Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	C
Gene	PR
Mutation	L10I
Rx	PI-naive
IncludeMixtures	No

References	51
Patients	117
Isolates	117

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Hierholzer (2002)	SU227	SU227	AY102497	None		L10I, M36I, R41K, L63I, H69Q, L89M, I93L	C
Kantor (2002)	TCDD-10	TCDD-10		None		L10I, T12S, G17D, L19I, M36L, N37S, D60E, L63T, H69K, L89M, I93L	C
Brindeiro (2003)	BRP2151	BRP2151	AY213457	None		L10I, I15V, M36I, N37K, R41I, H69K, L89M, I93L	C
	BRSC1812	BRSC1812	AY213508	None		L10I, G17E, M36I, N37K, R41N, H69K, L89M	C
	BRSP1501	BRSP1501	AY213239	None		L10I, G17GW, L19P, K20E, M36I, N37K, R41N, L63I, H69K, L89M, I93L	C
	BRP2097	BRP2097	AY213360	None		L10I, E34G, G40R, H69K, L89M, I93L	C
	BRP2105	BRP2105	AY213376	None		L10I, I15V, G16A, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2143	BRP2143	AY213445	None		L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2141	BRP2141	AY213441	None		L10I, I15V, L19S, N37K, R41N, L63P, H69K, K70R, I93L	C
	BRP2120	BRP2120	AY213403	None		L10I, A71V	C
	BRP2104	BRP2104	AY213374	None		L10I, I15V, L19I, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2102	BRP2102	AY213370	None		L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2100	BRP2100	AY213366	None		L10I, I15V, G16E, E21G, M36I, N37K, R41N, H69K, I93L	C
	BRP2150	BRP2150	AY213455	None		L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2142	BRP2142	AY213443	None		L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2121	BRP2121	AY213405	None		L10I, I13V, I15V, M36I, N37K, R41N, H69K, L89M, I93L	C
Gordon (2003)	ZA044p01	ZA044p01	AY136997	None		L10I, L19V, M36I, P39S, R41K, L63P, H69K, L89M, I93L	C
Soares (2003)	BRP2022	BRP2022	AF527205	None		L10I, M36T, N37K, R41N, H69K, L89M, I93L	C
	BRP2024	BRP2024	AF527207	None		L10I, K20R, M36I, N37K, R41N, L63T, H69K, L89M	C
	BRP2026	BRP2026	AF527211	None		L10I, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2039	BRP2039	AF527230	None		L10I, I13V, I15V, M36I, N37K, R41N, D60E, H69K, L89M, I93L	C
	BRP2044	BRP2044	AF527240	None		L10I, M36I, N37K, R41N, H69K, L89M, I93L	C
	BRP2045	BRP2045	AF527242	None		L10I, N37K, R41N, H69K, L89M, I93L	C
	BRP2053	BRP2053	AF527256	None		L10I, N37K, R41N, H69K, N88K, I93L	C
	BRRJ845	BRRJ845	AF527340	None		L10I, I15V, E34G, E35D, M36I, N37K, R41N, H69K, L89M, I93L	C
Deshpande (2004)	in31	in31	AY515752	None		L10I, T12S, K14R, I15V, L19T, M36V, P39Q, R41K, L63P, H69K, L89M, I93L	C
Arroyo (2005)	CO6770	CO6770	AY734554	None		L10I, I15V, M36I, N37K, R41N, K45R, C67S, H69K, L89M, I93L	C
Bellocchi (2005)	146	MC146	GU199536	None		L10I, I15V, L19I, K20R, M36I, R41K, C67D, H69K, V77I, L89M, I93L	C
Bussmann (2005)	01BW2210N	01BW2210N	AY829309	None		L10I, T12S, I15V, L19I, M36I, R41K, R57K, I62V, L63G, H69K, A71T, L89M, I93L	C
Grossman (2005)	18303	18303PR217		None		L10I, K20KR, M36I, R41K, L63X, H69Q, L89M, I93L	C
	23917	23917PR328		None		L10I, L19I, M36I, R41K, Q61Q*, H69K, L89M, I93L	C
	27503	27503PR449		None		L10I, I13V, M36I, R41K, D60E, L63T, H69K, L89M	C
