<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10M
Rx PI-naive
IncludeMixtures No
References 41
Patients 92
Isolates 92
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M3M3AY010393None   L10M, T12S, I15V, N37S, L63T, H69K, K70Q, L89M, I93LC
Brindeiro (2003)BRP2145BRP2145AY213447None  V11IL10M, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
Eshleman (2005)ESH7079ESH7079AY756873None   L10M, I15IV, L19I, M36I, P39PL, R41K, L63P, H69K, L89M, I93LC
Grossman (2005)2535825358PR392 None   L10M, I15V, G16E, N37NS, P39PS, D60DE, L63DH, H69K, T74TA, L89M, I93LC
Weber (2005)32769323276932AY677495None   L10M, T12S, G17D, L19I, K20R, M36I, R41K, L63AT, H69K, I72EV, I93LC
Parreira (2006)PG41PG41AM071420None   L10M, I15V, L19T, E35D, M36I, R41K, Q61E, L63P, H69K, L89M, I93LC
Rousseau (2006)Pt8903SK029B2AY772691None   L10M, I13V, K14R, L19I, M36I, R41K, I62V, L63V, H69K, T74A, L89M, I93LC
 Pt10803SK073B1AY901970None   L10M, T12S, I15V, L19I, M36I, R41K, H69K, K70R, L89MC
 Pt12103SK107B1DQ056410None   L10M, T12S, I15V, L19I, M36I, P39S, R41K, K45R, Y59C, H69K, L89M, I93LC
Vidal (2007)U182502BU.U1825AM260228None   L10M, T12S, I15V, L19I, M36I, N37K, R41N, L63T, H69K, I93LC
 U043502BU.U0435AM260284None   L10M, L19I, M36I, N37K, R41N, L63P, H69K, I93LC
Deho (2008)135135EU244657None   L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61D, L63N, H69K, L89M, I93LC
 127127EU244659None   L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, I62V, L63I, H69K, T74A, L89M, I93LC
 123123EU244688None   L10M, T12S, I15V, L19I, E35D, M36I, R41K, R57K, L63P, H69KC
Ferreira (2008)430BR05PR430EU340715None   L10M, I15V, E35D, N37K, R41N, I62V, L63I, H69K, T74A, L89M, I93LC
Jacobs (2008)18021802EF602235None   L10M, I15V, L19V, M36I, R41K, L63Q, H69K, L89M, I93LC
Matthews (2008)SK029SK029FJ199858None   L10M, I13V, K14R, L19I, M36I, R41K, I62V, L63V, H69K, T74A, L89M, I93LC
 SK073SK073FJ199880None   L10M, T12S, I15V, L19I, M36I, R41K, H69K, K70R, L89MC
 SK107SK107FJ199895None   L10M, T12S, I15V, L19I, M36I, P39S, R41K, K45R, Y59C, H69K, L89M, I93LC
Huang (2009)Blm_x0110Blm_x0110KT737006None   L10M, T12S, I15V, L19T, K20R, E35D, N37D, Q61E, L63P, H69K, V77I, L89M, I93LC
 Blm_x0408Blm_x0408KT737081None   L10M, V11A, I13V, G17N, L19T, K20R, M36I, R41K, L63P, H69K, L89M, I93LC
Wallis (2009)GT00238555GT00238555 None   L10M, I15V, L19I, E35D, M36I, R41K, K45R, H69K, L89M, I93LC
 TJC2378119TJC2378119 None   L10M, I13V, L19V, M36I, R41K, L63S, H69K, I72E, L89M, I93LC
Wright (2010)351SK351HM593357None   L10M, I15V, L19I, E35D, N37S, R41K, C67E, H69K, L89M, I93L, L97LIC
Ferreira (2011)BRMT3086BRMT3086HQ638743None   L10M, T12S, I13V, I15V, L19I, M36I, N37K, R41N, Q61E, I62V, L63V, E65D, H69K, T74S, L89M, I93LC
Green (2011)707PKE18F707PKE18FHM623508None   L10M, T12S, I15V, L19V, E35D, M36I, R41K, I62V, L63I, H69K, T74S, L89M, I93LC
Hamers (2011)300149CP076300149HM119725None   T4A, L10M, T12S, K14KR, I15V, L19V, M36I, R41K, Q61H, H69K, K70KE, L89M, I93LC
 300206CP076300206HM119775None   L10M, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
 300513CP076300513HM119930None   L10M, T12S, I15V, G17D, L19I, E35D, M36MI, R41K, I62V, L63AITV, C67CW, H69K, T74TA, L89M, I93LC
