<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10V
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 83
Isolates 94
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL384IL384aAY529618IDV, SQV, RTV, NFV154M46I, I54V, V82A, L90MT74PW6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93LC
  IL384bAY529622IDV, SQV, RTV, NFV239M46I, I54V, V82A, L90MT74PL10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93LC
Non-B Workgroup (2005)BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 BR42BR42AY900895NFV97M46I, L90M L10V, E35D, M36I, N37K, R41N, L63P, I64V, H69K, L89MC
 TK1002TK1002 RTV225M46I, I54V, V82A L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93LC
 TK3013TK3013 SQV, NFV205L90MG73SL10V, R41K, L63P, A71I, V77I, L89M, I93LC
 TK3016TK3016 SQV, NFV167I54V, L90MT74PL10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93LC
 TK4011TK4011 SQV, RTV, NFV, IDV261V82A, L90MQ58E, G73SL10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93LC
 PL2795660622 NFV, RTV, IDV184L90MR L10V, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62IV, L63P, H69K, A71AV, T74S, V77VI, I93LC
 PL472569936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Baxter (2006)48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-50965096-30901DQ878592PINAM46I, I54V, V82A, L90MK43KT, T74PL10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93LC
Sen (2007)T076NPT76EF186928NFV, RTV M46L, V82A, L90MT74PL10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93LC
von Wyl (2007)19702313EF449901PINAI54IV, N88NS, L90M L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93LC
 1017278778EF449991RTV, PINA  L10V, L19I, M36I, L63S, H69K, I72V, L89M, I93LC
Pillay (2008)DR68DR68AY589917RTV104M46I, I54V, V82A L10V, T12S, I15V, L19I, E35ED, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
El-Khatib (2010)Pat07811ZA_SAVE1172JF960528LPV   L10V, I15V, L19V, K20R, M36I, R41K, H69K, L89M, I93LC
Rodrigues (2010)320_07BR07SC320GQ401304LPV   L10V, T12S, I15V, K20R, E35D, M36I, N37K, R41N, H69K, L89M, I93LC
 301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Kouri (2012)CU728-10CU728-10JQ585411PINAM46I, I50V, L90ML33FW6G, L10V, N37S, R41K, K55R, Q61E, L63P, H69K, T74S, V77I, V82VI, I85V, L89M, I93LC
 CU2016-09CU2016-09JQ585331PINAM46I, I54M, V82A, L90MK43TL10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91TS, I93LC
 CU2035-09CU2035-09JQ585332PINAM46I, I54M, V82A, L90MK43TQ2H, L10V, K14R, L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70KR, A71V, L89I, T91S, I93LC
Van Zyl (2013)11701077KC422863LPV26M46I, I54V, V82AF53FLL10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
  959KC424396LPV27M46I, I54V, V82A L5LF, L10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
  1420KC423137LPV27M46I, I54V, V82AF53FLL10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 17041443KC423148LPV26I54V, L76LV, V82VAQ58QEL10V, T12S, I15V, L19I, K20KR, E34EQ, M36I, N37S, R41K, L63P, H69K, K70R, A71AV, L89M, I93LC
 15332947KC423906LPV26  L10V, T12TS, K14KR, I15V, G16E, L19I, M36I, K45R, L63T, H69K, L89M, I93LC
 13001765KC423388LPV26  L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LC
 1523326KC423987LPV26I54V, L76V, V82A L10V, T12TS, I15V, L19I, K20R, M36I, N37D, K55R, R57RK, D60E, I62V, L63P, H69K, A71V, L89M, I93LC
Grossman (2014)794794KF135147LPV52  L10V, T12S, I15V, K20R, E35D, M36I, R41K, H69K, T74S, L89IM, I93LC
 11141114KF134952LPV52M46I, I54V, L76V, V82A L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93LC
 638638KF135117IDV, LPV52L90M Q7T, L10V, I15V, K20T, M36I, N37NH, R41K, L63P, I64IV, H69K, I85IV, L89M, I93LC
