<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10I
Rx PI-naive
IncludeMixtures No
References 58
Patients 156
Isolates 156
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Hierholzer (2002)SU227SU227AY102497None   L10I, M36I, R41K, L63I, H69Q, L89M, I93LC
Kantor (2002)TCDD-10TCDD-10 None   L10I, T12S, G17D, L19I, M36L, N37S, D60E, L63T, H69K, L89M, I93LC
Brindeiro (2003)BRP2151BRP2151AY213457None   L10I, I15V, M36I, N37K, R41I, H69K, L89M, I93LC
 BRSC1812BRSC1812AY213508None   L10I, G17E, M36I, N37K, R41N, H69K, L89MC
 BRSP1501BRSP1501AY213239None   L10I, G17GW, L19P, K20E, M36I, N37K, R41N, L63I, H69K, L89M, I93LC
 BRP2097BRP2097AY213360None   L10I, E34G, G40R, H69K, L89M, I93LC
 BRP2105BRP2105AY213376None   L10I, I15V, G16A, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2143BRP2143AY213445None   L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2141BRP2141AY213441None   L10I, I15V, L19S, N37K, R41N, L63P, H69K, K70R, I93LC
 BRP2120BRP2120AY213403None   L10I, A71VC
 BRP2104BRP2104AY213374None   L10I, I15V, L19I, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2102BRP2102AY213370None   L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2100BRP2100AY213366None   L10I, I15V, G16E, E21G, M36I, N37K, R41N, H69K, I93LC
 BRP2150BRP2150AY213455None   L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2142BRP2142AY213443None   L10I, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2121BRP2121AY213405None   L10I, I13V, I15V, M36I, N37K, R41N, H69K, L89M, I93LC
Gordon (2003)ZA044p01ZA044p01AY136997None   L10I, L19V, M36I, P39S, R41K, L63P, H69K, L89M, I93LC
Soares (2003)BRP2022BRP2022AF527205None   L10I, M36T, N37K, R41N, H69K, L89M, I93LC
 BRP2024BRP2024AF527207None   L10I, K20R, M36I, N37K, R41N, L63T, H69K, L89MC
 BRP2026BRP2026AF527211None   L10I, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2039BRP2039AF527230None   L10I, I13V, I15V, M36I, N37K, R41N, D60E, H69K, L89M, I93LC
 BRP2044BRP2044AF527240None   L10I, M36I, N37K, R41N, H69K, L89M, I93LC
 BRP2045BRP2045AF527242None   L10I, N37K, R41N, H69K, L89M, I93LC
 BRP2053BRP2053AF527256None   L10I, N37K, R41N, H69K, N88K, I93LC
 BRRJ845BRRJ845AF527340None   L10I, I15V, E34G, E35D, M36I, N37K, R41N, H69K, L89M, I93LC
Deshpande (2004)in31in31AY515752None   L10I, T12S, K14R, I15V, L19T, M36V, P39Q, R41K, L63P, H69K, L89M, I93LC
Arroyo (2005)CO6770CO6770AY734554None   L10I, I15V, M36I, N37K, R41N, K45R, C67S, H69K, L89M, I93LC
Bellocchi (2005)146MC146GU199536None   L10I, I15V, L19I, K20R, M36I, R41K, C67D, H69K, V77I, L89M, I93LC
Bussmann (2005)01BW2210N01BW2210NAY829309None   L10I, T12S, I15V, L19I, M36I, R41K, R57K, I62V, L63G, H69K, A71T, L89M, I93LC
Grossman (2005)1830318303PR217 None   L10I, K20KR, M36I, R41K, L63X, H69Q, L89M, I93LC
 2391723917PR328 None   L10I, L19I, M36I, R41K, Q61Q*, H69K, L89M, I93LC
 2750327503PR449 None   L10I, I13V, M36I, R41K, D60E, L63T, H69K, L89MC
Non-B Workgroup (2005)BR1001BR1001AY900898None   L10I, M36T, N37K, R41N, H69K, L89M, I93LC
 BR1002BR1002AY900899None   L10I, K20R, M36I, N37K, R41N, L63T, H69K, L89MC
