<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation I13V
Rx >= 1 PI
IncludeMixtures No
References 22
Patients 69
Isolates 78
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weidle (2001)PW_UG4393PW_UG4393AF358747RTV51  I13V, K14R, E35D, M36I, R41K, H69K, L89MC
Gibb (2002)DMG5959_w32 NFV32 L76LFI13V, M36I, R41K, L63S, I64IL, H69K, L89M, I93LC
 DMG8686_w82 NFV65D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
 DMG9191_w22 NFV22D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
Kantor (2002)TCDD-27TCDD-27AY090853SQV149  T12S, I13V, I15V, G16E, L19I, K20R, M36I, R41K, H69K, I93LC
Soares (2003)BR54BR54AY275730NFV56  T12A, I13V, G16E, L19I, M36I, N37K, R41N, L63T, H69K, L89M, I93LC
Grossman (2004)IL217IL217AY529576NFV104D30NN88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93LC
 IL369IL369AY529591NFV111M46I, L90M T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93LC
Montes (2004)MB_patNIB01_NIB710AJ577964NFV94  T12S, I13V, I15V, L19I, M36I, N37K, R41N, Q61E, L63A, I64M, H69K, L89M, I93LC
  01_NIB719AJ577965NFV94L90ML23IT12S, I13V, I15V, L19I, K20T, E35D, M36I, N37R, R41N, Q61E, L63A, I64M, H69K, V82I, L89M, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)UK276UK276AY900768IDV, SQV, NFV52L90M L10IV, T12S, I13V, I15V, L19I, K20T, M36I, Q61E, L63P, I64L, H69K, L89M, I93L, C95FC
 UK496bUK496bAY900776NFV L90M T12S, I13V, L19I, K20T, M36I, R41K, D60E, L63P, I64V, H69K, L89M, I93LC
 UK594UK594AY900778SQV184  I13V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 UK1154UK1154AY900795NFV L90M T12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, D60E, L63P, I64V, H69K, V82I, L89M, I93LC
 UK2069UK2069AY900845NFV D30NN88DT12S, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, R41K, L63V, H69K, T74S, L89I, I93LC
 BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 TK2018TK2018 IDV, RTV, NFV218M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93LC
 TK3009TK3009a SQV, NFV, LPV232L90M I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93LC
 TK3019TK3019 SQV, NFV, RTV143I54V, I84IV, L90MV11VI, G73SL10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93LC
 TK3027TK3027 RTV, SQV, NFV190D30N, L90MN88DT12S, I13V, I15V, L19I, K20R, E35D, M36I, N37D, I62IV, L63P, H69K, T74S, L89I, I93LC
 TK5010TK5010 RTV, IDV27  I13V, I15V, L19I, M36I, N37D, R57K, L63S, H69K, L89MC
 PL3405796049 NFV82L90M I13V, I15V, L19T, K20T, E35G, M36I, P39PA, R41K, Q61QH, L63V, I64IV, H69K, A71V, T74S, L89I, I93LC
 PL4706685002 IDV, NFV104D30NN88DT12S, I13V, I15V, L19I, E35ED, M36I, R41K, L63P, H69K, T74A, L89M, I93LC
 PL4725100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Weber (2005)F68541F68541AY677417NFV198M46MI, L90M T12S, I13V, I15V, L19I, K20T, E35X, M36I, R41K, H69K, T74AS, L89I, I93LC
 M72003M72003AY677426NFV, RTV, IDV212I54IV, L90ML10FI13V, K14N, I15V, L19I, K20T, E35N, M36I, R41K, K45R, I62IV, L63P, I64V, H69K, K70R, T74S, L89M, I93LC
 F56949F56949AY677453NFV154D30N T12S, I13V, I15V, L19I, K20T, M36I, R41K, K45T, L63P, H69K, I93LC
 M86744M86744AY714447IDV, RTV13  T12PS, I13V, I15V, L19T, K20R, M36I, N37D, R41K, D60E, Q61E, H69K, I72IR, T74A, L89M, I93LC
Baxter (2006)48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
Doualla-Bell (2006)Pt2FDB_Pt2 NFV L90M T12S, I13V, I15V, L19V, K20T, E35G, M36I, R41K, H69K, K70R, A71V, T74S, V82I, L89I, I93LC
 Pt7FDB_Pt7 NFV D30NL33FL10M, V11F, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63T, H69K, I93LC
Sanabani (2006)04BR07304BR073AY727525PINA  T12S, I13V, I15V, L19I, M36I, N37K, R41N, L63P, I64M, H69K, L89M, I93LC
McGrath (2007)7DMG_7a ATV48  L10I, I13V, G16GE, L19T, K20R, M36I, R41K, L63AITV, I64IM, E65D, H69K, T74TA, L89M, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