 435435KF135075IDV, LPV52  L10V, I15V, K20R, M36I, R41K, H69K, L89M, I93LC
 293293KF135044NFV, LPV52  L10V, K14KR, I15V, M36I, N37D, R41RK, D60E, Q61E, H69K, L89M, I93LC
  293KF135045NFV, LPV80  L10V, I13K, M36I, N37D, R41K, D60E, Q61E, H69K, L89M, I93LC
  293KF135046NFV, LPV178  L10V, K14KR, I15V, M36I, N37D, R41K, D60E, Q61E, H69K, T74TS, L89M, I93LC
 5252KF135094RTV, LPV52M46I, I54IV, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63PT, H69K, I72IT, L89M, I93LC
  52KF135095RTV, LPV115M46I, I54V, L76V, V82A, L90M L10V, K14KQ, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135097RTV, LPV210M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55KR, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135098RTV, LPV267M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, L89M, I93LC
  52KF135099RTV, LPV314M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, T74TS, L89M, I93LC
 9292KF135163NFV, LPV52  W6C, R8Q, L10V, I15V, L19I, M36I, R41K, L63LV, H69K, T74S, L89M, I93LC
 18341834KF135004LPV52  L10V, K20R, M36I, R41K, Q61E, H69K, T74S, L89M, I93LC
 55KF135110RTV, LPV52M46L, I54V, V82AL24L*IR, N88NDL10V, I15V, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC
Diaz (2015)RenG17197RenG17197KT748225PINAI50IL, V82VA, L90M L10V, K20R, E35D, M36I, N37Q, R41N, K45KR, D60DE, L63P, H69K, K70KR, A71AV, L89M, I93LC
 RenG15600RenG15600KT746628PINA  L10V, I15V, G16E, K20R, M36I, N37K, R41N, L63V, H69K, I93LC
 RenG16711RenG16711KT747739PINAI54IV, N88S L10V, I15V, G16E, K20R, E35D, M36IV, N37K, P39S, R41N, K45KR, I62V, H69K, A71AV, T74S, L89M, I93LC
 RenG16793RenG16793KT747821PINAM46MI, I54V, V82M, L90ML24LI, L33F, T74PL10V, I13IV, I15IV, K20R, E35D, M36I, N37Q, R41N, Q61DN, I62V, L63PT, H69K, V77I, L89M, I93LC
 RenG16330RenG16330KT747358PINAM46I, I54V, V82A, L90M L10V, I13A, L19LI, K20M, E21K, A22V, E35D, M36I, N37DE, R41N, I62V, L63P, I64V, H69K, T74S, L89M, I93L, C95VC
 RenG15576RenG15576KT746604PINA  L10V, I15V, N37K, R41I, D60E, H69K, L89M, I93LC
 RenG15586RenG15586KT746614PINAM46I, I54V, I84V, L90M L10V, I13V, I15V, K20R, E35D, M36I, N37K, R41N, D60E, I62V, L63P, H69K, A71V, L89I, I93LC
 RenG17470RenG17470KT748498PINA  L10V, T12I, I15V, G16E, E35D, M36I, N37K, R41N, L63T, H69K, I72V, L89M, I93LC
 RenG17252RenG17252KT748280PINA  L10V, I15V, E35D, M36I, N37K, R41N, L63V, H69K, T74S, L89M, I93LC
 RenG16680RenG16680KT747708PINAI54V, L76V, V82A L10V, I15V, K20R, D25DN, E35D, M36I, N37K, R41N, R57RK, Q61DN, I62V, L63P, H69K, A71V, L89M, I93LC
 RenG16641RenG16641KT747669PINAM46I, I84V L10V, I15V, G16E, E35G, M36I, N37K, P39S, R41N, I62V, L63T, I64V, H69K, T74A, I85V, L89M, I93LC
 RenG15360RenG15360KT746388PINA  L10V, I15V, L19IT, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG14813RenG14813KT745841PINA  L10V, K14R, I15V, M36I, N37K, R41N, H69K, T74S, L89M, I93LC
 RenG15095RenG15095KT746123PINA  L10V, I15V, G16E, M36I, N37K, R41N, L63CS, H69K, I93LC
 RenG13551RenG13551KT744579PINAM46MI, I50V, I54V, V82M, N88SL33F, Q58E, T74PL10V, G16E, K20R, E35D, M36I, N37K, R41N, R57RK, L63T, H69K, L89F, I93LC
 RenG14258RenG14258KT745286PINA  L10V, I15V, G16A, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93LC
 RenG14843RenG14843KT745871PINA  L10V, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
 RenG15313RenG15313KT746341PINAM46L, G48A, I54V, V82A, L90ML33F, N83DL10V, K14KR, I15IV, G16E, K20R, E35D, M36I, N37K, R41N, R57K, Q61N, L63T, H69K, T74S, I85V, L89I, Q92K, I93LC
 RenG14545RenG14545KT745573PINAM46L, I50L, I54IV, V82VA, L90ML33LF, G73SL10V, I13IV, I15IV, K20KR, E35ED, N37K, R41N, K45R, L63P, H69K, A71AITV, T74S, V77VI, I85V, I93LC
 RenG14686RenG14686KT745714PINA  L10V, K20R, M36I, N37K, R41N, K43KE, L63AV, H69K, L89M, I93LC