 BR1003BR1003AY900900None   L10I, M36I, N37K, R41N, H69K, L89M, I93LC
 BR1008BR1008AY900904None   L10I, I13V, I15V, M36I, N37K, R41N, D60E, H69K, L89M, I93LC
 BR1009BR1009AY900905None   L10I, M36I, N37K, R41N, H69K, L89M, I93LC
 BR1010BR1010 None   L10I, N37K, R41N, H69K, L89M, I93LC
 BR1013BR1013AY900907None   L10I, N37K, R41N, H69K, N88K, I93LC
 BR1026BR1026AY900917None   L10I, I15V, G16E, E21G, M36I, N37K, R41N, H69K, I93LC
Rousseau (2006)Pt6303PS119MB1DQ351238None   L10I, E35D, M36I, R41K, L63Q, H69K, L89MC
Santos (2006)097097PR_RTAY275757None   L10I, T12P, I13V, K14R, I15V, K20R, M36I, N37K, R41N, H69K, L89M, I93LC
 C077PRC077PRDQ191013None   L10I, M36T, N37K, R41N, L63P, H69K, L89M, I93LC
Gatanaga (2007)C04-51110164-1C04-51110164-1AB640264None   L10I, K14R, I15V, L19I, E35D, M36IV, R41K, L63P, C67E, H69K, V82I, L89M, I93LC
McGrath (2007)7DMG_7 None   L10I, I13V, G16GE, L19T, K20R, M36I, R41K, L63AITV, I64IM, E65D, H69K, L89M, I93LC
Novitsky (2007)16461646_3858EF026222None   L10I, T12S, I15V, L19I, M36I, R41K, D60E, Q61E, L63PS, I64IL, H69K, L89M, I93LC
 18981898_4401EF026226None   L10I, T12S, I13V, I15V, L19I, M36I, R41K, I62V, L63V, H69K, A71T, L89M, I93LC
Vidal (2007)U012702BU.U0127AM260221None   L10I, I15V, G16E, M36I, N37K, R41N, H69K, L89M, I93LC
Deho (2008)145145EU244686None   L10I, T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93LC
Ferreira (2008)448BR05PR448EU340722None   L10I, I15V, L19I, M36L, N37R, R41N, H69K, L89M, I93LC
Lahuerta (2008)P63745P63745_99EF407733None   L10I, K14R, I15V, L19I, M36I, R41K, H69K, L89M, I93LC
Marconi (2008)SW024sw024EU308037None   L10I, T12S, I15V, L19V, M36I, R41N, D60E, I62V, L63R, H69K, L89M, I93LC
 SW053sw053EU308064None   L10I, L19V, M36I, R41K, H69K, T74S, L89M, I93LC
Matthews (2008)J120MJ120MFJ199576None   L10I, I15V, L19V, M36I, R41K, L63S, H69K, L89M, I93LC
 PS401PS401FJ199808None   L10I, T12S, I15V, L19V, E35D, M36I, R41K, H69K, L89M, I93LC
Pillay (2008)DR41DR41AY589896None   L10I, T12S, I15V, M36I, R41K, Q61E, L63V, H69K, L89M, I93LC
 DR66DR66AY589915None   L10I, T12S, I15V, L19I, M36I, R41K, D60E, H69K, L89M, I93LC
Hosseinipour (2009)94029402GQ228241None   L10I, T12S, I15V, L19I, M36I, R41K, R57K, Q61E, I62V, L63V, E65D, H69K, T74A, L89MC
 93009300GQ228251None   L10I, K14N, I15V, L19I, M36I, L63T, H69K, I93LC
 93269326GQ228256None   L10I, K14R, I15V, L19I, M36I, R41K, L63V, H69K, T74A, L76L*, L89M, I93LC
Kandathil (2009)CD06_484CD06_484EU683783None   L10I, T12S, I15V, L19I, M36I, N37X, R41K, I62V, L63P, I64L, H69K, V82I, L89M, I93LC
 CD06_420CD06_420EU683772None   L10I, T12S, I15V, L19I, M36I, R41K, K45Q, L63T, I72T, I93LC
Rajesh (2009)N7TRCNPR7FJ595370None   L10I, T12S, I13V, K14R, I15V, L19I, M36I, R41K, L63A, H69K, L89MC
Vercauteren (2009)pt342IqebD7pmBrGQ400682None   L10I, T12S, I15V, L19I, M36I, N37S, R41K, L63T, H69Q, L89M, I93LC
Wallis (2009)GT00032651GT00032651 None   L10I, T12S, K14I, I15V, L19IK, K20R, M36I, R41K, D60E, Q61QE, I62V, L63LI, H69K, T74A, L89M, I93LC