Non-B Workgroup (2005)	BR1001	BR1001	AY900898	None		L10I, M36T, N37K, R41N, H69K, L89M, I93L	C
	BR1002	BR1002	AY900899	None		L10I, K20R, M36I, N37K, R41N, L63T, H69K, L89M	C
	BR1003	BR1003	AY900900	None		L10I, M36I, N37K, R41N, H69K, L89M, I93L	C
	BR1008	BR1008	AY900904	None		L10I, I13V, I15V, M36I, N37K, R41N, D60E, H69K, L89M, I93L	C
	BR1009	BR1009	AY900905	None		L10I, M36I, N37K, R41N, H69K, L89M, I93L	C
	BR1010	BR1010		None		L10I, N37K, R41N, H69K, L89M, I93L	C
	BR1013	BR1013	AY900907	None		L10I, N37K, R41N, H69K, N88K, I93L	C
	BR1026	BR1026	AY900917	None		L10I, I15V, G16E, E21G, M36I, N37K, R41N, H69K, I93L	C
Rousseau (2006)	Pt63	03PS119MB1	DQ351238	None		L10I, E35D, M36I, R41K, L63Q, H69K, L89M	C
Santos (2006)	097	097PR_RT	AY275757	None		L10I, T12P, I13V, K14R, I15V, K20R, M36I, N37K, R41N, H69K, L89M, I93L	C
	C077PR	C077PR	DQ191013	None		L10I, M36T, N37K, R41N, L63P, H69K, L89M, I93L	C
Gatanaga (2007)	C04-51110164-1	C04-51110164-1	AB640264	None		L10I, K14R, I15V, L19I, E35D, M36IV, R41K, L63P, C67E, H69K, V82I, L89M, I93L	C
McGrath (2007)	7	DMG_7		None		L10I, I13V, G16GE, L19T, K20R, M36I, R41K, L63AITV, I64IM, E65D, H69K, L89M, I93L	C
Novitsky (2007)	1646	1646_3858	EF026222	None		L10I, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, L63PS, I64IL, H69K, L89M, I93L	C
	1898	1898_4401	EF026226	None		L10I, T12S, I13V, I15V, L19I, M36I, R41K, I62V, L63V, H69K, A71T, L89M, I93L	C
Vidal (2007)	U0127	02BU.U0127	AM260221	None		L10I, I15V, G16E, M36I, N37K, R41N, H69K, L89M, I93L	C
Deho (2008)	145	145	EU244686	None		L10I, T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93L	C
Ferreira (2008)	448	BR05PR448	EU340722	None		L10I, I15V, L19I, M36L, N37R, R41N, H69K, L89M, I93L	C
Lahuerta (2008)	P63745	P63745_99	EF407733	None		L10I, K14R, I15V, L19I, M36I, R41K, H69K, L89M, I93L	C
Marconi (2008)	SW024	sw024	EU308037	None		L10I, T12S, I15V, L19V, M36I, R41N, D60E, I62V, L63R, H69K, L89M, I93L	C
	SW053	sw053	EU308064	None		L10I, L19V, M36I, R41K, H69K, T74S, L89M, I93L	C
Matthews (2008)	J120M	J120M	FJ199576	None		L10I, I15V, L19V, M36I, R41K, L63S, H69K, L89M, I93L	C
	PS401	PS401	FJ199808	None		L10I, T12S, I15V, L19V, E35D, M36I, R41K, H69K, L89M, I93L	C
Pillay (2008)	DR41	DR41	AY589896	None		L10I, T12S, I15V, M36I, R41K, Q61E, L63V, H69K, L89M, I93L	C
	DR66	DR66	AY589915	None		L10I, T12S, I15V, L19I, M36I, R41K, D60E, H69K, L89M, I93L	C
Hosseinipour (2009)	9402	9402	GQ228241	None		L10I, T12S, I15V, L19I, M36I, R41K, R57K, Q61E, I62V, L63V, E65D, H69K, T74A, L89M	C
	9300	9300	GQ228251	None		L10I, K14N, I15V, L19I, M36I, L63T, H69K, I93L	C
	9326	9326	GQ228256	None		L10I, K14R, I15V, L19I, M36I, R41K, L63V, H69K, T74A, L76L*, L89M, I93L	C
Kandathil (2009)	CD06_484	CD06_484	EU683783	None		L10I, T12S, I15V, L19I, M36I, N37X, R41K, I62V, L63P, I64L, H69K, V82I, L89M, I93L	C
	CD06_420	CD06_420	EU683772	None		L10I, T12S, I15V, L19I, M36I, R41K, K45Q, L63T, I72T, I93L	C
Rajesh (2009)	N7	TRCNPR7	FJ595370	None		L10I, T12S, I13V, K14R, I15V, L19I, M36I, R41K, L63A, H69K, L89M	C
