<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10V
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 32
Isolates 43
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL384IL384aAY529618IDV, SQV, RTV, NFV154M46I, I54V, V82A, L90MT74PW6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93LC
  IL384bAY529622IDV, SQV, RTV, NFV239M46I, I54V, V82A, L90MT74PL10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93LC
Non-B Workgroup (2005)BR6BR6AY900885SQV, RTV, IDV306I54V, I84V, L90ML89VL10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93LC
 BR42BR42AY900895NFV97M46I, L90M L10V, E35D, M36I, N37K, R41N, L63P, I64V, H69K, L89MC
 TK1002TK1002 RTV225M46I, I54V, V82A L10V, T12S, K14KR, I15V, L19I, K20R, M36I, R41K, Q61H, L63V, H69K, K70KR, T74S, L89M, I93LC
 TK3013TK3013 SQV, NFV205L90MG73SL10V, R41K, L63P, A71I, V77I, L89M, I93LC
 TK3016TK3016 SQV, NFV167I54V, L90MT74PL10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93LC
 TK4011TK4011 SQV, RTV, NFV, IDV261V82A, L90MQ58E, G73SL10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93LC
 PL2795660622 NFV, RTV, IDV184L90MR L10V, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62IV, L63P, H69K, A71AV, T74S, V77VI, I93LC
 PL472569936 Unknown, LPV>51G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95CFC
  80404 Unknown, LPV>90G48V, I54V, V82S, L90MQ58EL10V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95FC
  100703 Unknown, LPV, APV>159M46ML, G48V, I54V, V82S, L90MV11VI, L33F, Q58EL10V, I13V, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55R, I62V, L63P, H69K, K70KR, A71T, I72IM, T74S, I85V, L89I, I93L, C95F, T96SC
Baxter (2006)48-22542254-30930DQ877888PINAG48V, I54V, V82S, L90ML33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93L, C95F, T96TSC
 48-50965096-30901DQ878592PINAM46I, I54V, V82A, L90MK43KT, T74PL10V, I13A, K20IM, E21K, A22V, M36I, R41RK, K55R, Q61N, L63P, I64V, H69K, L89M, I93LC
Sen (2007)T076NPT76EF186928NFV, RTV M46L, V82A, L90MT74PL10V, T12A, I15V, L19I, K20R, M36I, N37D, K55N, L63P, H69K, A71V, I93LC
von Wyl (2007)19702313EF449901PINAI54IV, N88NS, L90M L10V, T12K, I15V, G16E, L19I, K20R, E35D, M36IV, N37Q, P39Q, R41N, D60DN, Q61QH, I62V, L63T, H69K, A71AV, I72IT, T74A, L89M, I93LC
 1017278778EF449991RTV, PINA  L10V, L19I, M36I, L63S, H69K, I72V, L89M, I93LC
Pillay (2008)DR68DR68AY589917RTV104M46I, I54V, V82A L10V, T12S, I15V, L19I, E35ED, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93LC
El-Khatib (2010)Pat07811ZA_SAVE1172JF960528LPV   L10V, I15V, L19V, K20R, M36I, R41K, H69K, L89M, I93LC
Rodrigues (2010)320_07BR07SC320GQ401304LPV   L10V, T12S, I15V, K20R, E35D, M36I, N37K, R41N, H69K, L89M, I93LC
 301_07BR07SC301GQ401314SQV, RTV, LPV M46L, G48V, I54V, V82SL24I, L33F, T74PL10V, I13V, I15V, G16E, K20M, E34Q, E35D, M36I, N37NKT, R41N, K55R, L63T, H69K, L89M, I93LC
Van Zyl (2013)11701077KC422863LPV26M46I, I54V, V82AF53FLL10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
  959KC424396LPV27M46I, I54V, V82A L5LF, L10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
  1420KC423137LPV27M46I, I54V, V82AF53FLL10V, I15V, L19V, K20R, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 17041443KC423148LPV26I54V, L76LV, V82VAQ58QEL10V, T12S, I15V, L19I, K20KR, E34EQ, M36I, N37S, R41K, L63P, H69K, K70R, A71AV, L89M, I93LC
 15332947KC423906LPV26  L10V, T12TS, K14KR, I15V, G16E, L19I, M36I, K45R, L63T, H69K, L89M, I93LC
 13001765KC423388LPV26  L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LC
 1523326KC423987LPV26I54V, L76V, V82A L10V, T12TS, I15V, L19I, K20R, M36I, N37D, K55R, R57RK, D60E, I62V, L63P, H69K, A71V, L89M, I93LC
Grossman (2014)794794KF135147LPV52  L10V, T12S, I15V, K20R, E35D, M36I, R41K, H69K, T74S, L89IM, I93LC
 11141114KF134952LPV52M46I, I54V, L76V, V82A L10V, T12S, I15V, L19I, K20R, M36I, R41K, L63V, E65ED, H69K, A71V, I72V, T74S, L89M, T91S, I93LC
 638638KF135117IDV, LPV52L90M Q7T, L10V, I15V, K20T, M36I, N37NH, R41K, L63P, I64IV, H69K, I85IV, L89M, I93LC
 435435KF135075IDV, LPV52  L10V, I15V, K20R, M36I, R41K, H69K, L89M, I93LC
 293293KF135044NFV, LPV52  L10V, K14KR, I15V, M36I, N37D, R41RK, D60E, Q61E, H69K, L89M, I93LC
  293KF135045NFV, LPV80  L10V, I13K, M36I, N37D, R41K, D60E, Q61E, H69K, L89M, I93LC
  293KF135046NFV, LPV178  L10V, K14KR, I15V, M36I, N37D, R41K, D60E, Q61E, H69K, T74TS, L89M, I93LC
 5252KF135094RTV, LPV52M46I, I54IV, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63PT, H69K, I72IT, L89M, I93LC
  52KF135095RTV, LPV115M46I, I54V, L76V, V82A, L90M L10V, K14KQ, I15V, L19V, K20R, M36I, N37D, R41K, Q61E, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135097RTV, LPV210M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55KR, Q61E, I62IV, L63P, H69K, A71V, I72IT, L89M, I93LC
  52KF135098RTV, LPV267M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, L89M, I93LC
  52KF135099RTV, LPV314M46I, I54V, L76V, V82A, L90M L10V, I15V, L19V, K20R, M36I, N37D, R41K, K55R, R57K, Q61E, L63P, H69K, A71V, T74TS, L89M, I93LC
 9292KF135163NFV, LPV52  W6C, R8Q, L10V, I15V, L19I, M36I, R41K, L63LV, H69K, T74S, L89M, I93LC
 18341834KF135004LPV52  L10V, K20R, M36I, R41K, Q61E, H69K, T74S, L89M, I93LC
 55KF135110RTV, LPV52M46L, I54V, V82AL24L*IR, N88NDL10V, I15V, K20R, E35D, M36I, R41K, Q61N, L63C, H69K, T74A, L89MC