 GT00103258GT00103258 None   L10I, T12S, I15V, L19I, M36I, R41K, L63T, C67Y, H69K, T74S, L89MC
Hattori (2010)F08-20081181F08-20081181AB866474None   L10I, T12S, K14R, I15V, L19I, M36I, N37D, R41K, I62V, L63T, C67D, H69R, L89M, I93LC
 F08-20081215F08-20081215AB866476None   L10I, T12S, K14R, I15V, L19I, N37S, R41K, I62V, L63T, C67D, H69R, L89M, I93LC
Mosha (2010)S33PolS33PolJQ071476None   L10I, I15V, M36L, N37K, R41N, L63P, H69K, I93LC
Wright (2010)308SK308HM593312None   L10I, T12S, I15V, G16E, L19I, E35D, M36I, R41K, L63Q, H69K, L89M, I93LC
 96SK96HM593507None   L10I, L19V, M36I, P39PS, R41K, H69K, L89M, I93LC
de Medeiros (2011)Pat085RS156JF487914None   L10I, I15V, L19Q, M36I, N37R, R41N, H69K, L89M, I93LC
Graf (2011)SC22SC22JF773996None   L10I, M36I, N37K, R41N, H69K, L89M, I93LC
 SC38SC38JF774005None   L10I, I15V, M36T, N37K, R41N, L63T, C67G, H69K, L89I, I93LC
 SC126SC126JF774050None   L10I, K14R, I15V, K20R, M36I, N37K, R41N, K45R, L63T, C67E, H69K, L89M, I93LC
Hamers (2011)300060CP076300060HM119649None   L10I, I15V, L19T, K20R, M36I, R41K, L63T, H69K, L89M, I93LC
 300127CP076300127HM119704None   L10I, T12S, I15V, L19I, R41K, K45R, L63P, H69Q, V77I, L89M, I93LC
 300228CP076300228HM119794None   L10I, T12S, I15V, L19I, E35D, M36I, N37T, R41K, H69K, L89M, I93LC
 300451CP076300451HM119872None   L10I, T12S, I15V, L19I, M36I, R41K, I62IV, L63H, H69K, L89IC
 300462CP076300462HM119883None   L10I, I15V, M36I, R41K, L63V, C67S, H69K, L89M, I93LC
 300479CP076300479HM119898None   L10I, I15V, L19T, M36I, N37K, R41N, L63T, H69K, I93LC
 300539CP076300539HM119953None   L10I, I15V, L19T, E35D, M36L, R41K, K45R, D60E, I62IV, H69Q, V77VI, L89M, I93LC
 300552CP076300552HM119962None   L10I, T12S, I15V, G16E, L19V, E35D, M36I, R41K, L63T, H69Q, L89M, I93LC
 CP076303237CP076303237HQ994236None   I3V, L10I, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
 CP076300309CP076300309HQ994357None   L10I, T12S, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93LC
 CP076300337CP076300337HQ994373None  V11IL10I, I15V, L19I, K20R, E35Q, M36I, N37D, R41K, R57K, L63X, H69K, L89M, I93LC
 CP076301432CP076301432HQ994409None   L10I, T12S, L19I, M36I, R41K, Q61N, L63V, E65D, H69K, L89M, I93LC
 CP076300906CP076300906HQ994534None   L10I, T12S, I15V, G16E, L19V, M36I, R41K, L63T, H69K, I93LC
 CP076300933CP076300933HQ994549None   L10I, T12S, I15V, G16E, L19I, M36I, R41K, L63IV, H69K, L89M, I93LC
 CP076302682CP076302682HQ994821None   L10I, T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93LC
 CP076302687CP076302687HQ994826None   I3V, L10I, I15V, L19I, M36I, N37NS, R41K, D60E, H69K, L89M, I93LC
 CP763A01781CP763A01781HQ994877None   L10I, I15V, L19I, M36I, R41K, L63S, H69K, L89M, I93LC
 CP076303066CP076303066HQ995246None   L10I, T12S, I15V, G16E, L19I, M36I, R41K, L63T, H69K, I93LC
Manasa (2011)10028711002871JN664997None   L10I, T12S, L19V, M36I, R41K, Q61H, L63S, H69K, L89M, I93LC
Nwobegahay (2011)BBVCT05ZABBVCT05ZAGU139621None   L10I, T12S, I15V, L19I, M36I, R41K, L63S, H69K, K70R, I72T, I93LC
