Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L10V
Rx	PI-naive
IncludeMixtures	No

References	51
Patients	112
Isolates	112

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Brindeiro (2003)	BRP2169	BRP2169	AY213488	None		L10V, I15V, Q18H, R41K, T74S, L89M, I93L	C
	BRC1563	BRC1563	AY213550	None		L10V, I13V, K14R, I15V, K20R, M36I, N37K, R41I, L63V, I64V, H69K, I93L	C
Soares (2003)	BRP2086	BRP2086	AF527299	None		L10V, I15V, M36I, N37E, H69K, L89M	C
	BRP2089	BRP2089	AF527305	None		L10V, I15V, M36T, N37K, R41N, L63V, H69K, L89M, N98K	C
Yang (2003)	HH003	HH003	AB090997	None		L10V, T12P, I15V, L19I, M36V, R41K, D60E, L63P, I93L	C
Eshleman (2004)	ESH_Pat37	ESH406	AY435268	None		L10V, I13V, E35D, M36I, R41K, R57K, C67Y, H69K, L89M	C
Snoeck (2004)	BE72	BE72	AY900957	None		L10V, T12S, I15V, L19I, M36I, R41K, H69Q, L89I, I93L	C
Eshleman (2005)	ESH1140	ESH1140	AY756826	None		L10V, I15V, L19T, L38F, R41K, H69K, L89M, I93L	C
	ESH7040	ESH7040	AY756864	None		L10V, T12S, K14KR, L19I, M36MI, R41K, D60E, H69K, L89M, I93L	C
	ESH7056	ESH7056	AY756869	None		L10V, I15V, L19I, K20G, M36I, R41K, H69K, L89M, I93L	C
Non-B Workgroup (2005)	UK1998	UK1998	AY900828	None		L10V, I15V, M36I, R41K, L63P, H69K, I93L	C
	UK2002	UK2002	AY900834	None		L10V, I15V, L19I, M36I, R41K, L63IS, H69K, L89M, I93L	C
	BR1023	BR1023		None		L10V, I15V, M36I, N37E, H69K, L89M	C
	BR1024	BR1024	AY900915	None		L10V, I15V, M36T, N37K, R41N, L63V, H69K, L89M, N98K	C
Saad (2005)	SM_02YE511	02YE511	AY795906	None		L10V, I15V, L19I, M36I, R41K, H69K, K70R, L89M, I93L	C
Parreira (2006)	PG224	PG224	AM071446	None		L10V, K14R, I15V, L19I, M36I, N37S, R41K, H69K, L89M, I93L	C
Rousseau (2006)	Pt20	03PS042MB1	DQ369977	None		L10V, T12S, I15V, L19V, E35D, M36I, R41K, D60E, H69K, L89M, I93L	C
	Pt195	04SK164B1	DQ056405	None		L10V, T12S, I15V, G16E, L19I, M36I, N37S, R41K, L63S, H69K, I93L	C
Santos (2006)	C57PR	C57PR	DQ190963	None		L10V, T12X, K14R, I15V, G16E, L23P, M36I, N37K, P39S, R41N, H69K, I93L	C
	C057	C057	DQ191003	None		L10V, K14R, I15V, G16E, M36I, N37K, P39S, R41N, H69K, L89M, I93L	C
	C054PR	C054PR	DQ191011	None		L10V, M36I, N37K, R41N, L63P, H69K, L89M, I93L	C
	C034PR	C034PR	DQ191025	None		L10V, I15V, M36I, N37K, R41N, L63P, H69K, L89M, I93L	C
	PA244	PA244	DQ343999	None		Q7H, L10V, K14R, I15V, M36I, N37K, R41N, L63T, H69K, L89M, I93L	C
Dilernia (2007)	F098	F098	EF120337	None		L10V, T12S, I15V, L19I, M36MI, N37K, R41N, R57K, L63T, H69K, A71T, I93L	C
Kassu (2007)	ETH-G-068	G-068	AB285779	None		L10V, I15V, G16E, K20KR, M36I, N37T, P39S, L63C, H69K, L89M	C
	ETH-G-124	G-124	AB285804	None		L10V, T12TA, I15V, L19Q, K20R, M36I, R41K, K43R, L63S, H69K, I93L	C
Vidal (2007)	U1133	02BU.U1133	AM260305	None		L10V, L33V, E35K, M36I, N37K, R41N, L63T, I64V, H69K, L89M, I93L	C
	U1206	02BU.U1206	AM260306	None		L10V, G16E, M36I, R41K, L63A, H69K, I93L	C
von Wyl (2007)	101	5053478	EF449917	None		L10V, L19I, A22V, L23F, M36I, L63S, H69K, L89M, I93L	C
