<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10V
Rx PI-naive
IncludeMixtures No
References 57
Patients 132
Isolates 132
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Brindeiro (2003)BRP2169BRP2169AY213488None   L10V, I15V, Q18H, R41K, T74S, L89M, I93LC
 BRC1563BRC1563AY213550None   L10V, I13V, K14R, I15V, K20R, M36I, N37K, R41I, L63V, I64V, H69K, I93LC
Soares (2003)BRP2086BRP2086AF527299None   L10V, I15V, M36I, N37E, H69K, L89MC
 BRP2089BRP2089AF527305None   L10V, I15V, M36T, N37K, R41N, L63V, H69K, L89M, N98KC
Yang (2003)HH003HH003AB090997None   L10V, T12P, I15V, L19I, M36V, R41K, D60E, L63P, I93LC
Eshleman (2004)ESH_Pat37ESH406AY435268None   L10V, I13V, E35D, M36I, R41K, R57K, C67Y, H69K, L89MC
Snoeck (2004)BE72BE72AY900957None   L10V, T12S, I15V, L19I, M36I, R41K, H69Q, L89I, I93LC
Eshleman (2005)ESH1140ESH1140AY756826None   L10V, I15V, L19T, L38F, R41K, H69K, L89M, I93LC
 ESH7040ESH7040AY756864None   L10V, T12S, K14KR, L19I, M36MI, R41K, D60E, H69K, L89M, I93LC
 ESH7056ESH7056AY756869None   L10V, I15V, L19I, K20G, M36I, R41K, H69K, L89M, I93LC
Non-B Workgroup (2005)UK1998UK1998AY900828None   L10V, I15V, M36I, R41K, L63P, H69K, I93LC
 UK2002UK2002AY900834None   L10V, I15V, L19I, M36I, R41K, L63IS, H69K, L89M, I93LC
 BR1023BR1023 None   L10V, I15V, M36I, N37E, H69K, L89MC
 BR1024BR1024AY900915None   L10V, I15V, M36T, N37K, R41N, L63V, H69K, L89M, N98KC
Saad (2005)SM_02YE51102YE511AY795906None   L10V, I15V, L19I, M36I, R41K, H69K, K70R, L89M, I93LC
Parreira (2006)PG224PG224AM071446None   L10V, K14R, I15V, L19I, M36I, N37S, R41K, H69K, L89M, I93LC
Rousseau (2006)Pt2003PS042MB1DQ369977None   L10V, T12S, I15V, L19V, E35D, M36I, R41K, D60E, H69K, L89M, I93LC
 Pt19504SK164B1DQ056405None   L10V, T12S, I15V, G16E, L19I, M36I, N37S, R41K, L63S, H69K, I93LC
Santos (2006)C57PRC57PRDQ190963None   L10V, T12X, K14R, I15V, G16E, L23P, M36I, N37K, P39S, R41N, H69K, I93LC
 C057C057DQ191003None   L10V, K14R, I15V, G16E, M36I, N37K, P39S, R41N, H69K, L89M, I93LC
 C054PRC054PRDQ191011None   L10V, M36I, N37K, R41N, L63P, H69K, L89M, I93LC
 C034PRC034PRDQ191025None   L10V, I15V, M36I, N37K, R41N, L63P, H69K, L89M, I93LC
 PA244PA244DQ343999None   Q7H, L10V, K14R, I15V, M36I, N37K, R41N, L63T, H69K, L89M, I93LC
Dilernia (2007)F098F098EF120337None   L10V, T12S, I15V, L19I, M36MI, N37K, R41N, R57K, L63T, H69K, A71T, I93LC
Kassu (2007)ETH-G-068G-068AB285779None   L10V, I15V, G16E, K20KR, M36I, N37T, P39S, L63C, H69K, L89MC
 ETH-G-124G-124AB285804None   L10V, T12TA, I15V, L19Q, K20R, M36I, R41K, K43R, L63S, H69K, I93LC
