<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10R
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 11
Isolates 11
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Grossman (2004)IL401IL401AY529596NFV209L90LM L10R, V11F, K14R, D29DV, E35D, M36V, N37ND, R41K, L63P, I64IV, H69K, I72IV, L89LM, I93LC
Non-B Workgroup (2005)TK3032TK3032 SQV, IDV239M46I, I54V, V82T, L90M L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63P, G68GE, H69K, L89M, I93L, C95FC
 TK4004TK4004 IDV, SQV, RTV, NFV, LPV278M46I, L90M L10R, I15V, L19I, K20M, M36I, R41K, L63P, H69K, K70R, L89M, I93LC
Pillay (2008)DR9303ZA.DR93AY589932IDV, LPV M46I, L90M L10R, T12S, G17D, L19T, K20M, M36I, R41K, K55KR, L63T, H69K, I72T, L89M, I93LC
Waleria-Aleixo (2008)08PR04015708PR040157FJ591188PINAM46L, I54V, V82A, L90M L10R, L19LI, K20R, E35D, M36I, N37K, R41N, I62V, L63P, H69K, A71V, I93LC
 08PR05043908PR050439FJ591436PINAI54V, V82T, L90M L10R, I13V, I15V, K20T, E35D, M36I, N37K, R41N, L63P, H69K, A71I, L89I, I93L, C95FC
 08PR05039508PR050395FJ591420PINAM46I, I84V L10R, K14R, I15V, K20T, E35G, M36I, N37K, P39S, R41N, I62V, L63P, H69K, A71T, L89M, I93LC
Van Zyl (2013)77111.ZA.WC161KC423531LPV M46I, I50V, I54V, V82A L10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69R, K70Q, A71V, I93LC
Diaz (2015)RenG14186RenG14186KT745214PINAD30N, M46L, I54V, V82AQ58QE, N88DL10R, I15V, K20T, E35D, M36I, N37K, R41N, D60DE, Q61QH, L63P, I64IL, H69K, A71V, L89I, I93LC
Steegen (2016)ZA14GFLPC006ZA14GFLPC006KU253131LPV I54V, V82A L10R, T12S, I15V, L19I, K20R, M36I, R41K, Q61H, L63P, H69K, A71V, V77I, I93LC
Posada Cespedes (2017)492715.ZA.GT4033 DRV, RTV M46IQ58EL10R, T12S, I15V, L19I, K20R, E35D, M36I, R41K, D60E, L63P, H69K, L89T, I93LC