Lahuerta (2008)	P348418	p348418_04	EF407731	None		L10V, T12S, I15V, L19I, M36I, N37S, R41K, H69K, I93L	C
Marconi (2008)	SW063	sw063	EU308074	None		L10V, I15V, L19I, M36I, R41K, H69K, L89M, I93L	C
Matthews (2008)	PS042	PS042	FJ199623	None		L10V, I15V, L19V, E35D, M36I, R41K, D60E, H69K, L89M, I93L	C
	PS129	PS129	FJ199700	None		L10V, I15V, L19V, M36I, R41K, H69K, L89M, I93L	C
	PS204	PS204	FJ199760	None		L10V, L19I, K20R, M36I, R41K, H69K, L89M, I93L	C
Nyombi (2008)	TBK049	TBK049	EU251744	None		L10V, I15V, L19I, N37K, R41N, D60E, H69K, V77I, L89M, I93L	C
	TMS009	TMS009	EU251790	None		L10V, I13V, I15V, G16E, L19Q, K20R, M36I, L63N, H69K, L89M, I93L	C
Bartolo (2009)	CSE134	01AOCSE134	EU068212	None		L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M	C
Brown (2009)	CAS_1350_4_1257	CAS_1350_4_1257	FJ030696	None		L10V, I15V, M36T, N37K, R41N, H69K, L89M, I93L	C
Hosseinipour (2009)	8269	8269	GQ228211	None		L10V, I15V, L19I, M36I, N37T, R41K, H69K, L89M, I93L	C
	8080	8080	GQ228289	None		L10V, G16E, M36I, R41K, H69K, L89M, I93L	C
Orrell (2009)	GT609	GT6092006		None		L10V, T12S, I15V, L19I, M36I, R41K, D60E, H69K, L89M, I93L	C
Vercauteren (2009)	pt2031	1135084962	GQ398993	None		L10V, Q18QK, K20KR, M36I, N37K, R41N, H69K, L89M, I93L	C
	pt208	pfvo5PpoMp	GQ400816	None		L10V, I13V, I15V, G16E, K20R, M36I, R41K, L63T, I64IL, H69K, I93L	C
Wallis (2009)	TJC2415406	TJC2415406		None		L10V, I15V, L19I, E35D, M36I, R41K, I62IV, L63V, H69K, T74S, V77I, L89M, I93L	C
	TJC2475972	TJC2475972		None		L10V, I15V, L19I, M36I, R41K, H69K, L89M, I93L	C
Bonura (2010)	1223_116	1223_116	GU969560	None		L10V, I15V, G16GE, M36T, N37K, R41N, L63T, H69K, L89I, I93L	C
Chin (2010)	K056	K056	GQ290728	None		L10V, I15IMV, G16GE, K20KR, E34EA, M36MI, N37X, P39PS, R41K, H69K, L89M	C
Gonzalez (2010)	914_M00m	914_M00m	GQ427114	None		L10V, I15V, Q18H, L19I, M36I, N37S, R41K, L63S, H69K, A71T, P79S, I93L	C
Hamers (2010)	300038	CP076300038	HM119632	None		L10V, I15V, L19I, E35D, M36I, R41K, K45KR, L63V, H69K, T74S, L89M, I93L	C
	300059	CP076300059	HM119648	None		L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, T74A, I93L	C
	300290	CP076300290	HM119823	None		L10V, I15V, G16E, L19I, K20R, M36L, N37S, R41K, L63T, I64IV, H69K, I93L	C
	300439	CP076300439	HM119861	None		L10V, G16E, M36I, R41K, L63LV, H69K, I93L	C
	300571	CP076300571	HM119976	None		L10V, T12S, I15V, L19IV, K20R, M36I, R41K, D60E, Q61E, L63M, H69K, L89M, I93L	C
	300577	CP076300577	HM119981	None		L10V, T12S, I15V, L19I, M36I, R41K, L63P, H69K, A71T, I72T, I93L	C
	300651	CP076300651	HM120045	None		L10V, I13V, I15V, K20R, M36I, R41K, Q61E, I64L, H69K, L89M, I93L	C
Papathanasopoulos (2010)	17071	06ZA17071	GU253410	None	V11VI	L10V, T12S, I15V, L19I, E35D, M36I, R41K, L63P, H69K, I93L	C
Wright (2010)	421	SK421	HM593430	None		L10V, T12S, L19I, N37S, L63M, H69K, L89M, I93L	C
