<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I13V
Rx >= 1 PI
IncludeMixtures No
References 26
Patients 201
Isolates 211
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG4393PW_UG4393AF358747RTV51  I13V, K14R, E35D, M36I, R41K, H69K, L89MC
Gibb (2002)DMG5959_w32 NFV32 L76LFI13V, M36I, R41K, L63S, I64IL, H69K, L89M, I93LC
 DMG8686_w82 NFV65D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
 DMG9191_w22 NFV22D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
Kantor (2002)TCDD-27TCDD-27AY090853SQV149  T12S, I13V, I15V, G16E, L19I, K20R, M36I, R41K, H69K, I93LC
Soares (2003)BR54BR54AY275730NFV56  T12A, I13V, G16E, L19I, M36I, N37K, R41N, L63T, H69K, L89M, I93LC
Grossman (2004)IL217IL217AY529576NFV104D30NN88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93LC
 IL369IL369AY529591NFV111M46I, L90M T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93LC
Montes (2004)MB_patNIB01_NIB710AJ577964NFV94  T12S, I13V, I15V, L19I, M36I, N37K, R41N, Q61E, L63A, I64M, H69K, L89M, I93LC
  01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)UK276UK276AY900768IDV, SQV, NFV52L90M L10IV, T12S, I13V, I15V, L19I, K20T, M36I, Q61E, L63P, I64L, H69K, L89M, I93L, C95FC
 UK496bUK496bAY900776NFV L90M T12S, I13V, L19I, K20T, M36I, R41K, D60E, L63P, I64V, H69K, L89M, I93LC
 UK594UK594AY900778SQV184  I13V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 UK1154UK1154AY900795NFV L90M T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, D60E, L63P, I64V, H69K, V82I, L89M, I93LC
 UK2069UK2069AY900845NFV D30NN88DT12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93LC
 BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 TK2018TK2018 IDV, RTV, NFV218M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93LC
 TK3009TK3009a SQV, NFV, LPV232L90M I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93LC
 TK3019TK3019 SQV, NFV, RTV143I54V, I84IV, L90MV11VI, G73SL10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93LC
 TK3027TK3027 RTV, SQV, NFV190D30N, L90MN88DT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93LC
 TK5010TK5010 RTV, IDV27  I13V, I15V, L19I, M36I, N37D, R57K, L63S, H69K, L89MC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
 PL4706685002 IDV, NFV104D30NN88DT12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93LC
 PL4725100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Weber (2005)F68541F68541AY677417NFV198M46MI, L90M T12S, I13V, I15V, L19I, K20T, E35X, M36I, R41K, H69K, T74AS, L89I, I93LC
 M72003M72003AY677426NFV, RTV, IDV212I54IV, L90ML10FI13V, K14N, I15V, L19I, K20T, E35N, M36I, R41K, K45R, I62IV, L63P, I64V, H69K, K70R, T74S, L89M, I93LC
 F56949F56949AY677453NFV154D30N T12S, I13V, I15V, L19I, K20T, M36I, R41K, K45T, L63P, H69K, I93LC
 M86744M86744AY714447IDV, RTV13  T12PS, I13V, I15V, L19T, K20R, M36I, N37D, R41K, D60E, Q61E, H69K, I72IR, T74A, L89M, I93LC
Baxter (2006)48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
Doualla-Bell (2006)Pt2FDB_Pt2 NFV L90M T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93LC