Nwobegahay (2011)08MB18ZA08MB18ZAGU188814None  L33FT4A, L5F, Q7K, R8E, L10I, T12P, I15V, L19I, K20R, A22G, L24F, T31S, M36I, L38F, R41K, K43E, K55N, V56K, R57G, L63P, H69K, V77I, I93LC
 08MB41ZA08MB41ZAGU188824None   L10I, I15V, L19T, M36I, R41K, L63T, H69K, I93LC
 08MB49ZA08MB49ZAGU188831None   L10I, T12S, I15V, L19V, E35D, M36I, R41K, L63T, E65D, H69K, L89M, I93LC
 08MB50ZA08MB50ZAGU188832None   L10I, T12S, I15V, L19T, M36L, N37S, R41K, L63V, H69K, L89MC
 08MB74ZA08MB74ZAGU188849None   L10I, T12S, I15V, L19V, E35D, M36I, R41K, K45R, D60E, I62V, L63V, H69Q, L89M, I93LC
Sanabani (2011)BR2040BR2040JN692442None   L10I, I15V, L19I, M36T, N37K, R41N, L63T, C67G, H69K, L89I, I93LC
Santos (2011)J124J124_PRJN010500None   L10I, V11A, I15V, G16E, M36I, N37K, R41N, L63V, H69K, L89M, I93LC
 J335J335_PR_RT_CNJN010712None   L10I, I13V, I15V, E35ED, N37K, R41I, D60E, H69K, T74TA, L89M, I93LC
Sigaloff (2011)GP25416072GP25416072_2JN381562None   L10I, T12S, I15V, L19T, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
Thorat (2011)Pat011IN-NARI-HIVDR-5-011HQ166849None   L10I, T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LC
van Zyl (2011)A216A216JN638127None   L10I, T12S, I15V, L19I, M36I, R41K, L63V, H69K, T74S, L89M, I93LC
De Gascun (2012)IRL40593IRL40593JN622886None   W6WL, L10I, V11VF, T12S, I15V, L19I, E35ED, M36MI, N37NS, R41K, L63I, H69K, V82I, L89M, I93LC
 IRL04107IRL04107JN622983None   L10I, I15V, L19V, E35D, M36I, R41K, K45R, L63V, G68GE, H69K, T74S, L89M, I93LC
 IRL72441IRL72441JN623037None   L10I, T12S, I15V, L19I, M36I, R41K, D60E, Q61N, L63T, C67S, H69K, T74A, L89M, I93LC
Hingankar (2012)IN-NARI-4-048IN-NARI-4-048JN314934None   L10I, T12S, I15V, G16E, L19I, M36I, L63T, H69K, I72IV, I93LC
 IN-NARI-4-071IN-NARI-4-071JN314952None   L10I, T12P, L19I, M36V, R41K, D60E, L63P, C67D, H69K, L89M, I93LC
Hunt (2012)KZN08_330956KZN08_330956KF736687None   L10I, K14R, I15V, L19I, M36I, R41K, L63V, H69K, I93LC
 GP07_225683GP07_225683KF736605None   L10I, T12S, I15V, G16E, L19I, E35D, M36T, R41K, L63T, H69K, L89M, I93LC
 GP06_193039GP06_193039KF736553None   L10I, E35D, P39Q, R41K, Q61N, L63AV, H69K, A71T, I93LC
 GP06_192768GP06_192768KF736552None   L10I, I15V, L19I, M36I, R41K, D60E, H69K, L89M, I93LC
 GP07_218072GP07_218072KF736581None   L10I, T12S, K14R, L19IV, M36I, R41K, K45R, G51G*, L63V, H69K, T74S, L89M, I93LC
 GP09_1178GP09_1178KF736730None   L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63A, H69K, L89M, I93LC
Iweriebor (2012)07M20ZA07M20ZAGU201815None   L10I, L19V, M36I, R41K, L63S, H69K, I93LC
Musyoki (2012)DGM.1DGM.1JN176286None   L10I, T12S, I15V, L19V, M36I, R41K, Q61E, L63V, H69K, L89M, I93LC
 DGM.16DGM.16JN176295None   L10I, T12S, I15V, G16E, L19I, M36I, R41K, D60E, L63T, H69K, L89M, I93LC
Nwobegahay (2012)BBCRO1ZABBCRO1ZAGU177466None   L10I, T12S, I15V, L19V, E35D, M36I, R41K, K45R, D60E, I62V, H69N, V82I, L89M, I93LC
Ssemwanga (2012)6441HR6441HRJF800206None  V11IL10I, I15V, L19I, M36I, N37D, R41K, L63V, H69K, I93LC
Alencar (2013)RJ2-0001RJ2-0001JQ237932None   L10I, N37K, R41N, L63A, I64M, H69K, I93LC