Vercauteren (2009)	pt342	IqebD7pmBr	GQ400682	None		L10I, T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69Q, L89M, I93L	C
Wallis (2009)	GT00032651	GT00032651		None		L10I, T12S, K14I, I15V, L19IK, K20R, M36I, R41K, D60E, Q61QE, I62V, L63LI, H69K, T74A, L89M, I93L	C
	GT00103258	GT00103258		None		L10I, T12S, I15V, L19I, M36I, R41K, L63T, C67Y, H69K, T74S, L89M	C
Hamers (2010)	300060	CP076300060	HM119649	None		L10I, I15V, L19T, K20R, M36I, R41K, L63T, H69K, L89M, I93L	C
	300127	CP076300127	HM119704	None		L10I, T12S, I15V, L19I, R41K, K45R, L63P, H69Q, V77I, L89M, I93L	C
	300228	CP076300228	HM119794	None		L10I, T12S, I15V, L19I, E35D, M36I, N37T, R41K, H69K, L89M, I93L	C
	300451	CP076300451	HM119872	None		L10I, T12S, I15V, L19I, M36I, R41K, I62IV, L63H, H69K, L89I	C
	300462	CP076300462	HM119883	None		L10I, I15V, M36I, R41K, L63V, C67S, H69K, L89M, I93L	C
	300479	CP076300479	HM119898	None		L10I, I15V, L19T, M36I, N37K, R41N, L63T, H69K, I93L	C
	300539	CP076300539	HM119953	None		L10I, I15V, L19T, E35D, M36L, R41K, K45R, D60E, I62IV, H69Q, V77VI, L89M, I93L	C
	300552	CP076300552	HM119962	None		L10I, T12S, I15V, G16E, L19V, E35D, M36I, R41K, L63T, H69Q, L89M, I93L	C
Mosha (2010)	S33Pol	S33Pol	JQ071476	None		L10I, I15V, M36L, N37K, R41N, L63P, H69K, I93L	C
Wright (2010)	308	SK308	HM593312	None		L10I, T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63Q, H69K, L89M, I93L	C
	96	SK96	HM593507	None		L10I, L19V, M36I, P39PS, R41K, H69K, L89M, I93L	C
de Medeiros (2011)	Pat085	RS156	JF487914	None		L10I, I15V, L19Q, M36I, N37R, R41N, H69K, L89M, I93L	C
Graf (2011)	SC22	SC22	JF773996	None		L10I, M36I, N37K, R41N, H69K, L89M, I93L	C
	SC38	SC38	JF774005	None		L10I, I15V, M36T, N37K, R41N, L63T, C67G, H69K, L89I, I93L	C
	SC126	SC126	JF774050	None		L10I, K14R, I15V, K20R, M36I, N37K, R41N, K45R, L63T, C67E, H69K, L89M, I93L	C
Hamers (2011)	CP076303237	CP076303237	HQ994236	None		I3V, L10I, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
	CP076300309	CP076300309	HQ994357	None		L10I, T12S, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93L	C
	CP076300337	CP076300337	HQ994373	None	V11I	L10I, I15V, L19I, K20R, E35Q, M36I, N37D, R41K, R57K, L63X, H69K, L89M, I93L	C
	CP076301432	CP076301432	HQ994409	None		L10I, T12S, L19I, M36I, R41K, Q61N, L63V, E65D, H69K, L89M, I93L	C
	CP076300906	CP076300906	HQ994534	None		L10I, T12S, I15V, G16E, L19V, M36I, R41K, L63T, H69K, I93L	C
	CP076300933	CP076300933	HQ994549	None		L10I, T12S, I15V, G16E, L19I, M36I, R41K, L63IV, H69K, L89M, I93L	C
	CP076302682	CP076302682	HQ994821	None		L10I, T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93L	C
	CP076302687	CP076302687	HQ994826	None		I3V, L10I, I15V, L19I, M36I, N37NS, R41K, D60E, H69K, L89M, I93L	C
	CP763A01781	CP763A01781	HQ994877	None		L10I, I15V, L19I, M36I, R41K, L63S, H69K, L89M, I93L	C
	CP076303066	CP076303066	HQ995246	None		L10I, T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93L	C