 Pt7FDB_Pt7 NFV D30NL33FL10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93LC
Sanabani (2006)04BR07304BR073AY727525PINA  T12S, I13V, I15V, L19I, M36I, N37K, R41N, L63P, I64M, H69K, L89M, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
 DR58DR58AY589910NFV D30N T12S, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45Q, I64V, H69K, L89I, I93LC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Kandathil (2009)VL06_253VL06_253EU030406PINAD30NN88D, L89VL10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93LC
Kassaye (2009)TCDD-19TC19_2003FJ445710IDV, RTV26  I13V, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93LC
Dau (2010)06552A06552AGU581760PINAM46I, I54V, L76V, V82A L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93LC
 07344A07344AGU581841PINAL90M T12S, I13V, I15V, L19I, K20T, M36I, N37ND, R41K, L63P, H69K, V82I, L89M, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Malan DR (2010)7DMG_7a ATV48  L10I, I13V, G16GE, L19T, K20R, M36I, R41K, L63AITV, I64IM, E65D, H69K, T74TA, L89M, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
 305_07BR07SC305GQ401315NFV L90ML89VI13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93LC
Kouri (2012)CU522-10CU522-10JQ585402PINAM46I, I54L, V82A, L90ML33F, T74PI13V, N37S, R41K, K55R, I62V, L63P, H69K, L89M, I93LC
 CU1452-09CU1452-09JQ585296PINAD30N, I54M, L90ML33F, N88DT12S, I13V, K14R, I15V, E35D, M36I, N37S, R41K, L63P, H69K, T74S, L89I, I93LC
 CU1340-10CU1340-10JQ585423PINAM46I, I54AT, V82A, I84IVL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74TA, L89M, I93LC
Van Zyl (2013)14602908KC423889LPV26M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 1576168KC423322LPV26M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 14071550KC423222LPV26I54V, I84V T12S, I13V, I15V, G16E, L19I, K20T, M36I, R41K, K45V, D60E, Q61E, I66V, H69K, K70R, I72V, V82I, L89M, I93LC
 4841764KC423387LPV156  T12S, I13V, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
  1831KC423444LPV157  T12S, I13V, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 1660584KC424152LPV26  T12S, I13V, I15V, G16A, L19T, K20R, M36I, R41K, L63V, H69K, I72IT, L89M, I93LC
  1015KC422807LPV78  T12S, I13V, I15V, G16A, L19T, K20R, M36I, R41K, Q61QH, L63V, H69K, I72IT, L89M, I93LC
 4502121KC423634LPV104 V11IL10I, I13V, G16E, Q18K, L19T, K20R, M36I, R41K, K43I, R57RK, L63T, H69K, L89M, I93LC
 1524773KC424279LPV26I54V, V82M T12S, I13V, L19I, K20R, M36I, N37S, R41K, D60E, Q61E, L63P, H69K, L89MC
 1274883KC424337LPV26  I13V, G16E, L19T, L33V, P39S, D60E, L63P, H69K, L89I, I93LC
  909KC424352LPV27  I13V, G16E, L19T, L33V, P39S, D60E, L63P, H69K, L89I, I93LC
 16361248KC422997LPV26M46MI, I54V, V82A, L90ML10F, L33F, K43T, G73ST12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
  3119KC423977LPV130  T12TS, I13V, K14R, M36I, R41K, L63P, H69K, L89LMC
 15822753KC423813LPV26M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
 16322976KC423913LPV26  T12A, I13V, I15V, G16E, L19I, K20R, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