 DR58DR58AY589910NFV D30N T12S, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45Q, I64V, H69K, L89I, I93LC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Kandathil (2009)VL06_253VL06_253EU030406PINAD30NN88D, L89VL10M, T12S, I13V, I15V, L19T, K20T, E21D, E35K, M36I, P39A, R41K, K45R, Q61D, L63P, H69K, T74S, V82I, I93LC
Kassaye (2009)TCDD-19TC19_2003FJ445710IDV, RTV26  I13V, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93LC
Dau (2010)06552A06552AGU581760PINAM46I, I54V, L76V, V82A L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93LC
 07344A07344AGU581841PINAL90M T12S, I13V, I15V, L19I, K20T, M36I, N37ND, R41K, L63P, H69K, V82I, L89M, I93LC
El-Khatib (2010)Pat09211ZA_SAVE1489JF960542RTV, ATV N88NS, L90ML23I, F53FLT12S, I13V, I15V, L19I, K20T, E35D, M36I, R41K, I62IV, H69K, A71IV, T74S, V77VI, L89I, I93LC
Rodrigues (2010)301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
 305_07BR07SC305GQ401315NFV L90ML89VI13V, I15V, K20T, E35G, M36I, N37K, R41N, I62V, H69K, I72IV, T74S, V82I, I93LC
Van Zyl (2013)14602908KC423889LPV26M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 1576168KC423322LPV26M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 14071550KC423222LPV26I54V, I84V T12S, I13V, I15V, G16E, L19I, K20T, M36I, R41K, K45V, D60E, Q61E, I66V, H69K, K70R, I72V, V82I, L89M, I93LC
 4841764KC423387LPV156  T12S, I13V, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
  1831KC423444LPV157  T12S, I13V, L19I, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 1660584KC424152LPV26  T12S, I13V, I15V, G16A, L19T, K20R, M36I, R41K, L63V, H69K, I72IT, L89M, I93LC
  1015KC422807LPV78  T12S, I13V, I15V, G16A, L19T, K20R, M36I, R41K, Q61QH, L63V, H69K, I72IT, L89M, I93LC
 4502121KC423634LPV104 V11IL10I, I13V, G16E, Q18K, L19T, K20R, M36I, R41K, K43I, R57RK, L63T, H69K, L89M, I93LC
 1524773KC424279LPV26I54V, V82M T12S, I13V, L19I, K20R, M36I, N37S, R41K, D60E, Q61E, L63P, H69K, L89MC
 1274883KC424337LPV26  I13V, G16E, L19T, L33V, P39S, D60E, L63P, H69K, L89I, I93LC
  909KC424352LPV27  I13V, G16E, L19T, L33V, P39S, D60E, L63P, H69K, L89I, I93LC
 16361248KC422997LPV26M46MI, I54V, V82A, L90ML10F, L33F, K43T, G73ST12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
  3119KC423977LPV130  T12TS, I13V, K14R, M36I, R41K, L63P, H69K, L89LMC
 15822753KC423813LPV26M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
 16322976KC423913LPV26  T12A, I13V, I15V, G16E, L19I, K20R, M36I, R41K, L63H, H69K, K70R, L89M, I93LC
 20167KC424217LPV52  T12S, I13V, K14R, I15V, L19IV, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
Grossman (2014)471471KF135082IDV, LPV52M46I, I54V, V82AL10F, L24I, L33FI13V, K14R, I15V, K20KT, M36I, R41K, L63P, H69K, T74TS, L89M, I93LC
 882882KF135160NFV, LPV52M46I, I50V, I54V, L90ML23II13V, K20T, L33V, E35D, M36I, R41RK, K55KNRS, I62IV, H69K, T74S, V82I, L89I, I93LC
 255255KF135031SQV, LPV52I54V, V82AL10F, N88D, L89VT12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93LC
  255KF135032SQV, LPV90M46I, I54V, V82AL10F, L33F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93LC
 512512KF135092LPV52  I13V, K14R, I15V, K20T, M36I, R41K, H69K, V82I, L89M, I93LC
 4949KF135089NFV, LPV52I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93LC
 285285KF135040IDV, LPV52  L10I, I13V, K14R, I15V, M36I, N37D, R41K, L63V, E65D, H69K, T74S, L89M, I93LC
 10931093KF134941LPV52  I13V, K14R, I15V, M36I, R41K, H69K, T74S, L89M, I93LC
  1093KF134942LPV113  I13V, K14KR, I15V, M36I, R41K, H69K, T74S, L89M, I93LC
 183183KF135005NFV, LPV52M46I, I54V, V82F, L90M L10I, I13V, I15V, L19T, K20T, E35N, M36I, R41K, K45R, H69K, A71T, T74S, V77I, L89I, I93L, C95YC
 217217KF135024NFV, LPV52D30N, I54V, V82AL33F, N88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, H69Q, V75I, L89I, I93LC
  217KF135025NFV, LPV273M46I, I50V, I54V, V82A, L90ML33FL10I, I13V, K14R, I15V, K20R, E35D, M36I, N37DE, R41K, K55R, L63E, G68GE, H69Q, A71AV, L89I, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC