A, K20I, E35G, M36I, N37K, R41N, K55R, R57K, D60E, Q61E, L63P, H69K, I85V, L89I, I93LC
 RenG13882RenG13882KT744910PINAL90M L10I, V11F, I15V, L19I, K20I, L33V, R41K, K45R, L63P, H69K, A71I, L89T, I93LC
 RenG13044RenG13044KT744072PINAI54V, V82A, L90ML10FI13V, K14KR, I15V, G16A, K20I, E35D, M36I, N37K, R41N, Q61QH, L63LP, H69K, T74S, L89I, T91TS, I93ILC
 RenG12519RenG12519KT743547PINAM46I, I54V, V82A, L90ML10F, L23II13V, K14R, I15V, K20I, E35N, M36I, N37E, R41N, Q61H, I62V, L63P, H69K, A71T, T74S, L89I, I93LC
 RenG10282RenG10282KT741310PINAM46MIV, L90MV11VIL10V, I13V, K14R, I15V, K20I, N37K, R41N, Q61QH, H69K, K70KR, T74S, L89I, I93LC
 RenG11780RenG11780KT742808PINAI54IV L10Y, I15V, K20I, E35G, M36I, N37K, R41N, K45R, H69K, A71I, T74S, I85V, L89T, I93LC
 RenG10518RenG10518KT741546PINAM46I, I47A L10V, I13V, I15V, G16A, L19P, K20I, M36MI, N37K, R41N, R57K, L63P, H69K, T74S, L89I, I93LC
 RenG10631RenG10631KT741659PINAM46L, I54V, V82A, I84VV11I, L24I, K43TL10I, T12E, I13V, L19I, K20I, M36I, Q61N, L63T, I64V, H69K, A71V, I72IV, T74S, I93LC
Novitsky (2015)bcpp_395bcpp_395KR860753PINAM46I, N88S T12P, I15V, L19I, K20I, E35G, M36I, R41K, Q61E, L63P, H69K, T74A, L89M, I93LC