 20167KC424217LPV52  T12S, I13V, K14R, I15V, L19IV, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
Grossman (2014)609609 LPV134M46I, I54V, V82A, L90MG73S, N83D, L89VL10I, V11L, I13V, K20R, A22V, E35N, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, T91S, I93LC
 471471KF135082IDV, LPV52M46I, I54V, V82AL10F, L24I, L33FI13V, K14R, I15V, K20KT, M36I, R41K, L63P, H69K, T74TS, L89M, I93LC
 882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 255255KF135031SQV, LPV52I54V, V82AL10F, N88D, L89VT12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93LC
  255KF135032SQV, LPV90M46I, I54V, V82AL10F, L33F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93LC
 512512KF135092LPV52  I13V, K14R, I15V, K20T, M36I, R41K, H69K, V82I, L89M, I93LC
 4949KF135089NFV, LPV52I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93LC
 285285KF135040IDV, LPV52  L10I, I13V, K14R, I15V, M36I, N37D, R41K, L63V, E65D, H69K, T74S, L89M, I93LC
 10931093KF134941LPV52  I13V, K14R, I15V, M36I, R41K, H69K, T74S, L89M, I93LC
  1093KF134942LPV113  I13V, K14KR, I15V, M36I, R41K, H69K, T74S, L89M, I93LC
 183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 217217KF135024NFV, LPV52D30N, I54V, V82AL33F, N88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, H69Q, V75I, L89I, I93LC
  217KF135025NFV, LPV273M46I, I50V, I54V, V82A, L90ML33FL10I, I13V, K14R, I15V, K20R, E35D, M36I, N37DE, R41K, K55R, L63E, G68GE, H69Q, A71AV, L89I, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC
 504504 IDV, LPV52  T12TA, I13V, K14KR, I15V, M36I, R41K, L63T, I64M, H69K, L89M, I93LC
 610610 NFV, IDV, LPV52M46I, I54V, V82A, L90ML10F, T74PST12S, I13V, I15V, L19Q, K20I, E35D, M36I, N37ND, R41K, Q61H, I62V, L63T, I64V, I66L, H69K, L89M, I93LC
  610 NFV, IDV, LPV69M46I, I54V, L76V, V82A, L90ML10FT12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95FC
Diaz (2015)RenG17227RenG17227KT748255PINA L23IL10M, I13V, K20T, E35N, M36I, N37K, R41N, K45Q, I62V, L63P, H69K, T74K, V82VI, L89I, I93LC
 RenG17295RenG17295KT748323PINA  I13V, K14R, I15V, L19I, K20R, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG16098RenG16098KT747126PINA  I13V, K20KR, M36MI, N37K, R41N, D60E, L63P, H69K, L89M, I93LC
 RenG16337RenG16337KT747365PINAM46I, I54V, V82A, L90ML10LF, L33F, G73ST12TS, I13V, K14R, I15V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, I93LC
 RenG16729RenG16729KT747757PINAM46I I13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, R57K, L63P, H69K, K70KR, A71AT, L89T, I93LC
 RenG15755RenG15755KT746783PINAI50L, L90ML33F, G73SI13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, L63P, H69K, K70E, A71I, I93LC
 RenG17316RenG17316KT748344PINA  I13V, K20KR, M36MIL, N37K, R41N, L63P, H69K, L89IM, I93LC
 RenG16898RenG16898KT747926PINA  L10I, I13V, M36I, N37K, R41N, I62V, L63V, C67Y, H69K, T74S, L89MC
 RenG15719RenG15719KT746747PINAI54V, L90ML23I, K43T, F53LI13V, I15V, L19I, K20T, E35D, M36I, N37K, R41N, I62IV, L63P, H69K, A71IV, T74S, V77I, L89I, I93LC