 300575CP076300575HM119979None   L10M, L19I, E35D, M36I, R41K, C67CG, H69K, L89M, I93LC
 CP076300332CP076300332HQ994369None   L10M, T12S, L19I, K20R, M36I, P39S, R41K, L63V, H69K, L89M, I93LC
 CP076300394CP076300394HQ994398None   L10M, M36I, R41K, H69Q, V77I, L89M, I93LC
 CP076301498CP076301498HQ994451None  V11VIL10M, T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63IV, H69K, L89M, I93LC
 CP076301009CP076301009HQ994565None   L10M, T12S, L19I, M36I, R41K, Q61E, L63P, C67Y, H69K, L89M, I93LC
 CP763A03377CP763A03377HQ994911None   L10M, K14R, I15V, L19I, E35D, M36I, R41K, I62IV, H69K, T74TS, L89LM, T91I, I93LC
Manasa (2011)10053711005371JN665023None   L10M, T12S, I15V, L19I, M36I, N37A, R41K, R57K, L63H, H69K, L89M, I93LC
Nwobegahay (2011)08MB69ZA08MB69ZAGU188847None   I3V, L10M, I13V, I15K, G17S, L19I, K20R, M36I, P39Q, L63Q, H69K, L89M, I93LC
van Zyl (2011)A142A142JN638086None   L10M, T12S, I15V, L19V, K20M, E35D, M36I, P39Q, R41K, L63V, H69K, L89M, I93LC
 A268A268JN638160None   L10M, L19I, E35D, R41K, R57RK, L63S, H69Q, L89M, I93LC
 A89A89JN638229None   L10M, T12A, K14R, I15V, G16E, R41K, D60DE, Q61QE, L63ST, E65ED, I66IV, H69K, L89M, I93LC
De Gascun (2012)IRL32246IRL32246JN622879None   L10M, T12A, L19I, M36I, R41K, L63V, H69K, V77I, L89M, I93LC
Hingankar (2012)IN-NARI-4-029IN-NARI-4-029JN314918None   L10M, T12S, I15V, L19I, M36I, R41K, L63AS, H69KQ, I93LC
Hunt (2012)KZN09_384685KZN09_384685KF736779None   L10M, T12TS, I15V, L19V, M36I, R41K, L63T, H69K, L89M, I93LC
Manak (2012)16_LH0316_LH03JN687644None   L10M, T12S, L19V, E35D, R41K, K45R, L63P, H69K, L89M, I93LC
 16_LH0116_LH01JN687643None   L10M, T12S, L19V, E35D, R41K, K45R, L63P, H69K, L89M, I93LC
 16_LH0416_LH04JN687645None   L10M, T12S, L19V, E35D, R41K, K45R, L63P, H69K, L89M, I93LC
Nwobegahay (2012)MC43ZAMC43ZAGU177526None  V11IT4I, L10M, T12S, K14R, I15V, L19T, E35D, M36I, N37E, R57K, L63V, H69K, L89M, I93LC
Kiertiburanakul (2013)R12109R12109KC994250None   L10M, T12S, I15V, L19I, M36I, R41K, D60E, L63LAPV, H69K, L89M, I93LC
Manasa (2013)RES325RES325KC951781None   L10M, V11A, T12S, I15V, N37S, R41K, L63T, H69K, V77I, L89M, I93LC
 RES320RES320KC951776None   L10M, I15V, L19I, E35D, R41K, H69K, L89M, I93LC
Sunpath (2013)CAS031CAS031 None   L10M, T12S, L19V, M36I, R41K, L63V, H69K, L89M, I93LC
 CAS069CAS069 None   L10M, I15V, L19V, M36I, N37D, L63S, H69K, I72V, L89M, I93LC
Van Zyl (2013)392011.ZA.GT1583KC423371None   L10M, I15V, L19T, K20M, E35D, M36I, R41K, Q61H, H69K, L89M, I93LC
 175109.ZA.GT676KC423267None   L10M, T12S, G16E, L19I, N37S, P39L, D60E, I62V, L63T, H69K, L89M, I93LC
 212809.ZA.GT658KC424226None   L10M, T12S, K14R, I15V, L19I, M36I, R41K, D60E, H69K, L89M, I93LC
 194612.ZA.GT2317KC423953None   L10M, T12P, I15V, L19V, M36I, R41K, L63P, H69K, L89M, I93LC
 316608.ZA.GT599KC423999None   L10M, T12S, I15V, L19V, M36I, P39S, R41K, L63V, H69K, L89M, I93LC
 372110.ZA.GT1392KC423199None   L10M, T12S, I15V, L19I, K20R, M36I, N37S, R41K, L63AS, H69K, V77I, L89M, I93LC
 264811.ZA.GT1697KC423493None   L10M, T12E, I15V, L19T, K20I, M36I, R41K, Q61H, L63H, H69K, L89M, I93LC
 348509.ZA.GT855KC424351None   L10M, K14R, I15V, L19I, E35D, R41K, H69K, L89M, I93LC
 266008.ZA.GT478KC423670None   L10M, I15V, A28AT, M36I, R41K, L63V, H69K, L89M, I93LC
