Protease Inhibitors

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Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L10M
Rx	PI-naive
IncludeMixtures	No

References	24
Patients	41
Isolates	41

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Yahi (2001)	NY_M3	M3	AY010393	None		L10M, T12S, I15V, N37S, L63T, H69K, K70Q, L89M, I93L	C
Brindeiro (2003)	BRP2145	BRP2145	AY213447	None	V11I	L10M, I15V, M36I, N37K, R41N, H69K, L89M, I93L	C
Eshleman (2005)	ESH7079	ESH7079	AY756873	None		L10M, I15IV, L19I, M36I, P39PL, R41K, L63P, H69K, L89M, I93L	C
Grossman (2005)	25358	25358PR392		None		L10M, I15V, G16E, N37NS, P39PS, D60DE, L63DH, H69K, T74TA, L89M, I93L	C
Weber (2005)	3276932	3276932	AY677495	None		L10M, T12S, G17D, L19I, K20R, M36I, R41K, L63AT, H69K, I72EV, I93L	C
Parreira (2006)	PG41	PG41	AM071420	None		L10M, I15V, L19T, E35D, M36I, R41K, Q61E, L63P, H69K, L89M, I93L	C
Rousseau (2006)	Pt89	03SK029B2	AY772691	None		L10M, I13V, K14R, L19I, M36I, R41K, I62V, L63V, H69K, T74A, L89M, I93L	C
	Pt108	03SK073B1	AY901970	None		L10M, T12S, I15V, L19I, M36I, R41K, H69K, K70R, L89M	C
	Pt121	03SK107B1	DQ056410	None		L10M, T12S, I15V, L19I, M36I, P39S, R41K, K45R, Y59C, H69K, L89M, I93L	C
Vidal (2007)	U1825	02BU.U1825	AM260228	None		L10M, T12S, I15V, L19I, M36I, N37K, R41N, L63T, H69K, I93L	C
	U0435	02BU.U0435	AM260284	None		L10M, L19I, M36I, N37K, R41N, L63P, H69K, I93L	C
Deho (2008)	135	135	EU244657	None		L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61D, L63N, H69K, L89M, I93L	C
	127	127	EU244659	None		L10M, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, I62V, L63I, H69K, T74A, L89M, I93L	C
	123	123	EU244688	None		L10M, T12S, I15V, L19I, E35D, M36I, R41K, R57K, L63P, H69K	C
Ferreira (2008)	430	BR05PR430	EU340715	None		L10M, I15V, E35D, N37K, R41N, I62V, L63I, H69K, T74A, L89M, I93L	C
Jacobs (2008)	1802	1802	EF602235	None		L10M, I15V, L19V, M36I, R41K, L63Q, H69K, L89M, I93L	C
Matthews (2008)	SK029	SK029	FJ199858	None		L10M, I13V, K14R, L19I, M36I, R41K, I62V, L63V, H69K, T74A, L89M, I93L	C
	SK073	SK073	FJ199880	None		L10M, T12S, I15V, L19I, M36I, R41K, H69K, K70R, L89M	C
	SK107	SK107	FJ199895	None		L10M, T12S, I15V, L19I, M36I, P39S, R41K, K45R, Y59C, H69K, L89M, I93L	C
Wallis (2009)	GT00238555	GT00238555		None		L10M, I15V, L19I, E35D, M36I, R41K, K45R, H69K, L89M, I93L	C
	TJC2378119	TJC2378119		None		L10M, I13V, L19V, M36I, R41K, L63S, H69K, I72E, L89M, I93L	C
Hamers (2010)	300149	CP076300149	HM119725	None		T4A, L10M, T12S, K14KR, I15V, L19V, M36I, R41K, Q61H, H69K, K70KE, L89M, I93L	C
	300206	CP076300206	HM119775	None		L10M, L19I, M36I, R41K, L63T, H69K, L89M, I93L	C
	300513	CP076300513	HM119930	None		L10M, T12S, I15V, G17D, L19I, E35D, M36MI, R41K, I62V, L63AITV, C67CW, H69K, T74TA, L89M, I93L	C
	300575	CP076300575	HM119979	None		L10M, L19I, E35D, M36I, R41K, C67CG, H69K, L89M, I93L	C
Wright (2010)	351	SK351	HM593357	None		L10M, I15V, L19I, E35D, N37S, R41K, C67E, H69K, L89M, I93L, L97LI	C
Ferreira (2011)	BRMT3086	BRMT3086	HQ638743	None		L10M, T12S, I13V, I15V, L19I, M36I, N37K, R41N, Q61E, I62V, L63V, E65D, H69K, T74S, L89M, I93L	C
Green (2011)	707PKE18F	707PKE18F	HM623508	None		L10M, T12S, I15V, L19V, E35D, M36I, R41K, I62V, L63I, H69K, T74S, L89M, I93L	C
Hamers (2011)	CP076300332	CP076300332	HQ994369	None		L10M, T12S, L19I, K20R, M36I, P39S, R41K, L63V, H69K, L89M, I93L	C
	CP076300394	CP076300394	HQ994398	None		L10M, M36I, R41K, H69Q, V77I, L89M, I93L	C
	CP076301498	CP076301498	HQ994451	None	V11VI	L10M, T12S, I15V, G16E, L19I, K20M, E35D, M36I, R41K, L63IV, H69K, L89M, I93L	C
	CP076301009	CP076301009	HQ994565	None		L10M, T12S, L19I, M36I, R41K, Q61E, L63P, C67Y, H69K, L89M, I93L	C
	CP763A03377	CP763A03377	HQ994911	None		L10M, K14R, I15V, L19I, E35D, M36I, R41K, I62IV, H69K, T74TS, L89LM, T91I, I93L	C
Manasa (2011)	1005371	1005371	JN665023	None		L10M, T12S, I15V, L19I, M36I, N37A, R41K, R57K, L63H, H69K, L89M, I93L	C
Nwobegahay (2011)	08MB69ZA	08MB69ZA	GU188847	None		I3V, L10M, I13V, I15K, G17S, L19I, K20R, M36I, P39Q, L63Q, H69K, L89M, I93L	C
van Zyl (2011)	A142	A142	JN638086	None		L10M, T12S, I15V, L19V, K20M, E35D, M36I, P39Q, R41K, L63V, H69K, L89M, I93L	C
	A268	A268	JN638160	None		L10M, L19I, E35D, R41K, R57RK, L63S, H69Q, L89M, I93L	C
	A89	A89	JN638229	None		L10M, T12A, K14R, I15V, G16E, R41K, D60DE, Q61QE, L63ST, E65ED, I66IV, H69K, L89M, I93L	C
De Gascun (2012)	IRL32246	IRL32246	JN622879	None		L10M, T12A, L19I, M36I, R41K, L63V, H69K, V77I, L89M, I93L	C
Hingankar (2012)	IN-NARI-4-029	IN-NARI-4-029	JN314918	None		L10M, T12S, I15V, L19I, M36I, R41K, L63AS, H69KQ, I93L	C
Nwobegahay (2012)	MC43ZA	MC43ZA	GU177526	None	V11I	T4I, L10M, T12S, K14R, I15V, L19T, E35D, M36I, N37E, R57K, L63V, H69K, L89M, I93L	C

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