 RenG17353RenG17353KT748381PINAM46I, I54V, L76V, V82AL10F, L33FI13V, K14KR, K20R, E35D, M36I, R41N, I62V, L63T, H69K, A71V, I72V, T74TA, L89M, I93LC
 RenG16300RenG16300KT747328PINAD30N, L90LML10LF, N88DI13V, I15V, E35D, M36I, N37K, R41N, K45R, L63AP, I64IV, H69K, L89I, I93LC
 RenG15990RenG15990KT747018PINA  I13V, G16E, K20R, T26TI, M36I, N37K, R41N, K45KR, L63LIPT, H69K, L89IM, I93LC
 RenG16791RenG16791KT747819PINAM46I, I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, K20T, E35N, M36I, N37Q, R41N, I62IV, L63V, H69K, I72V, L89I, I93LC
 RenG15937RenG15937KT746965PINA  I13V, I15V, E35D, N37E, R41N, D60N, L63P, H69K, K70KR, V82I, L89I, I93LC
 RenG15586RenG15586KT746614PINAM46I, I54V, I84V, L90M L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, D60E, I62V, L63P, H69K, A71V, L89I, I93LC
 RenG15743RenG15743KT746771PINAM46I, I50L, V82AL24I, L33F, K43TL10I, I13V, K14KR, I15V, M36L, N37K, R41N, K55R, D60DEKN, I62V, L63P, H69K, A71V, T74S, I93LC
 RenG17106RenG17106KT748134PINAI50L, V82VA, N88SL33FI13V, K14R, I15V, K20KR, E35D, M36I, N37K, R41N, K45KR, Q61N, I64IV, H69K, A71IV, T74S, L89M, I93LC
 RenG16009RenG16009KT747037PINAI54V, L90M Q7QL, I13V, I15V, K20T, E35D, M36I, N37K, R41N, R57K, D60E, I62V, H69K, T74E, V77VI, V82I, L89M, I93LC
 RenG17418RenG17418KT748446PINAM46I, I54V, V82F, L90M L10I, V11L, I13V, I15V, K20IT, E35G, M36I, N37K, P39Q, R41N, F53Y, L63P, I64IV, H69K, T74S, L89I, I93LC
 RenG16101RenG16101KT747129PINA  I13V, I15V, G16E, M36MT, N37K, R41N, I64L, H69K, L89M, I93LC
 RenG17048RenG17048KT748076PINAM46I, I54L, L90ML33F, Q58E, N88G, L89VL10Y, I13V, I15V, K20T, E35D, M36I, N37Q, R41N, K43R, I62V, L63P, H69K, A71V, T74S, Q92K, I93LC
 RenG17213RenG17213KT748241PINA  I13V, I15IV, G16E, M36I, N37K, R41N, I64L, H69K, L89M, I93LC
 RenG15974RenG15974KT747002PINAM46MI, I50LL23LI, L33F, F53FL, N83NDL10LR, I13V, I15V, E35D, M36IL, N37K, R41N, I62V, L63V, H69K, A71V, T74A, L89IM, I93LC
 RenG15890RenG15890KT746918PINA  I13V, K14KR, I15V, L19Q, N37K, R41N, H69K, T74S, V77VI, L89I, I93LC
 RenG17080RenG17080KT748108PINAI50L, V82M, L90MQ58E, L89VI13V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, K70T, A71V, I93LC
 RenG16982RenG16982KT748010PINAM46L, I54IV, V82AL10LFPS, L23I, L33F, F53FLP9PR, T12I, I13V, I15V, G16E, M36L, N37K, R41R_N, G51A, D60E, I62LV, L63T, H69K, A71V, L89I, T91TA, I93LC
 RenG17445RenG17445KT748473PINAI50IL, L90ML23LI, L33LFI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, D60DE, I62V, L63LP, H69K, T74S, V82I, L89I, I93LC
 RenG15346RenG15346KT746374PINAM46MI, I54V, V82VA, I84V, L90ML10F, L23LI, L33F, F53FL, G73S, T74PS, L89VV11L, I13V, I15V, K20T, E34Q, E35D, M36IL, N37K, R41N, I62V, L63P, G68D, H69R, A71V, I93LC
 RenG14788RenG14788KT745816PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20R, E35D, M36I, N37K, R41Y, R57RK, Q61N, L63P, H69K, A71V, L89M, I93LC
 RenG14824RenG14824KT745852PINA  I13V, K20R, M36I, N37K, R41N, L63P, H69K, L89M, I93LC