	423	SK423	HM593432	None		L10V, I15V, L19I, E35D, M36I, R41K, H69K, L89M, I93L	C
	430	SK430	HM593440	None		L10V, T12A, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89M, I93L	C
Yang (2010)	2010693476	2010693476	JQ616901	None		L10V, I13V, L19V, M36L, R41K, H69K, L89M	C
Graf (2011)	SC40	SC40	JF774007	None		L10V, I15V, M36T, N37K, R41N, H69K, L89M, I93L	C
	SC107	SC107	JF774043	None		L10V, K14R, I15V, L19I, M36I, N37K, R41N, H69K, T74S, L89M, I93L	C
	SC121	SC121	JF774049	None		Q7K, L10V, I15V, N37K, R41N, L63P, H69T, L89M, I93L	C
Green (2011)	707PKE39F	707PKE39F	HM623526	None		L10V, T12TA, I15IV, L19V, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
Hamers (2011)	CP076303192	CP076303192	HQ994204	None		L10V, T12S, I13V, K14N, L19I, K20R, M36I, R41K, D60E, L63AITV, H69K, L89IM, I93L	C
	CP076303277	CP076303277	HQ994266	None		L10V, I15V, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93L	C
	CP076305056	CP076305056	HQ994295	None		L10V, K14NS, I15V, L19T, K20R, M36I, R41K, D60E, L63V, H69K, I72T, R87RG, L89M, I93L	C
	CP076300310	CP076300310	HQ994358	None		L10V, T12S, L19I, R41K, L63C, H69K, T74S, V77I, L89M	C
	CP076300390	CP076300390	HQ994396	None		L10V, L19V, M36I, R41K, H69K, T74S, L89M, I93L	C
	CP076301519	CP076301519	HQ994465	None		L10V, T12PS, I13IV, I15V, L19T, K20R, M36I, R41K, H69K, L89M, I93L	C
	CP076302144	CP076302144	HQ994508	None		L10V, I15V, L19I, M36I, R41K, L63A, H69K, I93L	C
	CP076302145	CP076302145	HQ994509	None		Q2S, I3N, T4P, L5F, W6L, L10V, L19I, M36I, N37S, R41K, L63V, H69K, T74S, L89M, I93L	C
	CP076301033	CP076301033	HQ994573	None		L10V, K14R, I15V, L19V, M36I, N37D, R41K, D60DE, Q61QE, L63LAPV, H69K, L89F, I93L	C
	CP076301048	CP076301048	HQ994580	None		L10V, T12S, I15V, L19T, K20R, E35D, M36I, R41K, L63H, H69K, L89M, I93L	C
	CP076301085	CP076301085	HQ994602	None		L10V, I15V, L19I, E35D, M36I, R41K, H69K, T74S, L89M, I93L	C
	CP763A03672	CP763A03672	HQ994691	None		L10V, I15V, L19I, K20R, M36I, R41K, L63V, H69K, T74S, V77I, L89LM, I93IL	C
	CP763A04108	CP763A04108	HQ994706	None		L10V, T12S, L19I, K20R, M36I, R41K, Q61E, H69K, L89M, I93L	C
	CP076300971	CP076300971	HQ994736	None		L10V, T12A, I15V, L19I, K20R, M36I, R41K, H69K, L89M, I93L	C
	CP076302652	CP076302652	HQ994796	None		L10V, T12TS, K14KR, I15IV, L19LI, M36I, N37ND, R41K, H69K, T74S, L89M, I93L	C
	CP076302727	CP076302727	HQ994863	None		L10V, K14T, I15V, L19T, E35D, M36I, N37H, R41K, K45R, L63P, H69K	C
	CP763A03382	CP763A03382	HQ994915	None		L10V, L19I, M36I, R41K, D60E, Q61QE, L63P, I64L, H69K, L89M, I93L	C
Manasa (2011)	1005280	1005280	JN665019	None		L10V, I15V, L19I, E35D, M36I, N37A, R41K, D60E, L63A, H69K, L89M, I93L	C
	1009017	1009017	JN665028	None		L10V, T12S, I15V, L19T, E35ED, M36I, R41K, Q61QE, H69K, L89M, I93L	C
Nwobegahay (2011)	08MB55ZA	08MB55ZA	GU188835	None		L10V, L19I, E35D, M36L, R41K, K45R, H69K, T74S, L89M	C