Bila (2013)MzNat117HIV-1KF927375None   L10I, R41K, H69K, L89MC
 MZ09-052HIV-1KF927207None   L10I, T12S, I15V, L19V, K20R, M36I, P39Q, R41K, K45R, H69K, L89M, I93LC
 MzPra25HIV-1KF927373None   L10I, I15V, L19M, K20R, M36I, R41K, H69K, L89M, I93LC
Frentz (2013)EHR-87037EHR-87037JX301014None   L10I, I13V, K14R, I15V, G16GE, L19LI, K20R, T26S, M36I, R41K, Q61QE, H69K, V82I, L89M, I93LC
Hoffmann (2013)399048_1399048_1KJ081319None   L10I, L19T, M36I, H69K, L89M, I93LC
 480206480206KJ081336None   L10I, G16E, L19I, N37T, R41K, D60E, Q61E, L63T, H69K, L89M, I93LC
 194437_1194437_1KJ081297None   L10I, T12S, I15V, L19T, M36I, R41K, D60E, L63S, H69K, I72IV, L89M, I93LC
 1960519605KJ081298None   L10I, I13V, I15V, M36I, N37D, R41K, D60DE, Q61E, L63T, I64IM, E65D, H69K, L89M, I93L, N98IC
 461994_2461994_2KJ081331None   L10I, L19T, M36I, H69K, L89M, I93LC
Mulu (2013)ETH-G-5669ETH-G-5669KF026153None   L10I, I13V, I15V, L19I, M36I, R41K, I64M, H69K, L89M, I93LC
 ETH-G-5573ETH-G-5573KF026121None   L10I, T12A, I15V, L19I, E35D, M36I, R41K, V56VL, L63Q, H69Q, L89M, I93LC
 ETH-G-5532ETH-G-5532KF026097None   L10I, T12S, I15V, L19T, M36I, L63P, I64L, H69K, L89M, I93LC
Rusine (2013)764H764HKC841774None   L10I, I15V, G16E, E35D, M36I, R41K, L63T, H69K, I93LC
Sunpath (2013)CAS070CAS070 None   L10I, T12S, I15V, L19V, M36I, R41K, L63V, L89M, I93LC
 CAS071CAS071 None   L10I, T12S, I15V, L19IV, E35D, M36I, R41K, K45R, L63T, H69K, T74S, L89M, I93LC
 CAS056CAS056 None   L10I, I15V, L19I, E35D, M36I, R41K, H69K, T74S, L89M, I93LC
Telan (2013)1106374311063743AB747463None   L10I, I15V, L19I, M36I, R41K, L63S, C67S, H69K, L89M, I93L, C95SC
Van Zyl (2013)476102KC422810None   L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, Q61E, L63I, H69K, T74K, L89M, I93LC
 9092082KC423606None   L10I, G16E, L19V, E35D, N37S, R41K, H69K, L89M, I93LC
 408618KC424180None   L10I, L19V, L23LF, N37S, R41K, H69K, L89M, I93LC
 18082658KC423766None   L10I, T12S, K14R, I15V, L19I, K20R, E35D, M36I, N37D, R41K, R57RK, H69K, L89M, I93LC
 22965KC423909None   L10I, I13V, G16E, L19I, M36I, R41K, L63H, H69Q, I93LC
 31516KC423261None   L10I, L19I, M36I, R41K, H69K, L89M, I93LC
 14692159KC423657None   L10I, T12S, I15V, L19I, E35G, M36I, R41K, D60E, Q61E, L63T, H69K, T74A, L89M, I93LC
 2561339KC423072None   L10I, L19T, K20R, M36I, R41K, L63S, E65D, H69K, L89M, I93LC
 938928KC424370None   L10I, T12S, I15V, L19I, E35D, M36I, R41K, K45R, L63T, H69Q, L89M, I93LC
 14402054KC423590None   L10I, I15V, L19I, M36I, R41K, H69K, L89M, I93LC
 17872204KC423681None   L10I, T12S, I15V, L19T, M36I, R41K, L63P, H69K, P79D, I93LC
 109380KC424025None   L10I, L19I, M36L, R41K, L63P, H69K, I93LC
 1292752KC424266None   L10I, T12S, I13V, K14R, I15V, L19I, M36I, R41K, L63P, H69Q, L89M, I93LC
 9701368KC423097None   L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, H69Q, L89M, I93LC
 15201877KC423477None   L10I, T12S, I15V, L19V, E35D, M36I, R41K, H69K, T74S, L89M, I93LC
 13011722KC423354None  Q58EL10I, T12S, K14I, I15V, L19R, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, V77I, I93LC