 RenG15065RenG15065KT746093PINAM46I, I50L, L90MQ58EI13V, I15V, L19I, K20R, E35D, M36I, N37K, R41N, K55R, L63P, H69K, A71T, L89I, I93LC
 RenG14462RenG14462KT745490PINA  I13V, I15IV, M36I, N37K, R41N, L63P, H69K, I72IV, T74S, L89M, I93LC
 RenG14125RenG14125KT745153PINAD30DNN88NDI13V, K14KR, I15V, G16A, L19I, E35ED, M36MIL, N37K, R41N, K45KR, R57RK, H69K, T74S, L89M, I93LC
 RenG15067RenG15067KT746095PINA  T12A, I13V, K14R, I15V, G16E, M36I, N37K, R41N, K45R, D60E, Q61N, L63T, H69K, L89I, I93LC
 RenG14916RenG14916KT745944PINAI50L, V82M, L90ML23I, L33FI13V, I15V, K20T, E35N, M36I, N37K, R41N, Q61E, L63PS, H69KN, A71V, T74S, L89I, I93LC
 RenG14362RenG14362KT745390PINAI50L, I54L, V82IML33F, Q58E, N83DI13V, I15V, M36L, N37K, R41N, D60E, L63P, H69K, L89I, I93LC
 RenG15438RenG15438KT746466PINA  I13V, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG13854RenG13854KT744882PINA  V11VA, T12X, I13V, I15V, M36I, N37K, R41N, L63P, H69K, L89IM, I93LC
 RenG15278RenG15278KT746306PINAM46L, I50L, V82ILM, L90LML24LI, L33F, Q58E, T74PI13V, I15V, K20R, E35D, M36I, N37K, R41N, K55R, L63AV, H69K, A71AV, L89M, I93LC
 RenG13855RenG13855KT744883PINAL90ML23I, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71I, T74A, L89I, I93LC
 RenG15194RenG15194KT746222PINA  L10LI, I13V, I15V, L19LIST, K20KR, M36I, N37K, R41N, H69K, T74K, L89M, I93LC
 RenG15373RenG15373KT746401PINA  I13V, E35D, N37K, R41N, L63P, H69K, T74A, L89M, I93LC
 RenG14844RenG14844KT745872PINAM46I, I54V, V82A, N88SL10F, L33F, L89VI13V, I15V, K20T, E21EK, E35D, M36IL, N37K, R41N, I62V, L63P, H69K, G73D, T74S, I93ILC
 RenG14243RenG14243KT745271PINA  T12P, I13V, K14KR, G16E, M36I, N37E, R41N, D60N, L63HR, H69K, L89I, I93LC
 RenG14330RenG14330KT745358PINA  L10I, I13V, I15V, K20R, M36I, N37K, R41N, H69K, I72V, L89I, I93LC
 RenG15344RenG15344KT746372PINA  I13V, I15V, L19V, M36I, N37K, R41N, L63AP, H69K, L89M, I93LC
 RenG14113RenG14113KT745141PINAG48V, I50V, I54V, V82AL33IL10I, I13V, L19IV, E35D, M36I, N37R, R41N, Q61E, I62V, L63P, H69K, T74S, I85V, L89IC
 RenG15500RenG15500KT746528PINAM46I, I47IV, I54V, V82F, L90ML23I, L33LI, F53FL, Q58EL10I, I13V, K14KR, K20R, E35D, M36I, N37K, R41N, K55KR, I62IV, L63P, H69K, L89I, Q92QK, I93LC
 RenG15029RenG15029KT746057PINA  I13V, K14R, I15V, K20R, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG14776RenG14776KT745804PINAI50L I13V, K14R, I15V, L19I, K20KT, E34EQ, E35D, M36I, N37K, R41N, L63P, H69K, A71AV, L89M, I93LC
 RenG14834RenG14834KT745862PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, Q61N, L63P, G68GE, H69K, K70KR, A71V, L89IM, I93LC
 RenG14024RenG14024KT745052PINAD30N, I50L, V82AL33F, N88DL10LR, I13V, I15IV, K20KRT, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, H69K, A71AV, T74S, V77VI, L89IM, I93LC
 RenG15066RenG15066KT746094PINA  I13V, K20R, M36I, N37K, R41N, R57K, L63V, H69K, T74S, L89M, I93LC
 RenG12144RenG12144KT743172PINAV32I, I54L, I84VL10F, L33I, L89VI13V, I15V, K20T, M36I, N37K, R41N, Q61N, L63P, I66FV, H69K, A71V, T74S, V77I, Q92KC