Budambula (2015)MK119MK119KP792113None   L10M, T12S, I15V, L19I, M36I, N37K, R41N, Q61E, L63T, H69K, I93LC
Giandhari (2015)50792005_ZA_5079BKP056169None   L10M, T12S, I15V, L19I, N37K, R41I, L63T, H69KC
Guimaraes (2015)BRSP321-12BRSP321-12KP115425None   L10M, M36I, N37K, R41N, R57K, H69Q, L89M, I93LC
Novitsky (2015)mpp_424mpp_424KR861187None   L10M, T12S, I15V, L19I, L63T, H69K, T74A, L89M, I93LC
Skhosana (2015)11ZALS03611ZALS036KM115719None   L10M, T12S, I15V, M36I, R41K, Q61E, H69K, L89M, I93LC
 11ZALS05311ZALS053KM115737None   L10M, T12TS, K14KR, I15V, L19IV, E35D, M36I, N37D, R41K, D60E, Q61E, L63V, H69K, L89M, I93LC
 11ZALS01411ZALS014KM115721None   I3V, L10M, I15IV, L19I, M36I, R41K, I62V, L63Q, H69K, A71T, I72E, I93LC
Amogne (2016)ET20ET20KU319742None   L10M, V11A, K20R, M36I, R41K, I62V, H69K, L89M, I93LC
 ET121ET121KU319689None   I3V, L10M, T12P, I13V, I15V, G16E, L19I, K20R, M36I, R41K, D60N, Q61E, L63T, H69K, L89M, I93LC
Baudi (2016)Zi14-176Zi14-176KX648553None   L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, C67S, H69K, L89M, I93LC
 Zi14-026Zi14-026KX648646None   L10M, K14R, I15V, L19I, M36I, N37E, R41K, R57K, L63A, C67G, H69K, T74A, L89M, I93LC
 Zi14-154Zi14-154KX648567None   L10M, T12S, K14R, I15V, L19I, M36I, R41K, L63T, H69Q, L89M, I93LC
Lam (2016)2001100620011006KR868157None   I3IL, L10M, T12S, L19I, E35D, M36I, R41K, R57K, D60E, I62V, H69K, L89MC
 9902202399022023KR867763None   L10M, L19T, M36I, R41K, K45R, R57K, Q61E, I62V, C67S, H69Q, L89M, I93LC
Neogi (2016)375913.ZA.GT2773KT593128None   L10M, T12S, I15V, L19I, M36I, N37D, L63T, H69Q, I93LC
 194913.ZA.GT2859KT593192None   L10M, T12S, G16E, L19V, M36I, R41K, D60E, Q61E, I62V, L63Q, C67S, H69K, L89M, I93LC
Steegen (2016)GFKZB133GFKZB133KU127986None  V11IL10M, T12S, I15V, L19I, M36I, R41K, I62V, L63T, C67S, H69K, I93LC
 GFKZB132GFKZB132KU128022None   L10M, T12A, I15V, L19I, M36L, R41K, H69K, L89M, I93LC
 GFMPB010GFMPB010KU127864None   L10M, T12S, I13V, I15V, L19I, E35D, N37NS, R41K, L63C, H69K, A71T, I93LC
 GFKZB162GFKZB162KU128053None   L10M, T12S, I15V, L19IT, M36I, R41K, H69K, L89M, I93LC
 GFKZB354GFKZB354KU128270None   I3V, L10M, T12S, I15V, L19I, K20R, M36I, R41K, L63T, H69K, V77I, L89M, I93LC
 GFKZB321GFKZB321KU128238None   L10M, T12S, L19I, E35D, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 GFKZB293GFKZB293KU128209None   L10M, T12S, I15V, L19V, E35D, M36I, R41K, Q61H, L63I, H69K, L89M, I93LC
 GFKZB234GFKZB234KU128141None   L10M, T12S, L19I, E35D, M36I, R41K, K45R, L63A, H69K, L89M, I93LC
 GFKZB390GFKZB390KU128305None   L10M, I15V, E35D, N37S, R41K, L63P, C67S, H69K, L89M, I93LC
Steegen (2016)GFECA021GFECA021KT893239None   L10M, I15V, L19T, M36I, N37D, L63HP, H69K, L89M, I93LC
 GFGPA003GFGPA003KT892981None   L10M, T12S, I15V, G16E, L19I, E35ED, M36I, R41K, I62IV, L63V, H69K, T74S, V77I, L89M, I93LC
 GFLPA002GFLPA002KT893119None   L10M, L19I, R41K, L63T, H69K, L89M, I93LC
 GFLPA014GFLPA014KT893219None   I3V, L10M, T12S, I15V, L19I, M36I, R41K, Q61E, L63S, H69K, I93LC
 GFNWA002GFNWA002KT893096None   L10M, T12S, I15V, L19I, E35ED, N37S, R41RK, L63I, H69K, L89M, I93LC
 GFECA013GFECA013KT893039None   L10M, T12S, I15V, L19T, M36I, P39S, H69K, L89M, I93LC