Vidal (2007)U113302BU.U1133AM260305None   L10V, L33V, E35K, M36I, N37K, R41N, L63T, I64V, H69K, L89M, I93LC
 U120602BU.U1206AM260306None   L10V, G16E, M36I, R41K, L63A, H69K, I93LC
von Wyl (2007)1015053478EF449917None   L10V, L19I, A22V, L23F, M36I, L63S, H69K, L89M, I93LC
Lahuerta (2008)P348418p348418_04EF407731None   L10V, T12S, I15V, L19I, M36I, N37S, R41K, H69K, I93LC
Marconi (2008)SW063sw063EU308074None   L10V, I15V, L19I, M36I, R41K, H69K, L89M, I93LC
Matthews (2008)PS042PS042FJ199623None   L10V, I15V, L19V, E35D, M36I, R41K, D60E, H69K, L89M, I93LC
 PS129PS129FJ199700None   L10V, I15V, L19V, M36I, R41K, H69K, L89M, I93LC
 PS204PS204FJ199760None   L10V, L19I, K20R, M36I, R41K, H69K, L89M, I93LC
Nyombi (2008)TBK049TBK049EU251744None   L10V, I15V, L19I, N37K, R41N, D60E, H69K, V77I, L89M, I93LC
 TMS009TMS009EU251790None   L10V, I13V, I15V, G16E, L19Q, K20R, M36I, L63N, H69K, L89M, I93LC
Bartolo (2009)CSE13401AOCSE134EU068212None   L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89MC
Brown (2009)CAS_1350_4_1257CAS_1350_4_1257FJ030696None   L10V, I15V, M36T, N37K, R41N, H69K, L89M, I93LC
Hosseinipour (2009)82698269GQ228211None   L10V, I15V, L19I, M36I, N37T, R41K, H69K, L89M, I93LC
 80808080GQ228289None   L10V, G16E, M36I, R41K, H69K, L89M, I93LC
Orrell (2009)GT609GT6092006 None   L10V, T12S, I15V, L19I, M36I, R41K, D60E, H69K, L89M, I93LC
Vercauteren (2009)pt20311135084962GQ398993None   L10V, Q18QK, K20KR, M36I, N37K, R41N, H69K, L89M, I93LC
 pt208pfvo5PpoMpGQ400816None   L10V, I13V, I15V, G16E, K20R, M36I, R41K, L63T, I64IL, H69K, I93LC
Wallis (2009)TJC2415406TJC2415406 None   L10V, I15V, L19I, E35D, M36I, R41K, I62IV, L63V, H69K, T74S, V77I, L89M, I93LC
 TJC2475972TJC2475972 None   L10V, I15V, L19I, M36I, R41K, H69K, L89M, I93LC
Bonura (2010)1223_1161223_116GU969560None   L10V, I15V, G16GE, M36T, N37K, R41N, L63T, H69K, L89I, I93LC
Chin (2010)K056K056GQ290728None   L10V, I15IMV, G16GE, K20KR, E34EA, M36MI, N37X, P39PS, R41K, H69K, L89MC
Gonzalez (2010)914_M00m914_M00mGQ427114None   L10V, I15V, Q18H, L19I, M36I, N37S, R41K, L63S, H69K, A71T, P79S, I93LC
Hattori (2010)F08-5112129F08-5112129AB866765None   L10V, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
Papathanasopoulos (2010)1707106ZA17071GU253410None  V11VIL10V, T12S, I15V, L19I, E35D, M36I, R41K, L63P, H69K, I93LC
Wright (2010)421SK421HM593430None   L10V, T12S, L19I, N37S, L63M, H69K, L89M, I93LC
 423SK423HM593432None   L10V, I15V, L19I, E35D, M36I, R41K, H69K, L89M, I93LC
 430SK430HM593440None   L10V, T12A, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89M, I93LC
Yang (2010)20106934762010693476JQ616901None   L10V, I13V, L19V, M36L, R41K, H69K, L89MC