 RenG13401RenG13401KT744429PINAM46I, I54V, V82F, L90MT74PSL10V, I13V, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, Q61QHKN, H69K, L89I, I93LC
 RenG12208RenG12208KT743236PINA  I13V, M36I, N37K, R41N, D60E, Q61DN, L63T, H69K, L89M, I93LC
 RenG13044RenG13044KT744072PINAI54V, V82A, L90ML10FI13V, K14KR, I15V, G16A, K20I, E35D, M36I, N37K, R41N, Q61QH, L63LP, H69K, T74S, L89I, T91TS, I93ILC
 RenG13278RenG13278KT744306PINAI54IL, I84V, N88SL33F, Q58EL10Y, I13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, D60E, Q61E, I62V, L63P, H69K, A71T, L89M, I93LC
 RenG12547RenG12547KT743575PINA  I13V, N37K, R41N, K45R, L63P, H69K, T74K, V77I, L89M, I93LC
 RenG13275RenG13275KT744303PINAN88SL10F, Q58EI13V, I15V, E35D, M36I, N37K, R41N, I62V, L63P, H69K, L89I, I93LC
 RenG12752RenG12752KT743780PINA  I13V, I15V, K20R, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG12050RenG12050KT743078PINA  I13V, I15V, M36IT, N37K, R41N, K43KE, Q61D, H69K, L89M, I93LC
 RenG12082RenG12082KT743110PINAM46I, I50V, V82A, L90ML10F, V11VI, L23I, L33F, Q58EI13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, G73V, T74S, L89T, I93LC
 RenG13403RenG13403KT744431PINA  I13V, M36T, N37K, R41N, L63P, H69K, L89I, I93LC
 RenG13271RenG13271KT744299PINA  T12TP, I13V, K14KR, I15V, G16A, M36I, N37K, R41N, L63LP, H69K, L89M, I93LC
 RenG12704RenG12704KT743732PINA  T12P, I13V, K14R, I15V, M36I, N37K, R41N, L63Q, I64M, H69K, L89M, I93LC
 RenG13419RenG13419KT744447PINAL90M I13V, I15V, K20T, E35D, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG13175RenG13175KT744203PINAI54V, V82AL33F, T74PI13V, K20R, E35D, M36I, N37K, R41N, R57K, Q61H, H69K, L89I, I93LC
 RenG12879RenG12879KT743907PINA  T12TS, I13V, K14R, I15V, G16E, K20M, M36IT, N37K, R41N, R57K, Q61K, H69K, L89I, I93LC
 RenG12037RenG12037KT743065PINA  I13V, K14KR, L19LI, K20R, M36I, N37R, R41N, L63P, H69K, L89IM, I93LC
 RenG13467RenG13467KT744495PINA  I13V, I15V, K20T, E35D, M36I, N37K, R41N, L63V, H69K, T74S, V82I, I93LC
 RenG11901RenG11901KT742929PINA  I13V, I15V, M36I, N37K, R41N, K43KR, I62V, L63Q, H69K, T74A, L89M, I93LC
 RenG13062RenG13062KT744090PINA  I13V, K20R, L33LV, M36I, N37K, R41S, H69K, L89M, I93LC
 RenG12519RenG12519KT743547PINAM46I, I54V, V82A, L90ML10F, L23II13V, K14R, I15V, K20I, E35N, M36I, N37E, R41N, Q61H, I62V, L63P, H69K, A71T, T74S, L89I, I93LC
 RenG12407RenG12407KT743435PINA  L10I, I13V, K20R, M36I, N37E, R41N, Q61K, L63I, H69K, T74K, L89M, I93LC
 RenG13284RenG13284KT744312PINA  L10I, I13V, I15V, G16E, M36T, N37K, R41N, L63T, H69K, L89M, I93LC
 RenG12578RenG12578KT743606PINAN88SL89IMVL10V, I13V, I15V, K20R, A22ACGS, E35D, M36I, N37K, R41N, K45R, I62IV, L63P, H69K, I93LC
 RenG12355RenG12355KT743383PINAM46I, L90ML89MVI13V, K14R, I15V, K20T, M36I, N37K, R41N, I62V, H69K, T74TS, V82VI, I93LC
 RenG12666RenG12666KT743694PINA  I13V, I15*K, K20R, M36I, N37K, R41N, Q61QE, L63P, H69K, L89M, I93LC
 RenG12846RenG12846KT743874PINAI50LL33FI13V, K14R, I15V, M36A, N37K, R41N, K45KR, L63P, H69K, A71IV, V82I, L89IT, I93LC