	08MB58ZA	08MB58ZA	GU188838	None		Q7E, R8G, L10V, V11F, T12Q, I13F, I15V, G16E, G17D, L19I, M36I, R41K, L63P, H69K, L89M, I93L	C
Parboosing (2011)	Pat052	HRS8	HQ844574	None		L10V, T12S, L19I, K20R, M36I, R41K, R57K, L63S, H69K, T74S, L89M, I93L	C
Santos (2011)	J120	J120_PR	JN010492	None		L10V, I15V, N37K, R41I, L63P, H69K, V77I, L89M, I93L	C
	J151	J151_PR_RT	JN010536	None		L10V, I15V, M36T, N37K, R41N, H69K, L89LM	C
	J154	J154_PR	JN010540	None		L10V, K14R, G16E, M36I, N37K, R41N, H69K, L89M, I93L	C
	J162	J162_PR_RT	JN010553	None		L10V, I15V, G16E, K20R, M36I, N37K, P39S, R41N, L63T, H69K, I93L	C
	J195	J195_PR	JN010601	None		L10V, I15V, M36T, N37K, R41S, H69K, L89M, I93L	C
	J198	J198_PR_RT	JN010606	None		L10V, T12S, I13IV, K14R, I15V, G16E, M36I, N37K, R41N, Q61QE, L63CST, C67CY, H69K, L89M, I93L	C
	J230	J230_PR	JN010637	None		L10V, K14R, G16E, N37K, P39S, R41N, I62K, H69K, L89M, I93L	C
	J357	J357_PR	JN010741	None		L10V, I15V, L19Q, M36I, N37K, R41N, L63V, H69K, L89M, I93L	C
van Zyl (2011)	A221	A221	JN638130	None		L10V, I15V, L19I, E35D, M36I, R41K, L63A, H69K, L89M, I93L	C
Wright (2011)	AS2-0483B2	AS2-0483B2	HQ696804	None		L10V, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	AS2-0483B7	AS2-0483B7	HQ696857	None		L10V, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
da Silveira (2012)	BRMS47	BRMS47	JF342298	None		L10V, I13V, I15V, L19I, M36T, N37K, R41N, K43R, L63T, H69K, L89I, I93L	C
De Gascun (2012)	IRL18299	IRL18299	JN622839	None		L10V, T12S, G16E, L19I, M36I, R41K, D60E, H69K, L89M, I93L	C
	IRL11734	IRL11734	JN622902	None		L10V, I15IV, G17GRS, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93L	C
	IRL43146	IRL43146	JN622923	None		L10V, V11VG, L19I, E35D, M36I, N37H, R41K, L63V, H69K, L89M, I93L	C
Gaspareto (2012)	DJF3	DJF3PT	HM752148	None		L10V, I15V, M36I, N37K, R41N, L63P, H69K, I93L	C
Iweriebor (2012)	07B10ZA	07B10ZA	GU201800	None		L10V, I15V, L19I, K20R, M36I, R41K, L63F, H69K, V77I, L89M, I93L	C
	07V9ZA	07V9ZA	GU201823	None		L10V, I15V, L19I, K20R, M36I, R41K, L63S, H69K, V77I, L89M, I93L	C
Karlsson (2012)	SE_31	SE_31	JQ698687	None		L10V, I15V, G16E, M36I, R41K, L63V, H69K, L89M, I93L	C
Ssemwanga (2012)	5675HR	5675HR	JF800227	None		L10V, I15V, G16E, L19I, E35D, M36T, N37K, P39S, R41N, H69K, L89M, I93L	C
Telan (2012)	12031744	12031744	AB747504	None		L10V, I15V, M36L, R41K, L63T, H69K, T74A, L89M, I93L	C
Alencar (2013)	RJ2-0009	RJ2-0009	JQ237941	None		L10V, I15V, M36I, N37K, R41N, D60E, H69K, L89M, I93L	C
	MG2-0040	MG2-0040	JQ238210	None		L10V, I15V, G16E, M36I, N37K, P39S, R41N, L63V, H69K, T74A, L89M, I93L	C
Frentz (2013)	EHR-25848	EHR-25848	JX299990	None		L10V, T12S, I15V, L19V, E35D, M36I, R41K, L63M, H69K, L89M, I93L	C
	EHR-58400	EHR-58400	JX300513	None		L10V, I13V, M36I, N37K, R41NS, H69K, L89M	C
Hawke (2013)	16237825	16237825	KC237971	None		L10V, K14KR, I15V, M36I, N37K, R41N, R57RK, L63LP, H69K, L89M, I93L	C

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