Manasa (2011)	1002871	1002871	JN664997	None		L10I, T12S, L19V, M36I, R41K, Q61H, L63S, H69K, L89M, I93L	C
Nwobegahay (2011)	BBVCT05ZA	BBVCT05ZA	GU139621	None		L10I, T12S, I15V, L19I, M36I, R41K, L63S, H69K, K70R, I72T, I93L	C
Nwobegahay (2011)	08MB18ZA	08MB18ZA	GU188814	None	L33F	T4A, L5F, Q7K, R8E, L10I, T12P, I15V, L19I, K20R, A22G, L24F, T31S, M36I, L38F, R41K, K43E, K55N, V56K, R57G, L63P, H69K, V77I, I93L	C
	08MB41ZA	08MB41ZA	GU188824	None		L10I, I15V, L19T, M36I, R41K, L63T, H69K, I93L	C
	08MB49ZA	08MB49ZA	GU188831	None		L10I, T12S, I15V, L19V, E35D, M36I, R41K, L63T, E65D, H69K, L89M, I93L	C
	08MB50ZA	08MB50ZA	GU188832	None		L10I, T12S, I15V, L19T, M36L, N37S, R41K, L63V, H69K, L89M	C
	08MB74ZA	08MB74ZA	GU188849	None		L10I, T12S, I15V, L19V, E35D, M36I, R41K, K45R, D60E, I62V, L63V, H69Q, L89M, I93L	C
Sanabani (2011)	BR2040	BR2040	JN692442	None		L10I, I15V, L19I, M36T, N37K, R41N, L63T, C67G, H69K, L89I, I93L	C
Santos (2011)	J124	J124_PR	JN010500	None		L10I, V11A, I15V, G16E, M36I, N37K, R41N, L63V, H69K, L89M, I93L	C
	J335	J335_PR_RT_CN	JN010712	None		L10I, I13V, I15V, E35ED, N37K, R41I, D60E, H69K, T74TA, L89M, I93L	C
Sigaloff (2011)	GP25416072	GP25416072_2	JN381562	None		L10I, T12S, I15V, L19T, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
Thorat (2011)	Pat011	IN-NARI-HIVDR-5-011	HQ166849	None		L10I, T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93L	C
van Zyl (2011)	A216	A216	JN638127	None		L10I, T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93L	C
De Gascun (2012)	IRL40593	IRL40593	JN622886	None		W6WL, L10I, V11VF, T12S, I15V, L19I, E35ED, M36MI, N37NS, R41K, L63I, H69K, V82I, L89M, I93L	C
	IRL04107	IRL04107	JN622983	None		L10I, I15V, L19V, E35D, M36I, R41K, K45R, L63V, G68GE, H69K, T74S, L89M, I93L	C
	IRL72441	IRL72441	JN623037	None		L10I, T12S, I15V, L19I, M36I, R41K, D60E, Q61N, L63T, C67S, H69K, T74A, L89M, I93L	C
Hingankar (2012)	IN-NARI-4-048	IN-NARI-4-048	JN314934	None		L10I, T12S, I15V, G16E, L19I, M36I, L63T, H69K, I72IV, I93L	C
	IN-NARI-4-071	IN-NARI-4-071	JN314952	None		L10I, T12P, L19I, M36V, R41K, D60E, L63P, C67D, H69K, L89M, I93L	C
Iweriebor (2012)	07M20ZA	07M20ZA	GU201815	None		L10I, L19V, M36I, R41K, L63S, H69K, I93L	C
Musyoki (2012)	DGM.1	DGM.1	JN176286	None		L10I, T12S, I15V, L19V, M36I, R41K, Q61E, L63V, H69K, L89M, I93L	C
	DGM.16	DGM.16	JN176295	None		L10I, T12S, I15V, G16E, L19I, M36I, R41K, D60E, L63T, H69K, L89M, I93L	C
Nwobegahay (2012)	BBCRO1ZA	BBCRO1ZA	GU177466	None		L10I, T12S, I15V, L19V, E35D, M36I, R41K, K45R, D60E, I62V, H69N, V82I, L89M, I93L	C
Ssemwanga (2012)	6441HR	6441HR	JF800206	None	V11I	L10I, I15V, L19I, M36I, N37D, R41K, L63V, H69K, I93L	C
Telan (2012)	11063743	11063743	AB747463	None		L10I, I15V, L19I, M36I, R41K, L63S, C67S, H69K, L89M, I93L, C95S	C
Alencar (2013)	RJ2-0001	RJ2-0001	JQ237932	None		L10I, N37K, R41N, L63A, I64M, H69K, I93L	C
Frentz (2013)	EHR-87037	EHR-87037	JX301014	None		L10I, I13V, K14R, I15V, G16GE, L19LI, K20R, T26S, M36I, R41K, Q61QE, H69K, V82I, L89M, I93L	C

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