 RenG13493RenG13493KT744521PINA  I13V, I15V, K20R, M36I, N37K, R41N, L63V, H69K, L89M, I93LC
 RenG10128RenG10128KT741156PINA L23LIL10V, I13V, K14KR, I15V, K20T, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, H69K, A71AT, T74S, L89I, I93LC
 RenG10282RenG10282KT741310PINAM46MIV, L90MV11VIL10V, I13V, K14R, I15V, K20I, N37K, R41N, Q61QH, H69K, K70KR, T74S, L89I, I93LC
 RenG10325RenG10325KT741353PINAI50L, V82ML23LI, L33F, F53LT12TA, I13V, K14KR, I15V, K20R, E35D, M36L, N37K, R41N, L63P, H69K, A71V, T74S, L89M, I93LC
 RenG10627RenG10627KT741655PINAL90M I13V, I15V, K20T, M36I, N37R, R41N, D60E, I62V, L63P, I64V, H69K, A71AV, V82VI, L89M, I93LC
 RenG11612RenG11612KT742640PINAI54V, V82F, L90ML23LI, F53LI13V, I15V, K20T, E35D, M36I, N37K, R41N, R57RK, L63P, H69K, A71IV, T74S, L89I, I93LC
 RenG11098RenG11098KT742126PINAD30NN88DI13V, K14KR, I15V, K20T, E35D, M36I, N37Q, R41NS, D60E, Q61N, L63Q, H69K, T74A, V77VI, L89M, I93LC
 RenG10356RenG10356KT741384PINA L23II13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, R57K, L63P, H69K, T74S, L89T, I93LC
 RenG11593RenG11593KT742621PINAD30NN88DI13V, I15V, K20R, E35D, M36I, N37K, R41N, L63P, H69K, T74S, L89M, I93LC
 RenG11346RenG11346KT742374PINAM46MI, L90M I13V, I15V, G16E, K20T, M36I, N37K, P39S, R41N, I62V, H69K, T74KR, V82I, L89M, I93LC
 RenG11494RenG11494KT742522PINAI50L, V82L, L90ML33F, K43TT12S, I13V, I15V, K20R, E35D, M36IV, N37K, R41N, Q61HN, L63T, I64V, H69K, A71V, T74S, L89M, I93LC
 RenG10573RenG10573KT741601PINAD30NN88DI13V, I15V, K20Q, E35G, M36I, N37K, R41N, K45R, L63P, H69K, T74S, L89I, I93LC
 RenG10624RenG10624KT741652PINAL90MQ58EI13V, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, Q61N, L63T, I64IV, H69K, A71T, T74A, V82I, L89I, I93LC
 RenG11084RenG11084KT742112PINAL90LML10FR8RH, I13V, I15V, K20T, E35D, M36I, N37AEKT, R41N, H69K, T74S, L89I, I93LC
 RenG10161RenG10161KT741189PINAM46I, I54V, V82F, L90M L10IV, I13V, G16E, L19LI, K20R, E35D, M36I, N37Q, P39S, R41K, I62V, L63P, H69K, T74AE, L89M, I93L, N98ITC
 RenG10167RenG10167KT741195PINA  I13V, I15S, G16R, N37K, R41N, H69K, L89M, I93LC
 RenG10445RenG10445KT741473PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, G16A, N37K, R41N, K55R, R57K, L63P, H69K, L89IC
 RenG10763RenG10763KT741791PINA  L10V, I13V, L19I, E35D, N37K, R41N, I62IV, L63P, H69K, I72IV, T74S, L89MC
 RenG10144RenG10144KT741172PINA  L10V, I13V, K14KR, G16E, K20R, M36I, N37K, R41N, D60DN, Q61QE, L63T, H69K, L89M, I93LC
 RenG10518RenG10518KT741546PINAM46I, I47A L10V, I13V, I15V, G16A, L19P, K20I, M36MI, N37K, R41N, R57K, L63P, H69K, T74S, L89I, I93LC
 RenG10600RenG10600KT741628PINA L33FT12TAP, I13V, K14KR, M36I, N37K, P39S, R41N, I62V, L63Q, I64M, H69K, T74A, L89M, I93LC
 RenG11097RenG11097KT742125PINA  I13V, I15V, G16A, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG10952RenG10952KT741980PINA L23II13V, I15V, K20R, E35D, M36I, N37K, R41N, K45R, Q61H, L63P, H69K, A71T, L89T, I93LC
 RenG10097RenG10097KT741125PINAM46ML, I54V, V82ML24LI, L33F, T74P, N83DL10V, I13V, K14R, I15V, K20KR, E35D, M36IL, N37K, R41N, L63V, H69K, L89M, I93LC