Graf (2011)SC40SC40JF774007None   L10V, I15V, M36T, N37K, R41N, H69K, L89M, I93LC
 SC107SC107JF774043None   L10V, K14R, I15V, L19I, M36I, N37K, R41N, H69K, T74S, L89M, I93LC
 SC121SC121JF774049None   Q7K, L10V, I15V, N37K, R41N, L63P, H69T, L89M, I93LC
Green (2011)707PKE39F707PKE39FHM623526None   L10V, T12TA, I15IV, L19V, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
Hamers (2011)300038CP076300038HM119632None   L10V, I15V, L19I, E35D, M36I, R41K, K45KR, L63V, H69K, T74S, L89M, I93LC
 300059CP076300059HM119648None   L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, T74A, I93LC
 300290CP076300290HM119823None   L10V, I15V, G16E, L19I, K20R, M36L, N37S, R41K, L63T, I64IV, H69K, I93LC
 300439CP076300439HM119861None   L10V, G16E, M36I, R41K, L63LV, H69K, I93LC
 300571CP076300571HM119976None   L10V, T12S, I15V, L19IV, K20R, M36I, R41K, D60E, Q61E, L63M, H69K, L89M, I93LC
 300577CP076300577HM119981None   L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, A71T, I72T, I93LC
 300651CP076300651HM120045None   L10V, I13V, I15V, K20R, M36I, R41K, Q61E, I64L, H69K, L89M, I93LC
 CP076303192CP076303192HQ994204None   L10V, T12S, I13V, K14N, L19I, K20R, M36I, R41K, D60E, L63AITV, H69K, L89IM, I93LC
 CP076303277CP076303277HQ994266None   L10V, I15V, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 CP076305056CP076305056HQ994295None   L10V, K14NS, I15V, L19T, K20R, M36I, R41K, D60E, L63V, H69K, I72T, R87RG, L89M, I93LC
 CP076300310CP076300310HQ994358None   L10V, T12S, L19I, R41K, L63C, H69K, T74S, V77I, L89MC
 CP076300390CP076300390HQ994396None   L10V, L19V, M36I, R41K, H69K, T74S, L89M, I93LC
 CP076301519CP076301519HQ994465None   L10V, T12PS, I13IV, I15V, L19T, K20R, M36I, R41K, H69K, L89M, I93LC
 CP076302144CP076302144HQ994508None   L10V, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
 CP076302145CP076302145HQ994509None   Q2S, I3N, T4P, L5F, W6L, L10V, L19I, M36I, N37S, R41K, L63V, H69K, T74S, L89M, I93LC
 CP076301033CP076301033HQ994573None   L10V, K14R, I15V, L19V, M36I, N37D, R41K, D60DE, Q61QE, L63LAPV, H69K, L89F, I93LC
 CP076301048CP076301048HQ994580None   L10V, T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63H, H69K, L89M, I93LC
 CP076301085CP076301085HQ994602None   L10V, I15V, L19I, E35D, M36I, R41K, H69K, T74S, L89M, I93LC
 CP763A03672CP763A03672HQ994691None   L10V, I15V, L19I, K20R, M36I, R41K, L63V, H69K, T74S, V77I, L89LM, I93ILC
 CP763A04108CP763A04108HQ994706None   L10V, T12S, L19I, K20R, M36I, R41K, Q61E, H69K, L89M, I93LC
 CP076300971CP076300971HQ994736None   L10V, T12A, I15V, L19I, K20R, M36I, R41K, H69K, L89M, I93LC