 RenG15206RenG15206KT746234PINAM46I, G48V, I54V, V82AQ58E, T74PL10V, I15V, K20R, E35D, M36I, N37K, R41N, F53Y, K55R, R57K, I62V, L63V, H69K, L89M, I93LC
 RenG15333RenG15333KT746361PINA  L10V, G16E, M36I, N37K, R41N, L63T, H69K, L89M, I93LC
 RenG13401RenG13401KT744429PINAM46I, I54V, V82F, L90MT74PSL10V, I13V, K14R, I15V, K20T, E35DN, M36I, N37K, R41N, Q61QHKN, H69K, L89I, I93LC
 RenG12420RenG12420KT743448PINA  L10V, K14R, I15V, G16E, M36T, N37K, R41N, H69K, L89M, I93LC
 RenG13457RenG13457KT744485PINA  L10V, I13IV, K14KNRS, L19I, K20KR, M36I, N37K, R41N, L63T, H69K, L89MC
 RenG12273RenG12273KT743301PINA M46MTL10V, I15V, G16E, M36I, N37K, P39S, R41N, D60E, L63P, H69K, L89M, I93LC
 RenG12578RenG12578KT743606PINAN88SL89IMVL10V, I13V, I15V, K20R, A22ACGS, E35D, M36I, N37K, R41N, K45R, I62IV, L63P, H69K, I93LC
 RenG10128RenG10128KT741156PINA L23LIL10V, I13V, K14KR, I15V, K20T, E35D, M36I, N37K, R41N, D60E, Q61E, I62V, H69K, A71AT, T74S, L89I, I93LC
 RenG10282RenG10282KT741310PINAM46MIV, L90MV11VIL10V, I13V, K14R, I15V, K20I, N37K, R41N, Q61QH, H69K, K70KR, T74S, L89I, I93LC
 RenG11073RenG11073KT742101PINA  L10V, K14KR, I15IV, K20KR, M36I, N37K, R41N, L63P, H69K, I93LC
 RenG10554RenG10554KT741582PINAM46L, I54V, V82M, L90ML33F, F53LL10V, I15V, G16E, L19I, K20R, E35D, M36I, N37T, P39Q, R41N, K55R, I62V, L63AITV, H69K, A71V, T74S, V77I, L89M, I93L, C95LC
 RenG11086RenG11086KT742114PINAM46I, I47A, I84VF53LL10V, G16E, E35D, M36V, N37E, P39S, R41N, I62V, L63T, H69R, A71V, T74S, L89M, I93LC
 RenG11410RenG11410KT742438PINAI54V, V82A, L90M L10V, I13A, K20V, A22V, E35N, M36I, N37K, R41H, R57RK, D60E, I62V, L63P, I64V, H69K, A71V, I93MC
 RenG10036RenG10036KT741064PINA  L10V, I15V, M36I, N37K, R41N, D60DE, I62IV, L63IT, H69K, L89M, I93LC
 RenG10763RenG10763KT741791PINA  L10V, I13V, L19I, E35D, N37K, R41N, I62IV, L63P, H69K, I72IV, T74S, L89MC
 RenG10144RenG10144KT741172PINA  L10V, I13V, K14KR, G16E, K20R, M36I, N37K, R41N, D60DN, Q61QE, L63T, H69K, L89M, I93LC
 RenG10518RenG10518KT741546PINAM46I, I47A L10V, I13V, I15V, G16A, L19P, K20I, M36MI, N37K, R41N, R57K, L63P, H69K, T74S, L89I, I93LC
 RenG10097RenG10097KT741125PINAM46ML, I54V, V82ML24LI, L33F, T74P, N83DL10V, I13V, K14R, I15V, K20KR, E35D, M36IL, N37K, R41N, L63V, H69K, L89M, I93LC
 RenG11404RenG11404KT742432PINAM46I, I54V, V82AV11I, L24I, L33FL10V, I13V, I15V, K20R, E35D, M36I, N37NK, R41P, K45KR, I62V, L63Q, G68DE, H69K, A71I, L89T, I93LC
 RenG10299RenG10299KT741327PINAM46I, I54V, L76V, V82A L10V, I15V, L19V, K20R, M36I, N37K, R41N, I62V, L63P, H69K, A71V, L89M, I93LC
 RenG10239RenG10239KT741267PINA  L10V, L19I, M36T, N37K, R41N, H69K, L89M, I93LC
 RenG11439RenG11439KT742467PINAI54V, V82A L10V, T12S, I15V, L19LI, K20R, E35D, M36I, N37K, R41N, Q61N, L63P, H69Q, L89M, I93LC
 RenG11741RenG11741KT742769PINAM46MI, I54V, V82A, L90ML33F, K43T, N88DL10V, I13V, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, T74KR, L89M, I93LC
 RenG10527RenG10527KT741555PINA  L10V, I13V, I15V, K20R, M36I, N37K, R41N, I62V, L63T, H69K, T74A, L89M, I93LC
 RenG11250RenG11250KT742278PINAM46I, I50IL, I54V, V82F, L90M L10V, V11VL, K14R, I15V, Q18P, K20T, E35D, M36I, N37K, R41N, K55H, Q61QE, I62V, L63P, H69K, A71AV, T74A, L89I, I93ILC
Rossouw (2015)RP053RP053KT032014LPV63  L10V, I15V, L19I, E35D, M36I, R41K, K43R, H69K, T74S, L89M, I93LC
 RP123-1RP123-1KT032043PINAM46I, I47V, I54V, L76V, V82AQ58EL10V, I15V, L19I, K20R, M36I, K55KR, D60E, L63P, H69K, A71V, L89M, I93LC
 RP102-1RP102-1KT032034PINAM46I, I54V, L76V, V82A L10V, I15V, L19I, K20R, M36I, R41K, D60E, Q61E, I62V, L63P, H69K, I72IV, L89M, I93LC