 RenG11404RenG11404KT742432PINAM46I, I54V, V82AV11I, L24I, L33FL10V, I13V, I15V, K20R, E35D, M36I, N37NK, R41P, K45KR, I62V, L63Q, G68DE, H69K, A71I, L89T, I93LC
 RenG10418RenG10418KT741446PINA  T12P, I13V, K14KR, I15V, G16E, E35D, N37K, R41N, L63R, I64L, H69K, T74S, L89M, I93LC
 RenG11227RenG11227KT742255PINAI50L, V82A, L90ML33FT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37E, R41N, K45R, L63P, H69K, A71V, T74A, L89I, I93LC
 RenG10922RenG10922KT741950PINA  I13V, K20R, M36I, N37K, R41N, Q61HN, I64IM, H69K, L89M, I93LC
 RenG10774RenG10774KT741802PINAV82F, I84V, L90ML33FI13V, I15V, K20AT, E35D, M36I, R41N, K45V, I62V, L63P, H69K, T74S, L89M, I93LC
 RenG11741RenG11741KT742769PINAM46MI, I54V, V82A, L90ML33F, K43T, N88DL10V, I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74KR, L89M, I93LC
 RenG10527RenG10527KT741555PINA  L10V, I13V, I15V, K20R, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93LC
 RenG10242RenG10242KT741270PINAM46I, I54V, V82A, L90M I13V, I15V, K20T, L33L_L, M36I, N37K, R41N, I62V, H69K, T74S, L89I, I93LC
 RenG10498RenG10498KT741526PINAD30N, I50L, V82VAL33F, N88DI13V, I15V, K20R, E35D, M36I, N37E, P39PS, R41N, K45KR, L63P, G68GE, H69K, A71AITV, T74S, L89M, I93LC
 RenG10491RenG10491KT741519PINAI50L, V82VA, N88S, L90LML33FL10M, I13V, I15IV, K20R, E35D, M36I, N37K, R41N, K45R, H69K, A71V, L89I, I93LC
 RenG10661RenG10661KT741689PINAM46I, I54V, V82A, L90ML33F, Q58E, G73SL10I, I13V, L19I, K20R, E35D, M36I, N37K, R41K, K55N, L63P, H69K, A71T, T74S, Q92K, I93LC
 RenG10978RenG10978KT742006PINAI54V, V82AL33F, T74PL10I, I13V, G16E, K20R, M36I, N37K, R41N, L63T, H69Q, L89M, I93LC
 RenG11088RenG11088KT742116PINAI54V, V82C, L90ML10F, L33F, T74PT12S, I13V, I15V, G16E, L19AV, K20M, D25DN, E35DN, M36I, N37K, R41N, Q61H, L63T, I66IM, H69K, L89M, I93LC
 RenG10474RenG10474KT741502PINAG48S, I54V, V82F, L90ML33F, K43T, T74P, N83DL10I, I13V, K14R, I15V, E35D, M36L, N37K, R41IN, Q61N, I62V, C67CR, H69Q, L89I, I93LC
 RenG11083RenG11083KT742111PINA  P9PL, T12S, I13V, I15V, L19I, M36I, N37K, R41N, K45R, L63V, I64M, H69K, L89M, I93LC
 RenG10982RenG10982KT742010PINAM46I, I50V, I54V, V82A, L90MV11I, L33F, K43T, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37K, R41N, I62IV, L63P, H69R, A71V, L89LM, I93LC
 RenG10493RenG10493KT741521PINAL90ML23LI, F53L, G73GS, L89IVI13V, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71V, T74K, V77VI, I93LC
 RenG10631RenG10631KT741659PINAM46L, I54V, V82A, I84VV11I, L24I, K43TL10I, T12E, I13V, L19I, K20I, M36I, Q61N, L63T, I64V, H69K, A71V, I72IV, T74S, I93LC
Novitsky (2015)bcpp_012bcpp_012KR860607PINA  I13V, L19T, K20R, M36I, R41K, H69K, L89M, I93LC
 bcpp_147bcpp_147KR860659PINA  T12S, I13V, I15V, L19I, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
Rossouw (2015)RP177RP177KT032062LPV91  I13V, G16E, L19T, K20R, M36I, N37Q, P39S, H69K, T74S, L89M, I93LC
 RP032RP032KT032005LPV104  T12S, I13V, G16GE, L19I, K20R, M36I, R41K, D60E, H69K, L89M, I93LC