 CP076302652CP076302652HQ994796None   L10V, T12TS, K14KR, I15IV, L19LI, M36I, N37ND, R41K, H69K, T74S, L89M, I93LC
 CP076302727CP076302727HQ994863None   L10V, K14T, I15V, L19T, E35D, M36I, N37H, R41K, K45R, L63P, H69KC
 CP763A03382CP763A03382HQ994915None   L10V, L19I, M36I, R41K, D60E, Q61QE, L63P, I64L, H69K, L89M, I93LC
Manasa (2011)10052801005280JN665019None   L10V, I15V, L19I, E35D, M36I, N37A, R41K, D60E, L63A, H69K, L89M, I93LC
 10090171009017JN665028None   L10V, T12S, I15V, L19T, E35ED, M36I, R41K, Q61QE, H69K, L89M, I93LC
Nwobegahay (2011)08MB55ZA08MB55ZAGU188835None   L10V, L19I, E35D, M36L, R41K, K45R, H69K, T74S, L89MC
 08MB58ZA08MB58ZAGU188838None   Q7E, R8G, L10V, V11F, T12Q, I13F, I15V, G16E, G17D, L19I, M36I, R41K, L63P, H69K, L89M, I93LC
Parboosing (2011)Pat052HRS8HQ844574None   L10V, T12S, L19I, K20R, M36I, R41K, R57K, L63S, H69K, T74S, L89M, I93LC
Santos (2011)J120J120_PRJN010492None   L10V, I15V, N37K, R41I, L63P, H69K, V77I, L89M, I93LC
 J151J151_PR_RTJN010536None   L10V, I15V, M36T, N37K, R41N, H69K, L89LMC
 J154J154_PRJN010540None   L10V, K14R, G16E, M36I, N37K, R41N, H69K, L89M, I93LC
 J162J162_PR_RTJN010553None   L10V, I15V, G16E, K20R, M36I, N37K, P39S, R41N, L63T, H69K, I93LC
 J195J195_PRJN010601None   L10V, I15V, M36T, N37K, R41S, H69K, L89M, I93LC
 J198J198_PR_RTJN010606None   L10V, T12S, I13IV, K14R, I15V, G16E, M36I, N37K, R41N, Q61QE, L63CST, C67CY, H69K, L89M, I93LC
 J230J230_PRJN010637None   L10V, K14R, G16E, N37K, P39S, R41N, I62K, H69K, L89M, I93LC
 J357J357_PRJN010741None   L10V, I15V, L19Q, M36I, N37K, R41N, L63V, H69K, L89M, I93LC
van Zyl (2011)A221A221JN638130None   L10V, I15V, L19I, E35D, M36I, R41K, L63A, H69K, L89M, I93LC
Wright (2011)AS2-0483B2AS2-0483B2HQ696804None   L10V, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 AS2-0483B7AS2-0483B7HQ696857None   L10V, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
da Silveira (2012)BRMS47BRMS47JF342298None   L10V, I13V, I15V, L19I, M36T, N37K, R41N, K43R, L63T, H69K, L89I, I93LC
De Gascun (2012)IRL18299IRL18299JN622839None   L10V, T12S, G16E, L19I, M36I, R41K, D60E, H69K, L89M, I93LC
 IRL11734IRL11734JN622902None   L10V, I15IV, G17GRS, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 IRL43146IRL43146JN622923None   L10V, V11VG, L19I, E35D, M36I, N37H, R41K, L63V, H69K, L89M, I93LC
Gaspareto (2012)DJF3DJF3PTHM752148None   L10V, I15V, M36I, N37K, R41N, L63P, H69K, I93LC
Hunt (2012)GP07_219767GP07_219767KF736587None   L10V, T12S, I15V, L19I, K20R, E35D, M36I, R41K, D60E, L63V, H69K, I85V, L89M, I93LC
Iweriebor (2012)07B10ZA07B10ZAGU201800None   L10V, I15V, L19I, K20R, M36I, R41K, L63F, H69K, V77I, L89M, I93LC
 07V9ZA07V9ZAGU201823None   L10V, I15V, L19I, K20R, M36I, R41K, L63S, H69K, V77I, L89M, I93LC
Karlsson (2012)SE_31SE_31JQ698687None   L10V, I15V, G16E, M36I, R41K, L63V, H69K, L89M, I93LC
Manak (2012)35_LH0135_LH01JN687654None   L10V, T12S, I15V, L19I, K20R, E35D, M36I, N37S, R41K, L63S, H69K, I93LC
Ssemwanga (2012)5675HR5675HRJF800227None   L10V, I15V, G16E, L19I, E35D, M36T, N37K, P39S, R41N, H69K, L89M, I93LC
Alencar (2013)RJ2-0009RJ2-0009JQ237941None   L10V, I15V, M36I, N37K, R41N, D60E, H69K, L89M, I93LC
 MG2-0040MG2-0040JQ238210None   L10V, I15V, G16E, M36I, N37K, P39S, R41N, L63V, H69K, T74A, L89M, I93LC
Brooks (2013)CAN2013-190CAN13-190KF727718None   L10V, K14R, K20R, M36I, N37K, R41N, H69K, L89M, I93LC
Frentz (2013)EHR-25848EHR-25848JX299990None   L10V, T12S, I15V, L19V, E35D, M36I, R41K, L63M, H69K, L89M, I93LC
 EHR-58400EHR-58400JX300513None   L10V, I13V, M36I, N37K, R41NS, H69K, L89MC
Hawke (2013)1623782516237825KC237971None   L10V, K14KR, I15V, M36I, N37K, R41N, R57RK, L63LP, H69K, L89M, I93LC
Leye (2013)SN.MS422SN.MS422FM210709None   L10V, G16E, L19I, M36I, L63S, H69K, I72V, I93LC
Mulu (2013)ETH-G-5530ETH-G-5530KF026095None   L10V, I15V, L19IT, K20R, M36I, R41K, H69K, L89M, I93LC
 ETH-G-5540ETH-G-5540KF026102None   L10V, K14R, I15V, G16E, M36I, R41K, H69K, L89M, I93LC
Telan (2013)1203174412031744AB747504None   L10V, I15V, M36L, R41K, L63T, H69K, T74A, L89M, I93LC
Van Zyl (2013)2962666KC423771None   L10V, T12S, L19I, E35D, M36I, R41K, Q58QR, D60E, I66IV, H69K, L89M, I93LC
 5271970KC423536None   L10V, I15IV, L19V, M36I, R41K, H69K, T74S, L89M, I93LC
 1232899KC423882None   L10V, T12S, K14R, I15V, G16E, L19T, K20R, M36I, R41K, L63H, H69K, L89M, I93LC
 1199735KC424254None   L10V, K14R, I15V, L19I, E35D, M36I, R41K, H69K, L89M, I93LC
 1321765KC424272None   L10V, T12S, L19I, K20R, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
 726651KC424202None   L10V, K14KR, G16GE, L19I, M36I, R41K, D60E, H69K, L89M, I93LC
 5031833KC423446None   L10V, T12TS, I15V, L19V, E35D, M36I, R41K, H69K, I72IV, L89M, I93LC
 16131677KC423319None   L10V, T12A, I15V, G16E, L19I, E35D, M36I, R41K, L63V, H69K, L89M, I93LC
 513134KC423073None   L10V, L19I, M36MIL, N37NS, R41K, L63P, H69K, L89M, I93LC
 227810KC424289None   L10V, K14I, I15IV, L19I, N37S, H69K, V77I, L89M, I93LC
 13321738KC423367None   L10V, K14E, G16E, L19I, M36I, D60E, I62V, L63LP, E65K, H69K, L89M, I93LC
 6111113KC422889None   L10V, I15V, G16A, L19I, M36I, N37D, R41K, H69K, L89F, I93LC
 124397KC424039None   L10V, I15V, L19V, M36I, R41K, R57K, D60E, L63T, H69K, L89M, I93LC